Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury

Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.

Design and analysis of an advanced thermal management system for the solar close observations and proximity experiments spacecraft

In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.

A review of closed-loop reservoir management

The closed-loop reservoir management technique enables a dynamic and real-time optimal production schedule under the existing reservoir conditions to be achieved by adjusting the injection and production strategies. This is one of the most effective ways to exploit limited oil reserves more economically and efficiently. There are two steps in closed-loop reservoir management： automatic history matching and reservoir production opti- mization. Both of the steps are large-scale complicated optimization problems. This paper gives a general review of the two basic techniques in closed-loop reservoir man- agement; summarizes the applications of gradient-based algorithms, gradient-free algorithms, and artificial intelligence algorithms; analyzes the characteristics and application conditions of these optimization methods; and finally discusses the emphases and directions of future research on both automatic history matching and reservoir production optimization.

Improving the Performance of Urban Waste Management Systems in the Context of a Closed-Loop Supply Chain

The saving of non-renewable energies, as well as the reduction of emissions into the environment, are two crucial objectives of industrial production. The recovery of post-consumer products associated with the use of end-of-life products is part of a context of optimization of these objectives. This recovery maximizes the use of resources from end-of-life products in a circular logic while recording the environmental footprint. This study considers a recycling strategy adapted to the need and urgency to reduce greenhouse gas emissions caused by global warming. The proposed model aims to optimize the profits of the circular manufacturing strategies while minimizing operational costs (collection, sorting, recycling), transport, GHG emissions and recycling. In this paper, a compromise between the gains of CM and the costs associated with it was studied. The robustness of the designed model was tested using a case study based on real-world scenarios. A sensitivity analysis was carried out to study the impact of the emission cost on the overall objective, considering the two options currently offered to industries. The obtained results support companies to take the ecological aspect into account and integrate sustainable development into their strategic axes for their logistics supply chains.

Study the closed loop management system for the coal mines based on risk management

In recent years, the coal safety has been become the urgent problem in China,and severe and fatal coal mine accidents occurred frequently.Must pay attention to coal safety management immediately, because the coal mine accidents not only caused serious economic losses to the country and people but also had negative impact on the society and politics.A closed loop management system was put forward to build to improve the coal safety management.The closed loop management system was formed four parts,identifying the hazard sources, classifying the hidden troubles hazard sources, the risk prealarm and risk control, and the evaluation system.

GJB/Z 194-2021《装备质量问题归零实施指南》应用解析

GJB/Z 194—2021《装备质量问题归零实施指南》以国家军用标准的形式对装备质量问题技术归零和管理归零工作进行法律化、制度化管理。其典型特征是具有权威性、全面性、程序性、指导性,对装备质量问题归零具体实践工作具有良好的指导意义。

基于闭环管理理念的国有企业战略管理模式构建研究--以南方电网A公司为例

随着国有企业进入了深化改革阶段,战略管理已经成为国有企业现代化建设的重要内容,更是国企转型发展、高质量发展的必然要求。当前对于国有企业特别是电网企业如何运用战略管理理论和方法来开展体系化的战略管理模式构建,缺乏系统性研究。本文以南方电网A公司为例,系统分析战略管理存在的问题,在坚持“两个一以贯之”原则的基础上,研究提出国有企业战略管理模式框架,为国有企业战略管理改革提供了新思路及落地参考,具有一定的理论价值和实践意义。

Obstacles to the Integrated Care of Children Aged 6 to 59 Months Suffering from Acute and Severe Malnutrition at the Chu-Me and HATC of N’Djamena/Chad

Introduction: the problem of Severe Acute Malnutrition (SAM) and its consequences concern and challenge all social actors worldwide. The objective of the study was to identify the real obstacles that actors face in the integrated management of children aged 6 - 59 months suffering from SAM at the University Hospital of Mother and Child (CHUME) and the Chad-China Friendship Hospital (HATC) of N’Djamena. Methodology: this is a cross-sectional descriptive and interpretative study conducted from January to October 2023 at the CHUME and HATC of N’Djamena. It is based on questionnaires and direct observation of two hundred and thirty-six (236) parents or guardians of malnourished children admitted to these health facilities. All 236 agreed to participate freely in this study. Results: it appears from this study that the obstacles to the integrated management of malnourished children were: poor care-care relationship (26.7%) permanent product breaks (22.9%), the direct costs of services ranged from 30,000 to 60,000 FCFA (41.53%), drugs used for the treatment of patients came from the street (66.10%), malaria and anemia occupy an important place (27.5%), 57.2% respondents had monthly income below 60,000 CFAF. Conclusion: the present study carried out has identified the real bottlenecks to the integrated management of children suffering from SAM in the therapeutic nutritional units of the city of N’Djamena. .

