Therapeutic effect of regulating autophagy in spinal cord injury: a network meta-analysis of direct and indirect comparisons

Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,the effect of regulating autophagy and whether autophagy is detrimental or beneficial after spinal cord injury remain unclear.Therefore,in this study we evaluated the effects of autophagy regulation on spinal cord injury in rats by direct and indirect comparison,in an effort to provide a basis for further research.Data source:Relevant literature published from inception to February 1,2018 were included by searching Wanfang,CNKI,Web of Science,MEDLINE(OvidSP),PubMed and Google Scholar in English and Chinese.The keywords included"autophagy","spinal cord injury",and"rat".Data selection:The literature included in vivo experimental studies on autophagy regulation in the treatment of spinal cord injury(including intervention pre-and post-spinal cord injury).Meta-analyses were conducted at different time points to compare the therapeutic effects of promoting or inhibiting autophagy,and subgroup analyses were also conducted.Outcome measure:Basso,Beattie,and Bresnahan scores.Results:Of the 622 studies,33 studies of median quality were included in the analyses.Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=1.80,95%CI:0.81-2.79,P=0.0004),3 days(MD=0.92,95%CI:0.72-1.13,P<0.00001),1 week(MD=2.39,95%CI:1.85-2.92,P<0.00001),2 weeks(MD=3.26,95%CI:2.40-4.13,P<0.00001),3 weeks(MD=3.13,95%CI:2.51-3.75,P<0.00001)and 4 weeks(MD=3.18,95%CI:2.43-3.92,P<0.00001)after spinal cord injury with upregulation of autophagy compared with the control group(drug solvent control,such as saline group).Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=6.48,95%CI:5.83-7.13,P<0.00001),2 weeks(MD=2.43,95%CI:0.79-4.07,P=0.004),3 weeks(MD=2.96,95%CI:0.09-5.84,P=0.04)and 4 weeks(MD=4.41,95%CI:1.08-7.75,P=0.01)after spinal cord injury with downregulation of autophagy compared with the control group.Indirect comparison of upregulation and downregulation of autophagy showed no differences in Basso,Beattie,and Bresnahan scores at 1 day(MD=-4.68,95%CI:-5.840 to-3.496,P=0.94644),3 days(MD=-0.28,95%CI:-2.231-1.671,P=0.99448),1 week(MD=1.83,95%CI:0.0076-3.584,P=0.94588),2 weeks(MD=0.81,95%CI:-0.850-2.470,P=0.93055),3 weeks(MD=0.17,95%Cl:-2.771-3.111,P=0.99546)or 4 weeks(MD=-1.23,95%Cl:-4.647-2.187,P=0.98264)compared with the control group.Conclusion:Regulation of autophagy improves neurological function,whether it is upregulated or downregulated.There was no difference between upregulation and downregulation of autophagy in the treatment of spinal cord injury.The variability in results among the studies may be associated with differences in research methods,the lack of clearly defined autophagy characteristics after spinal cord injury,and the limited autophagy monitoring techniques.Thus,methods should be standardized,and the dynamic regulation of autophagy should be examined in future studies.

Differences in pathological changes between two rat models of severe traumatic brain injury

The rat high-impact free weight drop model mimics the diffuse axonal injury caused by severe traumatic brain injury in humans,while severe controlled cortical impact can produce a severe traumatic brain injury model using precise strike parameters.In this study,we compare the pathological mechanisms and pathological changes between two rat severe brain injury models to identify the similarities and differences.The severe controlled cortical impact model was produced by an electronic controlled cortical impact device,while the severe free weight drop model was produced by dropping a 500 g free weight from a height of 1.8 m through a plastic tube.Body temperature and mortality were recorded,and neurological deficits were assessed with the modified neurological severity score.Brain edema and bloodbrain barrier damage were evaluated by assessing brain water content and Evans blue extravasation.In addition,a cytokine array kit was used to detect inflammatory cytokines.Neuronal apoptosis in the brain and brainstem was quantified by immunofluorescence staining.Both the severe controlled cortical impact and severe free weight drop models exhibited significant neurological impairments and body temperature fluctuations.More severe motor dysfunction was observed in the severe controlled cortical impact model,while more severe cognitive dysfunction was observed in the severe free weight drop model.Brain edema,inflammatory cytokine changes and cortical neuronal apoptosis were more substantial and blood-brain barrier damage was more focal in the severe controlled cortical impact group compared with the severe free weight drop group.The severe free weight drop model presented with more significant apoptosis in the brainstem and diffused blood-brain barrier damage,with higher mortality and lower repeatability compared with the severe controlled cortical impact group.Severe brainstem damage was not found in the severe controlled cortical impact model.These results indicate that the severe controlled cortical impact model is relatively more stable,more reproducible,and shows obvious cerebral pathological changes at an earlier stage.Therefore,the severe controlled cortical impact model is likely more suitable for studies on severe focal traumatic brain injury,while the severe free weight drop model may be more apt for studies on diffuse axonal injury.All experimental procedures were approved by the Ethics Committee of Animal Experiments of Tianjin Medical University,China(approval No.IRB2012-028-02)in Febru ary 2012.

