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The Bacterial Inhibitory Ability and In Vivo Drug Release Pattern of a New Drug Delivery System:Ciprofloxacine/tricalcium Phosphate Delivery Capsule
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作者 郑启新 吴宏斌 +2 位作者 杜靖远 李世普 阎玉华 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1998年第3期172-176,共5页
The bacterial inhibitory ability of a new drug delivery system (DDS):Ciprofloxacine/tricalcium phosphate delivery capsule (CTDC), its in vivo drug release pattern, and the influence of ultrasonic irradiation on its dr... The bacterial inhibitory ability of a new drug delivery system (DDS):Ciprofloxacine/tricalcium phosphate delivery capsule (CTDC), its in vivo drug release pattern, and the influence of ultrasonic irradiation on its drug release were investigated. It was found that CTDC had a strong and sustained inhibitory ability to some common pathogens of bone and joint infections, such as staphylococcus aureus, escherichia coli and pseudomonas aeruginosa. In vivo drug-release study in animals demonstrated a high concentration of ciprofloxacine in the bone tissue surrounding CTDC which was placed in the greater trochanter of the rabbit and continued to release ciprofloxacine for at least 5 weeks and the blood level of ciprofloxacine was low. In vivo study also showed ultrasonic irradiation could increase the amount of ciprofloxacine released from CTDC, which may be an economical, effecient and safe new method to achieve the control of drug release from DDS. 展开更多
关键词 drug delivery system tricalcium phosphate ciprofloxacine ULTRASOUND
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Prevalence and Characterization of Pathogens Responsible for Enteric Fever and Assessment of Their Antibiotic Susceptibility Pattern in Bangladesh
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作者 Saima Mollick Md. Jabir Hasnain +1 位作者 Md. Saiful Islam Tumpa Dasgupta 《Pharmacology & Pharmacy》 2024年第9期303-313,共11页
In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the... In Bangladesh, Enteric fever is a persistent health issue throughout the year, occasionally reaching epidemic levels. The growing antibiotic resistance makes treatment increasingly challenging. Therefore, studying the antibiotic resistance patterns within the population is crucial to ensure a more effective treatment strategy. This study was designed to determine the prevalence, antimicrobial susceptibility profile, and factors associated with Salmonella spp. infections among clinically suspected Enteric fever patients in Bangladesh. This study also aimed to investigate whether there has been a re-emergence in the susceptibility of bacterial strains to conventional drugs. Data were collected from February 2024 to July 2024, from patients suspected Enteric fever (fever less than seven days duration) in a Private Diagnostic Center of Bangladesh. A total of 195 blood samples were cultured, where 53.85% came out positive, among which 79.05% Salmonella typhi and 20.95% Salmonella paratyphi A were found. Prevalence of Typhoid fever was observed high among the school-going age group (0 - 15 years) patients. Both these organisms were susceptible to ceftazidime, cefixime, ceftriaxone and cefepime but resistant to nalidixic acid, ciprofloxacin and levofloxacin. Nalidixic Acid is resistant to all S. paratyphi A and sensitive to few S. typhi. Ciprofloxacin and levofloxacin showed delayed response (36.14% and 22.72% sensitive to S. typhi and S. paratyphi A, respectively) and resistance (63.85% and 77.27% resistant to S. typhi and S. paratyphi A, respectively). In case of S. typhi, the resistance was found against ampicillin (32.53%), chloramphenicol (27.71%), cotrimoxazole (24.09%) and the resistance of S. paratyphi A found against ampicillin (4.54%), chloramphenicol (0%) and cotrimoxazole (0%). This study will provide clinicians with alternative drug options and facilitate the effective treatment of Enteric fever. 展开更多
关键词 TYPHOID SALMONELLA Nalidixic Acid CIPROFLOXACIN CHLORAMPHENICOL COTRIMOXAZOLE
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Pharmacokinetics of Enrofloxacin and Its Metabolite in Carp (Cyprinus carpio) After a Single Oral Administration in Medicated Feed 被引量:1
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作者 LIU Ying LI Zhaoxin +6 位作者 ZHANG Dahai XING Lihong SUN Weihong SUN Xiaojie PENG Jixing ZHANG Yonggang LI Xianguo 《Journal of Ocean University of China》 SCIE CAS CSCD 2023年第1期171-180,共10页
