Evaluation of Clinical Efficacy of Combined Use of Acupuncture and Medicine in Treating Sleep Disorder in Patients with Anxiety Disorder

[Objectives]To evaluate the clinical efficacy of combined acupuncture and medicine in the treatment of sleep disorders in patients with anxiety disorders.[Methods]A total of 300 anxiety patients with sleep disorders were randomly selected and divided into a research group and a control group,with 150 cases in each group.The control group was administered with western medicine,and the research group was treated with acupuncture and medicine to compare their clinical treatment effects.[Results]The total effective rate of treatment in the research group was significantly higher than that in the control group;after treatment,both the PSQI and SAS scores of the two groups were significantly reduced,and the reduction degree of the research group was higher than that of the control group,the difference was statistically significant(P<0.05).[Conclusions]Combined use of acupuncture and medicine to treat sleep disorders in patients with anxiety disorders has better curative effect and fewer adverse reactions,so it has high clinical application value.

COMBINED TREATMENT OF HEBETIC SCANTY MENSTRUATION WITH ACUPUNCTURE AND DRUGS

According to a random distribution table, 60 cases of scanty menstruation patients were evenly divided into 3 groups: A) estrin (n = 20), B) acupuncture (n = 20), and C) acupuncture +estrin (n = 20) for comparing their therapeutic effect. Results showed that after treatment, 5 cases in estrin group, 12 cases in acupuncture group and 14 cases in acupuncture + estrin group respectively had an ovulation response. Statistical analysis displayed significant differences between acupuncture group or acupuncture + estrin group and estrin group. (P < 0.05, P <0.05 ); and between acupuneture and acupuncture + estrin groups in the estradiol level of the early phase of follicles in patients with ovulation and without ovulation (P < 0. 05, P < 0.01 ). The fact indicates a close interrelation between acupuncture-induced ovulatory effect and the estradiol level of the patient’s body.

DEVELOPMENT ON CLINICAL TREATMENT OF CONSTIPATION WITH ACUPUNCTURE AND MOXIBUSTION

In the present paper, the authors review recent developmarrt of clinical treatment of constipation with acupunctire and moxibustion from ① body acupuncture therapy including special needling manipulations, as Ziwu Daojiu Needling, etc. and acupoint combination,②electrcacupunture therapy, ③ scalp-acupuncture therapy, ④ auricular acupuncture therapy, ⑤ needleembedding and acupoint-catgut-embedding therapies, ⑥ acupoint-application therapy, ⑦ combinged acupuncture aud medication therapy, ⑧ other therapies such as cupping therapy and holo-therapy, and ⑨ considerations about the action of acupuncture in the treatmnt of constipation and its prospect. Up to now, researches on the effect of acupuncture in treating constipation are seldom seen, thus, much attention should be paid about this by clinical and experimental researchers.

COMMENTS ON THE STUDY OF ACUPOINT COMBINATION AND REMEDIES FOR TREATMENT OF DIABETES MELLITUS WITH ACUPUNCTURE AND MOXIBUSTION

In the present paper, the author reviews the progresses in the study on acumoxi (acupuncture-moxi-bustion) treatment of diabetes mellitus (DM) from Chinese ancient classical works, Chinese and foreign journals. The therapeutic results reveal that acupuncture treatment of DM is effective in improving DM patients' symptoms via vagal-nerve reflex, regulation of neuroendocrine and immune functions. The author holds that ① correct selection of acupoints in accordance with syndrome differentiation and the related meridians and combined application of acupuncture and Chinese herbal medicines (for oral administration) are the key points for raising the therapeutic effect; and ② acupoint combination and curative methods need to be researched further.

