超声E-cervix弹性成像参数与妊娠期高血压孕晚期分娩方式的关系

目的分析超声E-cervix弹性成像参数与妊娠期高血压孕晚期分娩方式的关系。方法纳入进行产检的孕晚期妊娠期高血压孕产妇100例,所有孕产妇均实施超声E-cervix弹性成像参数检查,所有孕产妇均随访至最终分娩,统计所有孕产妇的分娩方式并依据分娩方式分为2组(自然分娩及剖宫产),分析超声超声E-cervix弹性成像参数对妊娠期高血压孕晚期分娩方式选择的影响。结果经随访统计,100例妊娠期高血压孕晚期孕产妇自然分娩共63例,占比63.00%;剖宫产共37例,占37.00%;自然分娩组弹性对比指数(elasticity contrast index,ECI)、宫颈外口应变(external os strain,EOS)值均大于剖宫产组,硬度比值(hardness ratio,HR)、宫颈长度(cervical length,CL)、宫颈内口应变(internal os strain,IOS)、宫颈内外口应变比值(IOS/EOS)值小于剖宫产组,差异有统计学意义(P<0.05);经点二列相关性证实,超声E-cervix弹性成像参数与妊娠期高血压孕晚期分娩方式间的关系呈正相关(P<0.05)。结论超声E-cervix弹性成像参数可评价宫颈组织变化情况,或可作为评价宫颈成熟度的半定量指标,对妊娠期高血压孕晚期分娩方式的选择具有一定的指导意义。

E-Cervix弹性成像评估不同分娩史孕妇妊娠期宫颈组织差异的研究

目的探讨不同分娩方式生育史孕妇宫颈E-Cervix参数随孕周的变化规律,以及不同分娩方式对再次妊娠时的宫颈软硬度和长度的影响。方法前瞻性收集2022年6月—2023年6月在我院定期产检的单胎妊娠孕妇,分别于11~14周、20~24周、28~32周经阴道超声测量孕妇宫颈的E-Cervix弹性参数。根据既往有无生育史及分娩方式,将研究对象分为初产妇组(A组)、经产妇无剖宫产史组(B组)和经产妇合并剖宫产史组(C组)。采用Friedman检验比较各组孕妇3个孕周段各宫颈参数值的差异,Mann-Whitney U检验比较初产妇与经产妇无剖宫产史及经产妇合并剖宫产史的宫颈各参数值差异。结果共纳入191例孕妇,其中A组101例,B组49例,C组41例。A组宫颈弹性值3个孕周段的差异均具有统计学意义(P<0.05);B组除应变比值(Ratio)外,余宫颈弹性值在3个孕周段的差异均具有统计学意义(P<0.05);C组除弹性对比指数(ECI)及Ratio外,余宫颈弹性值在3个孕周段的差异均具有统计学意义(P<0.05)。随着孕周段的增加,3组硬度比值(HR)逐渐减小,宫颈内口平均应变值(IOS)、宫颈外口平均应变值(EOS)逐渐增大。A组3个孕周段宫颈长度(CL)值中位数分别为3.36、3.51、3.49(P<0.05);B组3个孕周段CL值中位数分别为3.27、3.58、3.50(P<0.05);C组3个孕周段CL值中位数分别为3.38、3.73、3.63(P=0.057)。3组孕妇宫颈长度呈现出先增长再缩短的发展趋势。中孕期A组ECI值中位数小于B组(2.34比2.63),HR值中位数大于B组(89.81%比87.20%),CL值中位数小于C组(3.51比3.73),且差异均有统计学意义(P=0.008、P=0.024、P=0.034)。早孕期及晚孕期各项宫颈参数值在A组与B组及A组与C组间的差异均无明显统计学意义(P>0.05)。结论E-Cervix技术客观地反映出不同分娩方式生育史孕妇妊娠期宫颈组织随孕周增加均产生一系列生理变化。不同分娩方式会影响再次妊娠时的宫颈弹性和宫颈长度的变化,中孕期经产妇无剖宫产史孕妇宫颈组织较初产妇软且均质性差,经产妇合并剖宫产史孕妇宫颈长度明显长于初产妇。

