Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. Moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased complexity and restructuring of neural network structures, as well as the addition of new granule granule cells that aid in olfactory adaptation. Additionally, the manuscript underscores the importance of employing precise methodologies to elucidate the specific roles of adult neurogenesis amidst conflicting data and varying experimental paradigms. Understanding these processes is essential for gaining insights into the complexities of olfactory function and behavior.

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid neurotransmission.This review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain disorders.Improving understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these conditions.However,the mechanisms that regulate gamma-aminobutyric acidergic systems remain elusive.It is also unclear as to whether the mechanisms are presynaptic or postsynaptic.Further exploration of the complexities of this system may reveal new pathways for research and drug development.

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord injury.While exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains unclear.To investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord injury.Subsequently,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted exosomes.The results showed that necroptosis did not significantly impact the fundamental characteristics or number of exosomes.Transcriptome sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control group.Construction of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord injury.TSC2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury zone.Furthermore,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other cells.Further assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling pathways.In addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling pathways.Collectively,these findings confirm that exosomes derived from neural stem cells undergoing necroptosis play an important role in cellular communication after spinal cord injury and induce TSC2 upregulation in recipient cells.

Creating an English Environment to Foster the Students' Ability in Communicating

English is becoming more and more important in communicating as the further development of the reform and opening up. We English teacher should try our best to create and arrange a kind of language environment according to our students' practical life in order to improve and enhance their interest in English studying, to encourage them to practice English during their daily life and to cultivate their ability to communicate in English.

Research on Fatigue Invalidation of A Submarine Pipeline Span Subjected to Waves and Currents

Considering both the axial force on the spanning pipeline and influence of sea waves and currents, a perpendicular nonlinear vibration equation which satisfies given boundary conditions is .set up according to the factual soil supports for the pipeline. Based on the inherent modes of vibration determined from the equation of motion describing free vibrations, the differential equations for the time domain of the equation solution are deduced and established. By the application of time and frequency domain analysis, the sea wave and current force spectrum is derived from wave spectrum and is used as the input spectrum of the vibration equation to deduce the output spectrum, and further determine the probability distribution of displacement and strain. On this basis, the fatigue invalidation probability of the spanning pipeline is found out according to the theory of reliability. Finally, by means of calculation and analysis of a practical sample, the degree of effect of some important parameters on fatigue invalidation of the spanning pipeline span is determined.

Influence of Clip Locations on Intraaneurysmal Flow Dynamics in Patient-specific Anterior Communicating Aneurysm Models with Different Aneurysmal Angle

To improve aneurysm treatment,this study examined the influence of clip locations on hemodynamic factors in patient-specific anterior communicating artery(ACoA)aneurysms with different aneurysmal angle.We proposed a simplified classification of ACoA aneurysms using aneurysmal angle,defined by the angle of pivot of the aneurysmal dome and the virtual two-dimensional plane created by both proximal A2 segments of anterior cerebral artery(ACA).ACoA aneurysms with three different aneurysmal angles,which are 15°,80°and 120°,were analyzed in our study.In this work,we obtained hemodynamics before and after clipping surgery with three clip locations based on clinical clipping strategies in three ACoA aneurysms with different aneurysm angles.Results showed that local high pressure occurs at impingement region of the ACoA aneurysm before clipping and new impingement region close to the clipping location after clipping treatment.For clipping the aneurysm with aneurysmal angle 15°and a wide neck,wall shear stress(WSS)distribution is more uniform when the clipping angle of two clips close to 180°comparing with other two angles.In addition,for clipping the aneurysm with aneurysmal angle 80°and 120°,local high pressure appears on new impingement region and high WSS distributes around the clipping location when the clip plane is normal to the direction of inflow of aneurysm from the dominance of A1 segment of ACA.Hence,we should avoid the impingement of inflow from the A1 segment and choose a favorable clipping location for the fastness of clip.The results of our study could preoperatively give a useful information to the decision of surgical plan.

A Novel Cache Invalidation Scheme for Mobile Networks

In this paper, we propose a strategy of maintaining cache consistency in wireless mobile environments, which adds a validation server （VS） into the GPRS network, utilizes the location information of mobile terminal in SGSN located at GPRS backbone, just sends invalidation information to mobile terminal which is online in accordance with the cached data, and reduces the information amount in asynchronous transmission. This strategy enables mobile terminal to access cached data with very little computing amount, little delay and arbitrary disconnection intervals, and excels the synchronous IR and asynchronous slate （AS） in the total performances.

