This paper presents a nonlinear profile order scheme for three-dimensional（3D） hybrid radial acquisition applied to self-gated, free-breathing cardiac cine magnetic resonance imaging（MRI）. In self-gated, free-brea...This paper presents a nonlinear profile order scheme for three-dimensional（3D） hybrid radial acquisition applied to self-gated, free-breathing cardiac cine magnetic resonance imaging（MRI）. In self-gated, free-breathing cardiac cine MRI,respiratory and cardiac motions are unpredictable during acquisition, especially for retrospective reconstruction. Therefore,the non-uniformity of the k-space distribution is an issue of great concern during retrospective self-gated reconstruction. A nonlinear profile order with varying azimuthal increments was provided and compared with the existing golden ratio-based profile order. Optimal parameter values for the nonlinear formula were chosen based on simulations. The two profile orders were compared in terms of the k-space distribution and phantom and human image results. An approximately uniform distribution was obtained based on the nonlinear profile order for persons with various heart rates and breathing patterns.The nonlinear profile order provides more stable profile distributions and fewer streaking artifacts in phantom images. In a comparison of human cardiac cine images, the nonlinear profile order provided results comparable to those provided by the golden ratio-based profile order, and the images were suitable for diagnosis. In conclusion, the nonlinear profile order scheme was demonstrated to be insensitive to various motion patterns and more useful for retrospective reconstruction.展开更多
Objectives To reveal the relationship of brain motion and cerebrospinal fluid (CSF) flow by phase-contrast cine MRI, and to evaluate this technique in differentiating between arachnoid cysts and subarachnoid space en...Objectives To reveal the relationship of brain motion and cerebrospinal fluid (CSF) flow by phase-contrast cine MRI, and to evaluate this technique in differentiating between arachnoid cysts and subarachnoid space enlargement. Methods Using a phase-contrast cine MRI pulse sequence, we measured brain motion and CSF flow during the cardiac cycle in 10 healthy volunteers and 10 patients with MRI-suspected arachnoid cyst or subarachnoid space enlargement. CSF stroke volume curve was illustrated according to flow quantification, and time-signal intensity curve was traced. The two curves were compared. Results This study showed that brain motion was due to the volume difference between arterial and venous blood flow during a cardiac cycle, and thus drives CSF pulsation. Arachnoid cysts and subarachnoid space enlargement carried different curve patterns, demonstrating that phase-contrast MRI and flow quantification can be a useful and reliable technique for non-invasive evaluation of brain motion and CSF flow. Conclusion Arachnoid cysts can be successfully differentiated using phase-contrast cine MRI from subarachnoid space enlargement.展开更多
目的通过建立稳态流体模型,验证3.0 T MRI快速电影相位对比(fast cine PC)序列进行血流动力学测量的准确性。方法将直径为3.0mm的医用塑料管固定在水模中,塑料管的一端连接高压注射器,高压注射器以不同流速(0.5、1.0、1.5、2.0、2.5、3....目的通过建立稳态流体模型,验证3.0 T MRI快速电影相位对比(fast cine PC)序列进行血流动力学测量的准确性。方法将直径为3.0mm的医用塑料管固定在水模中,塑料管的一端连接高压注射器,高压注射器以不同流速(0.5、1.0、1.5、2.0、2.5、3.0、3.5、4.0 mL/s)向管腔内注射0.9%氯化钠溶液,管的另一端连入量筒。将流体模型中心置于头部8通道线圈中心,平行放置的医用塑料管与磁体长轴一致。应用3.0TMRI扫描仪进行fastcine PC序列扫描,扫描层面垂直于所测管腔长轴。在不同流速、不同观测者(2名)、不同流动方向(相向和相反)、不同倾斜角度(0°、20°、30°、45°)对流速进行测量。对图像进行后处理。测定感兴趣区流速,进行统计学分析。结果实际流动方向与流速编码方向相同时测得的流速值分别为6.75、13.90、21.14、28.69、36.52、42.48、50.49、57.10 cm/s;实际流动方向与流速编码方向相反时测得的流速值分别为8.09、14.76、22.53、29.79、36.61、44.75、51.08、54.94 cm/s。管腔内实际流速为42.46 cm/s时,不同倾斜角度测得的流速值分别为42.48、42.77、42.38、42.94、42.47、42.62、42.59 cm/s。测量速度与实际速度间差异无统计学意义,且呈正相关(r=0.99,P<0.000 1)。2名观察者的测量值之间差异无统计学意义(t=-0.87,P=0.41>0.05)。液体流动方向与流速编码方向相同、相反测得的流速与实际流速两两之间差异无统计学意义(F=3.51,P=0.06>0.05)。不管管腔在各个方向有无角度,测得的流速与实际流速之间差异均无统计学意义(t=2.01,P=0.09>0.05)。结论 3.0 T fast cine PC序列可以准确测量稳态流体模型流速,为人体血流动力学检测的临床应用提供了可靠的实验依据。展开更多