经阴道超声E-cervix技术对中孕期妇女自发性早产的预测价值

目的探讨应用经阴道超声宫颈弹性成像(E-Cervix)技术预测中孕期妇女自发性早产的价值。方法选取2022年1月至2023年3月在江西省妇幼保健院进行产检的225例孕产妇为研究对象。根据是否孕足月将其划分为早产组(n=105)和足月产组(n=120),回顾性分析2组临床资料和超声检查参数[宫颈长度(CL)、宫颈弹性成像]。运用多元逻辑回归分析影响自发性早产发生的相关因素,应用受试者工作特征曲线(ROC)评估妊娠中期CL及宫颈弹性值预测自发性早产的效能。结果双胎(Z=9.909,P=0.002)和宫颈机能不全(Z=14.189,P<0.001)是早产的危险因素。妊娠中期CL越短(t=2.312,P=0.022),硬度比值(t=6.189,P<0.001)越小,弹性对比指数(t=-3.002,P=0.003)、宫颈内口(t=-4.890,P<0.001)应变值、宫颈外口应变值(t=-5.787,P<0.001)越大,早产发生的风险越高。ROC分析结果显示,宫颈内口应变值(AUC=0.689)、宫颈外口应变值(AUC=0.612)、弹性对比指数(AUC=0.718),各指标联合诊断较单一指标具有更高的预测早产的价值(AUC=0.764)。结论应用E-Cervix技术能够有效地预测中孕期孕妇自发性早产的可能性。

E-Cervix imaging displaying cervical elasticity characteristics of healthy adult nulliparous women at different age groups and different menstrual cycle stages

Objective To observe the cervical elasticity of healthy adult nulliparous women at different age groups and different stages of menstrual cycle with E-Cervix imaging technology.Methods A total of 218 healthy adult nulliparous women who underwent transvaginal ultrasound examination for routine physical examination were retrospectively enrolled,including 103 in follicular phase,78 in ovulation phase and 37 in luteal phase.Cervical canal length(CL)and E-Cervix elasticity parameters were compared among different age groups and different stages of menstrual cycle,including elasticity contrast index(ECI),hardness ratio(HR),cervical internal and external orifice strain values(IOS and EOS)and IOS/EOS ratio.Results No significant difference of CL nor cervical elasticity parameters was detected among healthy adult nulliparous women at different age groups(all P>0.05).There were significant differences of ECI,HR and IOS among different menstrual cycle stages(all P<0.05),among which women in follicular phase had higher ECI and IOS but lower HR than those in luteal phase(all P<0.05).Conclusion No significant difference of cervical elasticity existed among healthy adult nulliparous women at different age groups.Meanwhile,cervical elasticity of healthy adult nulliparous women changed during menstrual cycle,in follicular phase had higher ECI and IOS but lower HR than in luteal phase.

E-Cervix超声弹性成像参数在足月妊娠引产中的应用价值

目的:探讨E-Cervix弹性成像参数预测足月妊娠引产宫颈反应的敏感性及与分娩活动期宫颈管扩张时间关系。方法:回顾性分析2021年5月-2022年1月在本院住院单胎足月妊娠拟引产的孕妇124例,按照引产期间宫口扩张时间分为敏感组(n=66)及不敏感组(n=58),采用E-Cervix技术检测孕妇引产前12h各弹性成像参数,评估各组宫颈成熟度评分(Bioshop);绘制受试者工作特征曲线(ROC)分析E-Cervix弹性成像各参数及Bioshop评分对宫颈反应敏感的预测价值;比较两组宫颈扩张时间;采用Pearson相关系数分析宫颈扩张时间与E-Cervix参数的相关性。结果:敏感组Bishop评分(3.26±0.56分)低于不敏感组(3.89±0.87分),E-Cervix弹性成像各参数均高于不敏感组(均P<0.05)。ROC曲线分析,E-Cervix弹性成像技术评估宫颈反应敏感的曲线下面积(0.869)高于Bishop评分(0.746),其敏感度87.4%,特异度82.7%;敏感组宫颈扩张时间(190.0±58.6min)短于不敏感组(226.8±57.6min)(均P<0.05)。Pearson相关性分析,宫颈扩张时间与E-Cervix弹性成像各参数均呈正相关(P<0.05)。结论:利用E-Cervix弹性成像能够有效预测宫颈反应敏感,且各参数与宫颈扩张时间成正相关。

