The“six-and-twelve”(6&12)score is a new hepatocellular carcinoma(HCC)prognostic index designed for recommended transarterial chemoembolization(TACE)candidates.Quick and easy to use by the sum of tumor size(cm)an...The“six-and-twelve”(6&12)score is a new hepatocellular carcinoma(HCC)prognostic index designed for recommended transarterial chemoembolization(TACE)candidates.Quick and easy to use by the sum of tumor size(cm)and number,this model identifies three groups with different survival time(the sum is≤6;or>6 but≤12;or>12);a survival benefit with TACE can be expected for HCC patients with a score not exceeding twelve.Recently,Wang ZW et al showed that the“6&12”model was the best system correlated with radiological response after the first TACE.Thus,we wanted to assess its survival prediction ability as well as its prognostic value and compared it to other systems(Barcelona Clinic Liver Cancer,Hong Kong Liver Cancer(HKLC)staging,Albumin-Bilirubin grade,tumor nodularity,infiltrative nature of the tumor,alpha-fetoprotein,Child-Pugh class,and Performance Status score,Cancer of the Liver Italian Program,Model to Estimate Survival for HCC scores,up-to-seven criteria)different from Wang ZW et al study in a multicenter French cohort of HCC including only recommended TACE candidates retrospectively enrolled.As previously demonstrated,we show that the"6&12”score can classify survival within this French cohort,with a prognostic value comparable to that of other systems,except HKLC staging.More importantly,the“6&12”score simplicity and ability in patients’stratification outperform other systems for a routine clinical practice.展开更多
Objective To study the relationship between severity of skeletal Class Ⅲ malocclusion and the patient's emotional status, as well as motivation for seeking surgical correction and satisfaction with the outcome o...Objective To study the relationship between severity of skeletal Class Ⅲ malocclusion and the patient's emotional status, as well as motivation for seeking surgical correction and satisfaction with the outcome of the surgery Methods One hundred and forty consecutive Chinese patients with skeletal Class Ⅲ malocclusion who had been treated with a combined orthodontic and surgical approach were studied Sixty seven percent (40 males and 54 females) responded to a questionnaire Fifty four percent had two jaw deformities, 32% mandibular hyperplasia and 14% maxillary hypoplasia Surgical procedures: 77% received two jaw surgeries, 15% maxillary advancement and 8% mandibular setback This was a retrospective study based on questionnaires with numerical scale ranked answers (0: not at all; 1: a little; 2: moderately; 3: quite a bit; and 4: extremely) Results ANB angle was significantly negatively correlated with feelings about the nickname related to their facial problems (embarrassment: r =-0 30, P <0 01; worn out r =-0 32, P <0 01; angry r = -0 24, P <0 05) ANB angle also had a significant negative correlation with the reasons for having the surgery (pressure from their friends: r =-0 21, P <0 05, and referred by physician: r =-0 24, P <0 05) Changes in life style as a result of surgery were significantly negatively correlated with the ANB angle before treatment, positive influence on relationships with the opposite sex ( r =-0 25, P <0 05), positive influence in social activiies ( r =-0 22, P <0 05) Conclusion The psychological status before surgery and the outcome following orthognathic surgery in patients with skeletal Class Ⅲ malocclusion were closely related to severity of the malocclusion展开更多
文摘The“six-and-twelve”(6&12)score is a new hepatocellular carcinoma(HCC)prognostic index designed for recommended transarterial chemoembolization(TACE)candidates.Quick and easy to use by the sum of tumor size(cm)and number,this model identifies three groups with different survival time(the sum is≤6;or>6 but≤12;or>12);a survival benefit with TACE can be expected for HCC patients with a score not exceeding twelve.Recently,Wang ZW et al showed that the“6&12”model was the best system correlated with radiological response after the first TACE.Thus,we wanted to assess its survival prediction ability as well as its prognostic value and compared it to other systems(Barcelona Clinic Liver Cancer,Hong Kong Liver Cancer(HKLC)staging,Albumin-Bilirubin grade,tumor nodularity,infiltrative nature of the tumor,alpha-fetoprotein,Child-Pugh class,and Performance Status score,Cancer of the Liver Italian Program,Model to Estimate Survival for HCC scores,up-to-seven criteria)different from Wang ZW et al study in a multicenter French cohort of HCC including only recommended TACE candidates retrospectively enrolled.As previously demonstrated,we show that the"6&12”score can classify survival within this French cohort,with a prognostic value comparable to that of other systems,except HKLC staging.More importantly,the“6&12”score simplicity and ability in patients’stratification outperform other systems for a routine clinical practice.
文摘Objective To study the relationship between severity of skeletal Class Ⅲ malocclusion and the patient's emotional status, as well as motivation for seeking surgical correction and satisfaction with the outcome of the surgery Methods One hundred and forty consecutive Chinese patients with skeletal Class Ⅲ malocclusion who had been treated with a combined orthodontic and surgical approach were studied Sixty seven percent (40 males and 54 females) responded to a questionnaire Fifty four percent had two jaw deformities, 32% mandibular hyperplasia and 14% maxillary hypoplasia Surgical procedures: 77% received two jaw surgeries, 15% maxillary advancement and 8% mandibular setback This was a retrospective study based on questionnaires with numerical scale ranked answers (0: not at all; 1: a little; 2: moderately; 3: quite a bit; and 4: extremely) Results ANB angle was significantly negatively correlated with feelings about the nickname related to their facial problems (embarrassment: r =-0 30, P <0 01; worn out r =-0 32, P <0 01; angry r = -0 24, P <0 05) ANB angle also had a significant negative correlation with the reasons for having the surgery (pressure from their friends: r =-0 21, P <0 05, and referred by physician: r =-0 24, P <0 05) Changes in life style as a result of surgery were significantly negatively correlated with the ANB angle before treatment, positive influence on relationships with the opposite sex ( r =-0 25, P <0 05), positive influence in social activiies ( r =-0 22, P <0 05) Conclusion The psychological status before surgery and the outcome following orthognathic surgery in patients with skeletal Class Ⅲ malocclusion were closely related to severity of the malocclusion