Conventional multiple breath-hold two-dimensional （2D） balanced steady-state free precession （SSFP） presents many difficulties in cardiac cine magnetic resonance imaging （MRI）. Recently, a self-gated free-breath...Conventional multiple breath-hold two-dimensional （2D） balanced steady-state free precession （SSFP） presents many difficulties in cardiac cine magnetic resonance imaging （MRI）. Recently, a self-gated free-breathing three-dimensional （3D） SSFP technique has been proposed as an alternative in many studies. However, the accuracy and effectiveness of selfgating signals have been barely studied before. Since self-gating signals are crucially important in image reconstruction, a systematic study of self-gating signals and comparison with external monitored signals are needed. Previously developed self-gated free-breathing 3D SSFP techniques are used on twenty-eight healthy volunteers. Both electrocardiographic （ECG） and respiratory bellow signals are also acquired during the scan as external signals. Self-gating signal and external signal are compared by trigger and gating window. Gating window is proposed to evaluate the accuracy and effectiveness of respiratory self-gating signal. Relative deviation of the trigger and root-mean-square-deviation of the cycle duration are calculated. A two-tailed paired t-test is used to identify the difference between self-gating and external signals. A Wilcoxon signed rank test is used to identify the difference between peak and valley self-gating triggers. The results demonstrate an excellent correlation （P = 0, R 〉 0.99） between self-gating and external triggers. Wilcoxon signed rank test shows that there is no significant difference between peak and valley self-gating triggers for both cardiac （H = 0, P 〉 0.10） and respiratory （H = 0, P 〉 0.44） motions. The difference between self-gating and externally monitored signals is not significant （two-tailed paired-sample t-test： H = 0, P 〉 0.90）. The self-gating signals could demonstrate cardiac and respiratory motion accurately and effectively as ECG and respiratory bellow. The difference between the two methods is not significant and can be explained. Furthermore, few ECG trigger errors appear in some subjects while these errors are not found in self-gating signals.展开更多
目的采用电影相位对比磁共振成像(Cine PC MRI)评价肝硬化门静脉高压患者门静脉血流动力学与Child-Pugh肝功能分级的关系。资料与方法49例肝硬化门静脉高压患者,男26例,女23例,平均年龄47.8岁;19名正常对照者,男10名,女9名,平均年龄43....目的采用电影相位对比磁共振成像(Cine PC MRI)评价肝硬化门静脉高压患者门静脉血流动力学与Child-Pugh肝功能分级的关系。资料与方法49例肝硬化门静脉高压患者,男26例,女23例,平均年龄47.8岁;19名正常对照者,男10名,女9名,平均年龄43.5岁。按Child-Pugh肝功能分级,A级10例,B级31例,C级8例。采用Cine PC MRI对门静脉血流进行定量测量。结果肝硬化组按照Child A、B、C顺序,门静脉血流速度逐渐降低,组内差异具有显著性统计学意义(P<0.05);Child C级的门静脉流速与A、B级及正常组相比,流速明显减低,差异具有显著性统计学意义(P<0.01)。肝硬化Child B、C级患者较正常组门静脉直径增宽、截面积明显增大(P<0.05)。Child C级较B级门静脉血流量明显减少(P<0.05)。结论Cine PC MRI监测门静脉血流动力学有助于评价肝硬化患者的肝功能、门静脉高压严重程度。展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.81501463,61671026,81571669,and 81671853)the Natural Science Foundation of Guangdong Province,China(Grant No.2014A030310360)+3 种基金Guangdong Innovative Research Team Program of China(Grant No.2011S013)the Basic Research Project of Shenzhen City,China(Grant Nos.JCYJ20140417113430639 and JCYJ20160429172357751)the High-level Oversea Talent Program of Shenzhen City,China(Grant No.KQJSCX20160301144248)Beijing Center for Mathematics and Information Interdisciplinary Sciences of China