A precise and reliable analytical method of high performance liquid chromatography-tandem mass spectrometry(HPLCMS/MS)was developed to measure trace levels of enrofloxacin(ENR)and its major metabolite ciprofloxacin(CI... A precise and reliable analytical method of high performance liquid chromatography-tandem mass spectrometry(HPLCMS/MS)was developed to measure trace levels of enrofloxacin(ENR)and its major metabolite ciprofloxacin(CIP)in carp tissues.Optimized chromatographic separation was obtained on a Waters Xterra MS C_(18) reversed-phase column using gradient elution with methanol and 0.1%formic acid aqueous solution including 5mmolL^(-1) of ammonium acetate.The established method was applied to study the pharmacokinetics and distribution of ENR and CIP in tissues of carp following a single oral administration in feed at a dosage of 40mgkg^(-1) bw(body weight).Data were analyzed using DAS 2.0 dynamics software,and the experimental results suggest that ENR was rapidly absorbed and extensively distributed in carp tissues through systemic circulation,and the pharmacokinetic characteristics can be described with a two-compartment model.The elimination half-lives(t_(1/2β))from muscle,liver,gill,plasma and skin were 131,160,104,132 and 310 h,respectively.The areas under the drug concentration-time curves(AUC)for these tissues were 491,972,750,249 and 706hmgkg^(-1),respectively.The maximum concentration(C_(max))values were 13,29,37,9 and 5mgkg^(-1) with peak times(t_(max))of 8,4,4,2 and 4 h,respectively.Ciprofloxacin,the active metabolite of ENR,was also detected in carp tissues,indicating that only 1.54%of de-ethylation of ENR occurs in carp.At a water temperature of 18℃,the drug withdrawal time was determined to be no less than 24 d while the carp was fed at a single dosage of 40mgkg^(-1). 展开更多
关键词 Cyprinus carpio ENROFLOXACIN CIPROFLOXACIN PHARMACOKINETICS liquid chromatography-tandem mass spectrometry
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Oxidation of ciprofloxacin by the synergistic effect of DBD plasma and persulfate:reactive species and influencing factors analysis
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作者 宋世林 黄玉月 +7 位作者 杜彦生 肖思思 韩松 胡坤 张会会 王慧娟 吴春笃 阿琼 《Plasma Science and Technology》 SCIE EI CAS CSCD 2023年第2期194-206,共13页
A synergistic system of water falling film dielectric barrier discharge(DBD)plasma and persulfate(PS)was set up and used for oxidizing ciprofloxacin(CIP)in water.Results of reactive species formation in the DBD-only s... A synergistic system of water falling film dielectric barrier discharge(DBD)plasma and persulfate(PS)was set up and used for oxidizing ciprofloxacin(CIP)in water.Results of reactive species formation in the DBD-only system as well as the DBD–PS system verified the PS activation in the DBD system.Influencing factors on CIP degradation and the degradation process were also been studied.The obtained results showed that the presence of PS could greatly improve the degradation and mineralization of CIP and that the degradation efficiency could reach 97.73%after only 40 min treatment with 4 m M PS addition.The increase of PS concentration,the lower CIP concentration,the acidic solution p H and the addition of metal ions(Fe^(2+)and Cu^(2+))enhanced the CIP degradation,while the existence of Cl^(-)and HCO_(3)^(-)had a negative effect.The experiments related to scavenger addition confirmed the contribution of the main reactive species to the CIP oxidation.Three probable degradation pathways were proposed by analyzing the inorganic ions and organic byproducts formed during the CIP degradation.The toxicity evaluation results of the CIP and its intermediates confirmed the effectiveness of the DBD–PS synergistic system. 展开更多
关键词 dielectric barrier discharge plasma PERSULFATE reactive species ciprofloxacin oxidation influencing factors
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Preparation of sodium alginate gel microspheres catalysts and its high catalytic performance for treatment of ciprofloxacin wastewater
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作者 Gaoyan Shao Jianjie Chen +4 位作者 Yuming Tu Feng Liu Zhiyong Zhou Shichao Tian Zhongqi Ren 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第11期158-170,共13页
