Meizhou is committed to creating a more open and inclusive"Capital of Hakka Culture",fully demonstrating its unique cultural charm,so as to provide strong spiritual power and cultural support for Meizhou'...Meizhou is committed to creating a more open and inclusive"Capital of Hakka Culture",fully demonstrating its unique cultural charm,so as to provide strong spiritual power and cultural support for Meizhou's revitalization acceleration and commonprosperity.展开更多
While the world remains committed to upholding the principle of human rights protection,this universal sacrosanct value of humanity has been endlessly put to severe tests in the prevailing global governance.The incohe...While the world remains committed to upholding the principle of human rights protection,this universal sacrosanct value of humanity has been endlessly put to severe tests in the prevailing global governance.The incoherent global response to the Covid-19 pandemic in 2020 was merely the proverbial last straw that broke the camel’s back.展开更多
The Uranium-238 (<sup>238</sup>U), Thorium-232 (<sup>232</sup>Th) families and Potassium-40 (<sup>40</sup>K) are of terrestrial origin and contribute generally to an individual’s e...The Uranium-238 (<sup>238</sup>U), Thorium-232 (<sup>232</sup>Th) families and Potassium-40 (<sup>40</sup>K) are of terrestrial origin and contribute generally to an individual’s external exposure through our presence in this environment. They also contribute to the internal exposure through the ingestion of products and beverages such as water that are close to the earth. The aim of this work is to determine the committed effective dose or Total Indicative Dose (TID) due to gamma radioactivity of the borehole water from the Nord Riviera (NR) well field operated by the Côte d’Ivoire Water Distribution Company (SODECI) for the supply of drinking water to part of the population of Abidjan. In addition, the populations, with their habits, could use these borehole waters directly as drinking water. To this end, water samples from the seven (07) functional boreholes were collected and analyzed on a gamma spectrometry chain, equipped with an HPGe detector in the laboratory of the Radiation Protection Institute (RPI) of the GHANA Atomic Energy Commission (GAEC). The results of the specific activities of <sup>238</sup>U, <sup>232</sup>Th and <sup>40</sup>K obtained were transcribed into TID. As the natural radioactivity of the borehole water is high [1], the TIDs calculated from the activity results of the natural radionuclides<sup>238</sup>U, <sup>232</sup>Th, and <sup>40</sup>K vary for the seven boreholes from 0.150 to 0.166 mSv/yr with an average of 0.161 ± 0.034 mSv/yr. The TID of the control tower, where the borehole water is mixed and treated for household use, is equal to 0.136 ± 0.03 mSv/yr. The TIDs obtained are therefore all slightly greater than the WHO reference dose value of 0.1 mSv/yr. But all remain below the UNSCEAR reference dose of 0.29 mSv/yr.展开更多
A Chinese scientist and his university are committed to improving the health situation on the African continent For around 30 years, Li Xiaokun has been in charge of his research team in China studying growth factors....A Chinese scientist and his university are committed to improving the health situation on the African continent For around 30 years, Li Xiaokun has been in charge of his research team in China studying growth factors. Li, who was born in 1964, spent his early years in Fuping County of Shaanxi Province, where he frequently saw his relatives’lives being ruined by illness. These events caused him pain, but they also triggered his passion for medicine.展开更多
Human induced pluripotent stem cells(hiPSCs)are invaluable resources for producing high-quality differentiated cells in unlimited quantities for both basic research and clinical use.They are particularly useful for st...Human induced pluripotent stem cells(hiPSCs)are invaluable resources for producing high-quality differentiated cells in unlimited quantities for both basic research and clinical use.They are particularly useful for studying human disease mechanisms in vitro by making it possible to circumvent the ethical issues of human embryonic stem cell research.However,significant limitations exist when using conventional flat culturing methods especially concerning cell expansion,differentiation efficiency,stability maintenance and multicellular 3D structure establishment,differentiation prediction.Embryoid bodies(EBs),the multicellular aggregates spontaneously generated from iPSCs in the suspension system,might help to address these issues.Due to the unique microenvironment and cell communication in EB structure that a 2D culture system cannot achieve,EBs have been widely applied in hiPSC-derived differentiation and show significant advantages especially in scaling up culturing,differentiation efficiency enhancement,ex vivo simulation,and organoid establishment.EBs can potentially also be used in early prediction of iPSC differentiation capability.To improve the stability and feasibility of EB-mediated differentiation and generate high quality EBs,critical factors including iPSC pluripotency maintenance,generation of uniform morphology using micro-pattern 3D culture systems,proper cellular density inoculation,and EB size control are discussed on the basis of both published data and our own laboratory experiences.Collectively,the production of a large quantity of homogeneous EBs with high quality is important for the stability and feasibility of many PSCs related studies.展开更多
