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Impact of COVID-19 on the clinical status of patients with Wilson disease 被引量:1
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作者 Yu-Pei Zhuang Hao-Jie Zhong 《World Journal of Gastroenterology》 SCIE CAS 2021年第26期4248-4251,共4页
The coronavirus disease 2019(COVID-19)pandemic has greatly impacted health systems.Many guidelines on chronic liver diseases have been released to optimize the use of medical resources and patient management.However,m... The coronavirus disease 2019(COVID-19)pandemic has greatly impacted health systems.Many guidelines on chronic liver diseases have been released to optimize the use of medical resources and patient management.However,most of these guidelines have been established through expert consensus because the existing data do not provide strong evidence for developing effective recommendations.As Wilson disease(WD)is a rare chronic liver disease,the impact of COVID-19 on the clinical status of patients with WD is unclear.The present study showed a marked shortage of medical resources for clinically managing patients with WD during the pandemic.Although patients with WD who consistently took anticopper therapy showed no significant differences in hepatic and extrahepatic markers before and after the pandemic,their complication incidences,especially the infection incidence,were significantly increased during the study period.Therefore,patients with WD should be encouraged to adhere to anticopper therapy and be closely monitored to prevent infections and other complications.The present study provides a clinical basis for further managing WD during the pandemic. 展开更多
关键词 Coronavirus disease 2019 Wilson disease clinical status COMPLICATIONS INFECTIONS Anticopper therapy
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Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction:A randomized clinical trial 被引量:60
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《South China Journal of Cardiology》 CAS 2013年第1期77-78,共2页
Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, paralle... Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial of 216 sta- ble outpatients with HF, ejection fraction ≥ 50%, elevated N-terminal brain-type natriuretic peptide or elevat- ed invasively measured filling pressures, and reduced exercise capacity. Participants were randomized from October 2008 through February 2012 at 26 centers in North America. Follow-up was through August 30, 2012. 展开更多
关键词 time HF Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction
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Status of Clinical Researches on Treatment of Lupus Erythematosus at Our Hospital in Recent 30 Years 被引量:3
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作者 秦万章 《Chinese Journal of Integrative Medicine》 SCIE CAS 2010年第2期180-185,共6页
Lupus erythematosus(LE) is one of autoimmune diseases which could be classified,according to the spectrum of severity,into the chronic discoid type (DLE),profundal type(PLE),subacute skin type(ScLE), systemic ... Lupus erythematosus(LE) is one of autoimmune diseases which could be classified,according to the spectrum of severity,into the chronic discoid type (DLE),profundal type(PLE),subacute skin type(ScLE), systemic type(SLE),overlap type(OLE) and its subtype, i.e.,mixed connective tissue disease(MCTD).The injury of mild LE is limited mainly at the local skin, 展开更多
关键词 SLE status of clinical Researches on Treatment of Lupus Erythematosus at Our Hospital in Recent 30 Years
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