Clinical observation of acupuncture combined with medication for mild-to-moderate depression

Objective:To discuss the clinical efficacy and plausible mechanism of Tiao Yang Qu Xie(regulating Yang to eliminate pathogenic factors)needling method plus paroxetine in treating mild-to-moderate depression.Methods:Sixty-six patients with mild-to-moderate depression were divided into an observation group and a control group using the random number table method,each consisting of 33 cases.Another 25 healthy subjects were recruited as a healthy group.The control group took oral paroxetine tablets for treatment,and the observation group received additional acupuncture treatment 3 times weekly.Both groups underwent 4-week treatment.Before treatment,after 2-week and 4-week treatment,and 2 weeks after treatment(follow-up),the patients were assessed using the Hamilton depression scale-17-item(HAMD-17),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and traditional Chinese medicine(TCM)pattern element identification scale for depression.The two groups each randomly contributed 25 cases to detect the protein content of brain-derived neurotrophic factor(BDNF)before treatment and after 4-week treatment,and compared with the healthy group.Results:After 2-week treatment,the markedly effective and total effective rates were significantly higher in the observation group than in the control group(P<0.05);after 4-week treatment,the observation group significantly surpassed the control group in comparing the markedly effective rate(P<0.05).After 2 and 4 weeks of treatment and at the follow-up,the HAMD-17 total score and sleep disorder factor score were lower in the observation group than in the control group(P<0.05);the anxiety-somatic score was lower in the observation group than in the control group after 2-week treatment(P<0.05).After 2 and 4 weeks of treatment and at the follow-up,the observation group was lower than the control group in comparing the scores of SDS,SAS,and TCM pattern element identification scale for depression(P<0.05).After 4-week treatment,the observation group had an increased serum BDNF protein content,higher than that in the control group(P<0.05)and had no significant difference compared to the healthy group(P>0.05).Conclusion:Compared to the use of oral paroxetine alone,acupuncture plus paroxetine can produce more significant efficacy in treating mild-to-moderate depression and act faster in improving sleep disorder and anxiety-somatic symptoms;increasing the serum BDNF protein content may be a part of the mechanism underlying its antidepressant actions.

Clinical Observation on the Combined Use of Acupuncture and Herbal Medicine for Treatment of Chloasma

Objective:To observe the clinical effects of the combined use of acupuncture and herbal medicine for treatment of chloasma.Methods:Totally 60 patients were randomly divided into a treatment group of 30 cases,treated by acupuncture and herbal medicine,and a control group of 30 cases,administered Vitamin C and Vitamin E.The clinical effects were observed.Results:The total effective rate of the treatment group is 93.3%better than that of the control group(76.7%) ,the difference was significant(P<0.01) .Conclusion:Combined use of acupuncture and herbal medicine may yield definite therapeutic effects in treating chloasma patients.

Clinical Study on Treatment of Knee Osteoarthritis with Combined Acupuncture and Medication

Objective： To observe the effect of treatment for proliferative knee osteoarthritis （KOA） using combined acupuncture and medicated compression. Method： All 328 cases were randomized into an observation and control group, 164 cases in each. Combined acupuncture and medicated compression were adopted in the observation group, while oral administration of Zhui Feng Tou Gu Wan （Wind-removing and Bone-penetrating Pills） were adopted in the control group. The clinical effects in the two groups were evaluated 40 days after the treatment. Result： There were significant differences in both marked and total effective rates （P〈0.05）. Conclusion Combined acupuncture and medicated compression can obtain better effect for KOA than oral administration of the Wind-Removing and Bone-Penetrating pills.

Some Consideration on Combined Use of Acupuncture and Drug

Combined use of acupuncture and drug is extensively applied for its wide indications, simple manipulation and good results. Combined use of acupuncture and drug is not in effect the mechanic addition of acupuncture and drugs. It has been proved that acupuncture and drug are of synergism, but there may be an antagonism between acupuncture and drug. How to choose the optimum acupoint in the combination of acupuncture and drug to exert better effects is of great theoretical and practical significance for acupuncturists to make further researches.

Clinical Observation of Combined Acupuncture and Medications in Treating 90 Cases of Facial Palsy

Peripheral facial palsy, namely Bell palsy, is one of the common diseases in the department of acupuncture. Facial palsy, popularly called wry mouth and eye, is primarily manifested by the motor malfunction of the muscles of the expression on the affected side. The author adopted combined acupuncture and medications to treat 90 cases of facial palsy from June 2005 to June 2007, and attained good effects. It is now reported as follows.

