In a recent study published in Cell1 and two bioRxiv pre-prints,2,3 three studies investigate the structure of the endosomal Commander complex through a combination of X-ray crystal-lography,cryogenic-electron microsc...In a recent study published in Cell1 and two bioRxiv pre-prints,2,3 three studies investigate the structure of the endosomal Commander complex through a combination of X-ray crystal-lography,cryogenic-electron microscopy(Cryo-EM),Alphafold predictions and extensive site-directed mutagenesis(Fig.1a),which sheds lights on the molecular characteristics of this evolutionarily-conserved protein machinery,and enables the mapping of mutations causing X-linked intellectual disability(XILD)and Ritscher-Schinzel syndrome(RSS).When proteins enter the endosomal network,they are either transported to lysosome for degradation,or recycled to the plasma membrane or the trans-Golgi network for reuse.Multiple protein machineries are essential for the process,including Retromer,Commander,and several members of the sorting nexin(SNX)family.Commander genes are highly conserved in metazoa and can be found in almost all tissues and cells.展开更多
The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and e...The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.展开更多
In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated...In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated estimation guidance and control nonlinear model with limited actuator deflection angle is established considering the seeker's FOV constraint.The boundary time-varying integral barrier Lyapunov function(IBLF)is employed in backstepping design to constrain the body line-of-sight(BLOS)in IEGC system to fit a circular FOV.Then,the nonlinear adaptive controller is designed to estimate the changing aerodynamic parameters.The generalized extended state observer(GESO)is designed to estimate the acceleration of the maneuvering targets and the unmatched time-varying disturbances for improving tracking accuracy.Furthermore,the command filters are used to solve the"differential expansion"problem during the backstepping design.The Lyapunov theory is used to prove the stability of the overall closed-loop IEGC system.Finally,the simulation results validate the integrated system's effectiveness,achieving high accuracy strikes against maneuvering targets.展开更多
Purpose-To optimize train operations,dispatchers currently rely on experience for quick adjustments when delays occur.However,delay predictions often involve imprecise shifts based on known delay times.Real-time and a...Purpose-To optimize train operations,dispatchers currently rely on experience for quick adjustments when delays occur.However,delay predictions often involve imprecise shifts based on known delay times.Real-time and accurate train delay predictions,facilitated by data-driven neural network models,can significantly reduce dispatcher stress and improve adjustment plans.Leveraging current train operation data,these models enable swift and precise predictions,addressing challenges posed by train delays in high-speed rail networks during unforeseen events.Design/methodology/approach-This paper proposes CBLA-net,a neural network architecture for predicting late arrival times.It combines CNN,Bi-LSTM,and attention mechanisms to extract features,handle time series data,and enhance information utilization.Trained on operational data from the Beijing-Tianjin line,it predicts the late arrival time of a target train at the next station using multidimensional input data from the target and preceding trains.Findings-This study evaluates our model’s predictive performance using two data approaches:one considering full data and another focusing only on late arrivals.Results show precise and rapid predictions.Training with full data achieves aMAEof approximately 0.54 minutes and a RMSEof 0.65 minutes,surpassing the model trained solely on delay data(MAE:is about 1.02 min,RMSE:is about 1.52 min).Despite superior overall performance with full data,the model excels at predicting delays exceeding 15 minutes when trained exclusively on late arrivals.For enhanced adaptability to real-world train operations,training with full data is recommended.Originality/value-This paper introduces a novel neural network model,CBLA-net,for predicting train delay times.It innovatively compares and analyzes the model’s performance using both full data and delay data formats.Additionally,the evaluation of the network’s predictive capabilities considers different scenarios,providing a comprehensive demonstration of the model’s predictive performance.展开更多
To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situ...To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situation and international situation,and is an important part of the CPCCC‘s展开更多