The discharge of the antibiotic wastewater has increased dramatically in our country with the development of medical science and wide application of antibiotic,resulting in serious harm to human body and ecological en... The discharge of the antibiotic wastewater has increased dramatically in our country with the development of medical science and wide application of antibiotic,resulting in serious harm to human body and ecological environment.In this work,ciprofloxacin(CIP)was selected as one of typical antibiotics and heterogeneous Fenton-like catalysts were prepared for the treatment of ciprofloxacin wastewater.The sodium alginate(SA)gel microspheres catalysts were prepared by polymerization method using double metal ions of Fe^(3+)and Mn^(2+)as cross-linking agents.Preparation conditions such as metal ions concentration,mass fraction of SA,polymerization temperature and dual-metal ions as crosslinking agent were optimized.Moreover,the effects of operating conditions such as initial concentration of CIP,pH value and catalyst dosage on CIP removal were studied.The kinetic equation showed that the effect of the initial concentration of CIP on the degradation rate was in line with second-order kinetics,and the effects of catalyst dosage and pH value on the degradation rate of CIP were in line with first-order kinetics.The SA gel microspheres catalysts prepared by dual-metal ions exhibited a high CIP removal and showed a good reusability after six recycles.The SA gel microspheres catalysts with an easy recovery performance provided an economical and efficient method for the removal of antibiotics in the future. 展开更多
关键词 Sodium alginate gel microspheres Heterogeneous Fenton-like catalysts Dual-metal ions Hydroxyl radical Ciprofloxacin wastewater
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Recurrent ciprofloxacin induced hypoglycemia in a non-diabetic patient:A case report
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作者 Shereen A Dasuqi Linah M Alshaer +1 位作者 Rasha A Omran Mohammed A Hamad 《World Journal of Pharmacology》 2023年第2期12-17,共6页
BACKGROUND Fluoroquinolones are a class of broad-spectrum antimicrobials used for various bacterial infections.Frequent use of fluoroquinolones has been questioned due to severe associated adverse effects,including dy... BACKGROUND Fluoroquinolones are a class of broad-spectrum antimicrobials used for various bacterial infections.Frequent use of fluoroquinolones has been questioned due to severe associated adverse effects,including dysglycemia(hypoglycemia or hyperglycemia)due to an alternation in glucose metabolism.Recent clinical trials showed the association of poor clinical outcomes with hypoglycemia in critically ill patients without diabetes.Many predisposing factors worsen fluoroquinolone-induced hypoglycemia,including diabetes,concomitant medication use like sulfonylureas or insulin,renal disease,and the elderly.CASE SUMMARY We report a case of recurrent hypoglycemia after ciprofloxacin initiation for a 71-year-old,non-diabetic,critically ill patient despite the presence of total parenteral nutrition and nasogastric tube feeding.The adverse drug reaction probability(Naranjo)scale was completed with a probable adverse drug reaction.The hypoglycemia resolved entirely after ciprofloxacin discontinuation.CONCLUSION Although ciprofloxacin-induced hypoglycemia is rare,special consideration is needed for the elderly due to their higher susceptibility to adverse side effects. 展开更多
关键词 CIPROFLOXACIN HYPOGLYCEMIA FLUOROQUINOLONES Total parenteral nutrition Side effect Case report
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Preparation, Characterization and in Vitro Release of Ciprofloxacin Polylactic Acid Microspheres 被引量:1
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作者 杨帆 梁仁 +3 位作者 潘育方 赵耀明 旺朝阳 徐安龙 《Journal of Chinese Pharmaceutical Sciences》 CAS 2005年第2期95-99,共5页
Aim Ciprofloxacin polylactic acid microspheres (CFX-PLA-MS) were preparedusing solvent evaporation method from a solid-in-oil-in-water emulsion system. Methods Orthogonalexperiment was used to optimize the method of C... Aim Ciprofloxacin polylactic acid microspheres (CFX-PLA-MS) were preparedusing solvent evaporation method from a solid-in-oil-in-water emulsion system. Methods Orthogonalexperiment was used to optimize the method of CFX-PLA-MS preparation. Microspheres werecharacterized in terms of morphology, size, encapsulation efficiency, drug loading and in vitro drugrelease. Results The physical state of CFX-PLA-MS was determined by scanning electron microscopy(SEM) and differential scanning calorimetry (DSC) . Microspheres formed were spherical with smoothsurfaces. Drug was enveloped