United States Healthcare Data Breaches: Insights for NIST SP 800-66 Revision 2 from a Review of the NIST SP 800-66 Revision 1

Healthcare security and privacy breaches are occurring in the United States (US), and increased substantially during the pandemic. This paper reviews the National Institute of Standards and Technology (NIST) publication base as an effective solution. The NIST Special Publication 800-66 Revision 1 was an essential standard in US healthcare, which was withdrawn in February 2024 and superseded by SP 800-66 Revision 2. This review investigates the academic papers concerning the application of the NIST SP 800-66 Revision 1 standard in the US healthcare literature. A systematic review method was used in this study to determine current knowledge gaps of the SP 800-66 Revision 1. Some limitations were employed in the search to enforce validity. A total of eleven articles were found eligible for the study. Consequently, this study suggests the necessity for additional academic papers pertaining to SP 800-66 Revision 2 in the US healthcare literature. In turn, it will enhance awareness of safeguarding electronic protected health information (ePHI), help to mitigate potential future risks, and eventually reduce breaches.

新冠疫情期间高校图书馆“云”阅读推广新体验--以江西师范大学图书馆读书季系列活动为例

2022年,新冠疫情反复下不可预期的闭环管理增加了在校大学生陷入“浅阅读”与“沉迷游戏”的可能。疫情爆发之初,高校图书馆尝试推出的“云”阅读推广至此有了更广阔的创新空间。江西师范大学图书馆创新阅读资源、阅读平台与服务模式,利用“云”技术,围绕经典图书品读汇、主题读书分享会、游园与技能大赛、红色精品创作与诵读等主题,开展系列“云”阅读推广活动,为处在封闭管理状态下的在校学生提供知识发现与心灵安放之所。文章具体介绍了“云”阅读推广系列活动开展的背景与目的、实施步骤、流程与影响,总结了疫情反复期间“云”阅读推广的经验,以期为突发事件下高校图书馆的阅读服务工作提供参考。

2016-2021年南亚热带近自然化改造马尾松人工林土壤水热动态数据集

本研究依托崇左凭祥友谊关森林生态系统广西野外科学观测研究站,在中国林业科学研究院热带林业实验中心林区,利用南亚热带近自然化改造马尾松(Pinus massoniana)人工林内的自动气象观测站,开展土壤水热动态监测和研究,样地布设、指标监测和数据质量控制均按照规范进行。本数据集对2016–2021年近自然化改造马尾松人工林的土壤温度、土壤体积含水量、土壤热通量、空气温度和空气相对湿度等观测数据,经过异常值剔除、数据插补等标准数据处理,统计得到马尾松人工林日尺度的土壤水热动态数据,并对数据集的构建进行了说明。建立和共享本数据集对于理解近自然化改造马尾松人工林的土壤水热特征有重要价值,同时可为深入研究针阔叶混交林对全球气候变化的响应提供基础数据,也为南亚热带森林资源的可持续经营和管理提供数据基础支撑。

Stochastic Design of Enhanced Network Management Architecture and Algorithmic Implementations

The paper is focused on available server management in Internet connected network environments. The local backup servers are hooked up by LAN and replace broken main server immediately and several different types of backup servers are also considered. The remote backup servers are hooked up by VPN (Virtual Private Network) with high-speed optical network. A Virtual Private Network (VPN) is a way to use a public network infrastructure and hooks up long-distance servers within a single network infrastructure. The remote backup servers also replace broken main severs immediately under the different conditions with local backups. When the system performs a mandatory routine maintenance of main and local backup servers, auxiliary servers from other location are being used for backups during idle periods. Analytically tractable results are obtained by using several mathematical techniques and the results are demonstrated in the framework of optimized networked server allocation problems. The operational workflow give the guidelines for the actual implementations.

