Objective This study attempted to seek a new Doppler-derived index for estimating ventricularsystolic function. Methods With custom - made software the aortic and pulmonic flow profiles were digitized andconverted to ...Objective This study attempted to seek a new Doppler-derived index for estimating ventricularsystolic function. Methods With custom - made software the aortic and pulmonic flow profiles were digitized andconverted to their 4V2 curves, their maximum value of the first derivative, max (dk/dt) were obtained separately in23 and 25patients with congenital heart disease (mean age 4.5 years). Aortic max(dk/dt) and pulmonic max(dk/dt)measured by Doppler were compared with left ventricular max(dp/dt) and right ventricular max(dp/dt) measuredby cardiac catheterization. Results Aortic max(dk/dt) correlated well with LV max(dp/dt) (r=0.817, P<0.001).An excellent correlation of pulmonic max(dk/dt) with RV max(dp/dt) was established (r=0.926, P<0.0001). Therewas a significant correlation between RVSP and RV max(dp/dt) (r= 0.839, P<0.0001). Conclusion Doppler - derived aortic max(dk/dt) and pulmonic max(dk/dt) could be reliable index of left ventricular contractility and rightventricular contractility respectively. When max(dp/dt) is used for assessing RV systolic function, the impact ofRVSP on that should be taken into consideration.展开更多
【目的】探讨达格列净治疗糖尿病肾病(DN)的临床疗效及其对患者β细胞功能、肾功能指标的影响。【方法】两院收治的100例DN患者,随机分为观察组和对照组,每组50例。两组均接受常规治疗,包括生活方式调整、低脂和低盐饮食、运动锻炼、注...【目的】探讨达格列净治疗糖尿病肾病(DN)的临床疗效及其对患者β细胞功能、肾功能指标的影响。【方法】两院收治的100例DN患者,随机分为观察组和对照组,每组50例。两组均接受常规治疗,包括生活方式调整、低脂和低盐饮食、运动锻炼、注射胰岛素等,对照组另外口服厄贝沙坦和阿托伐他汀,观察组在对照组基础上给予达格列净治疗,两组均治疗3个月。比较两组临床疗效及血尿素氮(BUN)、尿蛋白定量(UTP)、血肌酐(Scr)水平;分别检测患者空腹C肽(FC-P)、餐后2 h C肽(2hC-P)水平,计算并比较两组患者β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR);比较两组不良反应发生情况。【结果】观察组治疗总有效率为84.00%(42/50),明显高于对照组的64.00%(32/50),且差异有统计学意义(P<0.05)。治疗前,两组各项指标水平比较,差异均无统计学意义(P>0.05);治疗后,两组UTP、BUN、Scr水平较治疗前降低(P<0.05),且观察组三项指标均低于对照组(P<0.05);治疗后,两组2hC-P、HOMA-β水平较治疗前提高,HOMA-IR降低(P<0.05);且观察组HOMA-β水平高于、HOMA-IR水平低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】达格列净治疗DN有利于提高临床疗效,改善β细胞功能和肾功能指标,且安全性较高,具有推广价值。展开更多
文摘Objective This study attempted to seek a new Doppler-derived index for estimating ventricularsystolic function. Methods With custom - made software the aortic and pulmonic flow profiles were digitized andconverted to their 4V2 curves, their maximum value of the first derivative, max (dk/dt) were obtained separately in23 and 25patients with congenital heart disease (mean age 4.5 years). Aortic max(dk/dt) and pulmonic max(dk/dt)measured by Doppler were compared with left ventricular max(dp/dt) and right ventricular max(dp/dt) measuredby cardiac catheterization. Results Aortic max(dk/dt) correlated well with LV max(dp/dt) (r=0.817, P<0.001).An excellent correlation of pulmonic max(dk/dt) with RV max(dp/dt) was established (r=0.926, P<0.0001). Therewas a significant correlation between RVSP and RV max(dp/dt) (r= 0.839, P<0.0001). Conclusion Doppler - derived aortic max(dk/dt) and pulmonic max(dk/dt) could be reliable index of left ventricular contractility and rightventricular contractility respectively. When max(dp/dt) is used for assessing RV systolic function, the impact ofRVSP on that should be taken into consideration.
基金Supported by the Research Foundation Program for Doctor of Liaoning Province(20170520084)Fundamental Research Funds for the Central Universities(DUT16RC3018)
文摘【目的】探讨达格列净治疗糖尿病肾病(DN)的临床疗效及其对患者β细胞功能、肾功能指标的影响。【方法】两院收治的100例DN患者,随机分为观察组和对照组,每组50例。两组均接受常规治疗,包括生活方式调整、低脂和低盐饮食、运动锻炼、注射胰岛素等,对照组另外口服厄贝沙坦和阿托伐他汀,观察组在对照组基础上给予达格列净治疗,两组均治疗3个月。比较两组临床疗效及血尿素氮(BUN)、尿蛋白定量(UTP)、血肌酐(Scr)水平;分别检测患者空腹C肽(FC-P)、餐后2 h C肽(2hC-P)水平,计算并比较两组患者β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR);比较两组不良反应发生情况。【结果】观察组治疗总有效率为84.00%(42/50),明显高于对照组的64.00%(32/50),且差异有统计学意义(P<0.05)。治疗前,两组各项指标水平比较,差异均无统计学意义(P>0.05);治疗后,两组UTP、BUN、Scr水平较治疗前降低(P<0.05),且观察组三项指标均低于对照组(P<0.05);治疗后,两组2hC-P、HOMA-β水平较治疗前提高,HOMA-IR降低(P<0.05);且观察组HOMA-β水平高于、HOMA-IR水平低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】达格列净治疗DN有利于提高临床疗效,改善β细胞功能和肾功能指标,且安全性较高,具有推广价值。
