The potential clinical and economic impact of mesenchymal stem cell(MSC)therapy is immense.MSCs act through multiple pathways:(1)as“trophic”cells,secreting various factors that are immunomodulatory,anti-inflammatory...The potential clinical and economic impact of mesenchymal stem cell(MSC)therapy is immense.MSCs act through multiple pathways:(1)as“trophic”cells,secreting various factors that are immunomodulatory,anti-inflammatory,antiapoptotic,proangiogenic,proliferative,and chemoattractive;(2)in conjunction with cells native to the tissue they reside in to enhance differentiation of surrounding cells to facilitate tissue regrowth.Researchers have developed methods for the extraction and expansion of MSCs from animal and human tissues.While many sources of MSCs exist,including adipose tissue and iliac crest bone graft,compact bone(CB)MSCs have shown great potential for use in orthopaedic surgery.CB MSCs exert powerful immunomodulatory effects in addition to demonstrating excellent regenerative capacity for use in filling boney defects.CB MSCs have been shown to have enhanced response to hypoxic conditions when compared with other forms of MSCs.More work is needed to continue to characterize the potential applications for CB MSCs in orthopaedic trauma.展开更多
The allele rrequencles or the vWF locus were determined in a chinese Han populationsample (n=112) using the polymerase chain reaction (PCR). 7 alleies and 23 genotypes were observed. Distribution of allellc frequencie...The allele rrequencles or the vWF locus were determined in a chinese Han populationsample (n=112) using the polymerase chain reaction (PCR). 7 alleies and 23 genotypes were observed. Distribution of allellc frequencies in our data showed a different pattern from those reportedin the literature ror European Caucasians. No deviation from Hardy--Weinberg equilibrium wasfound. The observed heterozygoslty was 79. I %. The vWF Is one of the useful genetic markers forpaternity testing and identity testing, with an exclusion power (EP) value or 0. 7337 and a discrimination power (DP) value of 0. 9438. The results of compact bone and dens were in perrect agreementwith those of the blood and blood stains.展开更多
文摘The potential clinical and economic impact of mesenchymal stem cell(MSC)therapy is immense.MSCs act through multiple pathways:(1)as“trophic”cells,secreting various factors that are immunomodulatory,anti-inflammatory,antiapoptotic,proangiogenic,proliferative,and chemoattractive;(2)in conjunction with cells native to the tissue they reside in to enhance differentiation of surrounding cells to facilitate tissue regrowth.Researchers have developed methods for the extraction and expansion of MSCs from animal and human tissues.While many sources of MSCs exist,including adipose tissue and iliac crest bone graft,compact bone(CB)MSCs have shown great potential for use in orthopaedic surgery.CB MSCs exert powerful immunomodulatory effects in addition to demonstrating excellent regenerative capacity for use in filling boney defects.CB MSCs have been shown to have enhanced response to hypoxic conditions when compared with other forms of MSCs.More work is needed to continue to characterize the potential applications for CB MSCs in orthopaedic trauma.
文摘The allele rrequencles or the vWF locus were determined in a chinese Han populationsample (n=112) using the polymerase chain reaction (PCR). 7 alleies and 23 genotypes were observed. Distribution of allellc frequencies in our data showed a different pattern from those reportedin the literature ror European Caucasians. No deviation from Hardy--Weinberg equilibrium wasfound. The observed heterozygoslty was 79. I %. The vWF Is one of the useful genetic markers forpaternity testing and identity testing, with an exclusion power (EP) value or 0. 7337 and a discrimination power (DP) value of 0. 9438. The results of compact bone and dens were in perrect agreementwith those of the blood and blood stains.
