Analysis and Optimization of Key Dimensions of Co-Axial Dual-Mechanical-Port Flux-Switching Permanent Magnet Machines for Fuel-Based Extended Range Electric Vehicles

In this paper,key dimensions of a co-axial dual-mechanical-port flux-switching permanent magnet(CADMP-FSPM)machine for fuel-based extended range electric vehicles(ER-EVs),including split ratio,stator/rotor pole arcs,rotor yoke thickness,etc.,are analyzed and optimized.Firstly,the topologies and operation principles of an exampled 3-phase CADMP-FSPM are introduced briefly,in which an inner-rotor FSPM machine with 12-stator-slots/10-rotor-poles for high-speed generation and an outer-rotor FSPM machine with 12-stator-slots/22-rotor-poles for low-speed motoring are assembled co-axially.Then,the relationship between the key dimensions and electromagnetic performance,particularly for electromagnetic torque(power),of the CADMP-FSPM machine is studied by 2D-finite element analysis(FEA).Further,the reasonable matches of split ratio,rotor/stator pole arcs and rotor yoke are determined and the original CADMP-FSPM machine is optimized correspondingly.Finally,the static characteristics,including no-load PM flux-linkage,electro-motive-force(EMF),winding inductances,cogging torques and electromagnetic torques,of the original and optimized machines are compared by 2D-FEA.The results verify that the optimized CADMP-FSPM machine can exhibit improved torque characteristics than the original one,i.e.,the torque ripples of the inner and outer machines can be reduced by 22.7%and 4.7%,respectively,and the average torque of the inner and outer machines can be increased by 0.43Nm and 2Nm,respectively.

基于多台电子经纬仪全站仪的工业测量系统

介绍了基于多台电子经纬仪 全站仪的工业测量系统MetroIn的系统设计思想、系统的主要数学原理、系统的构成与功能 ,测试表明 :该系统最高精度可达± 0 .0 5mm。在大型闸门的安装与检测中 ,MetroIn已成功地得到了应用。

3D biofabrication of vascular networks for tissue regeneration:A report on recent advances

Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3D fabrication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.

Parametric study of droplet size in an axisymmetric flow-focusing capillary device

A conventional technique for microfluidic droplet generation is Co-axial Flow Focusing(CFF)in which a contraction zone is placed downstream of the dispersed phase nozzle.In this contraction zone,the dispersed-phase(dphase)fluid is pinched off by continuous-phase(c-phase)fluid to generate micro-droplets.Studying the influence of multiple parameters such as the fluids velocities and viscosities,the interfacial tension,and nozzle and orifice diameters on the droplet size is of great importance for the design and application of CFF devices.Thus,development of more complete numerical models is required.In this paper,we show our model is compatible with experimental data and then numerically investigate the effects of aforementioned parameters on the droplet generation in a CFF microfluidic device.Simulation results showed that the c-phase flow rate,viscosity and the interfacial tension had great impacts on the droplet size.The effect of the nozzle diameter on the generated droplet size was small compared to that of the orifice in a CFF device.Using the simulation results,a correlation was also developed and suggested which predicts the droplet size with less than 15%error in a wide range of the introduced dimensionless parameters.

The effect of neural cell integrated into 3D co-axial bioprinted BMMSC structures during osteogenesis

A three-dimensional(3D)bioprinting is a new strategy for fabricating 3D cell-laden constructs that mimic the structural and functional characteristics of various tissues and provides a similar architecture and microenvironment of the native tissue.However,there are few reported studies on the neural function properties of bioengineered bone autografts.Thus,this study was aimed at investigating the effects of neural cell integration into 3D bioprinted bone constructs.The bioprinted hydrogel constructs could maintain long-term cell survival,support cell growth for human bone marrow-derived mesenchymal stem cells(BMMSCs),reduce cell surface biomarkers of stemness,and enhance orthopedic differentiation with higher expression of osteogenesis-related genes,including osteopontin(OPN)and bone morphogenetic protein-2.More importantly,the bioprinted constructs with neural cell integration indicated higher OPN gene and secretory alkaline phosphatase levels.These results suggested that the innervation in bioprinted bone constructs can accelerate the differentiation and maturation of bone development and provide patients with an option for accelerated bone function restoration.

