Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregna...Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective medication.In this study,extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri,Rhizoma Coptidis,Olibanum,Myrrha,borneol and catechu were formulated to facilitate intravaginal administration and improve efficacy.An extract of the first four components was formulated with borneol as a thermosensitive gel(TG)while an extract of catechu used to prepare a regular gel(CG)because of a chemical incompatibility.The optimized TG was prepared using poloxamer 407 and poloxamer 188.The CG was prepared using glycerin,carbopol and triethanolamine.The gels were characterized in vitro in terms of release of berberine(TG)and total catechins(CG)and in vivo in a rat model of cervical erosion.Trea tment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal tissues.Gel formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion.展开更多
目的:观察不同腧穴配伍对颈型颈椎病患者体表肌电即时效应的影响,探讨腧穴配伍之间的相互作用及规律。方法:90例颈型颈椎病患者前后进行3种不同腧穴配伍的针刺,远部取穴组(A组:昆仑、后溪);近部取穴组(B组:风池、天柱);远近取穴组(C组:...目的:观察不同腧穴配伍对颈型颈椎病患者体表肌电即时效应的影响,探讨腧穴配伍之间的相互作用及规律。方法:90例颈型颈椎病患者前后进行3种不同腧穴配伍的针刺,远部取穴组(A组:昆仑、后溪);近部取穴组(B组:风池、天柱);远近取穴组(C组:昆仑、后溪、风池、天柱),采用自身前后对照,观察针刺前后体表肌电(Surface Electromyography,SEMG)平均振幅值,测量肌电积分(Integrated Electromyography,IEMG)及肌电均方根(Root Mean Square,RMS)均值,计算肌电振幅变化率,组内比较不同腧穴配伍针刺前后对体表肌电即时效应影响的差异,组间比较各组针刺后差异。结果:组内针刺前后比较,A、B、C组的肌电平均振幅值、肌电振幅变化率、IEMG、RMS差异有统计学意义(P<0.05)。组间针刺后比较,A、B、C组针刺后肌电平均振幅值、肌电振幅变化率、IEMG、RMS都有不同程度的改变,但无显著性差异(P>0.05)。结论:不同腧穴配伍的针刺治疗均可以明显改善颈部前屈的耐疲劳性;针刺对颈型颈椎病的治疗作用与取穴数目的多少无关,并不能简单地认为腧穴配伍越多,疗效就会越好。展开更多
基金This study was supported as a Key Project by the Bureau of Zhejiang Traditional Chinese Medicine,China(No.2008ZA010).
文摘Cervical eropion,a pathological change associated with chronic cervicitis,is a common condition that is difficult to cure.M any pa tients particularly those with mild or medium infection and those preparing for pregnancy require a simple but effective medication.In this study,extracts of an empirical herbal prescription composed of six Chinese traditional drugs viz Cortex Phellodendri,Rhizoma Coptidis,Olibanum,Myrrha,borneol and catechu were formulated to facilitate intravaginal administration and improve efficacy.An extract of the first four components was formulated with borneol as a thermosensitive gel(TG)while an extract of catechu used to prepare a regular gel(CG)because of a chemical incompatibility.The optimized TG was prepared using poloxamer 407 and poloxamer 188.The CG was prepared using glycerin,carbopol and triethanolamine.The gels were characterized in vitro in terms of release of berberine(TG)and total catechins(CG)and in vivo in a rat model of cervical erosion.Trea tment by once daily application of the TG for 7 days followed by once daily application of the CG for 3 days produced a restoration of normal tissues.Gel formulation of the empirical Chinese traditional remedy appears to provide a promising treatment for cervical erosion.
文摘目的:观察不同腧穴配伍对颈型颈椎病患者体表肌电即时效应的影响,探讨腧穴配伍之间的相互作用及规律。方法:90例颈型颈椎病患者前后进行3种不同腧穴配伍的针刺,远部取穴组(A组:昆仑、后溪);近部取穴组(B组:风池、天柱);远近取穴组(C组:昆仑、后溪、风池、天柱),采用自身前后对照,观察针刺前后体表肌电(Surface Electromyography,SEMG)平均振幅值,测量肌电积分(Integrated Electromyography,IEMG)及肌电均方根(Root Mean Square,RMS)均值,计算肌电振幅变化率,组内比较不同腧穴配伍针刺前后对体表肌电即时效应影响的差异,组间比较各组针刺后差异。结果:组内针刺前后比较,A、B、C组的肌电平均振幅值、肌电振幅变化率、IEMG、RMS差异有统计学意义(P<0.05)。组间针刺后比较,A、B、C组针刺后肌电平均振幅值、肌电振幅变化率、IEMG、RMS都有不同程度的改变,但无显著性差异(P>0.05)。结论:不同腧穴配伍的针刺治疗均可以明显改善颈部前屈的耐疲劳性;针刺对颈型颈椎病的治疗作用与取穴数目的多少无关,并不能简单地认为腧穴配伍越多,疗效就会越好。
