The structural feature shown on a remote sensing image is a synthetic result ofcombination of the deformations produced during the entire geological history of an area.Therefore, the respective tectonic stress field o...The structural feature shown on a remote sensing image is a synthetic result ofcombination of the deformations produced during the entire geological history of an area.Therefore, the respective tectonic stress field of each of the different stages in the complexdeformation of an area can be reconstructed in three steps: (1) geological structures formed atdifferent times are distinguished in remote sensing image interpretation; (2) structuraldeformation fields at different stages are determined by analyzing relationships betweenmicrostructures (joints and fractures) and the related structures (folds and faults); and (3)tectonic stress fields at different stages are respectively recovered through a study of the featuresof structural deformation fields in different periods. Circular structures and related circlular and radial joints are correlated in space to con-cealed structural rises. The authors propose a new method for establishing a natural model ofthe concealed structural rises and calculating the tectonic stress field by using quantitative dataof the remote sensing information of circular structures and related linear structures.展开更多
A theoretical model of a circular flexure-mode piezoelectric bimorph ac- tuator is established. The circular bimorph structure, consisting of two flexible layers of piezoelectric material and a layer of metallic mater...A theoretical model of a circular flexure-mode piezoelectric bimorph ac- tuator is established. The circular bimorph structure, consisting of two flexible layers of piezoelectric material and a layer of metallic material in the middle, is powered to the flexural deformation. The analytical solutions including the statics solution and the dynamics solution are derived from the 3D equations of the linear theory of piezoelectric- ity. Numerical results are included to show the circular bimorph piezoelectric actuator (CBPA) performance, depending on the physical parameters.展开更多
In this article, the general text structure of English and Chinese will be stated respectively at first. Then the issue of whether different rhetoric between Chinese and English will influence the reading comprehensio...In this article, the general text structure of English and Chinese will be stated respectively at first. Then the issue of whether different rhetoric between Chinese and English will influence the reading comprehension of the Chinese students will be analyzed and evaluated.展开更多
Oligonucleotide drugs have been used widely as therapeutic agents for gene therapy,while their instability in biological media and inefficiency for intracellular delivery remain major hurdles for practical in vivo app...Oligonucleotide drugs have been used widely as therapeutic agents for gene therapy,while their instability in biological media and inefficiency for intracellular delivery remain major hurdles for practical in vivo applications.Herein,we report a circular Y-shaped aptamer–DNAzyme conjugate(cYAD)for highly efficient in vivo gene silencing via RNA cleavage,which can been employed in various disease treatments,including cancer,inflammation,as well as viral infections.Systematic studies revealed that cyclization of the DNA structure could improve the stability of oligonucleotide drugs in vivo.Besides,the bivalent aptamer motifs provided a specific and enhanced tumor cell targeting ability for accumulation and retention of the oligonucleotide drugs at the tumor site.As a proof of concept,a widely applicable Na+-dependent fluorescent sensor,NaA43 DNAzyme,was used to inhibit MET gene expression in mice tumor model tissues,which exhibited highly efficient gene silencing performance in vivo,which confirmed our findings with cYAD.This strategy provides a novel approach for the construction of oligonucleotide drugs for practical therapeutic applications.展开更多
基金This study was sponsored by The Open Research Laboratory of Quantitative Prediction,Exploration and Assessment of Mineral Resources,MGMR,China.
文摘The structural feature shown on a remote sensing image is a synthetic result ofcombination of the deformations produced during the entire geological history of an area.Therefore, the respective tectonic stress field of each of the different stages in the complexdeformation of an area can be reconstructed in three steps: (1) geological structures formed atdifferent times are distinguished in remote sensing image interpretation; (2) structuraldeformation fields at different stages are determined by analyzing relationships betweenmicrostructures (joints and fractures) and the related structures (folds and faults); and (3)tectonic stress fields at different stages are respectively recovered through a study of the featuresof structural deformation fields in different periods. Circular structures and related circlular and radial joints are correlated in space to con-cealed structural rises. The authors propose a new method for establishing a natural model ofthe concealed structural rises and calculating the tectonic stress field by using quantitative dataof the remote sensing information of circular structures and related linear structures.
基金Project supported by the National Natural Science Foundation of China(Nos.11403109,11190014,10921063,and 11373073)the Natural Science Foundation of Jiangsu Province(No.BK20141042)
文摘A theoretical model of a circular flexure-mode piezoelectric bimorph ac- tuator is established. The circular bimorph structure, consisting of two flexible layers of piezoelectric material and a layer of metallic material in the middle, is powered to the flexural deformation. The analytical solutions including the statics solution and the dynamics solution are derived from the 3D equations of the linear theory of piezoelectric- ity. Numerical results are included to show the circular bimorph piezoelectric actuator (CBPA) performance, depending on the physical parameters.
文摘In this article, the general text structure of English and Chinese will be stated respectively at first. Then the issue of whether different rhetoric between Chinese and English will influence the reading comprehension of the Chinese students will be analyzed and evaluated.
基金supported by grants from the National Natural Science Foundation of China(nos.81601597,21904119,319009919,21621003,and U1704178)Innovation Talent Support Program of Henan Province(no.19HASTIT006)+2 种基金Key Scientific Research Projects(Education Department of Henan Province,nos.17A350003 and 20A350009)Key Scientific Research Projects(Science and Technology Department of Henan Province,no.192102310147)Postdoctoral Science Foundation of China(nos.2018T110745 and 2017M622380).
文摘Oligonucleotide drugs have been used widely as therapeutic agents for gene therapy,while their instability in biological media and inefficiency for intracellular delivery remain major hurdles for practical in vivo applications.Herein,we report a circular Y-shaped aptamer–DNAzyme conjugate(cYAD)for highly efficient in vivo gene silencing via RNA cleavage,which can been employed in various disease treatments,including cancer,inflammation,as well as viral infections.Systematic studies revealed that cyclization of the DNA structure could improve the stability of oligonucleotide drugs in vivo.Besides,the bivalent aptamer motifs provided a specific and enhanced tumor cell targeting ability for accumulation and retention of the oligonucleotide drugs at the tumor site.As a proof of concept,a widely applicable Na+-dependent fluorescent sensor,NaA43 DNAzyme,was used to inhibit MET gene expression in mice tumor model tissues,which exhibited highly efficient gene silencing performance in vivo,which confirmed our findings with cYAD.This strategy provides a novel approach for the construction of oligonucleotide drugs for practical therapeutic applications.