Spilled gallstone mimicking metastasis from cervix cancer on positron emission tomography–computed tomography

BACKGROUND Spilled gallstones from previous cholecystectomy is not an uncommon situation.It may further mimic neoplastic disease and can be misled by fluorine 18 fluorodeoxyglucose position emission tomography with computed tomography([18F]FDG PET/CT).CASE SUMMARY A 63 year-old patient was diagnosed with a cancer of the cervix.Pretreatment[18F]FDG PET/CT showed a peritoneal lesion suspicious for metastasis.Surgical exploration and histologic examination revealed the lesion to be a spilled gallstone from a previous cholecystectomy.CONCLUSION[18F]FDG PET/CT carries pitfalls since benign conditions such as intraperitoneal gallstones may be confused as malignant lesions.This case highlights the importance to be aware of the possible implications of dropped gallstones for the future,minimize its occurrence,and make all efforts to properly evaluate cancer staging,particularly for the cervix cancer.

超声E-cervix宫颈弹性成像预测早产的临床价值

目的应用超声E-cervix宫颈弹性成像评估宫颈机能,分析其预测早产的临床价值。方法选取于我院建档并规律接受产检孕妇200例(妊娠组)和行孕前常规检查者100例(体检组),妊娠组根据生产情况再分为早产组31例和足月产组169例。各组均行超声E-cervix宫颈弹性成像检查,获取宫颈长度(CL)、弹性对比指数(ECI)、硬度比值(HR)、宫颈外口应变率(EOS)、宫颈内口应变率(IOS)及其比值(IOS/EOS)。比较早产组与足月产组、体检组与妊娠组各临床资料和弹性参数的差异;采用多因素Logistic回归分析早产的相关影响因素,绘制受试者工作特征(ROC)曲线分析各弹性参数单独及联合应用预测早产的效能。结果早产组宫颈手术史占比、ECI、IOS、IOS/EOS均高于足月产组,CL、HR均低于足月产组,差异均有统计学意义(均P<0.05)。妊娠组CL、IOS、IOS/EOS均高于体检组,HR低于体检组,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析表明,宫颈手术史、ECI、IOS、IOS/EOS是早产的相关危险因素,CL、HR是早产的相关保护因素(均P<0.05)。ROC曲线分析表明,CL、ECI、IOS、IOS/EOS、HR预测早产的曲线下面积分别为0.802、0.745、0.795、0.795、0.803,各参数联合应用的曲线下面积为0.928。结论应用超声E-cervix宫颈弹性成像评估宫颈机能可准确预测早产,其中ECI、IOS、IOS/EOS是早产的相关危险因素,CL、HR是早产的相关保护因素。

Anti Cervix Cancer Activity of Co-immobilized Tumor Necrosis Factor-α and Interferon-γ

Tumor necrosis factor α （TNF-α） and interferon-γ （IFN-γ） are cytokines with strong antitumor activities. They were reacted with a photoactive arylazide-4-azidobenzoic acid, resulting in photoactive TNF-α and IFN-γ. The infrared （IR） spectra of these products showed the characteristic absorption of an azido group at 2127 cm^-1. By photo-immobilization, this modified TNF-α and IFN-γ were immobilized on polystyrene membranes for cell culture to prepare biomaterials. The micro-morphology of photoactive cytokines was observed with a scanning electron microscope （SEM）. The inhibitory effect on growth of Hela cells and inducing apoptosis activity of these two cytokines were analyzed by growth curve, transmission electron microscope （TEM） and fluorescence active cell sorter （FACS）. The results showed that co-immobilization of IFN-γ and TNF-α had significant inhibitory effect on growth of Hela cells, inhibitory rate up to 82%, and IFN-γ had obviously synergistic action.