Background: Numerous studies of tissues’ regeneration have confessed the recovery of damaged liver by hematopoietic stem cells. The cells act not only by cell replacement in the target organ but also by delivering tr...Background: Numerous studies of tissues’ regeneration have confessed the recovery of damaged liver by hematopoietic stem cells. The cells act not only by cell replacement in the target organ but also by delivering trophic factors that support endogenous liver regeneration. A little is known of how organ-derived signals recruit such committed cells into circulation. Objective: We investigated the roles of noninvasive mechanical percutaneous stress of cirrhotic human liver in numbers fluctuation of trophic, liver-specific alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of patients waiting for liver transplantation. Methods: To promote in blood the number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells, committed to liver’ tissue, we activated mechanically the cirrhotic liver of patient by transcutaneous micro vibration received from skin-contacted electro-magnetic vibraphones generated mechanical pulses with amplitude 10 μm and smoothly changing frequency from 0.03 kHz to 18 kHz and back forth during one cycle duration 1 minute. The number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of potential recipients was controlled by flow cytometry before and during daily sonication of skin area, which corresponds to liver projection on it. The 15 minutes cyclic sonication of the liver area performed daily for three weeks. Results: The sonication increased significantly averaged number of liver-specific alpha-fetoprotein-positive CD133-positive blood lymphocytes in 2 - 3 times compared to a base lane. The second similar sonication, the same zone after three weeks break showed differences with baseline, but it was statistically insignificant. The result was specifically related to the liver as it showed the control sonication of the backbone’s projection on the skin of a separate group of patients with cirrhotic liver from the waiting list. Conclusion: The stem cells committed to the liver recruit from the bone marrow into circulation, when organ mechanically stresses and secretes specific humoral signals to provoke of lymphopoiesis on host liver repair.展开更多
Established in 1921,CIGRE is a global community committed to the collaborative development and sharing of power system expertise.The community features thousands of professionals from over 90 countries and 1,250 membe...Established in 1921,CIGRE is a global community committed to the collaborative development and sharing of power system expertise.The community features thousands of professionals from over 90 countries and 1,250 member organizations,including some of the world's leading experts.展开更多
The Chinese Association of Automation(CAA)was founded on November 27,1961.It islegally registered in the Ministry of Civil Affairs as a non-profit national academic society organized on a voluntary basis of any indivi...The Chinese Association of Automation(CAA)was founded on November 27,1961.It islegally registered in the Ministry of Civil Affairs as a non-profit national academic society organized on a voluntary basis of any individual or enterprise comrnitted to R&D,education and application in the automation field in China.As the organizational member of China Association for Science&Technology(CAST),it serves as an important social force for the development of automation technology.Website:http://www.caa.org.展开更多
Military Medical Research(MMR;ISSN 2095-7467,elSSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cuttirig-edge findings on clinical research and basic medical sciences topics,with special focu...Military Medical Research(MMR;ISSN 2095-7467,elSSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cuttirig-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.展开更多
Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses trad...Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.展开更多
Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus...Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.展开更多
Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus...Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.展开更多
Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses trad...Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.Cell Cycle encourages articles that discuss novel concepts,paradoxes and controversy in the field.展开更多
Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus...Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.展开更多
Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses trad...Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.Cell Cycle encourages articles that discuss novel concepts,paradoxes and controversy in the field.展开更多
Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus...Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology展开更多
Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses trad...Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.展开更多
文摘Meizhou is committed to creating a more open and inclusive"Capital of Hakka Culture",fully demonstrating its unique cultural charm,so as to provide strong spiritual power and cultural support for Meizhou's revitalization acceleration and commonprosperity.