Social Values and Ethics for Communicating the Corporate Identity

The on-going changes--as both opportunities and threats--push companies to look for competitive advantages and differentiation from competitors by making the best use of certain strategic levers; they are mainly represented by intangible resources （as harder to imitate） such as trade marks, brands, intellectual properties, ethics, and social values. Values in particular become more relevant if taking into consideration the company as a set of ＂human beings＂; companies must be more integrated with its reference society and need to communicate with both external and internal audience covering different expectations, needs and cultures. In this sense, the traditional communication may be now defined as ＂integrated communication＂. Accordingly, ethical principles and corporate social responsibility values are fundamental drivers of this integrated communication policies and are more and more reflected into the company＇s mission. The aim of the present paper is to analyze--at both a quality and an empirical level--the effectiveness of ethics and corporate social responsibility values as drivers for integrated communication. A sample of Italian listed food and beverage companies has been considered to establish if and how ethical principles and sharing corporate values have been built and implemented during the last years; the expected results are to demonstrate the link between literature and empirical evidence concerning effectiveness of integrated communication and its impact on company＇s financial results and--in particular--on value creation for shareholders. Eventually, the study results show that there might be huge benefits in using an integrated communication; talking to people in a coherent way and sharing values constantly make firms achieve best results.

A Model for Communicating Social Problems: Perception,Knowledge,Incorporation,and Change

The article proposes a model to analyze, interpret, and construct the communication of social problems and everyday life. Four relevant aspects (perception, knowledge, integration, and change) of communication processes will be addressed, highlighting the issues to be addressed in light of the deep media coverage of our social world. In particular, it explores how perception changes profoundly in relation to the social conditions, groups, and communities to which one belongs. Furthermore, particular attention is paid to the difficult process of incorporation which allows concepts and social problems to become “family” through communication processes. Incorporation is a prerequisite for changing ideas and behaviors towards social problems. In conclusion, a strategy will be proposed to communicate social problems deepening dimensions and strongholds to be followed with particular reference to popularity and narratives in communication processes.

The Importance of Adopting Leadership Concepts inCommunicating Medicinal Culture of Chinese Medicine in theWestern World

Cultures are beliefs, knowledge, and languages people use to communicate with others. In the same rationale, the communication betweenChinese and Western medicinal cultures is the communication between two medicinal beliefs, knowledge, and languages. In this article,the key components of Chinese and Western cultures will be discussed to lay the foundations for better communication of TraditionalChinese Medicine (TCM) in the Western world. Besides the discussion of similarities and differences between the two cultures, the potentialof being complementary to each other in practices will be explored. Moreover, in this article, using key leadership skills to enable bettercommunication and practices of TCM in the Western world will be examined as well.

Anterior communicating artery aneurysm associated with duplicated hypoplastic right A1 segment

Variations of the anterior cerebral artery(ACA)-anterior communicating artery(ACo A) complex are commonly observed when associated with a symptomatic intracranial aneurysm. We report an asymptomatic ACo A aneurysm associated with duplicated hypoplastic A1 segment of the right ACA, observed in a 70-year-old female cadaver. Furthermore, the aneurysm, practically substituting the ACo A, caused a remarkable depression on the internal surface of the right frontal lobe, anterior to the optic chiasm. Aneurysms and other anomalies of the ACA and ACo A are common and their microvascular surgical management requires sound knowledge of the normal and variant vascular anatomy. Persistence of some embryonic vessels that normally disappear, disappearance of vessels that would normally persist or sprouting of new vessels due to hemodynamic and genetic factors are the usual causes for such anomalies. The high incidence of coexisting vascular anomalies and aneurysm suggests that such abnormalities predispose to aneurysm formation due to changes in the regional blood flow. A1 segment duplication has been reported to occur in 4% of subjects in cadaveric studies and in up to 0.5%-9.7% of cases of ACo A aneurysm surgery. Angiographic hypoplasias and aplasias of the A1 seg-ment have been also correlated with ACo A aneurysm patients.

INFLUENCE OF BLADES' STRESS STATE ON FRANCIS TURBINE RUNNER'S INVALIDATION

Numerical simulation on Francis turbine runner＇s welding temperature field and welding stress field is carded out on the base of solving the problem of welding heat source＇s movement along any spatial routes and the problem of heat elimination between the complicated blade and air. The evolvement law of welding stress and the distribution of the stress field after welding are obtained. The results indicate that the peak value of the welding residual stress appears on the outlet edge of blade near the contact area between blade and band or blade and crown. Associated with the distribution of the runner＇s working stress, the invalidation reason of the Francis turbine runner is explained.