Primary malignant melanoma of uterine cervix: a suggestion of new scheme of treatment combination

Historically, the lack of melanocytes in the vaginal and cervical mucus membranes has deterred the findings of primary melanomas. Mainly due to its rarity, difficulty to diagnose, and poor prognosis, there has been no absolute agreement on comprehensive treatment so far. In this case report, we present a case of a 46-year-old woman with primary malignant melanoma of uterine cervix. She underwent neo-adjuvant chemotherapy initially followed by a radical hysterectomy. After adjuvant concurrent chemo-radiation, the patient has been followed up for 24 months. So far, she has not shown any symptoms or signs of recurrence. Further studies with more cases based on variable combinations of treatment regimen have been on the way.

Water Soluble C_(60)-Liposome and the Biological Effect of C_(60) to Human Cervix Cancer Cells

A preparative technique to obtain water soluble C_(60)-liposome by means of molecular package of C_(60) with lecithin has been established.The concentration of C_(60) presented in liposome is 1.09 x 10-4mol/dm3.The molecular system of C_(60)-liposome with human cervix cancer cells is irradiated with laser(570nm,800mW),there is obvious biological effect of C_(60) to huma cervix cancer cells.

E-Cervix技术对妊娠期宫颈硬度的评价

目的探讨E-Cervix技术对正常妊娠期及羊水增多孕妇宫颈硬度的评价,为临床评估宫颈预测早产提供参考依据。方法收集2020年1月-2021年5月期间,于大连市妇女儿童医疗中心(集团)体育新城院区产科门诊进行常规检查的20-37周的孕妇,最终纳入有效病例432例,其中单胎组354例、单胎羊水多组(后文均简称羊水多组)78例,应用E-Cervix技术测量单胎组及羊水多组宫颈长度(CL)及弹性参数:宫颈硬度比(HR)、宫颈内口应变平均值(IOS)、宫颈外口应变平均值(EOS)。总结各弹性指标随妊娠周数的变化规律及分析羊水增多对宫颈硬度变化的影响。结果①弹性参数及宫颈长度的组内和组间一致性良好。②正常妊娠单胎组孕妇宫颈弹性参数HR、CL随着孕周的增加呈下降趋势,IOS、EOS随着孕周的增加而增高。③羊水多组孕妇宫颈弹性参数HR、CL随着孕周的增加呈下降趋势,IOS、EOS随着孕周的增加而增高。羊水多组CL与同孕周单胎组比较,呈下降趋势。羊水多组的HR均低于同孕周单胎组,IOS、EOS均高于同孕周单胎组。④正常妊娠单胎组HR、IOS与孕周呈线性相关(HR:r=0.73,P<0.01,IOS:r=0.51,P<0.01),经线性回归分析得出回归方程,单胎组:HR=-0.9891×孕周+104,IOS=0.0068×孕周+0.0403。结论正常单胎妊娠孕妇随着孕周的增加,宫颈长度及宫颈弹性指标HR呈下降趋势,IOS、EOS随孕周逐渐增加。当出现羊水多时,宫颈硬度较同孕周单胎宫颈变软。E-Cervix技术可以为临床评估宫颈硬度提供量化指标。

