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Long-term potentiation in autonomic ganglia:Potential role in cardiovascular disorders
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作者 Karim A Alkadhi 《World Journal of Pharmacology》 2016年第2期51-58,共8页
Ganglionic long-term potentiation(gLTP) is an activitydependent,enduring enhancement of ganglionic transmission.This phenomenon may be induced in autonomic ganglia of an organism under certain conditions whererepetiti... Ganglionic long-term potentiation(gLTP) is an activitydependent,enduring enhancement of ganglionic transmission.This phenomenon may be induced in autonomic ganglia of an organism under certain conditions whererepetitive impulses surge from the central nervous system(CNS) to the periphery.Chronic stress,repetitive epileptic seizure or chronic use of CNS stimulants could induce gL TP,which would result in a long lasting heightening of sympathetic tone to the cardiovascular system causing hypertension and disturbed cardiac rhythm that may lead to sudden cardiac death.These conditions are briefly reviewed in this article. 展开更多
关键词 ELECTROPHYSIOLOGY EPILEPSY Ganglionic longterm potentiation Sudden unexpected death in epilepsy central nervous system stimulants Sudden cardiac death
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