Purpose–The intelligent Central Traffic Control(CTC)system plays a vital role in establishing an intelligent high-speed railway(HSR)system.As the core of HSR transportation command,the intelligent CTC system is a new...Purpose–The intelligent Central Traffic Control(CTC)system plays a vital role in establishing an intelligent high-speed railway(HSR)system.As the core of HSR transportation command,the intelligent CTC system is a new HSR dispatching command system that integrates the widely used CTC in China with the practical service requirements of intelligent dispatching.This paper aims to propose key technologies and applications for intelligent dispatching command in HSR in China.Design/methodology/approach–This paper first briefly introduces the functions and configuration of the intelligent CTC system.Some new servers,terminals and interfaces are introduced,which are plan adjustment server/terminal,interface for automatic train operation(ATO),interface for Dynamic Monitoring System of Train Control Equipment(DMS),interface for Power Supervisory Control and Data Acquisition(PSCADA),interface for Disaster Monitoring,etc.Findings–The key technologies applied in the intelligent CTC system include automatic adjustment of train operation plans,safety control of train routes and commands,traffic information data platform,integrated simulation of traffic dispatching and ATO function.These technologies have been applied in the Beijing-Zhangjiakou HSR,which commenced operations at the end of 2019.Implementing these key intelligent functions has improved the train dispatching command capacity,ensured the safe operation of intelligent HSR,reduced the labor intensity of dispatching operators and enhanced the intelligence level of China’s dispatching system.Originality/value–This paper provides further challenges and research directions for the intelligent dispatching command of HSR.To achieve the objectives,new measures need to be conducted,including the development of advanced technologies for intelligent dispatching command,coping with new requirements with the development of China’s railway signaling system,the integration of traffic dispatching and train control and the application of AI and data-driven modeling and methods.展开更多
Owing to the ubiquitous use of smartphones by soldiers, military researchers have an increasing interest in potentially problematicside effects such as smartphone overdependence. This raises a question regarding the p...Owing to the ubiquitous use of smartphones by soldiers, military researchers have an increasing interest in potentially problematicside effects such as smartphone overdependence. This raises a question regarding the psychological mechanisms underlying thepotentially self-damaging use of smartphones. Here, we address this question by analyzing how heterogeneity in commander’sgood leadership explains subordinate soldiers’ differences in self-control and smartphone use. Specifically, we found thatsubordinate soldiers who thought their commander's leadership was good were self-regulated, less dependent on smartphones,less stressed, and finally had good mental health. This result indicates that commander’s good leadership can be used toestimate whether subordinate soldiers exert control over their impulses and use their smartphones properly. Thus, the currentfindings help to identify external factors that lead to a better understanding of problematic smartphone use and can potentiallyhelp to design appropriate preventive mechanisms or interventions that target commander’s good leadership.展开更多
基金This work was supported by Natural Science Foundation of China(NSFC#32200559,#92254302)National Key Research and Development Program of China(2022YFA1105200)+1 种基金National Science Fund for Distinguished Young Scholars(#32125012)National Institutes of Health grant DK107733 to D.D.B.
文摘In a recent study published in Cell1 and two bioRxiv pre-prints,2,3 three studies investigate the structure of the endosomal Commander complex through a combination of X-ray crystal-lography,cryogenic-electron microscopy(Cryo-EM),Alphafold predictions and extensive site-directed mutagenesis(Fig.1a),which sheds lights on the molecular characteristics of this evolutionarily-conserved protein machinery,and enables the mapping of mutations causing X-linked intellectual disability(XILD)and Ritscher-Schinzel syndrome(RSS).When proteins enter the endosomal network,they are either transported to lysosome for degradation,or recycled to the plasma membrane or the trans-Golgi network for reuse.Multiple protein machineries are essential for the process,including Retromer,Commander,and several members of the sorting nexin(SNX)family.Commander genes are highly conserved in metazoa and can be found in almost all tissues and cells.
基金supported by the Natural Science Foundation Research Plan of Shanxi Province (2023JCQN0728)。
文摘The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.
文摘In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated estimation guidance and control nonlinear model with limited actuator deflection angle is established considering the seeker's FOV constraint.The boundary time-varying integral barrier Lyapunov function(IBLF)is employed in backstepping design to constrain the body line-of-sight(BLOS)in IEGC system to fit a circular FOV.Then,the nonlinear adaptive controller is designed to estimate the changing aerodynamic parameters.The generalized extended state observer(GESO)is designed to estimate the acceleration of the maneuvering targets and the unmatched time-varying disturbances for improving tracking accuracy.Furthermore,the command filters are used to solve the"differential expansion"problem during the backstepping design.The Lyapunov theory is used to prove the stability of the overall closed-loop IEGC system.Finally,the simulation results validate the integrated system's effectiveness,achieving high accuracy strikes against maneuvering targets.
基金supported in part by the National Natural Science Foundation of China under Grant 62203468in part by the Technological Research and Development Program of China State Railway Group Co.,Ltd.under Grant Q2023X011+1 种基金in part by the Young Elite Scientist Sponsorship Program by China Association for Science and Technology(CAST)under Grant 2022QNRC001in part by the Youth Talent Program Supported by China Railway Society,and in part by the Research Program of China Academy of Railway Sciences Corporation Limited under Grant 2023YJ112.