文摘This paper presents a nonlinear profile order scheme for three-dimensional（3D） hybrid radial acquisition applied to self-gated, free-breathing cardiac cine magnetic resonance imaging（MRI）. In self-gated, free-breathing cardiac cine MRI,respiratory and cardiac motions are unpredictable during acquisition, especially for retrospective reconstruction. Therefore,the non-uniformity of the k-space distribution is an issue of great concern during retrospective self-gated reconstruction. A nonlinear profile order with varying azimuthal increments was provided and compared with the existing golden ratio-based profile order. Optimal parameter values for the nonlinear formula were chosen based on simulations. The two profile orders were compared in terms of the k-space distribution and phantom and human image results. An approximately uniform distribution was obtained based on the nonlinear profile order for persons with various heart rates and breathing patterns.The nonlinear profile order provides more stable profile distributions and fewer streaking artifacts in phantom images. In a comparison of human cardiac cine images, the nonlinear profile order provided results comparable to those provided by the golden ratio-based profile order, and the images were suitable for diagnosis. In conclusion, the nonlinear profile order scheme was demonstrated to be insensitive to various motion patterns and more useful for retrospective reconstruction.
文摘Objectives To reveal the relationship of brain motion and cerebrospinal fluid (CSF) flow by phase-contrast cine MRI, and to evaluate this technique in differentiating between arachnoid cysts and subarachnoid space enlargement. Methods Using a phase-contrast cine MRI pulse sequence, we measured brain motion and CSF flow during the cardiac cycle in 10 healthy volunteers and 10 patients with MRI-suspected arachnoid cyst or subarachnoid space enlargement. CSF stroke volume curve was illustrated according to flow quantification, and time-signal intensity curve was traced. The two curves were compared. Results This study showed that brain motion was due to the volume difference between arterial and venous blood flow during a cardiac cycle, and thus drives CSF pulsation. Arachnoid cysts and subarachnoid space enlargement carried different curve patterns, demonstrating that phase-contrast MRI and flow quantification can be a useful and reliable technique for non-invasive evaluation of brain motion and CSF flow. Conclusion Arachnoid cysts can be successfully differentiated using phase-contrast cine MRI from subarachnoid space enlargement.
文摘目的通过建立稳态流体模型,验证3.0 T MRI快速电影相位对比(fast cine PC)序列进行血流动力学测量的准确性。方法将直径为3.0mm的医用塑料管固定在水模中,塑料管的一端连接高压注射器,高压注射器以不同流速(0.5、1.0、1.5、2.0、2.5、3.0、3.5、4.0 mL/s)向管腔内注射0.9%氯化钠溶液,管的另一端连入量筒。将流体模型中心置于头部8通道线圈中心,平行放置的医用塑料管与磁体长轴一致。应用3.0TMRI扫描仪进行fastcine PC序列扫描,扫描层面垂直于所测管腔长轴。在不同流速、不同观测者(2名)、不同流动方向(相向和相反)、不同倾斜角度(0°、20°、30°、45°)对流速进行测量。对图像进行后处理。测定感兴趣区流速,进行统计学分析。结果实际流动方向与流速编码方向相同时测得的流速值分别为6.75、13.90、21.14、28.69、36.52、42.48、50.49、57.10 cm/s;实际流动方向与流速编码方向相反时测得的流速值分别为8.09、14.76、22.53、29.79、36.61、44.75、51.08、54.94 cm/s。管腔内实际流速为42.46 cm/s时,不同倾斜角度测得的流速值分别为42.48、42.77、42.38、42.94、42.47、42.62、42.59 cm/s。