Treatment of 140 cerebral palsied children with a combined method based on traditional Chinese medicine(TCM)and western medicine

Objective:To observe and evaluate a method that is effective and practical for treatment of cerebral palsied(CP)children in China.Method:The patient's age and disease type and individual specific conditions were considered in choosingtherapy methods accordingly:Chinese herbs,acupuncture,auricnlar seed pressure,point finger pressing,massage,orthopedichand manipulation,physiotherapy,occupational therapy,language therapy,etc.Meanwhile we created a new CP treatment modelthat combines hospitalized treatment with family therapy.Results:The majority of CP patients improved greatly in motor andsocial adaptation capacities after treatment.Wilcoxon paired rank sum test analysis showed that there were significant differencesbetween the data before and after treatment(P<0.01).Conclusion:This combined therapy method,based on traditional Chinesemedicine and western medicine plus family supplemental therapy,is an effective and practical treatment strategy for CP children inChina.

Evaluation of Clinical Efficacy on Acute Pancreatitis Treated with Combination of Traditional Chinese and Western Medicine: A Meta-Analysis

Objective: Meta-analysis was conducted to assess whether combination of traditional Chinese and western medicine could enhance clinical outcomes compared to single western medicine in the treatment of acute pancreatitis (AP). Methods: This systematic review will include prospective and retrospective comparative studies in all languages and evaluate the clinical efficacy of integrated traditional Chinese and western medicine versus single western medicine in treatment AP. Animal studies will not be considered. Published articles were acquired from Jan. 2001 to Dec. 2017 by a comprehensive search in Chinese National Knowledge Infrastructure database (CNKI), Chinese WANFANG database. Exclusion criteria were non-comparative studies, hybrid treatment. The main points include clinical efficacy;carefully evaluating and reviewing the literature and filtering the literature according to inclusion criteria and exclusion criteria. Statistical analyses were performed using software Review Manager (Version 5.0). Publication biases of main results were examined by Stata 12.0. Results: 1262 cases of 1342 cases were effective and the effective rate reaches 94.04% in the group of integrated traditional Chinese and western medicine, while 949 cases of 1223 cases were effective and its effective rate can be up to 77.60% in the group of single western medicine (P > 0.05%, I2 = 0%, Odds Ratio (OR) = 4.98, 95% CI = 3. 79 - 6.54, P Conclusion: These results suggest that the therapeutic effects of integrated traditional Chinese and Western medicine on AP are better in treatment of AP than that of western medicine alone.

Clinical Observation of Integrated Traditional Chinese and Western Medicine in the Treatment of Chronic Ulcerative Rectitis

Objective:To observe and compare whether the combination of traditional Chinese and Western medicine can achieve more satisfactory results in the treatment of patients with chronic ulcerative rectitis(UR).Methods:70 cases of chronic ulcerative rectitis were selected in all hospitals of our hospital for comparison.Observation and control were set up.The number of people was the same,but there were differences in methods.The control group retained enema,and the observation group was treated with traditional Chinese medicine.Rectal mucosa scores after different treatments were compared to evaluate the effect of intervention.Results:It was found that the observation group scored lower(P<0.05),and the effect was better.Conclusion:For the treatment of patients with chronic ulcerative rectitis,the combination of traditional Chinese and Western medicine will help to promote the prognosis of the disease,improve the problem of ulcer,promote the improvement of gastrointestinal function and bring a more positive impact.

Meta-analysis of traditional Chinese medicine and western medicine in treating retinal vein occlusion complicated by macular edema

Objective:TMeta-analysis was performed to evaluate the clinical efficacy of the combination of traditional Chinese medicine and western medicine in treating patients with retinal vein occlusion(RVO)complicated by macular edema(ME).Methods:We searched The CNKI,Wanfang Data,PubMed and Cochrane Library from database.All of randomized controlled trials(RCTs)of the combination of traditional Chinese medicine and western medicine in treating patients with RVO complicated by ME were searched.The Revman5.3 software were used for meta-analysis.Results:A total of 30 trials involving 1943 patients and 1976 eyes were included.Meta-analysis showed that compared with western medicine,the combination of traditional Chinese medicine and western medicine can significantly improve the best corrected visual acuity[(MD=0.08,95%CI=0.07~0.10,P<0.00001)(MD=-0.16,95%CI=-0.24^-0.08,P=0.0002)(MD=5.78,95%CI=1.30~10.25,P=0.01)],reduce the central macular thickness(MD=-54.6,95%CI=-73.76^-35.43,P<0.00001),and improve the clinical effective rate(RR=1.32,95%CI=1.22~1.43,P<0.00001).Conclusion:The combination of traditional Chinese and western medicine in treating patients with RVO complicated by ME was superior to western medicine in improving the best corrected visual acuity,reducing the thickness of macular fovea and improving the clinical efficacy.