文摘Purpose-To optimize train operations,dispatchers currently rely on experience for quick adjustments when delays occur.However,delay predictions often involve imprecise shifts based on known delay times.Real-time and accurate train delay predictions,facilitated by data-driven neural network models,can significantly reduce dispatcher stress and improve adjustment plans.Leveraging current train operation data,these models enable swift and precise predictions,addressing challenges posed by train delays in high-speed rail networks during unforeseen events.Design/methodology/approach-This paper proposes CBLA-net,a neural network architecture for predicting late arrival times.It combines CNN,Bi-LSTM,and attention mechanisms to extract features,handle time series data,and enhance information utilization.Trained on operational data from the Beijing-Tianjin line,it predicts the late arrival time of a target train at the next station using multidimensional input data from the target and preceding trains.Findings-This study evaluates our model’s predictive performance using two data approaches:one considering full data and another focusing only on late arrivals.Results show precise and rapid predictions.Training with full data achieves aMAEof approximately 0.54 minutes and a RMSEof 0.65 minutes,surpassing the model trained solely on delay data(MAE:is about 1.02 min,RMSE:is about 1.52 min).Despite superior overall performance with full data,the model excels at predicting delays exceeding 15 minutes when trained exclusively on late arrivals.For enhanced adaptability to real-world train operations,training with full data is recommended.Originality/value-This paper introduces a novel neural network model,CBLA-net,for predicting train delay times.It innovatively compares and analyzes the model’s performance using both full data and delay data formats.Additionally,the evaluation of the network’s predictive capabilities considers different scenarios,providing a comprehensive demonstration of the model’s predictive performance.
文摘To build a mankind community of shared future is an important concept and initiative put forward by the Communist Party of China Central Committee(CPCCC)with Comrade Xi Jinping as the core to co-ordinate domestic situation and international situation,and is an important part of the CPCCC‘s
基金This work was supported in part by the National Natural Science Foundation of China under Grant 62203468Young Elite Scientist Sponsorship Program by CAST under Grant 2022QNRC001+1 种基金Foundation of China State Railway Group Co.,Ltd.under Grant K2021X001Foundation of China Academy of Railway Sciences Corporation Limited under Grant 2021YJ315.
文摘Purpose–The intelligent Central Traffic Control(CTC)system plays a vital role in establishing an intelligent high-speed railway(HSR)system.As the core of HSR transportation command,the intelligent CTC system is a new HSR dispatching command system that integrates the widely used CTC in China with the practical service requirements of intelligent dispatching.This paper aims to propose key technologies and applications for intelligent dispatching command in HSR in China.Design/methodology/approach–This paper first briefly introduces the functions and configuration of the intelligent CTC system.Some new servers,terminals and interfaces are introduced,which are plan adjustment server/terminal,interface for automatic train operation(ATO),interface for Dynamic Monitoring System of Train Control Equipment(DMS),interface for Power Supervisory Control and Data Acquisition(PSCADA),interface for Disaster Monitoring,etc.Findings–The key technologies applied in the intelligent CTC system include automatic adjustment of train operation plans,safety control of train routes and commands,traffic information data platform,integrated simulation of traffic dispatching and ATO function.These technologies have been applied in the Beijing-Zhangjiakou HSR,which commenced operations at the end of 2019.Implementing these key intelligent functions has improved the train dispatching command capacity,ensured the safe operation of intelligent HSR,reduced the labor intensity of dispatching operators and enhanced the intelligence level of China’s dispatching system.Originality/value–This paper provides further challenges and research directions for the intelligent dispatching command of HSR.To achieve the objectives,new measures need to be conducted,including the development of advanced technologies for intelligent dispatching command,coping with new requirements with the development of China’s railway signaling system,the integration of traffic dispatching and train control and the application of AI and data-driven modeling and methods.
基金supported by 2023 Research Fund of Korea Military Academy(Hwarangdae Research Institute,RN:2023B1012).
文摘Owing to the ubiquitous use of smartphones by soldiers, military researchers have an increasing interest in potentially problematicside effects such as smartphone overdependence. This raises a question regarding the psychological mechanisms underlying thepotentially self-damaging use of smartphones. Here, we address this question by analyzing how heterogeneity in commander’sgood leadership explains subordinate soldiers’ differences in self-control and smartphone use. Specifically, we found thatsubordinate soldiers who thought their commander's leadership was good were self-regulated, less dependent on smartphones,less stressed, and finally had good mental health. This result indicates that commander’s good leadership can be used toestimate whether subordinate soldiers exert control over their impulses and use their smartphones properly. Thus, the currentfindings help to identify external factors that lead to a better understanding of problematic smartphone use and can potentiallyhelp to design appropriate preventive mechanisms or interventions that target commander’s good leadership.
