期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Comparison of neoadjuvant chemotherapy followed by surgery vs.surgery alone for locally advanced gastric cancer:a meta-analysis 被引量:9
1
作者 Jian-Hong Yu Zao-Zao Wang +9 位作者 Ying-Chong Fan Mao-Xing Liu Kai Xu Nan Zhang Zhen-Dan Yao Hong Yang Cheng-Hai Zhang Jia-Di Xing Ming Cui Xiang-Qian Su 《Chinese Medical Journal》 SCIE CAS CSCD 2021年第14期1669-1680,共12页
Background:The neoadjuvant chemotherapy is increasingly used in advanced gastric cancer,but the effects on safety and survival are still controversial.The objective of this meta-analysis was to compare the overall sur... Background:The neoadjuvant chemotherapy is increasingly used in advanced gastric cancer,but the effects on safety and survival are still controversial.The objective of this meta-analysis was to compare the overall survival and short-term surgical outcomes between neoadjuvant chemotherapy followed by surgery(NACS)and surgery alone(SA)for locally advanced gastric cancer.Methods:Databases(PubMed,Embase,Web of Science,Cochrane Library,and Google Scholar)were explored for relative studies from January 2000 to January 2021.The quality of randomized controlled trials and cohort studies was evaluated using the modified Jadad scoring system and the Newcastle-Ottawa scale,respectively.The Review Manager software(version 5.3)was used to perform this meta-analysis.The overall survival was evaluated as the primary outcome,while perioperative indicators and post-operative complications were evaluated as the secondary outcomes.Results:Twenty studies,including 1420 NACS cases and 1942 SA cases,were enrolled.The results showed that there were no significant differences in overall survival(P=0.240),harvested lymph nodes(P=0.200),total complications(P=0.080),and 30-day post-operative mortality(P=0.490)between the NACS and SA groups.However,the NACS group was associated with a longer operation time(P<0.0001),a higher R0 resection rate(P=0.003),less reoperation(P=0.030),and less anastomotic leakage(P=0.007)compared with SA group.Conclusions:Compared with SA,NACS was considered safe and feasible for improved R0 resection rate as well as decreased reoperation and anastomotic leakage.While unbenefited overall survival indicated a less important effect of NACS on long-term oncological outcomes. 展开更多
关键词 Neoadjuvant chemotherapy followed by surgery surgery alone Advanced gastric cancer GASTRECTOMY Overall survival META-ANALYSIS
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部