Effect of Combined Acupuncture and Medication for Hypertension due to Type 2 Diabetes Mellitus and Plasma Neuropeptide Y

Objective： To observe the effect of combined acupuncture and medication for hypertension due to type 2 diabetes and plasma Neuropeptide Y （NPY）. Methods： Sixty cases with hypertension due to type 2 diabetes were randomized into two groups. Thirty cases in the treatment group were treated with acupuncture and oral extended release nifedipine tablets, while 30 cases in the control group were treated with oral extended release nifedipine tablets alone. After 15 d of treatment, the blood pressure and NPY contents in two groups were observed. Results： The blood pressure and NPY contents in the two groups were remarkably reduced （P〈0.01） and the effect in the treatment group was superior to the control group （P〈0.01）. Conclusion： Combined acupuncture and medication can significantly reduce blood pressure and the NPY contents.

Effects of acupuncture combined with Fluoxetine on behavior and Treg in mice of chronic depression

Objective To investigate effects of acupuncture combined with Fluoxetine on behavior and regulatory T cell （Treg） proportion in mice of chronic depression. Methods Sixty Balb/c mice were randomly divided into a normal control group （group A, n=10） and depression model group （n=50）. Fifty Balb/c mice were irritated with a variety of chronic unpredictable moderate stress stimulations for 21 days to prepare the mouse depression model. After successfully modeling, 50 depression model mice were randomly divided into 5 groups, a model group （group B）, a fluoxetine group （group C）, an acupuncture group （group D） and a combined acupuncture and medicine group （group E） and a sham acupuncture group （group F）, 10 mice in each group. The mice in the group C were intragastrically administrated with Fluoxetine once （20 mg/kg）; for the group D, electroacupuncture （EA） was given at ＂Baihui＂ （百会 GV 20） and ＂Shenting＂ （神庭 GV 24） and for the group F, EA was given at non-acupoint of the buttock for 2 min; for the group E, acupuncture combined with Fluoxetine was used with the same acupoints, methods and medicine as those in the group D and C. The treatment was given once each day, for 21 consecutive days. After treatment the open-field behavior （retention period at the central square, horizontal movement,vertical movement, etc.）, sucrose preferences, body mass, food intake and other behaviors were observed, and the proportion of regulatory T cells （CD4^＋ CD2^＋5 Foxp3^＋ Treg cells） was analyzed with flow cytometry. Results Compared with the normal control group, the open-field behavior showed depression-like changes, and humoral consumption, sucrose preferences, body mass and food intake significantly decreased in the mice of the depression model group. After treatment, compared with the group B, the behaviors of the mice in the group E, C and D were improved in varying degrees; compared with other groups, the group E had more obvious effect on vertical movement; acupuncture combined with Fluoxetine could down-regulate the high-expressed Treg cells. Conclusion Acupuncture combined with Fluoxetine can improve depression behaviors of the mice of depression in the early stage. The mechanism possibly is related with regulating Treg cells which improve the immunosuppressive status of depression.

Clinical Observation of Combined Acupuncture and Herbs in Treating Parkinson's Disease

Objective： To observe the clinical efficacy of linear scalp-acupuncture combined with herbs in the treatment of Parkinson＇s disease （PD）. Methods： One hundred and fifty PD cases were randomized into four groups in the sequence of visit. Eighty-eight cases in group A, were treated by linear scalp-acupuncture and herbs effective to nourish the liver and kidneys, activate blood and remove wind, and acupuncture was performed every other day and 10 treatments made up one course; 20 cases in group B, were treated only by linear scalp-acupuncture; 20 cases in group C, were treated by herbs effective to nourish the liver and kidneys, activate blood and remove wind; 22 cases in group D, were treated by Dopamine. All groups were treated for three months. Results： The total response rate was 89.8% in group A, similar to 86.4% in group D （P〉0.05）, and higher than 65.0% in group C （P〈0.01）. Conclusion： Linear scalp-acupuncture combined with herbs is quite effective in the treatment of PD.

