We report the case of a 52-year-old man with a history of acute myeloid leukemia who presented to the emergency room with fatigue, dyspnea and chest pain. Initial routine examination showed signs of right heart failur...We report the case of a 52-year-old man with a history of acute myeloid leukemia who presented to the emergency room with fatigue, dyspnea and chest pain. Initial routine examination showed signs of right heart failure. A CT was requested to rule out pulmonary embolism. The imaging revealed the presence of a cardiac infiltrative mass involving the heart’s right free wall that proved to be a chloroma.展开更多
To the Editor:Chloroma is a rare solid tumor that was formed sometimes from malignant myeloid blast cells outside the hematopoietic system;these are known as chloroma or granulocytic sarcoma[1]Chloroma can be diagnose...To the Editor:Chloroma is a rare solid tumor that was formed sometimes from malignant myeloid blast cells outside the hematopoietic system;these are known as chloroma or granulocytic sarcoma[1]Chloroma can be diagnosed anywhere outside of the hematopoietic system,such as the head and neck,skeletal system,breast,uterus,and central nervous system.[2]This tumor is common in leukemic patients.[3]Chloroma presents as an epidural mass resulting in spinal cord compression with neurologic symptoms.[4]Spinal lesions occur most frequently at the thoracic level;however,the most common primary symptoms are low back pain and radiating pain in the legs[5].展开更多
Myeloid sarcoma(MS)is a rare neoplasm characterized by the proliferation of immature myeloid precursor cells outside the bone marrow.The pathogenesis of MS is complex and not completely understood.Moreover,it develops...Myeloid sarcoma(MS)is a rare neoplasm characterized by the proliferation of immature myeloid precursor cells outside the bone marrow.The pathogenesis of MS is complex and not completely understood.Moreover,it develops in any extramedullary site of the body.In this editorial,we discuss the article published by Li et al,which presents a clinical case involving a 32-year-old man who exhibited gingival inflammation in the maxillary region.It was initially diagnosed as periodontal disease.However,clinical evaluation revealed a firm,grayishwhite mass which underscored the need for comprehensive diagnostics to distinguish MS from other oral conditions.This article emphasizes the different clinical presentations of similar case studies in the literature,and highlights the difficulty in diagnosing oral MS due to its rarity and variability in clinical manifestation.The treatment of MS depends on the clinical presentation,tumor location,and the patient's response to conventional therapies.The various therapeutic options currently available are analyzed and discussed.Early intervention and multidisciplinary management are crucial for improving treatment outcomes.Increased awareness and education about the various clinical presentations of MS lead to earlier diagnosis and timely treatment,thereby enhancing patients'survival and quality of life.Continued research is essential for optimizing therapeutic strategies and addressing the challenges presented by this rare neoplasm.展开更多
Myeloid sarcoma, also known as granulocytic sarcoma or chloroma is an unusual accumulation of malignant myeloid precursor cells in an extramedullary site, which disrupts the normal architecture of the involved tissue....Myeloid sarcoma, also known as granulocytic sarcoma or chloroma is an unusual accumulation of malignant myeloid precursor cells in an extramedullary site, which disrupts the normal architecture of the involved tissue. It is known to occur more commonly in patients with acute myelogenous leukemia and less commonly in those with myelodysplastic syndrome and myeloproliferative neoplasm, such as chronic myelogenous leukemia. The most common sites of involvement include bone, skin and lymph nodes. However, rare cases have been reported in the gastrointestinal tract, genitourinary tract, or breast. Most commonly, a neoplastic extramedullary proliferation of myeloid precursors in a patient would have systemic involvement of a myeloid neoplasm, including in the bone marrow and peripheral blood. Infrequently, extramedullary disease may be the only site of involvement. It may also occur as a localized antecedent to more generalized disease or as a site of recurrence. Herein, we present the first case in the English literature of a patient presenting with an isolated site of myeloid sarcoma arising in the form of a colonic polyp which, after subsequent bone marrow biopsy, was found to be a harbinger of chronic myelogenous leukemia.展开更多
Granulocytic sarcoma or chloroma is a rare tumour derived from myeloid cell precursors. It is generally seen before or after or together with the onset of myelocytic leukaemia. Immunohistochemical staining of myeloper...Granulocytic sarcoma or chloroma is a rare tumour derived from myeloid cell precursors. It is generally seen before or after or together with the onset of myelocytic leukaemia. Immunohistochemical staining of myeloperoxidase is necessary for a definite diagnosis of granulocytic sarcoma. Recognition of this entity ensures an early aggressive chemotherapy that causes regression of the tumour.1-3 We present an unusual case of a 40-year-old woman who presented with back pain, numbness in the legs, and fatigue for 2 weeks. She was diagnosed as having synchronous granulocytic sarcomas of the breast and spine, confirmed surgically and histopathologically. After a subsequent systemic chemotherapy the patient was completely asymptomatic during a 20-month follow-up. We also reviewed the literature about the clinical manifestations, diagnosis, treatment, and prognosis of this condition.展开更多
文摘We report the case of a 52-year-old man with a history of acute myeloid leukemia who presented to the emergency room with fatigue, dyspnea and chest pain. Initial routine examination showed signs of right heart failure. A CT was requested to rule out pulmonary embolism. The imaging revealed the presence of a cardiac infiltrative mass involving the heart’s right free wall that proved to be a chloroma.