Fruit production and quality improvement in aonla （Emblica Officinalis Gaertn.） through canopy management

In order to maintain the health and vigour and to sustain the productivity, a pruning experiment was conducted on four year old ＂Balwant＂ cultivar of aonla grown in laterite soil, planted at a spacing of 5m×5m. To find out the best pruning method, six levels of pruning was performed i.e., （1） Light judicious pruning, （2） Detopping of primary branches at 8 feet from ground level ＋ removal of all secondary branches, （3） Detopping of primary branches at 8 feet from the ground level ＋ removal of all secondary branches at 2 feet from the base of primary branches, （4） Detopping of primary branches at 8 feet from the ground level ＋ removal of all secondary branches at 1 feet from the base of primary branches, （5） Light judicious pruning ＋ Detopping of plant canopy of at 8 feet from the ground level, （6） No pruning （control）. Results of three consecutive years of investigation revealed that light judicious pruning of thin, overlapping, criss-crossed, dead, unproductive and looping branches gave highest fruit yield in all the three years and resulted 64.4 percent yield increment over control when average of three years was considered. Severe pruning of primary and secondary branches caused drastic reduction of yield for two consecutive years after pruning. Judicious pruning helped to produce better sizeable and quality fruits.

基于ST-PRA的链式闭环管理措施在门诊西药房管理中的应用

目的探讨基于社会技术概率风险评估(ST-PRA)的链式闭环管理措施在门诊西药房管理中的应用效果。方法选择2020年3月至2021年3月期间上海市宝山区大场医院6个门诊西药窗口进行研究,按照抽签法分为研究组和对照组,每组3个窗口15名员工(其中研究组3个窗口有621例患者,对照组3个窗口有632例患者)。对照组采用常规管理措施,研究组采用ST-PRA的链式闭环管理措施,均进行5个月的管理。比较两组员工在药品周转及配药过程中各项工作的时间,配方出错率和药品纠纷发生率,以及两组患者对门诊西药房管理的满意度。结果研究组员工的补药时间、药品名目分类登记时间、周转库清点时间分别为(23.52±3.98)min、(46.08±6.29)min、(45.87±7.36)min,明显短于对照组的(31.96±3.67)min、(58.39±9.12)min、(75.92±8.28)min,差异均有统计学意义(P<0.05);研究组员工的处方编号时间、药品登记时间、生产药单时间、窗口实物清点时间分别为(132.87±36.28)s、(5.31±1.26)s、(62.87±8.36)s、(176.28±50.32)s,明显短于对照组的(176.58±39.67)s、(7.80±1.35)s、(85.35±10.32)s、(365.89±62.59)s,差异均有统计学意义(P<0.05);研究组员工的配方出差率、药品纠纷发生率分别为1.61%和0.97%,明显低于对照组的3.64%和2.85%,差异具有统计学意义(P<0.05);研究组接待的患者对管理措施的满意度为98.07%,明显高于对照组的90.98%,差异有统计学意义(P<0.05)。结论ST-PRA的链式闭环管理措施能够有效提高门诊西药房的管理质量,提高员工的工作效率和工作有效性,减少出错和纠纷,同时有利于提高患者对医院的满意度。

关闭/废弃矿井抽水蓄能开发利用现状与进展

探索清洁能源发展的创新途径是实现我国“双碳”目标的重要推动力。为解决大规模可再生能源电力供应不稳定的难题,新型电力系统的提出与加速成长促进了抽水蓄能电站的建设与发展,但生态保护与地形等因素制约了传统抽水蓄能电站发展。关闭/废弃矿井,由于具有丰富的地下空间及水资源,可创新性地开发抽水蓄能并延长矿区的经济寿命,降低对环境与经济的负面影响。为助力建立适合我国国情的废弃矿井抽水蓄能利用模式和管理体系,通过文献分析法综述了国内外废弃矿井抽水蓄能技术研究与应用进展。详细阐述了关闭/废弃矿井抽水蓄能技术原理、分类及其优缺点;总结了关闭/废弃矿井抽水蓄能电站利用模式,并在前人研究基础上对选址要素进行了修订;梳理了关闭/废弃矿井改建抽水蓄能电站的水-气两相流动特性、水泵水轮机工况特性、地下空间围岩稳定性及地下蓄水空间体积测算等的研究现状,明确了水泵-水轮机关键技术、地下空间稳定性控制关键技术等亟待解决的技术难题。此外,对关闭/废弃矿井抽水蓄能相关的生态与环境保护、市场需求与经济效益、政策与法规等研究成果进行了广泛的文献综述。发展关闭/废弃矿井地下空间抽水蓄能技术可为我国井下空间资源利用提供思路,为保障国家能源安全与经济社会高质量发展提供新途径。

