Increasing incidences showed that food allergies have attracted more and more attention from researchers.BALB/c mice were sensitized with wheat gluten combined with aluminum hydroxide adjuvant via intraperitoneal inje...Increasing incidences showed that food allergies have attracted more and more attention from researchers.BALB/c mice were sensitized with wheat gluten combined with aluminum hydroxide adjuvant via intraperitoneal injection,transdermal sensitization,and oral gavage sensitization route.Results showed that all the three sensitization methods could induce allergic symptoms;increase the serum antibody(total immunoglobulin E(IgE),specific IgE,IgG,IgA)and histamine content;promote the secretion of Th2 cytokines(interleukin(IL)-4,IL-5,IL-13)and inflammatory factors(IL-6,IL-17 A,IL-10);and inhibit the production of Th1 cytokines(IFN-γ,IL-2).However,the allergic symptoms of mice sensitized by intraperitoneal injection were the most obvious among the three models.The level of serum antibodies in intraperitoneal injection group was significantly higher than control.Subsequently,16 S rRNA sequencing technology was used to analyze the intestinal flora of mice.The results showed that the abundance of Firmicutes in the wheat protein sensitized group was lower than that in the normal group,while the abundance of Bacteroidetes was higher,and Lactobacillus was the difference marker in normal group.Bacterial species diversity analysis showed that the species richness and diversity of intestinal flora in mice were decreased,the difference between mice induced by intraperitoneal injection and normal control group mice was the most significant.Taken together,these results show that among three sensitization methods used to build a mouse model with aluminum hydroxide as adjuvant,intraperitoneal injection is the comparably best way to build a mouse sensitization mode.展开更多
In order to solve the problem of reliability modeling and the analysis of complex systems with multiple closed-loop feedbacks,a new reliability analysis method for repairable systems with multiple closed-loop feedback...In order to solve the problem of reliability modeling and the analysis of complex systems with multiple closed-loop feedbacks,a new reliability analysis method for repairable systems with multiple closed-loop feedbacks is proposed based on the goal-oriented(GO)methodology.Firstly,the basic theories and advantages of GO method are introduced.Secondly,a type-24B multiple closed-loop feedback structure operator is proposed through GO method with its operation formula given,which expands the types of GO method operators and the application scope of their reliability analysis.Finally,taking a certain type of diesel engine fuel supply system an example,the quantitative and qualitative analysis is carried out through GO method,Monte Carlo simulation as well as FTA respectively.The availability results verify the availability of the proposed type-24B operator in the reliability analysis of multiple closed-loop feedback systems.The qualitative analysis results indicate the accuracy and usability of the GO method as a qualitative analysis method.展开更多
近年来,具有健康作用的灭活菌体、菌体成分或代谢产物引起国内外研究者的关注,并相继提出后生元(Postbiotics)的术语定义。本文以2022年中国食品科学技术学会益生菌分会提出的后生元定义为依据,采用文献计量方法统计分析中国知网(CNKI)...近年来,具有健康作用的灭活菌体、菌体成分或代谢产物引起国内外研究者的关注,并相继提出后生元(Postbiotics)的术语定义。本文以2022年中国食品科学技术学会益生菌分会提出的后生元定义为依据,采用文献计量方法统计分析中国知网(CNKI)、PubMed、Web of Science(WoS)数据库中关于后生元的研究文献,基于WoS数据库分析国家分布和研究热点。结果显示,在PubMed和WoS数据库中,近3年的发文量超过近20年(2000-2018年)的发文总量,在2021年发文量达到最大值,分别有223篇和248篇,后生元的研究热度不断上升。日本是后生元研究文献数量最多的国家。CNKI数据库中关于后生元的发文量呈波动线性增长,年均增长率为21.76%。本文从体外、动物和临床研究等方面综述后生元的健康作用,分析表明后生元促进肠道健康和调节免疫方面的研究居多。国内外研究表明采用不同微生物灭活工艺制备的后生元,其成分组成和健康作用具有差异性。本文对比分析不同灭活方式的后生元的功效成分、健康作用机制等,为不同菌种/菌株制备后生元提供一定的参考。展开更多
Due to high power density,high efficiency,and accurate control performance,permanent magnet synchronous motors(PMSMs)have been widely adopted in equipment manufacturing and energy transformation fields.To expand the s...Due to high power density,high efficiency,and accurate control performance,permanent magnet synchronous motors(PMSMs)have been widely adopted in equipment manufacturing and energy transformation fields.To expand the speed range under finite DC-bus voltage,extensive research on field weakening(FW)control strategies has been conducted.This paper summarizes the major FW control strategies of PMSMs,which are categorized into calculation-based methods,voltage closed-loop control methods,and model predictive control related methods.The existing strategies are analyzed and compared according to performance,robustness,and execution difficulty,which can facilitate the implementation of FW control.展开更多