Clinicopathological Features and Prognosis of Small Cell Carcinoma of the Cervix

Small cell carcinoma of cervix (SCCC) is a rare disease with highly aggressive behaviour and is pathologically hard to diagnose.In this study, the clinicopathological features, diagnosis, treatment and prognosis of the condition were examined.Clinical records and follow-up data of 7 cases of SCCC were retrospectively studied.Our results showed that five non-recurrent cases initially presented irregular vaginal bleeding or increased apocenosis of varying degrees.Pathological examination revealed that the stroma was diffusely infiltrated with small monomorphous cells ranging from round to oval shape.Three cases were immunohistochemically confirmed.One case was accompanied with squamous cell cancer.Of the 7 cases, one case was classified as stage Ⅰb 1, two stageⅠ b2, one stage Ⅱ a, one stage Ⅱb , and one stage Ⅲ b.On the basis of their stages of condition, one subject with stage III b underwent chemotherapy, and one with stage Ib2 received extensive hysterectomy plus pelvic lymphadenectomy, while the other 5 cases were treated by extensive hysterectomy and pelvic lymphadenectomy in combination with pre-and/or post-operative adjuvant chemotherapy and radiotherapy.Of the 7 patients, 4 had relapse-free survival of 14, 14, 16 and 28 months respectively.It is concluded that SCCC is an aggressive tumor with propensity for early pelvis lymph node metastases.Early-stage patients should be treated by extensive hysterectomy and pelvic lymphadenectomy in combination with pre-and/or post-operative adjuvant chemotherapy and radiotherapy.

妊娠中期经阴道超声E-Cervix弹性成像技术对自发性早产的预测价值

目的 探讨妊娠中期经阴道超声弹性成像(E-Cervix)技术对自发性早产的预测价值。方法 选取我院2018年1月至2020年12月收治的122例孕产妇患者为研究对象,根据妊娠结局将其分为早产组和足月分娩组,对其病例资料及超声检测结果(妊娠中期宫颈长度和宫颈内口组织弹性)进行回顾性分析。采用多因素Logistic回归分析妊娠女性早产的影响因素;采用受试者工作特征(ROC)分析的曲线下面积(AUC)评估妊娠中期宫颈长度、宫颈内口组织弹性值对早产的预测价值。结果 多因素Logistic分析显示,年龄>29~36岁(OR=4.191,95%CI:2.426~7.240)、有流产史(OR=4.860,95%CI:2.813~8.395)、妊娠期高血压(OR=4.740,95%CI:2.744~8.188)、妊娠期糖尿病(OR=6.315,95%CI:3.656~10.909)均为孕妇自发性早产的危险因素。孕妇妊娠中期宫颈长度越短(OR=0.601,95%CI:0.315~0.948)、宫颈内口组织弹性值越小(OR=0.673,95%CI:0.319~0.971),其早产的发生风险越高。ROC分析显示,妊娠中期宫颈长度(AUC=0.755)、宫颈内口组织弹性值(AUC=0.738)均对孕妇自发性早产具有一定的预测价值,且两个指标联合的预测价值高于单一指标(AUC=0.849)。结论 妊娠中期经阴道超声E-Cervix弹性成像技术对自发性早产具有较高的预测效能。

Mesonephric adenocarcinoma of the uterine cervix with rare lung metastases: A case report and review of the literature

BACKGROUND Mesonephric adenocarcinoma(MNA)of the female reproductive system is a rare tumor arising from remnants of the mesonephric duct,which is mainly located in the cervix.MNA often occurs in adult women.Due to the rarity of the disease and few reports,the specific clinical features have not been established.CASE SUMMARY We present a case of a cervical MNA in a 48-year-old woman with an incidental intra-operative diagnosis who received postoperative chemotherapy.Rare lung metastases were detected during follow-up.The existing literature is reviewed.CONCLUSION The clinical manifestations,pathological characteristics,diagnosis,treatment,and prognosis of MNA have been summarized through the review of the existing literature and the case in this paper.Due to the rarity of this disease,it is very important for the research of MNA in the future.