Heparin/Growth Factors‑Immobilized Aligned Electrospun Nanofibers Promote Nerve Regeneration in Polycaprolactone/Gelatin‑Based Nerve Guidance Conduits

Injuries to the nervous system account for the widespread morbidity,mortality,and discomfort worldwide.Artificial nerve guidance conduits(NGCs)offer a promising platform for nerve reconstruction,however,they require extracellular matrix(ECM)-like features to better mimic the in vivo microenvironment.Consequently,this research was aimed to fabricate heparin/growth factors(GFs)-immobilized artificial NGCs.Heparin was covalently immobilized onto aligned electrospun polycapro-lactone/gelatin(PCL/Gel)nanofibers.Thereafter,basic fibroblast growth factor(bFGF)and nerve growth factor(NGF)were preferentially immobilized on heparinized nanofibers;the immobilization efficiency of GFs was found to be 50%with respect to(w.r.t.)their initial loaded amounts.The in vivo implantation of NGCs in a sciatic nerve defect model revealed the successful retention(~10%w.r.t the initial loaded amount)and bioactivity of NGF for up to 5 days.The permeability of bovine serum albumin(BSA)from nanofibrous membranes was further assessed and found to be comparable with the commercialized cel-lulose acetate membranes.The bioactivity of NGCs was assessed in a sciatic nerve defect model in rats for short-term(1 week)and long-term(1-month).The NGCs displayed good structural stability and biocompatibility in vivo.The in vivo evaluation revealed the accumulation of host cells into the transplanted NGCs.Taken together;these heparin/GFs-immobilized artificial NGCs may have broad implications for nerve regeneration and related tissue engineering disciplines.

一种高效稳定的大电流密度产氢电催化剂

电解水制氢具有工艺简单、原料来源广泛、无污染、氢气纯度高等优点,是最具发展前景的制氢技术之一.然而电解水制氢存在的最大问题是析氢析氧过程能耗过高,需要添加催化剂降低反应能垒.目前,电催化产氢性能最好的材料依然是价格昂贵且储量有限的贵金属铂基催化剂.发展高效稳定的大电流密度制氢非贵金属催化剂,对于氢气的规模化制备和商业化应用意义重大.本工作采用三维导电泡沫镍为自支撑电极材料,引入钼源和硫源构建高活性催化析氢Mo-Ni-S体系.通过水热反应和退火处理,在泡沫镍基底上制备得到了具有高担载量、细长浓密的Mo S2/Ni3S2同轴异质结构纳米线.催化剂结构设计方面,在水热反应过程中创新性地引入表面活性剂(P123),调控催化剂形貌,增加了活性位点数目.在组分调控方面,通过后期退火处理去除低活性物相,增强了催化性能.基于以上结构和组分设计调控,该催化剂在碱性体系下具有优异的大电流密度催化产氢性能,仅需较低过电势便可获得较高的电流密度,同时具有优异的大电流密度产氢稳定性,其电催化产氢性能超过了已报道的众多催化剂.

Three-dimensional-engineered bioprinted in vitro human neural stem cell self-assembling culture model constructs of Alzheimer’s disease

The pathogenic cascade of Alzheimer’s disease(AD)characterized by amyloid-β protein accumulation is still poorly understood,partially owing to the limitations of relevant models without in vivo neural tissue microenvironment to recapitulate cell-cell interactions.To better mimic neural tissue microenvironment,three-dimensional(3D)core-shell AD model constructs containing human neural progenitor cells(NSCs)with 2% matrigel as core bioink and 2% alginate as shell bioink have been bioprinted by a co-axial bioprinter,with a suitable shell thickness for nutrient exchange and barrier-free cell interaction cores.These constructs exhibit cell self-clustering and-assembling properties and engineered reproducibility with long-term cell viability and self-renewal,and a higher differentiation level compared to 2D and 3D MIX models.The different effects of 3D bioprinted,2D,and MIX microenvironments on the growth of NSCs are mainly related to biosynthesis of amino acids and glyoxylate and dicarboxylate metabolism on day 2 and ribosome,biosynthesis of amino acids and proteasome on day 14.Particularly,the model constructs demonstrated Aβ aggregation and higher expression of Aβ and tau isoform genes compared to 2D and MIX controls.AD model constructs will provide a promising strategy to facilitate the development of a 3D in vitro AD model for neurodegeneration research.