顾及BDS-3星钟约束的GNSS超快速轨道钟差解算方法

BDS-3高稳定星载原子钟作为北斗星座的显著技术优势,在GNSS数据处理中尚未得到充分利用。针对严格时效性限制下GNSS超快速轨道钟差参数精度受限问题,本文提出顾及BDS-3星钟约束的GNSS超快速轨道钟差解算方法。首先,以GNSS轨道钟差参数间相关性为基础,构建顾及BDS-3星钟参数特性的GNSS定轨模型;然后,基于GNSS精密钟差产品,分析星钟约束对GNSS轨道钟差参数精度的影响规律;最后,为克服预报钟差精度与约束筛选对定轨影响,建立BDS-3星钟建模与GNSS超快速轨道钟差估计的同步处理方法。试验结果表明,在BDS-3星钟参数最优约束下,BDS-3与GPS轨道钟差精度可分别提升27.5%、5.1%和20.2%、5.2%;且较传统BDS-3星钟单历元处理策略,基于BDS-3星钟建模与GNSS超快速定轨同步处理方法,GNSS超快速轨道钟差精度可分别提升至4.8%与34.2%,轨道精度实现了毫米级改善。因此,顾及BDS-3星钟约束的GNSS超快速轨道钟差解算方法可有效对BDS-3高稳星钟信息模型化,并实现GNSS超快速轨道钟差精度的优化处理。

广播星历旋转误差对低轨星载BDS-3/GPS实时精密定轨影响分析

基于LT-01A卫星星载BDS-3/GPS观测值进行了星载实时精密定轨研究,并重点分析了广播星历旋转误差对实时定轨精度的影响。通过赫尔默特转换评估了所选时段内GPS和BDS-3广播星历轨道旋转误差,显示BDS-3广播星历旋转误差可达-8.7 mas,平均量级较GPS大约2.5倍。BDS-3广播星历经旋转改正后,轨道切向、法向均方根(RMS)误差从25 cm左右提升至10 cm量级,提升幅度超过50%。因此,基于星载BDS-3以及BDS-3/GPS联合的实时定轨精度受BDS-3星历旋转误差影响严重,且主要作用于切向和法向。经过旋转改正后,单独BDS-3实时定轨在切向、法向、径向RMS分别为21.0 cm、10.7 cm及11.2 cm,其切向和法向精度比改正前分别提升15.0%和31.8%;BDS-3与GPS联合定轨进一步提升切向精度至19.4 cm。得益于BDS-3广播星历较高的精度,单BDS-3以及BDS-3/GPS联合的实时定轨在旋转改正前的三维RMS分别为31.9 cm和29.2 cm,较单GPS实时定轨分别提升9.1%和16.8%;添加旋转改正后,其定轨精度分别提升至26.7 cm和25.0 cm,较单GPS实时定轨分别提升22.6%和27.5%。