Papillary serous carcinoma of the uterine cervix:a clinicopathological analysis of 4 cases and a literature review

Objective To investigate the clinicopathological characteristics and clinical treatment outcomes of patients with papillary serous carcinoma of the uterine cervix(PSCC).Methods In this study, 4 patients with histologically confirmed papillary serous carcinoma of the uterine cervix were retrospectively investigated. Pap smears, human papillomavirus(HPV) screening, tumor marker status, biopsy analysis, and relevant imaging examinations were conducted for the confirmation of primary diagnosis and recurrence. Patients underwent surgery, chemotherapy, or radiotherapy, and survival were the main endpoint.Results The 4 patients were diagnosed with IB1, IB1, IIA, or IIIB disease. Two patients(2/4) presented with recurrence within 18 months after primary therapy. Compared with chemotherapy alone(progressionfree survival(PFS): 11 months), radiotherapy combined with adjuvant chemotherapy showed favorable PFS rates(PFS: 20, 36, 13 months in 3 cases), although valid statistical analysis was not feasible because of the small sample size. The 5-year survival rate was 0%, and the 3-year survival rate was 75%. Our data, in agreement with the literature evidence, showed that the number of moderate-risk and high-risk factors in patients diagnosed with PSCC at an early stage was higher than that in patients diagnosed with common adenocarcinoma/squamous carcinoma of the uterine cervix.Conclusion PSCC has a poor clinical prognosis, and compared with chemotherapy alone, radiotherapy combined with adjuvant chemotherapy may lead to improved PFS.

THE EFFECT OF ACTIVE COMPONENTS OF LYCIUM BARBARUM AND GARLIC (LB-GO) ON THE SYNTHESIS OF DNA AND ULTRASTRUCTURE OF U_(14) CERVIX CANCER CELLS IN MICE

Mice, inoculated with U_(14) ascitic type cervix cancer cells, were administered with effective components of Lycium barbarum (LB) and garlic (GO).On the 4th day after i.p.administration, general condition of the animals were found improved.Examination of ascitic fluid revealed damage of the cancer cells, blanching of fluorescence staining of DNA and RNA, and the cancer cells besieged by large numbers of macrophages and leucocytes. Flow cell metric (FCM) analysis found: accumulation of cells of G_1 stage. Ultrastructure study disclosed: swelling of mitochondria in cytoplasm and damage of mitochondrial crests even with cavity formation, enlargement and degranulation of rough ER. It seemed the effect of LBGO was affirmable. It was postulated that macrophages,being activated by LB, came in close contact with the cancer cells giving rise to carcinolysis. In addition to the direct but transient killing effect of GO, the anti-cancer results could be greatly enhanced.

Effects of antisense oligonucleotides targeting VEGF on radio sensitivity of uterine cervix cancer Hela cells

Objective： To determine the impact of antisense oligonucleotides targeting vascular endothelial growth factor （VEGF） on radiosensitivity of uterine cervix cancer Hela cells. Methods： VEGF antisense oligodeoxynucleotides （ASODN） was transfected into Hela cells by liposome-mediated method. Cells transfected with the oligodeoxynuclecotide and saline were used as control groups. Cells were irradiated by 6 MV X ray at the dose of 0 Gy, 2 Gy, 4 Gy and 6 Gy respectively. The expression of VEGF mRNA was determined by RT-PCR. Apoptosis were evaluated using FCM. Cloning efficiency was determined by colony formation assay. Results： The expression of VEGF mRNAwas inhibited by ASODN （P 〈 0.01） in Hela cells. The inhibited activation which was influenced by radiation resulted in increasing apoptosis （P 〈 0.01） and inhibiting plating efficiency （P 〈 0.01）. Conclusion： The expression of VEGF induced by X irradiation in Hela cells can be blocked by VEGF ASODN. Treatment with VEGF might increase apoptosis in HeLa cells and enhance radiosensitivity.

Detection and localization of the hemoglobin and collagen distribution of the uterine cervix

Changes of the blood vessels and collagen are associated with the development of abnormal cervical cells.Recently,optical coberence tomography and Mueller polarization images were 1used to provide information regarding the presence of collagen fibers in the cervical tissue.However,most of these methods need a lot of time for image recording and are expensive.In addition,the general survey on the absorption and distribution characteristics of collagen and blood in the cervical is still lacking.In this study,we developed a colposcopy combining cross-polarized inage and image procssing algorithm with an fficient analytical model to map the distribution of blood and collagen in the uterine.For this system's proof of concept,we captured and processed the case of cervical ectopy and Nabothian cyst.The results show that the distribution of blood and collagen maps matched with anatomical and physiological when compared with Lugol's iodline images.This technology has some advantages,such as low cost,real time,and can replace the 11se of acetic acid or Lugol's iodine in the future.