基金supported by the National Key Research and Development Program of China(2019YFC1605000)the National Natural Science Foundation(1872904)。
文摘Increasing incidences showed that food allergies have attracted more and more attention from researchers.BALB/c mice were sensitized with wheat gluten combined with aluminum hydroxide adjuvant via intraperitoneal injection,transdermal sensitization,and oral gavage sensitization route.Results showed that all the three sensitization methods could induce allergic symptoms;increase the serum antibody(total immunoglobulin E(IgE),specific IgE,IgG,IgA)and histamine content;promote the secretion of Th2 cytokines(interleukin(IL)-4,IL-5,IL-13)and inflammatory factors(IL-6,IL-17 A,IL-10);and inhibit the production of Th1 cytokines(IFN-γ,IL-2).However,the allergic symptoms of mice sensitized by intraperitoneal injection were the most obvious among the three models.The level of serum antibodies in intraperitoneal injection group was significantly higher than control.Subsequently,16 S rRNA sequencing technology was used to analyze the intestinal flora of mice.The results showed that the abundance of Firmicutes in the wheat protein sensitized group was lower than that in the normal group,while the abundance of Bacteroidetes was higher,and Lactobacillus was the difference marker in normal group.Bacterial species diversity analysis showed that the species richness and diversity of intestinal flora in mice were decreased,the difference between mice induced by intraperitoneal injection and normal control group mice was the most significant.Taken together,these results show that among three sensitization methods used to build a mouse model with aluminum hydroxide as adjuvant,intraperitoneal injection is the comparably best way to build a mouse sensitization mode.
基金supported by the Special Support Project of SASTIND and Technologyof SASTIND(No.JSZL2019XXXB001)。
文摘In order to solve the problem of reliability modeling and the analysis of complex systems with multiple closed-loop feedbacks,a new reliability analysis method for repairable systems with multiple closed-loop feedbacks is proposed based on the goal-oriented(GO)methodology.Firstly,the basic theories and advantages of GO method are introduced.Secondly,a type-24B multiple closed-loop feedback structure operator is proposed through GO method with its operation formula given,which expands the types of GO method operators and the application scope of their reliability analysis.Finally,taking a certain type of diesel engine fuel supply system an example,the quantitative and qualitative analysis is carried out through GO method,Monte Carlo simulation as well as FTA respectively.The availability results verify the availability of the proposed type-24B operator in the reliability analysis of multiple closed-loop feedback systems.The qualitative analysis results indicate the accuracy and usability of the GO method as a qualitative analysis method.
文摘近年来,具有健康作用的灭活菌体、菌体成分或代谢产物引起国内外研究者的关注,并相继提出后生元(Postbiotics)的术语定义。本文以2022年中国食品科学技术学会益生菌分会提出的后生元定义为依据,采用文献计量方法统计分析中国知网(CNKI)、PubMed、Web of Science(WoS)数据库中关于后生元的研究文献,基于WoS数据库分析国家分布和研究热点。结果显示,在PubMed和WoS数据库中,近3年的发文量超过近20年(2000-2018年)的发文总量,在2021年发文量达到最大值,分别有223篇和248篇,后生元的研究热度不断上升。日本是后生元研究文献数量最多的国家。CNKI数据库中关于后生元的发文量呈波动线性增长,年均增长率为21.76%。本文从体外、动物和临床研究等方面综述后生元的健康作用,分析表明后生元促进肠道健康和调节免疫方面的研究居多。国内外研究表明采用不同微生物灭活工艺制备的后生元,其成分组成和健康作用具有差异性。本文对比分析不同灭活方式的后生元的功效成分、健康作用机制等,为不同菌种/菌株制备后生元提供一定的参考。
基金supported by the Research Fund for the National Natural Science Foundation of China(52125701).
文摘Due to high power density,high efficiency,and accurate control performance,permanent magnet synchronous motors(PMSMs)have been widely adopted in equipment manufacturing and energy transformation fields.To expand the speed range under finite DC-bus voltage,extensive research on field weakening(FW)control strategies has been conducted.This paper summarizes the major FW control strategies of PMSMs,which are categorized into calculation-based methods,voltage closed-loop control methods,and model predictive control related methods.The existing strategies are analyzed and compared according to performance,robustness,and execution difficulty,which can facilitate the implementation of FW control.
