Detection of the Level of Urinary FPA in Chronic Nephritis with Renal Failure and Its Clinical Implication

The level of urinary FPA was assayed by high per formance liquid chromatography (HPLC ) in 42 normal controls, 57 cases of chronic glomeru-lonephritis, including 24 with normal renal function, 12 with renal insufficiency and 21 with uremia. Their levels were 24. 40± 10. 30 μg/L, 26. 99±5.77 μg/L,38. 81±6. 28 μg/L, 79. 74± 18. 76 μg/L, respectively. The level of urinary FPA in renal insufficiency function group was significantly higher than those of the con-trol group and normal renal function group (P<0.01). The patients with uremia presented dramatically higher level of urinary FPA than those in the renal insufficiency group (P<0.01). A positive correlation was found between the level of urinary FPA and the blood creatine (r= 0. 9120, P<0. 01 ). It was suggested that a hypercoagulable state existed in the patients with chronic nephritis with renal failure, in which the severity was closely related with the occurrence and development of the disease. The urinary FPA could serve as a good indicator for renal function.

Professor Yumao Du's Experience in Treating Chronic Nephritis

Chronic nephritis is a common clinical kidney disease,with insidious onset and long course,which can eventually develop into chronic renal failure.In Chinese medicine,it belongs to the categories of"edema,""back pain""deficiency,"and epertigo."Professor Du Yumao is a well-known Chinese medicine doctor and a well-known nephropathy expert in China.He has rich clinical experience and unique insights into the treatment of chronic nephritis.He believes that insufficient kidney yin is the key to this disease,and water dampness and blood stasis are important pathological factors.Appropriate change of method according to the situation and flexible use of medicine often lead to good clinical outcomes.

Clinical observation of 36 patients with chronic nephritis proteinuria treated with Zhuangshen Gujing decoction

Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups;one group was treated with Zhuangshen Gujing(n=36;treatment group)and the other group was treated with irbesartan(n=36;control group).After 6 months’treatment,urine protein and renal function were evaluated.Results:Proteinuria resolved completely in four patients in the treatment group;complete disease resolution was observed only among three individuals in the control group.Of the 32 cases remaining in the treatment group,15 had substantial responses to Zhuangshen Gujing decoction,9 had partial responses,and 8 had no response to treatment;the overall the response rate was 73.33%.Among the 33 cases remaining in the control group,12 had a substantial response to irbesartan,5 had a partial response,and 16 had no response to treatment;the overall response rate among the controls was 57.67%(P=0.031).We also observed statistically significant differences with respect to quantitative comparisons of urinary protein at 24 days after a single course of treatment(P=0.001).Conclusion:Zhuangshen Gujing decoction is effective in treating chronic nephritis proteinuria.

Exploring the mechanism of Astragalus and Salvia miltiorrhiza in the treatment of chronic glomerulonephritis:A network pharmacology approach

To elucidate the mechanism underlying the therapeutic impact of Astragalus-Danshen in chronic glomerulonephritis(CGN),a comprehensive exploration was conducted utilizing network pharmacology.The TCMSP database was employed to aggregate the chemical constituents and targets associated with Astragalus and Danshen.Simultaneously,disease targets specific to CGN were sourced from the Genecards database.The convergence of these datasets yielded a set of intersection genes,representing potential targets for CGN treatment through Astragalus-Danshen formulations.Subsequently,protein interaction networks and“chemical composition-target”networks were meticulously constructed.Core targets were subjected to GO and KEGG enrichment analyses.The investigation revealed a total of 240 targets corresponding to 20 and 65 chemical components of Astragalus and Danshen,respectively.From this pool,86 potential targets associated with CGN treatment were discerned,ultimately identifying 29 core targets.Noteworthy among these were TNF,JUN,TP53,IL1B,RELA,MMP9,CASP3,IL10,MAPK14,MYC,and TGFB1.KEGG enrichment analysis illuminated pathways pertinent to CGN,encompassing the IL-17 signaling pathway,TNF signaling pathway,and the AGE-RAGE signaling pathway in diabetic complications.In summary,Astragalus-Danshen exhibited a potential anti-inflammatory and renoprotective effect on CGN,particularly through modulating the IL-17 signaling pathway,TNF signaling pathway,and AGE-RAGE signaling pathway in diabetic complications,involving key regulators such as TNF,JUN,TP53,IL1B,MAPK14,and others.