Two cases of corona virus disease 2019(COVID-19)treated with the combination of acupuncture and medication in bedridden patients

The paper reports the experiences in treatment of two cases of corona virus disease 2019(COVID-19)with the combination of acupuncture and medication in bedridden patients confirmed in C7 Inpatient Ward,Wuhan Leishenshan Hospital,China.The combined treatment of acupuncture with the oral administration of"Shanghai leishen No.1 formula"was given every day.The prescription was modified weekly according the symptoms of the patients.Besides,the antivirus,anti-infectious and symptomatic treatment of western medicine was combined.Both of the two cases were improved and discharged.It is anticipated that the treatment experiences in these two cases may provide the instruction and enlightenment for the prevention and treatment of COVID-19.

Clinical Observation of Combined Acupuncture and Herbs in Treating Chronic Pelvic Inflammation

Objective： To observe the clinical efficacy of combined acupuncture and herbs in the treatment of chronic pelvic inflammation. Methods： Eighty-eight cases of chronic pelvic inflammation were randomized into two groups. Treatment group （45 cases） was treated by combined acupuncture and herbs, control group （43 cases） was treated by Fu Ke Qian Jin Jiao Nang （Female Herbal Capsule）. Results： After 3 menstrual cycles of treatments, in treatment group, 28 cases were cured, 9 cases got marked effect, 4 cases got effect, 4 cases were failure, and the total effective rate was 91.1%; in control group, 7 cases were cured, 8 cases got marked effectiveness, 15 cases got effectiveness, 13 cases were failure, and the total effective rate was 69.8%. The total effective rate was higher in treatment group than in control group （P〈0.05）; in the six-month survey, the relapse rate was lower in treatment group than in control group （P〈0.01）. Conclusion： Combined acupuncture and herbs is effective for chronic pelvic inflammation, with fewer relapses.

Therapeutic Effect Analysis on Combined Acupuncture and Medication for Peripheral Facial Paralysis

Objective： To investigate the therapeutic efficacy of combined acupuncture and medication for peripheral facial paralysis. Methods： Sixty-six cases with peripheral facial paralysis were randomly allocated into a treatment group and a control group, 33 cases in each group. The cases in the treatment group were treated with combined electroacupuncture and Chinese medicine formula, while the cases in the control group were treated by electroacupuncture alone. Results： The recovery rate in the treatment group was significantly higher than the control group （P〈0.05）. In addition, the time length for recovery in the treatment group tended to be shorter than the control group. Conclusion： Combined acupuncture and medication can obtain better effect than electroacupuncmre alone for peripheral facial paralysis.

Effect of Combined Acupuncture and Chinese Herbal Formula on the Motor Function and Activities of Daily Living in Post-stroke Patients

Objective： To observe the effect of combined acupuncture and Chinese herbal formula on the motor function and activities of daily living （ADL） of post-stroke patients and further evaluate the resultant clinical efficacy. Methods： A total of 80 acute stroke patients were randomly divided into a control group （40 cases） and an observation group （40 cases）. Conventional Western medicine management was employed in the control group, while additional acupuncture and Chinese herbal formula were employed in the observation group. After completing the sessions of treatment, changes of the motor function （using the US National Institutes of Health Stroke Scale, NIHSS） and activities of daily living （using Barthel Index） were measured. Results： The total effective rate in the observation group was 87.5%, versus 62.5% in the control group, showing a statistical difference （P〈0.05）. After the treatment, the motor function and activities of daily living of patients in both groups were markedly improved （P〈0.05）, and those in the observation group presented with a better result （P〈0.05）. Conclusion： Conventional Western medicine management coupled with acupuncture and Chinese herbal formula are beneficial to the treatment and rehabilitation of patients with cerebral infarction.