in microspheres without mixing physically with PLA. The averageparticle size was 280.80 ± 0.15 μm, with over 90% of microspheres falling in the range of 250 -390 μm. The encapsulation efficiency was 65.8% ± 0.58% and the drug loading was 34.1% ± 0.51% .In vitro release study revealed a profile of sustained release of Ciprofloxacin from CFX-PLA-MS. Theaccumulated release percentage and half-life (T_(1/2) of Ciprofloxacin microspheres were 84.0% in53.2 h, and 31.9 h, respectively. Higuchi equation was Q= -0.0043 + 0.003 9 t^(1/2), r = 0.9941.Conclusion Ciprofloxacin microspheres have been successfully prepared and sustained release of CFXfrom microspheres is achieved. 展开更多
关键词 CIPROFLOXACIN polylactic acid MICROSPHERES PREPARATION release in vitro
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Determination of Ciprofloxacin Lactate by Sodium Tetraphenylboron Method
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作者 赵彦生 李彦威 +1 位作者 魏文珑 王晋辉 《Journal of Chinese Pharmaceutical Sciences》 CAS 2002年第1期24-27,共4页
This paper describes an effective method for determining ciprofloxacin lactate. An excess of sodium tetraphenylboron was added to precipitate ciprofloxacin lactate in HAc-NaAc buffer solution (pH=4.0). After filtering... This paper describes an effective method for determining ciprofloxacin lactate. An excess of sodium tetraphenylboron was added to precipitate ciprofloxacin lactate in HAc-NaAc buffer solution (pH=4.0). After filtering off the precipitate, the excessive sodium tetraphenylboron in the filtrate was titrated with cetyltrimethylammonium bromide standard solution, with bromophenol blue as indicator. The method is simple and rapid, it has been applied to the determination of ciprofloxacin lactate raw material with satisfactory results. The recovery was between 99.66% and 100.2%, the relative error was less than ±0.40%. Experiments showed that the method gave the same results as the approach using nonaqueous titration (ChP). 展开更多
关键词 Ciprofloxacin lactate Sodium tetraphenylboron Bromophenol blue Cetyltrimethylammonium bromide
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Presence of an Active Effiux System in the Fluoroquinolones Resistance of Mycoplasma Hominis
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作者 姚艳冰 吴移谋 +2 位作者 朱翠明 曾铁兵 曾焱华 《Chinese Journal of Sexually Transmitted Infections》 2003年第2期58-61,71,共6页
Objective: To investigate the possible presence ofan active efflux system in resistance tofluoroquinolones in Mycoplasma hominis. Methods: The resistant strains of M. hominis wereselected from one hundred and three cl... Objective: To investigate the possible presence ofan active efflux system in resistance tofluoroquinolones in Mycoplasma hominis. Methods: The resistant strains of M. hominis wereselected from one hundred and three clinical strainsof M. hominis by broth microdilution method. The ac-cumulation of ciprofloxacin in M. hominis and the in-fluence of carbonyl cyanide m-chlorophenyl-hydrazone(CCCP) and reserpine were measured by a fluores-cence method. Results: Two resistant strains and two susceptiblestrains of M. hominis were selected in vitro. The accu-mulation of ciprofloxacin for resistant strains is lowerthan that of susceptible strains. CCCP and reserpinehad different influence on clinical strains of M.hominis. Reserpine could dramatically increase theaccumulation of ciprofloxacin, however CCCP had alittle effect on it. Conclusion: These results suggest that the pres-ence of an active efflux system implicated in thefluoroquinolones-resistant in M. hominis. 展开更多
关键词 mycoplasma hominis active efflux system CIPROFLOXACIN FLUORESCENCE
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氟喹诺酮类抗菌药与其他药物的相互作用
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作者 王临润 章可名 《中国临床药学杂志》 CAS 1994年第4期23-24,28,共3页
目前,临床评价很高的一类抗菌新药——氟喹诺酮类,如氟哌酸(NorfloxacinNOR)、氟嗪酸(Ofloxacin OFLO)、氟啶酸(Enoxacin ENO)、和环丙氟哌酸(Ciprofloxacin CIP)等。此类药物抗菌谱广,抗菌活性强,不仅对G^-和G^+细菌有极强的杀菌作用,... 目前,临床评价很高的一类抗菌新药——氟喹诺酮类,如氟哌酸(NorfloxacinNOR)、氟嗪酸(Ofloxacin OFLO)、氟啶酸(Enoxacin ENO)、和环丙氟哌酸(Ciprofloxacin CIP)等。此类药物抗菌谱广,抗菌活性强,不仅对G^-和G^+细菌有极强的杀菌作用,而且对耐第三代头孢菌素,耐广谱抗生素,耐新的氨基糖苷类药的病原体,均有优异的效果,同时与抗生素无交叉耐药性。 展开更多
关键词 氟喹诺酮类抗菌药 药物的相互作用 氟哇诺酮类药物 CIPROFLOXACIN 多价阳离子 伍用 抗酸剂 NSAIDS 华法令 生物利用度
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如何撰写医学论文的英文摘要
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作者 李强 丁荣施 《医学信息学杂志》 CAS 1997年第3期55-58,共4页
笔者日常编辑工作中,经常遇到许多作者的英文摘要不符合写作要求,达不到促进学术交流的目的。现从医学杂志编辑的角度,对英文摘要的写法做一些粗浅探讨.