文摘While the world remains committed to upholding the principle of human rights protection,this universal sacrosanct value of humanity has been endlessly put to severe tests in the prevailing global governance.The incoherent global response to the Covid-19 pandemic in 2020 was merely the proverbial last straw that broke the camel’s back.
文摘The Uranium-238 (<sup>238</sup>U), Thorium-232 (<sup>232</sup>Th) families and Potassium-40 (<sup>40</sup>K) are of terrestrial origin and contribute generally to an individual’s external exposure through our presence in this environment. They also contribute to the internal exposure through the ingestion of products and beverages such as water that are close to the earth. The aim of this work is to determine the committed effective dose or Total Indicative Dose (TID) due to gamma radioactivity of the borehole water from the Nord Riviera (NR) well field operated by the Côte d’Ivoire Water Distribution Company (SODECI) for the supply of drinking water to part of the population of Abidjan. In addition, the populations, with their habits, could use these borehole waters directly as drinking water. To this end, water samples from the seven (07) functional boreholes were collected and analyzed on a gamma spectrometry chain, equipped with an HPGe detector in the laboratory of the Radiation Protection Institute (RPI) of the GHANA Atomic Energy Commission (GAEC). The results of the specific activities of <sup>238</sup>U, <sup>232</sup>Th and <sup>40</sup>K obtained were transcribed into TID. As the natural radioactivity of the borehole water is high [1], the TIDs calculated from the activity results of the natural radionuclides<sup>238</sup>U, <sup>232</sup>Th, and <sup>40</sup>K vary for the seven boreholes from 0.150 to 0.166 mSv/yr with an average of 0.161 ± 0.034 mSv/yr. The TID of the control tower, where the borehole water is mixed and treated for household use, is equal to 0.136 ± 0.03 mSv/yr. The TIDs obtained are therefore all slightly greater than the WHO reference dose value of 0.1 mSv/yr. But all remain below the UNSCEAR reference dose of 0.29 mSv/yr.
文摘A Chinese scientist and his university are committed to improving the health situation on the African continent For around 30 years, Li Xiaokun has been in charge of his research team in China studying growth factors. Li, who was born in 1964, spent his early years in Fuping County of Shaanxi Province, where he frequently saw his relatives’lives being ruined by illness. These events caused him pain, but they also triggered his passion for medicine.
基金Supported by National Natural Science Foundation of China,No.81770621,No.81573053Ministry of Education,Culture,Sports,Science,and Technology of Japan,KAKENHI,No.16K15604,No.18H02866Natural Science Foundation of Jiangsu Province,No.BK20180281
文摘Human induced pluripotent stem cells(hiPSCs)are invaluable resources for producing high-quality differentiated cells in unlimited quantities for both basic research and clinical use.They are particularly useful for studying human disease mechanisms in vitro by making it possible to circumvent the ethical issues of human embryonic stem cell research.However,significant limitations exist when using conventional flat culturing methods especially concerning cell expansion,differentiation efficiency,stability maintenance and multicellular 3D structure establishment,differentiation prediction.Embryoid bodies(EBs),the multicellular aggregates spontaneously generated from iPSCs in the suspension system,might help to address these issues.Due to the unique microenvironment and cell communication in EB structure that a 2D culture system cannot achieve,EBs have been widely applied in hiPSC-derived differentiation and show significant advantages especially in scaling up culturing,differentiation efficiency enhancement,ex vivo simulation,and organoid establishment.EBs can potentially also be used in early prediction of iPSC differentiation capability.To improve the stability and feasibility of EB-mediated differentiation and generate high quality EBs,critical factors including iPSC pluripotency maintenance,generation of uniform morphology using micro-pattern 3D culture systems,proper cellular density inoculation,and EB size control are discussed on the basis of both published data and our own laboratory experiences.Collectively,the production of a large quantity of homogeneous EBs with high quality is important for the stability and feasibility of many PSCs related studies.