测量速度与实际速度间差异无统计学意义,且呈正相关(r=0.99,P<0.000 1)。2名观察者的测量值之间差异无统计学意义(t=-0.87,P=0.41>0.05)。液体流动方向与流速编码方向相同、相反测得的流速与实际流速两两之间差异无统计学意义(F=3.51,P=0.06>0.05)。不管管腔在各个方向有无角度,测得的流速与实际流速之间差异均无统计学意义(t=2.01,P=0.09>0.05)。结论 3.0 T fast cine PC序列可以准确测量稳态流体模型流速,为人体血流动力学检测的临床应用提供了可靠的实验依据。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.81501463,61471349,81671853,81571669,and 61671026)the National High Technology Research and Development Program of China(Grant No.2015AA043203)+5 种基金the Natural Science Foundation of Beijing,China(Grant No.7162112)Guangdong Innovative Research Team Program of China(Grant No.2011S013)the Natural Science Foundation of Guangdong Province,China(Grant Nos.2014A030310360 and 2014A0202015028)the Beijing Center for Mathematics and Information Interdisciplinary Sciences,Shenzhen Fundamental Research Program,China(Grant Nos.JCYJ201500731154850923 and JCYJ20140417113430665)Shenzhen High-level Oversea Talent Program,China(Grant No.KQJSCX20160301144248)the Nanshan Technology Research Fund,China(Grant No.KC2014JSQN0001A)
文摘Conventional multiple breath-hold two-dimensional （2D） balanced steady-state free precession （SSFP） presents many difficulties in cardiac cine magnetic resonance imaging （MRI）. Recently, a self-gated free-breathing three-dimensional （3D） SSFP technique has been proposed as an alternative in many studies. However, the accuracy and effectiveness of selfgating signals have been barely studied before. Since self-gating signals are crucially important in image reconstruction, a systematic study of self-gating signals and comparison with external monitored signals are needed. Previously developed self-gated free-breathing 3D SSFP techniques are used on twenty-eight healthy volunteers. Both electrocardiographic （ECG） and respiratory bellow signals are also acquired during the scan as external signals. Self-gating signal and external signal are compared by trigger and gating window. Gating window is proposed to evaluate the accuracy and effectiveness of respiratory self-gating signal. Relative deviation of the trigger and root-mean-square-deviation of the cycle duration are calculated. A two-tailed paired t-test is used to identify the difference between self-gating and external signals. A Wilcoxon signed rank test is used to identify the difference between peak and valley self-gating triggers. The results demonstrate an excellent correlation （P = 0, R 〉 0.99） between self-gating and external triggers. Wilcoxon signed rank test shows that there is no significant difference between peak and valley self-gating triggers for both cardiac （H = 0, P 〉 0.10） and respiratory （H = 0, P 〉 0.44） motions. The difference between self-gating and externally monitored signals is not significant （two-tailed paired-sample t-test： H = 0, P 〉 0.90）. The self-gating signals could demonstrate cardiac and respiratory motion accurately and effectively as ECG and respiratory bellow. The difference between the two methods is not significant and can be explained. Furthermore, few ECG trigger errors appear in some subjects while these errors are not found in self-gating signals.
文摘目的采用电影相位对比磁共振成像(Cine PC MRI)评价肝硬化门静脉高压患者门静脉血流动力学与Child-Pugh肝功能分级的关系。资料与方法49例肝硬化门静脉高压患者,男26例,女23例,平均年龄47.8岁;19名正常对照者,男10名,女9名,平均年龄43.5岁。按Child-Pugh肝功能分级,A级10例,B级31例,C级8例。采用Cine PC MRI对门静脉血流进行定量测量。结果肝硬化组按照Child A、B、C顺序,门静脉血流速度逐渐降低,组内差异具有显著性统计学意义(P<0.05);Child C级的门静脉流速与A、B级及正常组相比,流速明显减低,差异具有显著性统计学意义(P<0.01)。肝硬化Child B、C级患者较正常组门静脉直径增宽、截面积明显增大(P<0.05)。Child C级较B级门静脉血流量明显减少(P<0.05)。结论Cine PC MRI监测门静脉血流动力学有助于评价肝硬化患者的肝功能、门静脉高压严重程度。
