IM To study the effect of intraperitoneal hyperthermic double distilled water and cisdiaminodichloroplatinum (DDP) perfusion in treatment of cancerous ascites and radical gastrectomy.METHODS H22 cancer cells (2×...IM To study the effect of intraperitoneal hyperthermic double distilled water and cisdiaminodichloroplatinum (DDP) perfusion in treatment of cancerous ascites and radical gastrectomy.METHODS H22 cancer cells (2×107 tumor cells each mouse) were injected into the peritoneal cavity of LACA mice. Five days after the injection, intraperitoneal perfusion of 37℃ isotonic fluid (Group Ⅰ), simple hyperthermic (43℃) double distilled water (Group Ⅱ), isotonic fluid (group Ⅲ), DDP (group Ⅳ) and hyperthermic double distilled water perfusion combined with DDP (group Ⅴ) were performed. Based on the experiment from September 1991 through September 1993, intraperitoneal hyperthermic double distilled water perfusion with DDP was used to treat 32 advanced gastric cancer patients after radical gastrectomy.RESULTS In comparison with the control group, the cancer cells in the peritoneal cavity of LACA mice were almost completely destroyied, the ascites was markedly inhibited and the survival time was prolonged, the growth of peritoneal cancerous nodes was reduced in all groups, except the control group.Clinically, after oneyear followup, all 32 patients with advanced carcinoma got satisfactory results, but the 2year followup was not satisfactory.CONCLUSION The intraperitoneal hyperthermic double distilled water perfusion with DDP inhibited the occurrence of ascites in LACA mice, and prolonged the lifetime of gastric cancer patients after radical gastrectomy.展开更多
文摘IM To study the effect of intraperitoneal hyperthermic double distilled water and cisdiaminodichloroplatinum (DDP) perfusion in treatment of cancerous ascites and radical gastrectomy.METHODS H22 cancer cells (2×107 tumor cells each mouse) were injected into the peritoneal cavity of LACA mice. Five days after the injection, intraperitoneal perfusion of 37℃ isotonic fluid (Group Ⅰ), simple hyperthermic (43℃) double distilled water (Group Ⅱ), isotonic fluid (group Ⅲ), DDP (group Ⅳ) and hyperthermic double distilled water perfusion combined with DDP (group Ⅴ) were performed. Based on the experiment from September 1991 through September 1993, intraperitoneal hyperthermic double distilled water perfusion with DDP was used to treat 32 advanced gastric cancer patients after radical gastrectomy.RESULTS In comparison with the control group, the cancer cells in the peritoneal cavity of LACA mice were almost completely destroyied, the ascites was markedly inhibited and the survival time was prolonged, the growth of peritoneal cancerous nodes was reduced in all groups, except the control group.Clinically, after oneyear followup, all 32 patients with advanced carcinoma got satisfactory results, but the 2year followup was not satisfactory.CONCLUSION The intraperitoneal hyperthermic double distilled water perfusion with DDP inhibited the occurrence of ascites in LACA mice, and prolonged the lifetime of gastric cancer patients after radical gastrectomy.