血清金属蛋白酶组织抑制剂3和性别决定区Y框蛋白2在2型糖尿病肾损伤早期诊断中的临床应用

目的探究血清金属蛋白酶组织抑制剂3(tissue inhibitors of metalloproteinases 3,TIMP3)和性别决定区Y框蛋白2(transcription factor determining region Y box protein 2,SOX2)对2型糖尿病(type 2 diabetes mellitus,T2DM)肾损伤的早期诊断。方法选取2022年4月至2023年4月在华北石油管理局总医院就诊的102例T2DM患者为研究对象,根据24 h尿蛋白排泄率(uri-nary albumin excretion rate,UAER)将T2DM患者分为肾损伤组(n=40)和无肾损伤组(n=62),另选取同期在华北石油管理局总医院行体检的健康者50名为对照组。酶联免疫吸附法测定所有受试者血清TIMP3、SOX2水平;比较3组受试者一般资料、糖化血红蛋白(hemoglobin A1c,HbA1c)、UAER、血肌酐(serum creatinine,Scr)、估算肾小球滤过率(estimated glomerular filtration rate,eGFR)、血清TIMP3、SOX2水平;Pearson相关性分析血清TIMP3与SOX2及两者与HbA1c、UAER、Scr、eGFR之间的关系;受试者工作特征曲线(receiver operating characteristic curve,ROC)分析血清TIMP3、SOX2对T2DM患者肾损伤的诊断价值。结果T2DM患者血清TIMP3[(0.68±0.17)μg/L比(1.35±0.35)μg/L]及eGFR[(105.99±20.56)mL·min^(-1)·(1.73 m^(2))比(133.15±26.18)mL·min^(-1)·(1.73 m^(2))^(-1)]显著低于对照组(P<0.05),且肾损伤患者血清TIMP3[(0.47±0.11)μg/L比(0.82±0.21)^(-1)μg/L]及eGFR[(74.69±10.22)mL·min^(-1)·(1.73 m^(2))比(126.18±27.23)mL·min^(-1)·(1.73 m^(2))^(-1)]显著低于无肾损伤患者(P<0.05);血清SOX2[(8.91±1.82)kU/L比(5.15±1.31)kU/L]及HbA1c[(8.80±1.55)%比(5.52±0.83)%]、UAER[(70.13±18.06)mg/24 h比(13.22±3.61)mg/24 h]、Scr[(82.14±15.23)µmol/L比(53.19±5.62)µmol/L]显著高于对照组(P<0.05),且肾损伤患者血清SOX2[(10.81±2.13)kU/L比(5.15±1.31)kU/L]及UAER[(156.83±40.29)mg/24 h比(13.22±3.61)mg/24 h]、Scr[(113.77±13.58)µmol/L比(53.19±5.62)µmol/L]显著高于无肾损伤患者(P<0.05)。Pearson相关性分析结果显示,TIMP3与UAER、Scr、HbA1c呈显著负相关(P<0.05),与eGFR呈显著正相关(P<0.05);SOX2与UAER、Scr、HbA1c呈显著正相关(P<0.05),与eGFR呈显著负相关(P<0.05);血清TIMP3与SOX2呈显著负相关(r=-0.590,P<0.05)。ROC结果显示,血清TIMP3联合SOX2诊断T2DM患者肾损伤的敏感度和特异度分别为95.0%、85.3%,显著高于TIMP3、SOX2单独测定。结论T2DM肾损伤患者血清TIMP3水平显著降低,SOX2水平显著升高,且两者与T2DM患者肾损伤密切相关,可用于T2DM患者肾损伤早期诊断。

BDS-3全球短报文2种低轨卫星几何法定轨

针对低轨卫星实时在线精密定轨难以获取实时改正数问题,提出基于北斗三号全球卫星导航系统(BDS-3)全球短报文播发距离改正数和状态空间表达(SSR)改正数的低轨卫星精密定轨方法。基于提出的距离改正数和SSR改正数编码播发方案,利用Swarm A卫星7 d星载全球卫星导航系统(GNSS)数据进行验证,从定轨精度以及处理效率2方面进行分析,结果表明:基于BDS-3全球短报文播发的改正数可以实现低轨卫星几何法定轨精度约为0.1 m,且基于SSR改正数的低轨卫星定轨精度优于距离改正数。非差非组合模型的定轨精度略优于无电离层(IF)组合定轨精度;当BDS-3全球短报文通信成功率为90%时,定轨精度下降约15%。在处理效率上,IF组合较非差非组合提升明显,2种方法在主频为1.6 GHz的个人笔记本上单历元处理时间均小于0.003 s。

A Novel Approach for Determining the Orientation of 3-Hydroxyl Group of Some Steroids by CIMS

Trimethylchlorosilane was used as a stereoselective reagent to determine the e or a orientation of 3-hydroxyl group of some steroids by chemical ionization mass spectrometry.