关键词 医学论文 结构式英文摘要 医学英语 急性脑血管病 抗生素滥用 结构式摘要 CIPROFLOXACIN 医学情报工作 ACVD 英文期刊
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用Ciprofloxacin去除传代细胞株中的支原体污染的研究 被引量:3
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作者 陈如颖 喻峰 朱德厚 《细胞生物学杂志》 CSCD 1995年第2期90-93,共4页
在应用细胞培养手段的生物学研究和生物工程产品中,支原体污染仍是一个非常棘手的问题。对Vero和SP 2/0-Ag 14等细胞,应用Ciprofloxacin,10μg/ml处理14天,支原体检测全部转阴,经4个月的培养、传代、冻存、复苏,每次支原体检测均保持阴... 在应用细胞培养手段的生物学研究和生物工程产品中,支原体污染仍是一个非常棘手的问题。对Vero和SP 2/0-Ag 14等细胞,应用Ciprofloxacin,10μg/ml处理14天,支原体检测全部转阴,经4个月的培养、传代、冻存、复苏,每次支原体检测均保持阴性。对去除了支原体的Vero和LSC-116细胞株,测试了其生长特征和功能,均未见受影响。 展开更多
关键词 细胞培养 支原体去除 CIPROFLOXACIN
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Pharmacokinetics and tissue behavior of enrofloxacin and its metabolite ciprofloxacin in turbot Scophthalmus maximus at two water temperatures 被引量:13
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作者 梁俊平 李健 +2 位作者 赵法箴 刘萍 常志强 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2012年第4期644-653,共10页
Turbot Scophthalmus maximus, an important aquaculture species in China, currently suffers from epizootic diseases because of high density aquaculture. Enrofloxacin has been used to treat various systemic bacterial fis... Turbot Scophthalmus maximus, an important aquaculture species in China, currently suffers from epizootic diseases because of high density aquaculture. Enrofloxacin has been used to treat various systemic bacterial fish infections. However, studies concerning the pharmacokinetics of enrofloxacin in turbot are limited. In this study, the pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin, were investigated in the turbot following intravenous and oral administration at 10 mg enrofloxacin/kg body weight, at 16℃ and 10℃ water temperatures. The concentrations of enrofloxacin and ciprofloxacin in the main tissues (plasma, muscle, liver and kidney) were detected by HPLC. The results show that the plasma concentration-time data for enrofloxacin were best described as a two-compartment open model after intravenous and oral administration. Three pharmacokinetic equations were established between the concentrations and temperatures. The kinetic profile of enrofloxacin was temperature dependent. The absorption half-life of enrofloxacin was 1.99 h and 2.17 h after oral administration, whereas the elimination half-life of the drug was 98.63 h and 136.59 h at 16℃ and 10℃, respectively. The peak concentration of enrofloxacin in plasma and tissues was higher at 16℃ than that at 10℃, and the peak plasma concentration time in the liver was the shortest at both temperatures among those of other tissues. The plasma ℃/MIC ratio varied between 11.08 and 5 540.00 at 16℃; and between 7.92 and 3 960.00 at 10℃. The AUC/MIC ratio was 467.82-280 690.00 at 16℃, and 359.48-215 690.00 at 10℃. These ratios indicate that it is possible to obtain therapeutic efficacy. Very low levels of ciprofloxacin were detected. The AUC ratios of ciprofloxacin and enrofloxacin in plasma suggest that plasma ciprofloxacin might play a minor role in enrofloxacin treatment for turbot. 展开更多
关键词 Scophthalmus maximus ENROFLOXACIN CIPROFLOXACIN PHARMACOKINETICS
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Safety and efficacy of levofloxacin versus ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients 被引量:7
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作者 Zhi-Chao Zhang Feng-Shuo Jin +3 位作者 Dong-Ming Liu Zhou-Jun Shen Ying-Hao Sun Ying-Lu Guo 《Asian Journal of Andrology》 SCIE CAS CSCD 2012年第6期870-874,共5页
Levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis. We investigated the safety and efficacy of levofloxacin compared with ciprofloxacin for the treatment of chronic... Levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis. We investigated the safety and efficacy of levofloxacin compared with ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients. This was a multicenter, open-label, randomized controlled non-inferiority trial. Four hundred and seventy-one patients with clinical symptoms/ signs were enrolled into the study, and 408 patients were microbiologically confirmed chronic bacterial prostatitis, who were randomized to either oral levofloxacin (500 mg q,d.) or ciprofloxacin (500 mg b.i^d.) for 4 weeks. Bacterial clearance rate, clinical symptoms/signs, adverse reactions and disease recurrence were assessed. The clinical symptoms and signs (including dysuria, perineal