Meta-analysis on the treatment of adenoid hypertrophy in children with integrated traditional Chinese and western medicine

Objective: To evaluate the effect of combined Chinese and western medicine on children withadenoidal hypertrophy. Methods: System comprehensive retrieve hownet (CNKI), a database of ten thousand China (WanFang), Chinese biomedical database (CBM), weipu database (VIP), PubMed, Embase and Cochrane library database, retrieval time from March 1, 2009 to December 31, 2019, the use of "Cochrane bias risk assessment tools to have included in the quality of literature evaluation, and to use the literature on into RevMan 5.3 software for Meta quantitative analysis. A total of 10 references were included in this study, and a total of 464 clinical cases were included in the total sample size for meta-analysis, including 242 in the experimental group and 222 in the control group. Results: The statistical data show that the total effective rate of combined traditional Chinese and western medicine for the treatment of adenoid hypertrophy in children is higher than that of western medicine alone (OR = 4.27, 95% CI: 2.50, 7.13, P <0.00001) The effect of nasal congestion caused by adenoid hypertrophy in children is better than that of western medicine alone (MD =-0.64, 95% CI [-0.94, -0.35], P <0.0001);the effect of improving snoring symptoms in children Better than using western medicine alone, the difference is statistically significant (MD =-0.66, 95% CI [-1.11, -0.21], P <0.01);the effect of reducing the relative ratio of adenoid and posterior nostril is better than that of pure The difference was statistically significant when treated with Chinese or Western medicine (MD =-0.18, 95% CI [-0.24, -0.12], P <0.00001). Conclusion: Based on the existing data and methods, traditional Chinese medicine combined with western medicine has a reliable effect on adenoid hypertrophy in children. It is superior to western medicine alone in terms of treatment efficiency and improvement of clinical symptoms, without serious adverse reactions.

Etiology and Pathogenesis of Pericarditis from the Perspective of Traditional Chinese and Western Medicine

Pericarditis is a common clinical pericardial disease with complex etiology,pathogenesis,and high recurrence rate.Interleukin-1 is an important inflammatory cytokine,which regulates the occurrence and development of inflammation by regulating IL-1α,IL-1β,and IL-IRA;it plays an important role in pericarditis.In traditional Chinese medicine,the modem understanding of its etiology and pathogenesis has been improved.In this review,the etiology and pathogenesis of pericarditis are discussed from the perspective of traditional Chinese and Western medicine.

Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

Objective:Patients with diabetic peripheral neuropathy were treated with integrated traditional Chinese and western medicine,and the final results were observed.Methods:70 patients with such symptoms were randomly divided into two groups.The number of people is the same,and the treatment methods are different.The control group uses western medicine,while the observation group uses traditional Chinese medicine to evaluate the treatment effect.Results:After treatment,the effective rate of the observation group was(P<0.05),indicating that the treatment effect was significantly better.Conclusion:Patients with clinical diabetic peripheral neuropathy treated with routine nutrition and nerve repair,and with Chinese medicine,the effect is more satisfactory,and the effect is positive,so as to promote the optimization of their health.

Therapeutic effect of traditional Chinese medicine on coagulation disorder and accompanying intractable jaundice in hepatitis B virus-related liver cirrhosis patients

AIM： TO observe the therapeutic effects of new traditional Chinese medicine （TClVl） therapy on coagulation disorder and accompanying intractable jaundice in HBV-related liver cirrhosis patients. METHODS： Using stratified random sampling according to fibrinogen （Fib） levels, 145 liver cirrhosis patients due to hepatitis B complicated by coagulation disorder were treated. Of them, 70 in research group were treated with TCM by ＂nourishing yin, cooling blood and invigorating blood circulation＂ and Western medicine, 75 in control group were treated with conventional Western medicine. The indexes of liver function, coagulation function and bleeding events were observed and compared. RESULTS： The prothrombin time （PT） was shorter and the fibrinogen （Fib） level was higher in the research group than in the control group （Fib = 1.6-2.0 g/L, 1.1-1.5 g/L, and ≤ 1.0 g/L）. The total bilirubin （TBIL） level was significantly lower in the research group than in the control group, except for the subgroup of FIB ≤ 1.0 g/L. CONCLUSION： TCM therapy can improve coagulation fuction and decrease TBIL.

