Permanent loss of vital functions after central nervous system （CNS） injury, e.g., blindness in traumatic optic nerve （ON） injury or paralysis in spinal cord injury, occurs in part because axons in the adult mamma...Permanent loss of vital functions after central nervous system （CNS） injury, e.g., blindness in traumatic optic nerve （ON） injury or paralysis in spinal cord injury, occurs in part because axons in the adult mammalian CNS do not regenerate after injury. Growth failure is due to the diminished intrinsic regenerative capacity of mature neurons and the inhibitory environment of the adult CNS. Neutralizing extracellular inhibitory molecules genetically or pharmacologically yields only limited regeneration and functional recovery, highlighting the critical importance of neuron-intrinsic factors.展开更多
Scientists conclude that a combination of treatments involving rehabilitation,drug delivery,surgery and cell transplantation are necessary to achieve significant progress in regenerating the injured central nervous sy...Scientists conclude that a combination of treatments involving rehabilitation,drug delivery,surgery and cell transplantation are necessary to achieve significant progress in regenerating the injured central nervous system（CNS）.展开更多
基金supported by grants from National Eye Institute,Bright Focus Foundation and Shriners Hospital for Children
文摘Permanent loss of vital functions after central nervous system （CNS） injury, e.g., blindness in traumatic optic nerve （ON） injury or paralysis in spinal cord injury, occurs in part because axons in the adult mammalian CNS do not regenerate after injury. Growth failure is due to the diminished intrinsic regenerative capacity of mature neurons and the inhibitory environment of the adult CNS. Neutralizing extracellular inhibitory molecules genetically or pharmacologically yields only limited regeneration and functional recovery, highlighting the critical importance of neuron-intrinsic factors.
文摘Scientists conclude that a combination of treatments involving rehabilitation,drug delivery,surgery and cell transplantation are necessary to achieve significant progress in regenerating the injured central nervous system（CNS）.