Observation on Therapeutic Effect of Acupuncture and Medication for 30 Cases of Post-Stroke Depression

Objective： To investigate the therapeutic effects and adverse reaction of acupuncture plus medication and single medication for post-stroke depression（PSD）. Methods： In an open control study, 93 cases of the patients with depression were randomly allocated to three groups： 30 cases in the acupuncture-medication group （AM）, 30 cases in Prozac Group A （A）, and 33 cases in Prozac Group B （B）. The acupuncture-medication group was treated by oral administration of Prozac 20 mg/d plus acupuncture. Prozac Group A was treated by oral administration of Prozac 20 mg/d. Prozac Group B was treated by oral administration of Prozac 20-40 mg/d. All three groups were treated for 6 weeks. The therapeutic effects and adverse reaction were evaluated by Hamilton Depression Scale （HAMD） and Treatment Emergent Symptom Scale （TESS） respectively in the three groups. Results： The effective rate was 86.7% in the acupuncture-medication group, 63.3% in Prozac Group A and 87.9% in Prozac Group B. The therapeutic effect was better in the acupuncture-medication group than in Prozac Group A, and there was no significant difference in comparisonwith Prozac Group B （P〉0.05）. But the occurrence rate of drug adverse reaction was higher in Prozac Group B than in the acupuncture-medication group. Conclusion： Simultaneous application of acupuncture and medication is a therapeutic method with affirmative effect and less side effect for post-stroke depression.

Clinical Observation of Combined Acupuncture ＆ Medications in Treating Dysspermia Infertility

Objective： To observe the curative effect of combined acupuncture and medication on infertility due to seminal abnormality. Method： Thirty-eight patients with seminal abnormality were separately treated by acupuncture and traditional Chinese medications （“Erxian Decoction”） plus Clomiphene. Results and Conclusion： The total effective rate was 96.0% in the acupuncture plus traditional Chinese medication group （26 cases） and 66.7% in the acupuncture and western medication groups （12 cases）. Statistical analysis showed a significant difference （P〈0.05）. The cure rate and the pregnancy rate were 38.5% and 30.8% respectively in the acupuncture and traditional Chinese medication group. Both of them were higher than 8.3% and 8.3% in the acupuncture and western medication group respectively, but there were no statistically significant differences. In the two groups of patients, seminal volume, liquefaction time and viscosity and spermatozoal density, death rate and one-hour survival rate took a significant turn for the better after treatment as compared with before treatment （P〈 0.05）. In the acupuncture and traditional Chinese medication groups of patients, symptoms markedly improved after treatment as compared with before treatment.

Clinical Observation on Combined Acupuncture and Medication for Osteoporosis in Postmenopausal Women

Objective： To observe the clinical effect of combined acupuncture and medication for osteoporosis in postmenopausal women. Methods： A total of 100 cases with postmenopausal osteoporosis were randomly allocated into a treatment group and a control group, 50 in each group. The cases in the treatment group were treated with electroacupuncture coupled with Calcitriol soft capsules, while the cases in the control group were treated with electroacupuncture alone. Results： There were significant differences in treatment effects between the treatment group and control group （P〈0.05）. Conclusion： Combined acupuncture and medication can obtain a marked effect for postmenopausal osteoporosis.

Observation on Therapeutic Effect of Treating Traumatic Gonarthromeningitis by Combined Acupuncture and Chinese Herbs

Objective： To observe the therapeutic effects of treating traumatic gonarthromeningitis with acupuncture combined Chinese herbs. Methods： Seventy patients were randomly divided into two groups, with 35 cases in each group. The treatment group was treated with Chinese herbal medicine, acupuncture and cupping therapy. The control group was treated with Diclofenac Sodium Tablets, Corydalis Analgesic Tablets and Vitamin C Tablets. Results： The total effective rate of the treatment group was higher than that of the control group. There was a statistically significant difference between the two groups （P〈0.05）. Conclusion： The combined therapy with acupuncture and Chinese herbal medicine has a remarkable therapeutic effect on treating traumatic gonarthromeningitis.