Tissue optical clearing by use of optical clearing agents(OCAs)has been proven to have potential to reduce the highly scattering effect of biological tissues in optical techniques.However,the difference in tissue samp...Tissue optical clearing by use of optical clearing agents(OCAs)has been proven to have potential to reduce the highly scattering effect of biological tissues in optical techniques.However,the difference in tissue samples could lead to unreliable results,making it difficult to quantitatively control the dose of OCAs during the course of tissue optical clearing.In this work,in order to study the effects of optical clearing,we customized tissue-like phantoms with optical properties of some biological tissue.Diffuse reflectance and total transmittance of tissue-like phantoms with different OCAs(DMSO or glycerol)and porcine skin tissues were measured.Then optical property parameters were calculated by inverse adding-doubling(IAD)algorithm.Results showed that OCAs could lead to a reduction in scattering of tissue-like phantoms as it did to porcine skin tissue in vitro.Furthermore,a series of relational expressions could be fit to quantitatively describe the relationship between the doses of OCAs and the reduction of scattering effects.Therefore,proper tissue-like phantom could facilitate optical clearing to be used in quantitative control of tissue optical properties,and further promote the application potential of optical clearing to light-based noninvasive diagnostic and therapeutic techniques.展开更多
In our previous study, metals have been used as absorbers in the clear plastic laser transmission welding. The effects of metal thermal conductivity on the welding quality are investigated in the present work. Four me...In our previous study, metals have been used as absorbers in the clear plastic laser transmission welding. The effects of metal thermal conductivity on the welding quality are investigated in the present work. Four metals with distinctly different thermal conductivities, i.e., titanium, nickel, molybdenum, and copper, are selected as light absorbers. The lap welding is conducted with an 808 nm diode laser and simulation experiments are also conducted. Nickel electroplating test is carried out to minimize the side-effects from different light absorptivities of different metals. The results show that the welding with an absorber of higher thermal conductivity can accommodate higher laser input power before smoking, which produces a wider and stronger welding seam.The positive role of the higher thermal conductivity can be attributed to the fact that a desirable thermal field distribution for the molecular diffusion and entanglement is produced from the case with a high thermal conductivity.展开更多
基金supported by the National Natural Science Foundation of China(NSFC,Nos.30600126,30700168 and 30900275).
文摘Tissue optical clearing by use of optical clearing agents(OCAs)has been proven to have potential to reduce the highly scattering effect of biological tissues in optical techniques.However,the difference in tissue samples could lead to unreliable results,making it difficult to quantitatively control the dose of OCAs during the course of tissue optical clearing.In this work,in order to study the effects of optical clearing,we customized tissue-like phantoms with optical properties of some biological tissue.Diffuse reflectance and total transmittance of tissue-like phantoms with different OCAs(DMSO or glycerol)and porcine skin tissues were measured.Then optical property parameters were calculated by inverse adding-doubling(IAD)algorithm.Results showed that OCAs could lead to a reduction in scattering of tissue-like phantoms as it did to porcine skin tissue in vitro.Furthermore,a series of relational expressions could be fit to quantitatively describe the relationship between the doses of OCAs and the reduction of scattering effects.Therefore,proper tissue-like phantom could facilitate optical clearing to be used in quantitative control of tissue optical properties,and further promote the application potential of optical clearing to light-based noninvasive diagnostic and therapeutic techniques.
基金Supported by the National Key R&D Program of China under Grant No 2016YFA0401100the National Natural Science Foundation of China under Grant No 61575129the National High-Technology Research and Development Program of China under Grant No 2015AA021102
文摘In our previous study, metals have been used as absorbers in the clear plastic laser transmission welding. The effects of metal thermal conductivity on the welding quality are investigated in the present work. Four metals with distinctly different thermal conductivities, i.e., titanium, nickel, molybdenum, and copper, are selected as light absorbers. The lap welding is conducted with an 808 nm diode laser and simulation experiments are also conducted. Nickel electroplating test is carried out to minimize the side-effects from different light absorptivities of different metals. The results show that the welding with an absorber of higher thermal conductivity can accommodate higher laser input power before smoking, which produces a wider and stronger welding seam.The positive role of the higher thermal conductivity can be attributed to the fact that a desirable thermal field distribution for the molecular diffusion and entanglement is produced from the case with a high thermal conductivity.