美洲大蠊抗肿瘤活性部位CII-3指纹图谱的建立及多成分含量测定

建立美洲大蠊抗肿瘤活性部位CII-3的HPLC指纹图谱及其核苷类成分的含量测定方法。采用Phenomenex Gemini C_(18) 110A(4.6 mm×250 mm,5μm)色谱柱,以乙腈(A)-0.01%甲酸水(B)为流动相,梯度洗脱,测定16批供试品。采用“中药指纹图谱相似度评价系统(2012版)”进行相似度评价,并对结果进行聚类分析(HCA)、主成分分析(PCA)、正交偏最小二乘判别分析(OPLS-DA)。16批CII-3的HPLC指纹图谱中共有峰为16个,相似度介于0.870~0.982之间,HCA将CII-3分为3类,结合PCA、OPLS-DA分析筛选出3个导致批次间质量差异的标志物。指认出8种核苷类成分并测定了其含量,分别为胞嘧啶(0.50~1.17 mg·g^(-1))、腺嘌呤(0.54~2.10 mg·g^(-1))、鸟嘌呤(0.08~1.07 mg·g^(-1))、黄嘌呤(0.74~4.67 mg·g^(-1))、胸腺嘧啶(0.32~2.46 mg·g^(-1))、腺苷(1.02~7.67 mg·g^(-1))、肌苷(4.02~37.35 mg·g^(-1))、胸腺嘧啶核苷(0.56~1.86 mg·g^(-1)),8种核苷类成分在16批供试品中含量差异较大。该方法简单、准确,可为美洲大蠊抗肿瘤活性部位CII-3的质量控制提供理论依据。

碳酸钙D_(3)颗粒(Ⅱ)中维生素D_(3)含量测定的不确定度评定

目的建立测定碳酸钙D_(3)颗粒(Ⅱ)中维生素D_(3)含量不确定度的评定方法。方法采用《国家药品标准》WS1-XG-033-2021中维生素D_(3)含量测定方法进行测定,同时依据《测量不确定度评定与表示》JJF 1059.1-2012中的相关规定,建立测定维生素D_(3)的不确定度数学模型,并对不确定度来源进行分析和评定。结果维生素D_(3)含量的不确定度来源主要有对照品纯度(PR),对照品称量(MR),对照品溶液制备(VR),对照品溶液测定(AR),样品称量(MS),供试品溶液制备(VS),样品平均装量(W),样品溶液测定(AS),高效液相色谱仪(I)及方法偏倚(B)。高效液相色谱外标法测定碳酸钙D_(3)颗粒(Ⅱ)中维生素D_(3)含量的合成不确定度为0.0228,扩展不确定度为3.22%(k=2,置信概率为95%)。方法偏倚引入的相对标准不确定度为1.83×10^(-2),为潜在风险点。结论所建立的方法适用于高效液相色谱外标法测定碳酸钙D_(3)颗粒(Ⅱ)中维生素D_(3)含量测定的不确定度评定,但测定方法回收率较低。建议对该方法进行影响因素试验考察,以改进检验方法,提高平均回收率。

复杂环境下GPS+BDS-3 PPP/INS紧组合算法性能分析

针对城市复杂环境下精密单点定位(PPP)连续高精度定位受限的问题,本文基于北斗三号全球卫星导航系统(BDS-3)与全球定位系统(GPS)双系统,利用PPP与惯性导航系统(INS)紧组合算法来改善城市复杂环境下定位性能。通过构建GPS+BDS-3双系统PPP/INS紧组合滤波模型,分别对GPS PPP、GPS+BDS-3 PPP、GPS PPP/INS紧组合、GPS+BDS-3PPP/INS紧组合4种方案在城区开阔、复杂环境下的定位、测速、定姿性能进行了分析和评估。实验结果表明,开阔环境下PPP/INS紧组合相比PPP定位精度略有提升;而在复杂环境下PPP/INS紧组合可显著解决PPP定位结果连续性和有效性较差的问题;引入BDS-3后,PPP/INS紧组合导航性能进一步提升,GPS+BDS-3 PPP/INS紧组合相比GPS PPP/INS紧组合,在东、北、天方向上,开阔环境下定位精度分别提升18.5%、32.7%、43.2%,复杂环境下定位精度分别提升35.9%、49.1%、56.5%。

