The antigen gene of ABO blood group system,called ABO,is located on human chromosome 9,with a total length of 19.5 kb.It is the first blood group system found by human beings.[1]ABO blood group subtypes are formed by ...The antigen gene of ABO blood group system,called ABO,is located on human chromosome 9,with a total length of 19.5 kb.It is the first blood group system found by human beings.[1]ABO blood group subtypes are formed by ABO genovariation,i.e.,gene A variation for A subtype,gene B variation for B subtype and gene O variation for new O alleles.ABO subtypes contain A3,Ax,Ael,Aw,Am,B3,Bx,Bel,Bw,cis-AB,B(A).Generally,an individual with AB blood group has an A allele on one chromosome,with B allele on its paired chromosome.This phenomenon is called trans-AB.However,cis-AB is a unique ABO phenotype that A and B alleles are located on the same chromosome,so that it can be inherited by the next generation.[2]This special mode of inheritance often causes a discrepancy of ABO blood grouping and then reduces the effectiveness and safety of blood transfusion.Therefore,to accurately identify the blood group of cis-AB is a precondition for the safety of blood transfusion.[3]The serological and genotyping analysis on a case of cis-AB patient in our hospital is reported as follows.展开更多
ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide epitopes.The difference b...ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide epitopes.The difference between the consensus A gene （A101 allele） usually used as the reference and the consensus B gene （B101 allele） are 7 in-frame single nucleotide polymorphisms （SNPs）,among which only 4 alleles cause amino acid mutations in the enzyme.When A allele was inherited from one parent and B allele was inherited from the other which produced the AB blood group,this is known as trans-AB.Cis-AB is characterized as mutant ABO alleles encoding a glycosyltransferase capable of synthesizing both A and B antigens which is very rare.展开更多
文摘The antigen gene of ABO blood group system,called ABO,is located on human chromosome 9,with a total length of 19.5 kb.It is the first blood group system found by human beings.[1]ABO blood group subtypes are formed by ABO genovariation,i.e.,gene A variation for A subtype,gene B variation for B subtype and gene O variation for new O alleles.ABO subtypes contain A3,Ax,Ael,Aw,Am,B3,Bx,Bel,Bw,cis-AB,B(A).Generally,an individual with AB blood group has an A allele on one chromosome,with B allele on its paired chromosome.This phenomenon is called trans-AB.However,cis-AB is a unique ABO phenotype that A and B alleles are located on the same chromosome,so that it can be inherited by the next generation.[2]This special mode of inheritance often causes a discrepancy of ABO blood grouping and then reduces the effectiveness and safety of blood transfusion.Therefore,to accurately identify the blood group of cis-AB is a precondition for the safety of blood transfusion.[3]The serological and genotyping analysis on a case of cis-AB patient in our hospital is reported as follows.
文摘ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide epitopes.The difference between the consensus A gene （A101 allele） usually used as the reference and the consensus B gene （B101 allele） are 7 in-frame single nucleotide polymorphisms （SNPs）,among which only 4 alleles cause amino acid mutations in the enzyme.When A allele was inherited from one parent and B allele was inherited from the other which produced the AB blood group,this is known as trans-AB.Cis-AB is characterized as mutant ABO alleles encoding a glycosyltransferase capable of synthesizing both A and B antigens which is very rare.