政府投资工程监管项目的建设与效益分析--以宿迁市政府投资工程监管系统为例

政府投资工程监管对于保障工程项目的质量、进度和资金使用具有重要意义,它具有诸如投资金额巨大、工程意义重大、社会关注程度高等一系列特点。因此,加强政府投资工程的监管工作、完善我国政府投资工程的监管体系显得尤为重要。本文以宿迁市政府投资工程监管系统为例,以解决项目的协同管理为主要方向,旨在建立覆盖政府投资工程建设“前中后期”的全过程闭环监管体系,实现共享工程信息、落实管理责任、协调工程推进、提升监管质量水平等目标。

北京医院体外诊断试剂基于绩效管理的全流程闭环管理设计和效果评估

目的构建体外诊断试剂(in vitro diagnostic reagents,IVD reagent)全流程闭环管理方案并实施,优化IVD管理工作。方法基于北京医院IVD管理现状,设计IVD全流程闭环管理方案,包括IVD申请、IVD遴选、IVD申购、IVD采购、IVD领取、IVD入出库和IVD使用等环节。选择关键指标建立评估框架,运用访谈法、查阅相关信息系统的方法收集和统计方案实施前(2020年)和实施后(2023年)的管理数据、采购数据和检测数据,对流程管理、质量管理和成本管理进行评估。结果优化了管理流程,IVD申购时间平均缩短了约60%,IVD采购无需人工处理,实时拆分订单并发送至对应的供应商,IVD领取时间平均缩短了约75%;IVD和检测质量管理满意,供货商资质完善度达到100%,室间质评得到满分,无IVD相关不良事件;成本管理有效,IVD采购成本降低了约15%,分别建立了人免疫缺陷病毒抗体测定、丙型肝炎抗体测定、梅毒螺旋体抗体测定和乙型肝炎表面抗原定量测定四个项目的IVD成本精细化管理模型,IVD损耗的平均值为0.07%~1.21%,标准差为0.07%~0.66%。结论IVD全流程闭环管理方案切实可行,提高了IVD管理工作效率,保证了IVD质量和检测质量,降低了IVD成本,细化了成本管理工作。

基于智慧物联技术住院部药品闭环可追溯管理模式建立与效果评价

目的介绍医院住院部药品调剂全流程可追溯闭环管理模式应用。方法依据智慧医疗建设思路和六级电子病历要求,从硬件和软件两方面入手,设计了住院部药品调剂全流程的无纸化模式,建立可追溯闭环管理体系,并对体系的实践效果进行全面评价。结果流程改造后,任务派领时间缩短,药品调配时间缩短,退药时间压缩,提高药师培训效率,降低人力耗材成本,促进安全合理用药。结论基于智能设备和信息化手段对医院信息系统进行改造,实现住院药品调剂全流程闭环式可追溯管理,具有安全、规范、高效、闭环可追溯的优势,降低调剂差错风险,提高用药安全性,可推广性强。

内镜病理标本管理系统的设计

目的完善内镜病理标本的收费管理体系,实现内镜病理标本的全过程可追溯信息化管理。方法通过业务流程再造,将原来人工记录环节电子化,从内镜病理标本采集开始到病理报告发布,通过信息系统的联合改造实现标本的医疗信息、管理信息、费用信息纳入到信息系统统一管理。结果实现了内镜病理标本的电子化管理,解决了信息传递过程中的标本标签简化、费用漏收、纸质化管理、过程不可追溯等关键问题。结论利用信息系统可以提高内镜病理标本的闭环管理效率,有效解决内镜病理标本漏收费问题,具有实际的应用价值。

土木工程学科博士研究生培养质量提升的体系构建研究

高层次人才培养和创新创造是研究生教育的重要使命。近期,多部门联合发文要求加快新时代研究生教育改革。只有按照“四个面向”为国家破解“卡脖子”技术,取得原创新科技成果才能成为国家战略科技力量。围绕“立德树人、服务需求、提高质量、追求卓越”的新发展思路,结合同济大学深化综合改革方案和建设世界一流大学的总体需要,对于土木工程学科博士研究生培养质量提升体系的构建进行研究,进一步突显人才培养的质量与内涵,着重强调课程和培养中间环节的质量保证和过程监督、研究生培养分流退出机制、学院和导师的主体责任,构建闭环管理体系以提升博士研究生培养质量。