meta-analysis of randomized controlled trials of combined treatment with DGSN and western medicine on diabetic peripheral neuropathy

Objective:To systematically study the clinical effects of combined treatment with Dang gui si ni tang(DGSN)and western medicine(WM)on diabetic peripheral neuropathy.Methods:Seven databases,including Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical Database(CBM),Wanfang full-text database,VIP Database for Chinese Technical Periodicals,MEDLINE,PubMed,Embase,were retrieved.Related references about randomized controlled trials on the combination of DGSN and WM on diabetic peripheral neuropathy published during January 2012 up to now(recent 5 years)were reviewed.Related grey literatures were also reviewed according to the selected articles.RevMan5.3 software was used to analyze the publish bias,and to compare the total clinical effects of the combination of DGSN and WM with WM alone.Results:Ultimately,19 randomized controlled trials with 1690 patients were incorporated.The results of meta-analysis showed that combined treatment of diabetic peripheral neuropathy with DGSN and WM showed better general efficacy compared with control group,with a statistically significant difference(P<0.05).The results of study showed homogeneity(P=0.94>0.05).The general efficacy of combined treatment with DGSN and WM was significantly higher than that of control group(P<0.00001,OR=3.98,95%CI:3.01~5.27).Conclusion:Compared with treatment with WM alone,combined treatment of diabetic peripheral neuropathy with DGSN and WM is more effective.Meanwhile,due to the limited literature samples and low quality of literatures,large samples and high quality of multi-center randomized controlled double-blind trials are needed to verify these results.

Treatment of Helicobacter pylori-associated gastritis using traditional Chinese medicine

Helicobacter pylori is a pathogenic bacterium with strong pathogenicity, which can induce chronic gastritis and peptic ulcer in addition to causing gastric mucosal atrophy and intestinal metaplasia after longterm infection. It is even associated closely with the occurrence of gastric cancer and mucosa-associated lymphoid tissue lymphoma. Recently, the incidence of H. pylori-associated gastritis has increased rapidly worldwide, especially in China. The prevention and treatment of H. pylori infection has become an urgent issue to be resolved by the medical community. Traditional Chinese medicine and the combination of traditional Chinese medicine and Western medicine have recently shown unique advantages in the treatment of H. pylori–associated gastritis. The progress in this area is summarized in this review.

近5年中西医治疗小儿抽动秽语综合征的可视化分析

目的 探索发现国内近5年中西医治疗的小儿抽动秽语综合征(TS)的热点话题和发展情况。方法 检索中国知网、万方、维普数据库中2018—2022年中西医结合治疗TS的相关文献。使用CiteSpace软件对关键词绘制知识图谱并进行分析。结果 共纳入342篇相关文献,每年发文量稳定在60篇以上。关键词135个,其中频次≥5的关键词21个。该领域的研究热点包括神经递质、免疫因素、中医药治疗、临床疗效及不良反应。结论 近5年中西医治疗TS的临床对照试验较多,但涉及低频重复经颅磁刺激、行为干预疗法的研究较少,缺乏大规模、多中心、随机双盲的研究,该领域的试验研究较少,且试验研究偏向于神经递质、神经电生理领域的研究,从基因、免疫学角度探讨TS较少,研究的深度与广度均有待加强。

中西医结合治疗重症肺炎机械通气患者的疗效及对脱机效果的影响

目的探讨中西医结合治疗重症肺炎机械通气患者的疗效及对脱机效果的影响。方法选取2020年1月至2022年9月于滕州市中医医院接受机械通气治疗的108例重症肺炎患者作为研究对象,按照随机数字表法分为对照组与研究组,各54例。对照组采用机械通气治疗与常规药物治疗,研究组在对照组基础上开展中西医结合治疗。比较两组机械通气时间、住院时间、潮气量、CO_(2)分压、呼吸频率、心率、临床疗效、脱机成功情况及呼吸机相关性肺炎(VAP)发生情况。结果研究组机械通气时间、住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组潮气量高于治疗前,CO_(2)分压、呼吸频率及心率均低于治疗前,且研究组潮气量高于对照组,CO_(2)分压、呼吸频率及心率均低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组脱机成功率高于对照组,VAP发生率低于对照组,差异有统计学意义(P<0.05)。结论中西医结合治疗重症肺炎机械通气患者疗效显著,可缩短患者的机械通气与住院时间,改善脱机效果,且安全性较高,值得临床推广应用。

