Undenicylic acid(10:1)is known as an antifungal agent and an active ingredient of many topical medicines[1–6].The present research investigates the preparation of aliphatic esters of 10-undecylic acid with butanol an...Undenicylic acid(10:1)is known as an antifungal agent and an active ingredient of many topical medicines[1–6].The present research investigates the preparation of aliphatic esters of 10-undecylic acid with butanol and i-amyl alcohol by the conventional and ultrasound-assisted syntheses as well as the structural elucidation of the resulting compounds,by FTIR and NMR spectroscopy.The antimicrobial properties of the obtained 10-undecylenic esters were tested against Gram-positive bacteria(Staphylococcus aureus;Enterococcus faecalis;Listeria monocytogenes),Gram-negative bacteria(Escherichia coli;Salmonella sp.)and filamentous fungi(Penicillium sp.;Aspergillus niger;Fusarium moniliforme)using the conventional agar-well diffusion assay.The results demonstrated that all esters had insignificant antibacterial activity.i-Amyl-10-undecylenate and t-butyl-10-undecylenate showed activity against both Gram-positive and Gram-negative bacteria,while i-butyl-10-undecylenate and n-butyl-10-undecylenate were effective only against Gram-positive bacteria tested.In contrast,all 10-undecylenic esters demonstrated high antifungal activity,which was most pronounced in i-Amyl-10-undecylenate.Therefore,the obtained products can be successfully used as promising antifungal agents for various pharmaceutical formulations as well as biocontrol means against plant pathogens.展开更多
基金supported by Fund Science Contract No 1805С,Technical University of Gabrovo,Bulgaria.
文摘Undenicylic acid(10:1)is known as an antifungal agent and an active ingredient of many topical medicines[1–6].The present research investigates the preparation of aliphatic esters of 10-undecylic acid with butanol and i-amyl alcohol by the conventional and ultrasound-assisted syntheses as well as the structural elucidation of the resulting compounds,by FTIR and NMR spectroscopy.The antimicrobial properties of the obtained 10-undecylenic esters were tested against Gram-positive bacteria(Staphylococcus aureus;Enterococcus faecalis;Listeria monocytogenes),Gram-negative bacteria(Escherichia coli;Salmonella sp.)and filamentous fungi(Penicillium sp.;Aspergillus niger;Fusarium moniliforme)using the conventional agar-well diffusion assay.The results demonstrated that all esters had insignificant antibacterial activity.i-Amyl-10-undecylenate and t-butyl-10-undecylenate showed activity against both Gram-positive and Gram-negative bacteria,while i-butyl-10-undecylenate and n-butyl-10-undecylenate were effective only against Gram-positive bacteria tested.In contrast,all 10-undecylenic esters demonstrated high antifungal activity,which was most pronounced in i-Amyl-10-undecylenate.Therefore,the obtained products can be successfully used as promising antifungal agents for various pharmaceutical formulations as well as biocontrol means against plant pathogens.