基于罗丹明B类荧光探针的设计以及对Al^(3+)检测

印染废水中过高浓度的Al^(3+)不仅会破坏生态环境,而且还将危害人类健康。因此,对印染废水中Al^(3+)浓度的精准检测具有十分重要的研究意义。本文以罗丹明B、乙二胺和4-甲酰基-3-羟基苯甲酸为原料,合成了新型荧光探针RhB-AC,并利用高分辨质谱(HRMS)及核磁共振氢谱(1H NMR)对探针RhB-AC的分子结构进行了表征。探针RhB-AC在水中,由于光诱导的电子转移(Photoinduced electron transfer,PET)效应,其荧光发生猝灭。当与Al^(3+)作用后,PET效应被抑制,探针表现出很强的青绿色荧光。另外,该探针对Al^(3+)检测的速度快(3秒以内)、选择性好、灵敏度高(检测限为16 nM)。最后,该探针还能快速、定量检测实际印染废水中的Al^(3+)浓度。

顾及载体航向约束的单站BDS-3相位测速模型

速度是载体运动状态的重要表征,高精度定速能力是BDS-3系统高性能服务的重要体现。针对传统单站历元间相位差分模型易受误差积累与观测环境影响等问题,本文提出了顾及载体航向约束的单站BDS-3相位测速模型。首先,在传统BDS-3历元间相位差分方程矢量分解的基础上,构建载体位移增量微分表达式,联合非差模型与微分方程综合估计载体速度;其次,利用载体水平面内位移矢量与航向角之间的相关性,建立顾及航向角约束的N与E方向位移参数约束条件;最后,综合3组独立的函数方程进行载体速度分量逐历元解算。通过静态与动态试验表明,静态条件下,BDS-3相位不同方向均可实现mm/s的测速精度,相较于传统历元间差分模型,E与N方向分别提升了62.9%和87.5%,且有效避免了水平方向测速误差的积累效应,但U方向由于缺少约束导致精度提升不显著。动态条件下,BDS-3相位测速在直线运动状态水平面内可获得mm/s级的测速精度,且E与N方向较传统历元间差分模型分别提升了35.2%和21.8%,而转向状态E、N、U方向测速精度分别为2.81、2.03和1.91 cm/s,较传统模型分别提升了41.2%、45.9%和56.2%。因此,本文提出的顾及航向约束的单站相位测速模型可有效地提升BDS-3系统测速性能。

Grammian Determinant Solution and Pfaffianization for a (3+1)-Dimensional Soliton Equation

Based on the Pfaffian derivative formulae,a Grammian determinant solution for a(3+1)-dimensionalsoliton equation is obtained.Moreover,the Pfaffianization procedure is applied for the equation to generate a newcoupled system.At last,a Gram-type Pfaffian solution to the new coupled system is given.

Painleve Analysis and Determinant Solutions of a (3+1)-Dimensional Variable-Coefficient Kadomtsev-Petviashvili Equation in Wronskian and Grammian Form

In this paper, the investigation is focused on a （3＋1）-dimensional variable-coefficient Kadomtsev- Petviashvili （vcKP） equation, which can describe the realistic nonlinear phenomena in the fluid dynamics and plasma in three spatial dimensions. In order to study the integrability property of such an equation, the Painlevé analysis is performed on it. And then, based on the truncated Painlevé expansion, the bilinear form of the （3＋1）-dimensionaJ vcKP equation is obtained under certain coefficients constraint, and its solution in the Wronskian determinant form is constructed and verified by virtue of the Wronskian technique. Besides the Wronskian determinant solution, it is shown that the （3＋1）-dimensional vcKP equation also possesses a solution in the form of the Grammian determinant.

