Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)

AIM： TO establish which scolicidal agents are superior and more suitable for regular use. METHODS： Echinococcus granu/osus protoscoleces were obtained from 25 patients with liver hydatid cysts. Various concentrations of albendazole sulfone, albendazole sulfoxide, and albendazole sulfone and albendazole sulfoxide mixed together in concentrations of 50 μg/mL, and H202 in a concentration of 4%, NaCI 20%, and 1.5% cetrimide-0.15% chlorhexidine （10% Savlon-Turkey） were used to determine the scolicidal effects. Albendazole （ABZ） derivatives and other scolicidal agents were applied to a minimum of 100 scoleces for 5 and 10 min. The degree of viability was calculated according to the number of living scolices per field from a total of 100 scolices observed under the microscope. RESULTS： After 5 min, ABZ sulfone was 97.3% effective, ABZ sulfoxide was 98.4% effective, and the combined solution was 98.6% effective. When sulfone, sulfoxide and the combined solutions were compared, the combined solution seemed more effective than sulfone. However, there was no difference when the combined solution was compared with sulfoxide. After 10 min, hypertonic salt water, sulfone, sulfoxide, and the combined solution compared to other solutions looked more effective and this was statistically significant on an advanced level. When sulfone, sulfoxide, and the combined solutions were compared with each other, the combined solution appeared more effective than sulfone. When the combined solution was compared with sulfoxide, there was no difference. CONCLUSION： Despite being active, ABZ metabolites did not provide a marked advantage over 20% hypertonic saline. According to these results, we think creating a newly improved and more active preparation is necessary for hydatid cyst treatment.

An Exact Solution to the Combined KS and EdV Equation

The exact solution for the combined KS and KdV equation is obtained via introducing a simple and effective nonlinear transformations.This method is very concise and primary and can be applied to other unintegrable nonlinear evolution equations.It is common knowledge that the Korteweg de Vries(KdV) equation [1] (1)has been proposed as model equation for the weakly nonlinear long waves which occur in many different physical systems; the Kuramoto-Sivashinsky (KS) equationis one of the simplest nonliaear partial differential equations that exhibit Chaotic behavior frequently encounted in the study of continous media [2-4] . Many interesting mathematical and physical properties of eqs. (1) and (2) have been studied widely. But, in several problems where a lonq wavelength oscilatory instability is found, the noulineai evolution of the perturbations near rriticality is governed by the dispersion modified Kuramoto-Sivashi nsky equation(3)ft is clear that this equation is a combination of the KdV and

New Exact Solutions of Time Fractional Gardner Equation by Using New Version of F-Expansion Method

In this article, we consider analytical solutions of the time fractional derivative Gardner equation by using the new version of F-expansion method. With this proposed method multiple Jacobi elliptic functions are situated in the solution function. As a result, various exact analytical solutions consisting of single and combined Jacobi elliptic functions solutions are obtained.

PDE Surface Generation with Combined Closedand Non-Closed Form Solutions

Partial differential equations (PDEs) combined with suitably chosen boundaryconditions are effective in creating free form surfaces. In this paper, a fourth order partialdifferential equation and boundary conditions up to tangential continuity are introduced. Thegeneral solution is divided into a closed form solution and a non-closed form one leading to a mixedsolution to the PDE. The obtained solution is applied to a number of surface modelling examplesincluding glass shape design, vase surface creation and arbitrary surface representation.