At present,the study into inflammatory markers has become a new tool which is most useful for establishing the prognosis of patients with acute coronary syndrome.The inflammatory substrate involved is acute coronary s...At present,the study into inflammatory markers has become a new tool which is most useful for establishing the prognosis of patients with acute coronary syndrome.The inflammatory substrate involved is acute coronary syndrome is extremely complex,with a large number of factors involved both in its activation and its modulation.It is known that C-reactive protein play a key role in the physiopathology of the atherosclerosis.Furthermore,scientific literature reports that the existence of a circadian rhythm in the triggering of cardiovascular accidents can suggest the implication of,or association with these physiological rhythms that show activity peaks at particular times of the day or night.Keeping in mind the potential association between inflammation and circadian rhythm,a better understanding of the kinetics of said markers could lead to improvements in their use in cardiovascular diseases.Considering the diversity of the diurnal variations in the intrinsic properties of the cardiovascular system,these should be kept in mind during the design of in vivo experimental studies.As such,the information available reinforces our opinion when suitably validating the biomarkers and the need to demon-strate their reliability,stability,and lack of variability and standardise the methodology of their measurement.展开更多
目的：探讨原发性高血压患者血压变异性与冠状动脉病变程度的相关性。方法选择2013年1月-2014年11月于成都市第五人民医院诊治的216例原发性高血压患者,根据冠状动脉造影结果,分为合并冠脉病变组118例和单纯高血压组98例。合并冠脉病变...目的：探讨原发性高血压患者血压变异性与冠状动脉病变程度的相关性。方法选择2013年1月-2014年11月于成都市第五人民医院诊治的216例原发性高血压患者,根据冠状动脉造影结果,分为合并冠脉病变组118例和单纯高血压组98例。合并冠脉病变组根据冠状动脉Gensini评分分为轻度组、中度组和重度组,分析动态血压、心肌缺血总负荷（TIB）及冠状动脉Gensini评分的关系。结果合并冠脉病变组24 h平均收缩压（24 h SBP）、日间平均收缩压（dSBP）、夜间平均收缩压（nSBP）、24 h收缩压变异系数（24 h SCV）、24 h舒张压变异系数（24 h DCV）、日间收缩压变异系数（dSCV）、夜间收缩压变异系数（nSCV）、日间舒张压变异系数（dDCV）、夜间舒张压变异系数（nDCV）均明显高于单纯高血压组（P〈0.05）。轻度组、中度组和重度组24 h SCV、24 h DCV、dSCV、nSCV、TIB差异均有统计学意义（P〈0.05）。24 h SCV、dSCV均与TIB呈正相关（P〈0.05）,24 h SCV、dSCV、nSCV均与冠状动脉病变Gensini评分呈正相关（P〈0.05）。多元线性回归分析显示,24 h SCV、dSCV、nSCV与冠状动脉病变程度独立相关（P〈0.05）。结论血压变异性随冠状动脉病变程度及TIB增加而升高；24 h SCV、dSCV、nSCV与冠状动脉病变程度独立相关。展开更多
文摘At present,the study into inflammatory markers has become a new tool which is most useful for establishing the prognosis of patients with acute coronary syndrome.The inflammatory substrate involved is acute coronary syndrome is extremely complex,with a large number of factors involved both in its activation and its modulation.It is known that C-reactive protein play a key role in the physiopathology of the atherosclerosis.Furthermore,scientific literature reports that the existence of a circadian rhythm in the triggering of cardiovascular accidents can suggest the implication of,or association with these physiological rhythms that show activity peaks at particular times of the day or night.Keeping in mind the potential association between inflammation and circadian rhythm,a better understanding of the kinetics of said markers could lead to improvements in their use in cardiovascular diseases.Considering the diversity of the diurnal variations in the intrinsic properties of the cardiovascular system,these should be kept in mind during the design of in vivo experimental studies.As such,the information available reinforces our opinion when suitably validating the biomarkers and the need to demon-strate their reliability,stability,and lack of variability and standardise the methodology of their measurement.
文摘目的：探讨原发性高血压患者血压变异性与冠状动脉病变程度的相关性。方法选择2013年1月-2014年11月于成都市第五人民医院诊治的216例原发性高血压患者,根据冠状动脉造影结果,分为合并冠脉病变组118例和单纯高血压组98例。合并冠脉病变组根据冠状动脉Gensini评分分为轻度组、中度组和重度组,分析动态血压、心肌缺血总负荷（TIB）及冠状动脉Gensini评分的关系。结果合并冠脉病变组24 h平均收缩压（24 h SBP）、日间平均收缩压（dSBP）、夜间平均收缩压（nSBP）、24 h收缩压变异系数（24 h SCV）、24 h舒张压变异系数（24 h DCV）、日间收缩压变异系数（dSCV）、夜间收缩压变异系数（nSCV）、日间舒张压变异系数（dDCV）、夜间舒张压变异系数（nDCV）均明显高于单纯高血压组（P〈0.05）。轻度组、中度组和重度组24 h SCV、24 h DCV、dSCV、nSCV、TIB差异均有统计学意义（P〈0.05）。24 h SCV、dSCV均与TIB呈正相关（P〈0.05）,24 h SCV、dSCV、nSCV均与冠状动脉病变Gensini评分呈正相关（P〈0.05）。多元线性回归分析显示,24 h SCV、dSCV、nSCV与冠状动脉病变程度独立相关（P〈0.05）。结论血压变异性随冠状动脉病变程度及TIB增加而升高；24 h SCV、dSCV、nSCV与冠状动脉病变程度独立相关。