discomfort or pain) and bacteria cultures in 209 patients treated with levofloxacin and 199 patients treated with ciprofloxacin were similar. The most common bacteria were Escherichia cofiand Staphylococcus aureus. One to four weeks after the end of 4 weeks treatment, the bacterial clearance rate (86.06% vs. 60.03%; P〈O.05) and the clinical efficacy (including clinical cure and clinical improvement(93.30% vs. 71.86%; P〈0.05)) were significantly higher in the levofloxacin-treated group than in the ciprofloxacin-treated group. The microbiological recurrence rate was significantly lower in the levofloxacin-treated group than in the ciprofloxacin-treated group (4.00% vs. 19.25%; P〈0.05). Rates of adverse events and treatment-related adverse events were slightly lower in the levofloxacin-treated group than in ciprofloxacin-treated group. Levofloxacin showed some advantages over ciprofloxacin in terms of clinical efficacy and disease recurrence, with a low rate of adverse events, for the treatment of chronic bacterial prostatitis in Chinese patients. 展开更多
关键词 chronic bacterial prostatitis CIPROFLOXACIN LEVOFLOXACIN RECURRENCE
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Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction 被引量:13
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作者 Vittorio Magri Emanuele Montanari +5 位作者 Visnja Skerk Alemka Markotic Emanuela Marras Antonella Restelli Kurt G Naber Gianpaolo Perletti 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第6期819-827,共9页
We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category Ⅱ chronic bacterial prostatitis (CBP). The aim of this study is to retrospectively compare the microbi... We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category Ⅱ chronic bacterial prostatitis (CBP). The aim of this study is to retrospectively compare the microbiological and clinical findings of two treatment schemes for CBP based on the combination of azithromycin (500 rag, thrice-weekly) with a once-daily 500- or 750-mg dose of ciprofloxacin (Cipro-500 or Cipro-750 cohort, respectively). Combined administration of azithromycin (1500 mg week^-1) with ciprofloxacin at the rate of 750 mg day^- 1 for 4 weeks rather than at 500 mg day^- 1 for 6 weeks increased the eradication rates from 62.35% to 77.32% and the total bacteriological success from 71.76% to 85.57%. A significant decrease in pain and voiding signs/symptoms and a significant reduction in inflammatory leukocyte counts and serum prostate-specific antigen (PSA) were sustained throughout an 18-month follow-up period in both groups. Ejaculatory pain, haemospermia and premature ejaculation were significantly attenuated on microbiological eradication in both groups, but the latter subsided more promptly in the Cipro-750 cohort. In total, 59 Cipro-750 patients showed mild-to-severe erectile dysfunction (ED) at baseline, while 22 patients had no ED on microbiological eradication and throughout the follow-up period. In conclusion fluoroquinolone-macrolide therapy resulted in pathogen eradication and CBP symptom attenuation, including pain, voiding disturbances and sexual dysfunction. A once-daily 750-mg dose of ciprofloxacin for 4 weeks showed enhanced eradication rates and lower inflammatory white blood cell counts compared to the 500-mg dose for 6 weeks. Our results are open to further prospective validation. 展开更多
关键词 AZITHROMYCIN chronic bacterial prostatitis chronic pelvic pain syndrome CIPROFLOXACIN erectile dysfunction InternationalIndex of Erectile Function (IIEF) National Institutes of Health Chronic Prostatitis Symptom Index (NiH-CPSI)
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Construction of TiO_(2)-pillared multilayer graphene nanocomposites as efficient photocatalysts for ciprofloxacin degradation 被引量:7
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作者 Xiong-feng Zeng Jian-sheng Wang +2 位作者 Ying-na Zhao Wen-li Zhang Meng-huan Wang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2021年第3期503-510,共8页