文摘Background: Numerous studies of tissues’ regeneration have confessed the recovery of damaged liver by hematopoietic stem cells. The cells act not only by cell replacement in the target organ but also by delivering trophic factors that support endogenous liver regeneration. A little is known of how organ-derived signals recruit such committed cells into circulation. Objective: We investigated the roles of noninvasive mechanical percutaneous stress of cirrhotic human liver in numbers fluctuation of trophic, liver-specific alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of patients waiting for liver transplantation. Methods: To promote in blood the number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells, committed to liver’ tissue, we activated mechanically the cirrhotic liver of patient by transcutaneous micro vibration received from skin-contacted electro-magnetic vibraphones generated mechanical pulses with amplitude 10 μm and smoothly changing frequency from 0.03 kHz to 18 kHz and back forth during one cycle duration 1 minute. The number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of potential recipients was controlled by flow cytometry before and during daily sonication of skin area, which corresponds to liver projection on it. The 15 minutes cyclic sonication of the liver area performed daily for three weeks. Results: The sonication increased significantly averaged number of liver-specific alpha-fetoprotein-positive CD133-positive blood lymphocytes in 2 - 3 times compared to a base lane. The second similar sonication, the same zone after three weeks break showed differences with baseline, but it was statistically insignificant. The result was specifically related to the liver as it showed the control sonication of the backbone’s projection on the skin of a separate group of patients with cirrhotic liver from the waiting list. Conclusion: The stem cells committed to the liver recruit from the bone marrow into circulation, when organ mechanically stresses and secretes specific humoral signals to provoke of lymphopoiesis on host liver repair.
文摘Established in 1921,CIGRE is a global community committed to the collaborative development and sharing of power system expertise.The community features thousands of professionals from over 90 countries and 1,250 member organizations,including some of the world's leading experts.
文摘The Chinese Association of Automation(CAA)was founded on November 27,1961.It islegally registered in the Ministry of Civil Affairs as a non-profit national academic society organized on a voluntary basis of any individual or enterprise comrnitted to R&D,education and application in the automation field in China.As the organizational member of China Association for Science&Technology(CAST),it serves as an important social force for the development of automation technology.Website:http://www.caa.org.
文摘Military Medical Research(MMR;ISSN 2095-7467,elSSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cuttirig-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.
文摘Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.
文摘Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.
文摘Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.
文摘Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.Cell Cycle encourages articles that discuss novel concepts,paradoxes and controversy in the field.
文摘Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology Article,Clinical Image,and Letter to Editor.
文摘Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.Cell Cycle encourages articles that discuss novel concepts,paradoxes and controversy in the field.
文摘Military Medical Research(MMR;ISSN 2095-7467,eISSN 2054-9369,CN 10-2094/R),an Open Access international journal,publishes cutting-edge findings on clinical research and basic medical sciences topics,with special focus on military medicine related subjects.Article types included in MMR are:Editorial,Research Highlights,Perspective,Commentary Review,Original Article,Case Report,Methodology
文摘Cell Cycle is a bi-weekly,peer-reviewed journal that covers all aspects of cell cycle research from yeast to man,including basic cell cycle and its applications to cancer,development and cell death.It encompasses traditional disciplines as well as interdisciplinary investigations with translation from basic cell cycle research to cancer therapy.