Cohort Study on the Effect of a Combined Treatment of Traditional Chinese Medicine and Western Medicine on the Relapse and Metastasis of 222 Patients with Stage Ⅱ and Ⅲ Colorectal Cancer after Radical Operation

Objective： To evaluate the effectiveness of a comprehensive therapy of traditional Chinese medicine （TCM） in reducing the relapse and metastasis of stage Ⅱ and Ⅲ colorectal cancer based on conventional Western medicine （WM） therapy. Methods： Two hundred and twenty-two patients in total, diagnosed as stage Ⅱ and Ⅲ colorectal cancer from February 2000 to March 2006, were recruited from Xiyuan Hospital, China Academy of Chinese Medical Sciences and the General Hospital of Beijing Military Area. They were followed-up once every 3-6 months. Twenty cases dropped out from the cohort. The remaining 202 patients were all treated with routine WM treatment [including R0 radical operation, or chemotherapy or/and radiotherapy according to national comprehensive cancer network （NCCN） clinical guidelines]. These patients were assigned to two groups based on whether or not they were additionally treated with TCM comprehensive therapy （orally administered with a decoction according to syndrome differentiation, combined with a traditional patent drug over one year）. Ninety-eight patients from Xiyuan Hospital were treated with WM and TCM （combined group）, and 104 patients from the General Hospital of Beijing Military Area were treated with WM alone （WM group）. The demographic data at baseline were comparable, including the operation times, age, sex, TNM staging, and pathological types. The patients were followed-up for one to five years. Up to now, there are 98, 98, 77, 64, and 47 patients with 1, 2, 3, 4, and 5 years of follow-up in the combined group, respectively; and 104, 104, 97, 81, and 55 patients in the WM group, respectively. The results of the 5-year follow-up of all the patients will be available in 2011. Results： The relapse/metastasis rate of 1-, 2-, 3-, 4-, and 5-year were 0 （0/98）, 2.04% （2/98）, 11.69% （9/77）, 14.06% （9/64）, and 21.28% （10/47） in the combined group, and were 4.80%（5/104）, 16.35% （17/104）, 21.65% （21/97）, 25.93% （21/81）, and 38.18%（21/55） in the WM group, respectively. A significant difference was found in the second year between the two groups （X^2=12.117, P = 0.000）. Median relapse/metastasis time was 26.5 months in the combined group and 16.0 months in the WM group. Conclusion： The combined therapy of TCM and WM may have great clinical value and a potential for decreasing the relapse or metastasis rate in stage Ⅱ and Ⅲ colorectal cancer after conventional WM therapy.

中药脐疗治疗溃疡性结肠炎缓解期疗效观察

目的观察中药脐疗干预治疗溃疡性结肠炎缓解期临床效果。方法选取2021年1月至2023年3月在潍坊医学院附属高密市人民医院消化内科就诊溃疡性结肠炎缓解期患者,按照随机数表法分为治疗组、对照组,每组各35例。对照组口服美沙拉嗪肠溶片1.0 g,tid;治疗组同时给予中药脐疗“十味抗炎方”凝胶剂。采用改良Mayo评分评价溃疡性结肠炎严重程度;溃疡性结肠炎疾病活动指数评价疾病活动度;炎症性肠病生存量表评价生存质量;检查炎症因子白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α;选择抑郁自评量表和焦虑自评量表评价患者心理情况。结果治疗组第5、6个月Mayo评分和疾病活动指数得分低于对照组,差异有统计学意义(P<0.05);治疗组第3、4、5、6个月炎症性肠病生存量表得分高于对照组,差异有统计学意义(P<0.05);治疗组第3、6个月炎症因子低于对照组,差异有统计学意义(P<0.05);治疗组第3、6个月抑郁和焦虑自评量表评分低于对照组,差异有统计学意义(P<0.05)。结论中药脐疗提升患者生活质量,改善预后,临床疗效优于对照组。