We successfully constructed TiO_(2)-pillared multilayer graphene nanocomposites(T-MLGs)via a facile method as follows:dodecanediamine pre-pillaring,ion exchange(Ti4+pillaring),and interlayer in-situ formation of TiO_(... We successfully constructed TiO_(2)-pillared multilayer graphene nanocomposites(T-MLGs)via a facile method as follows:dodecanediamine pre-pillaring,ion exchange(Ti4+pillaring),and interlayer in-situ formation of TiO_(2) by hydrothermal method.TiO_(2) nanoparticles were distributed uniformly on the graphene interlayer.The special structure combined the advantages of graphene and TiO_(2) nanoparticles.As a result,T-MLGs with 64.3wt%TiO_(2) showed the optimum photodegradation rate and adsorption capabilities toward ciprofloxacin.The photodegradation rate of T-MLGs with 64.3wt%TiO_(2) was 78%under light-emitting diode light irradiation for 150 min.Meanwhile,the pseudofirst-order rate constant of T-MLGs with 64.3wt%TiO_(2) was 3.89 times than that of pristine TiO_(2).The composites also exhibited high stability and reusability after five consecutive photocatalytic tests.This work provides a facile method to synthesize semiconductor-pillared graphene nanocomposites by replacing TiO_(2) nanoparticles with other nanoparticles and a feasible means for sustainable utilization of photocatalysts in wastewater control. 展开更多
关键词 pillared structure titanium dioxide-pillared multilayer graphene nanocomposites photocatalysis CIPROFLOXACIN
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Synthesis and Crystal Structure of Rare Earth Complex withCiprofloxacin 被引量:6
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作者 Pin YANG Jia Bin LI +1 位作者 Yan Ni TIAN Kai Bei YU (1 Institute of molecular Science, Shanxi University, Taiyuan 0300062 Analysis and Test Cented, Chinese Academy of Sciences, Chengdu 610041) 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第10期879-880,共2页
The complex of rare earth with ciprofloxacin has been synthesized and characterized by means of x-ray single crystal diffraction. The structure features of the complex are decribed.
关键词 rare earth CIPROFLOXACIN complex of cerium
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Prior exposure to ciprofloxacin disrupts intestinal homeostasis and predisposes ayu(Plecoglossus altivelis)to subsequent Pseudomonas plecoglossicida-induced infection 被引量:4
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作者 Xiang-Yu Wu Jin-Bo Xiong +6 位作者 Chen-Jie Fei Ting Dai Ting-Fang Zhu Zi-Yue Zhao Jing Pan Li Nie Jiong Chen 《Zoological Research》 SCIE CAS CSCD 2022年第4期648-665,共18页
With the rapid development of intensive farming,the aquaculture industry uses a great many antibiotics for the prevention and treatment of bacterial diseases.Despite their therapeutic functions,the overuse and accumul... With the rapid development of intensive farming,the aquaculture industry uses a great many antibiotics for the prevention and treatment of bacterial diseases.Despite their therapeutic functions,the overuse and accumulation of antibiotics also pose a threat to aquaculture organisms.In the present study,ayu(Plecoglossus altivelis)was used as a fish model to study the impacts of ciprofloxacin(CIP)overuse on intestinal homeostasis and immune response during subsequent Pseudomonas plecoglossicida infection.Based on 16S rRNA gene amplification and Illumina sequencing,we found that CIP pre-exposure caused significant variation in intestinal microbiota,including increased species richness,altered microbiota composition and interaction networks,and increased metabolic dysfunction.Furthermore,immunohistochemical analysis indicated that CIP pre-exposure resulted in severe mucosal layer damage,goblet cell reduction,and epithelial cell necrosis of the intestinal barrier in infected ayu.Quantitative real-time polymerase chain reaction(qRT-PCR)showed that disruption of intestinal homeostasis impaired systemic antiinfection immune responses in the intestine,gill,spleen,and head kidney,while inhibiting IL-1β,TNF-α,and IL-10 expression and promoting TGF-βexpression.Our findings indicated that CIP administration can directly affect intestinal microbiota composition and intestinal integrity in ayu fish.This perturbation of intestinal homeostasis is likely responsible for the lower survival rate of hosts following subsequent infection as the capacity to mount an effective immune response is compromised.This study also provides preliminary clues for understanding the effects of antibiotic overuse on higher vertebrates through trophic transfer. 展开更多
关键词 CIPROFLOXACIN MICROBIOTA Intestinal barrier Immune responses AYU
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Bcl-2 down modulation in WEHI-3B/CTRES cells resistant to Cholera Toxin(CT)-induced apoptosis 被引量:4