Invalidation manner and mechanism of new type NbO electrolytic capacitor anode

Niobium suboxide powder was pressed and sintered in vacuum into NbO electrolytic capacitor sintered anode..High voltage and constant current formation experiment was performed on NbO electrolytic capacitor anode,during which electrolyte was 0.01 % Ha PO4 solution, temperature was 90 C and current was 50 mA per gram sample. Through the relationship between anode voltage and time and scanning electron microscopy(SEM) images of invalidated anode and normal forming anode, invalidation manner and mechanism of NbO electrolytic capacitor anode were discussed. The results show that, the main invalidation manner of NbO electrolytic capacitor anode is not short circuit but open circuit, which is different to that of traditional Ta electrolytic capacitor anode. The reason of invalidation is that anode oxide film whose thickness increases gradually penetrates the "connection neck" among anode powder particles, which leads to the open circuit invalidation of anode. Compared with Ta electrolytic capacitor,NbO electrolytic capacitor has better security.

2018-2022年四川省病原学阳性肺结核患者密切接触者筛查情况分析

目的:分析2018-2022年四川省病原学阳性肺结核患者密切接触者的结核病筛查情况,为密切接触者的筛查和管理工作开展提供理论依据。方法:选取“结核病管理信息系统”中登记日期在2018年1月1日至2022年12月30日期间的病原学阳性肺结核患者及其密切接触者(与病原学阳性肺结核患者在确诊3个月至开始抗结核治疗后14 d内直接接触的人员)作为调查对象,其中,2018年1月1日至2022年12月30日登记的病原学阳性肺结核患者的密切接触者均为筛查对象;2022年登记的病原学阳性肺结核患者的密切接触者为随访对象。分析不同时间、不同类型密切接触者结核病筛查及活动性肺结核检出情况。结果:2018-2022年四川省共报告病原学阳性肺结核患者99 273例,登记其密切接触者260 661名,其中260 291名密切接触者进行了结核病可疑症状筛查,症状筛查率为99.86%,共检出活动性肺结核患者2623例,平均检出率为1.01%。有结核病可疑症状的密切接触者的结核病检查率(98.50%,6425/6523)和检出率(4.54%,292/6425)均明显高于无结核病可疑症状密切接触者的结核病检查率(86.40%,219 247/253 768)和检出率(1.06%,2331/219 247),差异均有统计学意义(χ^(2)值分别为807.587和658.621,P值均<0.001)。家庭外密切接触者结核病检查率(96.53%,82 173/85 129)明显高于家庭内密切接触者(81.92%,143 499/175 162),差异有统计学意义(χ^(2)=10 595.710,P<0.001);家庭内密切接触者活动性肺结核检出率(1.58%,2264/143 499)明显高于家庭外密切接触者(0.44%,359/82 173),差异有统计学意义(χ^(2)=591.968,P<0.001)。对2022年新登记的42 078名病原学阳性肺结核患者密切接触者在患者诊断时开展症状筛查,39 056名(92.82%)开展了结核病检查,检出719例(1.84%)活动性肺结核患者;35.39%(9705/27 423)完成第2次随访(首次筛查6个月后),55.31%(5368/9705)接受结核病检查,检出2例(0.04%)活动性肺结核患者;仅7.08%(4072/57 474)完成第3次随访(首次筛查1年后),38.33%(1561/4072)接受了结核病检查,检出1例(0.06%)活动性肺结核患者。结论:2018-2022年四川省病原学阳性肺结核患者密切接触者筛查比例较高,但筛查效果不理想,应重视家庭外密切接触者结核病筛查工作,以及重视密切接触者首次筛查后6个月及1年后的随访工作。

Communicating in Product Harm Crises: Do the Right Thing

Food recalls can have very serious aftermath from many points of view: starting from the outbreak consequences on public health, on company’s reputation, sell-out, finance, up to putting at risk the survival of the firm itself. From a formal point of view, a product harm crisis presents similarities with other emergency situations: both of them consist in unpredictable events, often due to unknown or undervalued causes, which can significantly alter normal business and compromise the safety of the company, of its employees and customers. Given the potential damage resulting from a dangerous product crisis, it is surprising that in the food industry alongside mere procedures (often reducible to botched manuals compiled solely because their presence reassures auditors and authorities) there is still little attention to an approach based on a method. Formal corporate procedures (manuals and crisis management plans) are important, but can cause a false sense of security and preparedness, if executives do not possess an adequate crisis management culture, which depends, as well as on experience and training, also on the ability to assume the correct behavioral posture, and which involves psychological, organizational and communicational skills that can not be undervalued. The purpose of this article is to provide a practical approach based on the experience of crisis-management (applied in emergency situations by health professionals, armed forces and civil protection) useful to support food industry during a food recall, in order to avoid the most classic errors that can undermine speed of reaction, corrective measures effectiveness and leadership, in the most delicate moments for a company life. If it is true the way a firm manages the recall affects its impact, it is necessary to assess the fundamental factors to be observed at such times: timeliness, lucidity, responsibility, leadership.