Fe_3O_4 Magnetic Nanoparticles Modified Electrode as a Sensor for Determination of Nimesulide

A novel type of Fe3O4 nanoparticles modified glass carbon electrode（Fe3O4/GCE） was constructed and the electrochemical properties of N-（4-nitro-2-phenoxyphenyl）methanesulfonamide（nimesulide） were studied on the Fe3O4/GCE.In 0.4mol/L HAc-NaAc buffer solution（pH=5.0）,the electrode process of nimesulide was irreversible at bare GCE and Fe3O4/GCE.The Fe3O4/GCE exhibited a remarkable catalytic and enhancement effect on the reduction of nimesulide.The reduction peak potential of nimesulide shifted positively from-0.683 V at bare GCE to-0.625 V at Fe3O4/GCE,and the sensitivity was increased by ca.3 times.Some experimental conditions were optimized.The linear range between the peak current and the concentration of nimesulide was 2.6×10-6 ＂1.0×10-4mol/L（R=0.993） with a detection limit of 1.3×10-7mol/L.This method has been used to determine the content of nimesulide in medical tablets.The recovery was determined to be 96.9% ＂101.9% by means of standard addition method.The method is comparable to UV-Vis spectrometry.

Precise Orbit Determination for the FY-3C Satellite Using Onboard BDS and GPS Observations from 2013, 2015, and 2017

Using the FengYun-3C(FY-3C)onboard BeiDou Navigation Satellite System(BDS)and Global Positioning System(GPS)data from 2013 to 2017,this study investigates the performance and contribution of BDS to precise orbit determination(POD)for a low-Earth orbit(LEO).The overlap comparison result indicates that code bias correction of BDS can improve the POD accuracy by 12.4%.The multi-year averaged one-dimensional(1D)root mean square(RMS)of the overlapping orbit differences(OODs)for the GPS-only solution is 2.0,1.7,and 1.5 cm,respectively,during the 2013,2015,and 2017 periods.The 1D RMS for the BDS-only solution is 150.9,115.0,and 47.4 cm,respectively,during the 2013,2015,and 2017 periods,which is much worse than the GPS-only solution due to the regional system of BDS and the few BDS channels of the FY-3C receiver.For the BDS and GPS combined solution(also known as the GC combined solution),the averaged 1D RMS is 2.5,2.3,and 1.6 cm,respectively,in 2013,2015,and 2017,while the GC combined POD presents a significant accuracy improvement after the exclusion of geostationary Earth orbit(GEO)satellites.The main reason for the improvement seen after this exclusion is the unfavorable satellite tracking geometry and poor orbit accuracy of GEO satellites.The accuracy of BDS-only and GC combined solutions have gradually improved from 2013 to 2017,thanks to improvements in the accuracy of International GNSS Service(IGS)orbit and clock products in recent years,especially the availability of a high-frequency satellite clock product(30 s sampling interval)since 2015.Moreover,the GC POD(without GEO)was able to achieve slightly better accuracy than the GPS-only POD in 2017,indicating that the fusion of BDS and GPS observations can improve the accuracy of LEO POD.GC combined POD can significantly improve the reliability of LEO POD,simply due to system redundancy.An increased contribution of BDS to LEO POD can be expected with the launch of more BDS satellites and with further improvements in the accuracy of BDS satellite products in the near future.

Ab initio Structure Determination of [Co(NH_3)_5Br]Br_2 Using Conventional X-ray Powder Diffraction

The crystal structure of [Co(NH3)5Br]Br2 has been determined ab initio from the conventional X-ray powder diffraction data. The approximate structure with all 7 indeyendent non-H atoms was solved by direct methods. The final orthorhombic unit-cell parameters after Rietveld refinement are: a=13.6927, b=10.7071, c=6.9400A, V=1017.47A3, F30=93(0.0075,43), M20=49, Z=4. Space group is Pnma. The structure agreement factors are: Rp=0.066,Rwp=0.090, RF=0.041, RB=0.042.