Contribution of Colposcopy in the Diagnosis of Precancerous Lesions of the Uterine Cervix at the Douala Gynaeco-Obstetric and Pediatric Hospital, Cameroon

Introduction: Cervical cancer is a public health problem in Cameroon, due to low screening and late diagnosis. We sought to assess practice of colposcopy at the Douala Gyneco-Obstetric and Pediatric Hospital (DGOPH) in Cameroon and its contribution to the fight against cervical cancer in our context. Method: This is a retrospective cross-sectional study of 99 colposcopies after which 71 exploitable biopsies were retained at the Douala for a period of 1year (December 1, 2019-December 1, 2020). The nomenclature of the French Society of Colposcopy and Cervico-Vaginal Pathology (SFCPCV) was used. Results: Mean age of the participants was 44 years, mostly multiparous (80%). Cytological abnormalities were the main reference pattern. During the examination 22% of colposcopies were found to be normal, 37% of TAG 1-2A, 31% of TAG 2B-C, and 5% suspected of cancer. After histological analysis of biopsies guided by colposcopy, we found 42% (30/71) of Cervical Intraepithelial Neoplasia (CIN) 1, 15.5% (11/71) of CIN 2 - 3, and 24% (17/71) cancer. Upon analysis of the diagnosed CIN1/CIN2-3/Cancers, we noted a concordance with colposcopy in 62% (23/37), 37% (10/27) and 85% (6/7) respectively. Colposcopic performance in the detection of high-grade lesions and above was 36% (26/71), with a sensitivity of 92.86%, specificity 83.33%, PPV 78.79% and NPV 94.59%. Conclusion: Despite the difficult socioeconomic context, colposcopy retains all its importance in the diagnosis of precancerous lesions of the uterine cervix. With the imminent putting in place of a national health policy, the goals 90-70-90 by 2030 of the World Health Organization for the fight against cervical cancer can be achieved in our sub-Saharan African countries.

Epidemiological and Cytopathological Profile of Dysplastic Lesions of the Cervix in South-Kivu/Dr Congo

Background: Cervical cancer is one of the most common cancers in women in the world. The recrudescence of dysplastic lesions is increasing, especially in developing countries, because of the absence of screening. The objective of this work is to determine the prevalence of dysplastic lesions of the cervix in women who are sexually active in South Kivu province. Methods: It was a cross-sectional, descriptive and analytical study of 625 women who came for gynecological consultation, all of whom had cervical-uterine Pap smears, during the period from January 1st, 2017 to December 31st, 2018 at Panzi General Referral Hospital (South Kivu, DR Congo). Data analysis was done using Epi Info software version 7. Results: The median age of the respondents was 34 years, 47.0% of them were married, and 59.0% had a low socio-economic level. The majority had first sexual intercourse between the ages of 15 and 20 (67.5%), a number of former sexual partners estimated at 1 - 5 (87.8%), did not use tobacco (97.4%) and did not use contraception (78.1%). Pap smear was normal in 82.88% of cases, inflammatory in 2.4% of cases and with cytologic abnormalities in 14.72% of cases. Rates of dysplastic lesions were significantly higher among women aged ≥35 years (p = 0.0245), brides (p = 0.0183) and nulliparas (p = 0.0042). Multivariate analysis revealed the adjusted OR (95% CI) statistically insignificant (p < 0.05) for the age group, marital status and parity respondents. Conclusion: Cervical cancer remains a real scourge in the world, especially in sub-Saharan Africa, where the diagnosis is often made when the pathology is at its stage almost incurable. Early detection of dysplastic lesions by Pap smear is therefore imperative in the eradication of this pathology.