Objective To study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China. Methods Forty eight patients with pathologically diagnosed common warts were screened for the p...Objective To study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China. Methods Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct sequencing analysis. The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR. Results Forty one （85.5%） samples were positive for HPV DNA, 13（31.7%）-HPV-57, 12（29.3%）-HPV-la, 7（17%）-HPV-27 and 5（12.2%）-HPV-2a. Four cases were infected with two different HPV types, two （4.9%） with HPV-la and HPV-27, one （2.4%） with HPV-1 and HPV-57 and one （2.4%） with HPV-27 and HPV-57. In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype, two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing. Conclusion HPV-1, -2, -27 and -57 are predominantly prevalent in patients with common warts in Beijing.展开更多
Cutaneous warts are common skin diseases caused by human papillomavirus （HPV） infection. The prevalence of cutaneous warts varied from 2.4%-12.9%, with common warts, planta warts and genital warts being the most com...Cutaneous warts are common skin diseases caused by human papillomavirus （HPV） infection. The prevalence of cutaneous warts varied from 2.4%-12.9%, with common warts, planta warts and genital warts being the most common ones. About 67% of patients with warts might resolve spontaneously within 2 years, while in some patients warts persist for years. A cellular immune response is essential for the clearance of HPV. Treatment modalities are usually ablative.展开更多
文摘Objective To study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China. Methods Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct sequencing analysis. The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR. Results Forty one （85.5%） samples were positive for HPV DNA, 13（31.7%）-HPV-57, 12（29.3%）-HPV-la, 7（17%）-HPV-27 and 5（12.2%）-HPV-2a. Four cases were infected with two different HPV types, two （4.9%） with HPV-la and HPV-27, one （2.4%） with HPV-1 and HPV-57 and one （2.4%） with HPV-27 and HPV-57. In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype, two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing. Conclusion HPV-1, -2, -27 and -57 are predominantly prevalent in patients with common warts in Beijing.
基金This study was supported in part by grants from Program for Changjiang Scholars and Innovative Research Team in University （No. IRT0760）, National Natural Science Foundation （No. 30740082）, Program for postdoctoral training （No. 20070159020） and Liaoning BaiQianWan Talents Program.
文摘Cutaneous warts are common skin diseases caused by human papillomavirus （HPV） infection. The prevalence of cutaneous warts varied from 2.4%-12.9%, with common warts, planta warts and genital warts being the most common ones. About 67% of patients with warts might resolve spontaneously within 2 years, while in some patients warts persist for years. A cellular immune response is essential for the clearance of HPV. Treatment modalities are usually ablative.