Spectrofluorimetric Determination of Trace Terbium(III) Using 2,6-Bis-(1'-phenyl-3'-methyl-5'-oxopyrazole-4')pyridinediacyl and N-Cetylpyridium Bromide

A new spectrofluorimetric method for determination of trace terbium based on its reaction with 2.6-his-(1'-phenyl-3'-methyl-5'- pyridinediacyl (H_2PMBPP) and N- cetylpyridium bromide (CPB). at an apparent pH=5.0 provided by a hexamethylenetetramine (5% w/w)-hydrochloric acid buffer,is propesed. The calibration graph is linear in the ran ge from

SIMULTANEOUS DETERMINATION OF FAT SOLUBLE VITAMINS A, D_3, E AND K_1 IN FORTIFIED MILK POWDERS BY HPLC

A high performance liquid chromatographic method for the simultaneous determination of four fat soluble vitamins: retinol (vitamin A), cholecalciferol(vitamin D), tocopherol(vitamin E) and phylloquinone(vitamin K_1) in fortified milk powders and egg yolk has been developed. The method requires enzymatic hydrolysis of lipid component of the sample as a pretreatment. Several factors which influence the enzymatic hydrolysis were studied-Separation was achieved using μ-Bondapak C-18 column(3.9×300mm), 98% methanol as mobile phase, a double channel detection was selected; vitamins D_3 E_1 K_1 were detected by UV spectrophotometry (265 nm) first, then vitamin A by fluorometry (EX 325nm, EM 480mm). The retention times of vitamin A_1 D_3, E and K_1 4.87, 9.00, 10.58 and 15.45 min respectively. Detection limit were 0.64, 0.25, 0.50 and 0.07 ng; and the recoveries were 90.5%～103.6% 90.0%～95.6%, 91.7%～98.8%, 91.5%～98.6%, respectively. The vitamins A, D_0, E, K_1 contents in foods were determined satisfactorily.

SYNTHESIS AND CHARACTERIZATION OF 2-(2-HYDROXY-3,5-DINITROPHENYLAZO)-7-(4-CHLORO-PHOSPHONPHENYLAZO)-1, 8-DIHYDROXY-NAPHTHALENE-3, 6-DISULF-ONIC ACID (CPAP) AS NEW REAGENT FOR DETERMINATION OF TOTAL PARE EARTHS

This paper reports the synthesis and general properties of the new reagent CPFP. Its dissociation constants have been determined. The characterization in determinating total RE with CPAP reagent has been investigated in detail. Analytic data for synthetic sample are satisfactory.

基于智能手机BDS-3测速信息的行人运动识别

基于智能手机的北斗三号(BDS-3)定位与测速逐步成为大众获取位置服务的主要应用。随着北斗系统服务性能的提升,其提供的位置与速度信息催生了新的服务和应用场景,结合智能手机BDS-3的测速信息,提出了一种基于支持向量机(Support Vector Machine, SVM)的行人运动识别方法。该方法可应用于行为感知、优化健身方案等健康领域。评估了安卓智能手机BDS-3测速精度并基于手机持有者在运动过程中的BDS-3速度信息对行人的运动状态进行识别。结果表明,BDS-3的测速精度略优于GPS和BDS-2系统。多系统组合测速能提升测速精度。通过合理地选取特征,利用智能手机BDS-3测速信息对行人运动模式进行自动识别的正确率可达96.3%。

2-芳基丙烷-1,3-二亚甲基双异吲哚-1-酮的合成

异吲哚啉酮具有广泛的生物活性,合成结构多样的新型异吲哚啉-1-酮类化合物具有重要意义。为构建新型异吲哚啉-1-酮类化合物,以3-亚甲基异吲哚啉-1-酮和芳香醛为原料,在三氯硅烷作用下发生缩合反应,以普遍中等到良好的产率得到一系列2-芳基丙烷-1,3-二亚甲基双异吲哚-1-酮类化合物,所有产物结构由^(1)H NMR,^(13)C NMR和HR-MS(ESI)确证,另外还得到了产物3aa的单晶,通过X-射线衍射确定其构型为(3 E,3′E)。