文摘To the Editor:Chloroma is a rare solid tumor that was formed sometimes from malignant myeloid blast cells outside the hematopoietic system;these are known as chloroma or granulocytic sarcoma[1]Chloroma can be diagnosed anywhere outside of the hematopoietic system,such as the head and neck,skeletal system,breast,uterus,and central nervous system.[2]This tumor is common in leukemic patients.[3]Chloroma presents as an epidural mass resulting in spinal cord compression with neurologic symptoms.[4]Spinal lesions occur most frequently at the thoracic level;however,the most common primary symptoms are low back pain and radiating pain in the legs[5].
文摘Myeloid sarcoma(MS)is a rare neoplasm characterized by the proliferation of immature myeloid precursor cells outside the bone marrow.The pathogenesis of MS is complex and not completely understood.Moreover,it develops in any extramedullary site of the body.In this editorial,we discuss the article published by Li et al,which presents a clinical case involving a 32-year-old man who exhibited gingival inflammation in the maxillary region.It was initially diagnosed as periodontal disease.However,clinical evaluation revealed a firm,grayishwhite mass which underscored the need for comprehensive diagnostics to distinguish MS from other oral conditions.This article emphasizes the different clinical presentations of similar case studies in the literature,and highlights the difficulty in diagnosing oral MS due to its rarity and variability in clinical manifestation.The treatment of MS depends on the clinical presentation,tumor location,and the patient's response to conventional therapies.The various therapeutic options currently available are analyzed and discussed.Early intervention and multidisciplinary management are crucial for improving treatment outcomes.Increased awareness and education about the various clinical presentations of MS lead to earlier diagnosis and timely treatment,thereby enhancing patients'survival and quality of life.Continued research is essential for optimizing therapeutic strategies and addressing the challenges presented by this rare neoplasm.
文摘Myeloid sarcoma, also known as granulocytic sarcoma or chloroma is an unusual accumulation of malignant myeloid precursor cells in an extramedullary site, which disrupts the normal architecture of the involved tissue. It is known to occur more commonly in patients with acute myelogenous leukemia and less commonly in those with myelodysplastic syndrome and myeloproliferative neoplasm, such as chronic myelogenous leukemia. The most common sites of involvement include bone, skin and lymph nodes. However, rare cases have been reported in the gastrointestinal tract, genitourinary tract, or breast. Most commonly, a neoplastic extramedullary proliferation of myeloid precursors in a patient would have systemic involvement of a myeloid neoplasm, including in the bone marrow and peripheral blood. Infrequently, extramedullary disease may be the only site of involvement. It may also occur as a localized antecedent to more generalized disease or as a site of recurrence. Herein, we present the first case in the English literature of a patient presenting with an isolated site of myeloid sarcoma arising in the form of a colonic polyp which, after subsequent bone marrow biopsy, was found to be a harbinger of chronic myelogenous leukemia.
文摘Granulocytic sarcoma or chloroma is a rare tumour derived from myeloid cell precursors. It is generally seen before or after or together with the onset of myelocytic leukaemia. Immunohistochemical staining of myeloperoxidase is necessary for a definite diagnosis of granulocytic sarcoma. Recognition of this entity ensures an early aggressive chemotherapy that causes regression of the tumour.1-3 We present an unusual case of a 40-year-old woman who presented with back pain, numbness in the legs, and fatigue for 2 weeks. She was diagnosed as having synchronous granulocytic sarcomas of the breast and spine, confirmed surgically and histopathologically. After a subsequent systemic chemotherapy the patient was completely asymptomatic during a 20-month follow-up. We also reviewed the literature about the clinical manifestations, diagnosis, treatment, and prognosis of this condition.