阿尔茨海默病不同治疗方式研究新进展

阿尔茨海默病(Alzheimer’s disease,AD)是一种复杂的、起病隐秘的、病因不明的、缺乏特异性诊断方式的神经退行性病变。面对与日俱增的患病率,却缺乏有效的治疗方式。中医药治疗方式具有多层次、多靶点、多通路的独特优势,中西医结合方式的互补,非药物疗法的辅助,干细胞疗法、新的分子药物、抗体及蛋白疫苗、γ感官刺激等新颖的实验阶段新疗法等方式治疗AD。本文综述近年来的不同治疗方式治疗AD研究新进展,旨在为临床上治疗AD提供新思路、新方法及参考价值。

Combined Treatment of Advanced Primary Hepatocellular Carcinoma with Traditional Chinese Medicine and Western Medicine

Ｃｏｍｂｉｎｅｄ Ｔｒｅａｔｍｅｎｔ ｏｆ Ａｄｖａｎｃｅｄ Ｐｒｉｍａｒｙ Ｈｅｐａｔｏｃｅｌｌｕｌａｒ Ｃａｒｃｉｎｏｍａ ｗｉｔｈ Ｔｒａｄｉｔｉｏｎａｌ Ｃｈｉｎｅｓｅ Ｍｅｄｉｃｉｎｅ ａｎｄ Ｗｅｓｔｅｒｎ ＭｅｄｉｃｉｎｅＹＵＥｒ－ｘｉ...

中医理论视域下创新中药发现策略和实践

在现代科学技术飞速发展的新形势下,源于中医临床的中药创新药物发现在应对新发疾病、重大疾病具有鲜明的中医药特色和优势,探索合理的创新中药发现策略、研究路径是我国中医药创新发展的关键问题。中医药具有完整独特的理论体系和丰富的临床实践积累,在中医理论指导下,临床驱动、主动创新、中西医结合,是我国具有中医药特色的药物发现的重要途径。本文就中医理论指导下的中药创新药物发现研究思路进行阐述,列举了近年来基于中药的药物发现研究成果和相关新兴研究策略,为现代中药创新药物研发提供一定的思路和参考。

中西医结合治疗高脂血症性急性胰腺炎的研究进展

高脂血症性急性胰腺炎(hyperlipidemia in acute pancreatitis,HTG-AP)是由血清甘油三酯升高引起的急性胰腺炎,临床以保守治疗为主,除西医常规治疗以外,传统中医药治疗具有显著疗效,大柴胡汤、大承气汤等化裁被临床广泛应用,且联合中药外治法治疗,效果更佳。目前,中外学者从不同靶点探究HTG-AP的治疗。文章从靶向治疗、炎症机制及肠道菌群等方面介绍HTG-AP中西医治疗的研究进展。

《医学衷中参西录》治女子不月用药特点探析:从药性角度

药性理论是中医的重要组成部分,通过对药性的准确认识,可有效指导组方用药。“女子不月”首见于《黄帝内经》,意指月事不来、闭经。通过从药性角度对《医学衷中参西录》中治疗女子不月诸方的用药特点进行分析,发现张锡纯治不月喜用性平之品,五味常用甘、苦、辛,以健脾益胃、活血通经;重视冲脉,归经与脾、胃、肺、肾、肝、心经均有关;承《神农本草经》之旨,对药物有独特见解,胜病为主,敢于用毒;药物配伍合理,升降相因,气机平衡。该研究可为治疗闭经临床用药提供思路。

基于中西医临床病证特点的免疫性血小板减少动物模型分析

原发免疫性血小板减少(ITP)是一种出血性疾病,发病机制目前尚不明确,为了进一步探究ITP发病机制和临床新药的研究,故通过查阅大量国内外关于免疫性血小板减少模型的相关文献,参照中西医病因病机和临床疾病诊断标准,总结分析ITP相关动物模型特点和与临床吻合度。发现应用最为广泛的是抗血小板血清诱导法,其临床吻合度与病证结合脾不统血、气不摄血模型吻合度均较高,模型造模方式简单,可重复性强。但大多数模型将西医作为评价指标,模型无法完全模拟ITP完整发病过程和状态,缺少中医证候描述,在模型发展仍需进一步完善。