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作者 Augusto Pessina Cristina Croera +7 位作者 Nicoletta Savalli Arianna Bonomi Loredana Cavicchini Elisa Turlizzi Fabiana Guizzardi Lucia Guido Laura Daprai Maria GraziaNeri 《Cell Research》 SCIE CAS CSCD 2006年第3期306-312,共7页
The very different effects of Cholera Toxin (CT) on cell growth and proliferation may depend on the type of ganglioside receptors in cell membranes and different signal transduction mechanisms triggered, but other f... The very different effects of Cholera Toxin (CT) on cell growth and proliferation may depend on the type of ganglioside receptors in cell membranes and different signal transduction mechanisms triggered, but other functions related to the drug resistance mechanisms can not be excluded. The effect of CT treatment on the "in vitro" clonogenicity, the Population Doubling Time (PDT), apoptosis, PKA activation and Bax and Bcl-2 expression was evaluated in WEHI-3B cell line and its CT-resistant subclone (WEHI-3B/CTRES). In WEHI-3B parental cells the dramatic accumulation of cAMP induced by CT correlated well with PKA activation, increased PDT value, inhibition of clonogenicity and apoptosis. H-89 treatment inhibited PKA activation by CT but did not protect the cells from apoptosis and growth inhibition. In WEHI-3B/CTRES no significant CT-dependent accumulation of cAMP occurred with any increase of PKA activity and PDT. In CT resistant cells (WEHI-3B/CTRES), Bcl-2 expression was down regulated by both CT or drug treatment (eg, ciprofloxacin, CPX) although these cells were protected from CT-dependent apoptosis but not from drug-induced apoptosis. Differently from other cell models described, down regulation of Bcl-2 is proved to be independent on cAMP accumulation and PKA activation. Our observations support the implication of cAMP dependent kinase (PKA) in the inhibition of WEHI-3B cells growth and suggest that, in WEHI-3B/CTRES, Bcl-2 expression could be modulated by CT in the absence of cAMP accumulation. Also in consideration of many contradictory data reported in literature, our cell models (of one sensitive parental cell strain and two clones with different uncrossed specific resistance to CT and CPX) provides a new and interesting tool for better investigating the relationship between the CT signal transduction mechanisms and Bcl-2 expression and function. 展开更多
关键词 cholera toxin BCL-2 PKA apoptosis CIPROFLOXACIN resistance
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A granular adsorbent-supported Fe/Ni nanoparticles activating persulfate system for simultaneous adsorption and degradation of ciprofloxacin 被引量:4
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作者 Jiwei Liu Yufeng Du +2 位作者 Wuyang Sun Quanchao Chang Changsheng Peng 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2020年第4期1077-1084,共8页
In this work,Fe/Ni nanoparticles were produced through Fe(II)and Ni(II)reduction by NaBH4 and they were stabilized by a kind of prepared granular adsorbent(Fe/Ni@PGA).Fe/Ni@PGA as an environment-friendly activator was... In this work,Fe/Ni nanoparticles were produced through Fe(II)and Ni(II)reduction by NaBH4 and they were stabilized by a kind of prepared granular adsorbent(Fe/Ni@PGA).Fe/Ni@PGA as an environment-friendly activator was used to activate persulfate(PS)for the removal of ciprofloxacin from aqueous solution.Fe/Ni@PGA was systematically characterized via Brunauer-Emmett-Teller(BET)method,X-ray diffraction(XRD),scanning electron microscopy(SEM),and Fourier transform infrared spectroscopy(FTIR).The effects of PS concentration,initial solution pH,Fe/Ni@PGA dosage,initial ciprofloxacin concentration,reaction temperature,anions,and natural organic matters on the removal of ciprofloxacin by Fe/Ni@PGA/PS were analyzed.The removal efficiency of ciprofloxacin by Fe/Ni@PGA/PS was 93.24%under an initial pH of 3.0,PS concentration of 10 mM,Fe/Ni@PGA dosage of 0.1 g,and reaction temperature of 30℃.Fe/Ni@PGA could still exhibit high catalytic activity after nine cycles of regeneration.The removal mechanisms for ciprofloxacin by the Fe/Ni@PGA/PS system were proposed.In summary,the Fe/Ni@PGA/PS system could be applied as a promising technology for ciprofloxacin removal. 展开更多
关键词 Fe/Ni@PGA CIPROFLOXACIN PERSULFATE Sulfate radical Oxidation ADSORPTION
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