Communicating Geologically-Underpinned Issues： Drivers and Mechanisms

Geologists can offer key insights in regard to several high profile environmental issues that are faced today. At the same time, like scientists in most other disciplines, many geologists are not naturally adept at communicating in an effective manner with non-geologists. This paper firstly identifies the more subtle facets of topical major issues （the drivers） where geologists can contribute important perspectives. Next, the detractions to effective communication are identified, along with the recommended means to overcome them （the mechanisms）. Many topical issues are in fact geologically-underpinned （e.g. obviously, geohazards）, so geologists ought to have something meaningful to say. By the same token, if geologists have difficulty communicating with other scientists, how can they possibly hope to communicate with journalists and with the public at large？ Proper scientific contextualization is an ideal starting point, but this fundamental framing step does not always suit protagonists who have non-scientific agendas. Thus, geologists not only have to convey their science （geology） in an understandable way, but to do so in a truly effective manner must recognize and take into account possible predispositions that their audience may have.

The Invalidation Analysis of a Working 5CrMnMo Forging Die and Ways of Precaution

The paper introduced the 5 CrMnMo steel, including the chemical composition, the heat treatment technology, the forging die working condition, and the invalidation form （such as the cavity arris wear, the cavity subsidence, the cold and the heat fatigue crackle）. Then gave some precautions for prolonging the mould life by improving the heat treatment technology.

Communicating to the Religiously Secure： Kierkegaard, Luke, and Indirect Communication

Familiar material can be seen through fresh eyes when approached by those outside of our discipline. Soren Kierkegaard＇s （1962） work from the late 19th century helped a multitude of theologians re-evaluate their understanding of the New Testament （1992） and influenced many in the realm of philosophy in the opening half of the 20th century. It is possible that his work could shed new light on our understanding of the Controversy Sections in the Gospels between Jesus and the Pharisees. Kierkegaard＇s attempt to help those caught in ＂Christendom＂ move to ＂Christianity＂ will be compared with the ＂Gospel of Luke＂＇s presentation of Jesus attempting to move the Pharisees to true faith. Structural Analysis, an adaptation of Form Criticism, will be employed to demonstrate that the Gospel＇s presentation of Jesus＇ approach to the Religiously Secure parallels that of Kierkegaard

Communicating About Translation： Task-based Speaking

This study views pedagogical translation as a means of developing language skills, especially oral communication. Contrary to the claim that translation focuses only on reading and writing, this study presents anecdotal evidence showing that a learner-centered approach to translation can help foreign language students improve their speaking skill through group work, problem-solving, and cooperative learning. To this end, the paper presents practical examples of lexical, structural, textual, and cultural issues that students discussed in their process-oriented Arabic-English-Arabic pedagogical translation courses at the university level. The students were divided into groups of three or four to work together at all stages of the translation process. They spent most of the class time comprehending the source text, translating it, and discussing each other＇s target versions. In the remaining class time, the whole class discussed a target text translated by any one of the groups. The students were instructed to use English in their group and whole-class deliberations. They were also instructed to use the appropriate language functions, structures, and expressions to achieve objectivity in their arguments. The study calls for further empirical research to verify the usefulness of the proposed learner-centered translation-based technique of teaching speaking

Communicating the Probabilities of Extreme Surface Temperature Outcomes

The magnitude of the future global warming is uncertain, but the possible dramatic changes associated with high temperatures have seen rising attention in the literature. Projections of temperature change in the literature are often presented in probabilistic terms and typically highlight the most likely ranges of future temperature under assumed emission scenarios. However, focusing on these high probability outcomes of global warming omits important information related to the threats of low-probability but high-impact outcomes under more extreme change. As such, we argue that the literature should place more emphasis on communicating the probabilities of extreme temperature change, in a way that is accessible to policymakers and the general public. The damage associated with climate change is likely to be non-linear with temperature, and thus extreme temperature changes may pose a larger risk than the most likely outcomes. We use a simple climate model to explore the probabilities of high surface temperature under business as usual emissions scenarios, given current knowledge of the climate system. In a business as usual scenario (A1FI) we find the probability of “likely” warming (central 66%) to be approximately 4.4°C-6.9°C in 2100 (above 1900 levels). However, we find extreme (>7°C) warming to embody a notable portion of damage risk compared to this likely range.