A Discussion of Artificial Intelligence in Visual Art Education

Since ChatGPT emerged on November 30, 2022, Artificial Intelligence (AI) has been increasingly discussed as a radical force that will change our world. People have become used to AI in which such ubiquitous technologies as Siri, Google, and Netflix deploy AI algorithms to answer questions, impart information, and provide recommendations. However, many individuals including originators and backers of AI have recently expressed grave concerns. In this paper, the authors will assess what is occurring with AI in Visual Arts Education, outline positives and negatives, and provide recommendations addressed specifically for teachers working in the field regarding emerging AI usage from kindergarten to grade twelve levels as well as in higher education.

新编高中英语教材“Integrating Skills”的教学模式——“The Function Of Art”的教学设计及反思

自2003年修订版Senior English For China(人民教育出版社)正式使用以来，广大英语教师一直在努力寻找一种新的教学模式，以适应新课程标准提出的教学理念以及在此基础上编写的SEFC新教材。

Comparison of Digital Maps: Recognition and Quantitative Measure of Changes

A new methodology of comparing digital raster maps was proposed which allows not only detecting changes in the maps, but also obtaining quantitative measures of the importance of selected differences. Procedure of object interpretation of satellite images and forming of OMT (Object Map of Territory) is described. A list of allowable differences between two OMTs is defined. Two steps technique of quantitative measuring is proposed. At the first stage functions are constructed for calculating local measures of differences in the amount, areas and locations of objects on the map, as well as relations between the objects. In the second stage local measures are used to calculate the integral measure in order to get generalized assessment of difference between maps. The methods for constructing functions which calculate local and integral measures of differences are described. Examples of comparing and measuring the differences between OMTs are provided. Obtained results by utilizing this technique can be used to analyze trends, forecast of development and might be helpful for choosing most efficient scenarios for sustainable spatial planning and land management.

Comparison of visual quality in cataract patients with low astigmatism after ART2 or ReSTOR intraocular lens implantation

AIM: To compare visual quality in cataract patients with low corneal astigmatism who underwent intraocular lens(IOL) implantation, and evaluate effects of low levels of astigmatism on visual outcomes in multifocal pseudophakic eyes.METHODS: This retrospective review of clinical records comprised patients with preoperative regular corneal astigmatism of 0.75-1.0 diopters(D) with-the-rule or 0.5-0.75 D against-the-rule who had uneventful cataract surgery and AcrySof IQ ReSTOR Toric-2 IOL(ART2) or AcrySof IQ ReSTOR IOL(ReSTOR) implantation. Retrospective data collection included postoperative ART2 axis rotation, uncorrected astigmatism, uncorrected entire visual acuities, distance corrected entire visual acuities, average modulation transfer function(aMTF), Strehl ratio(SR), spectacle independence, and patient satisfaction between groups.RESULTS: Mean ART2 axis rotation was 3.12°±0.70°. No secondary surgery was required to realign IOL axis. Residual astigmatism values were-0.18±0.07 D and-0.91±0.25 D in groups ART2 and ReSTOR(P<0.05). Three months postoperatively, the mean uncorrected distant, intermediate, and near visual acuities of group A were 0.01±0.05, 0.05±0.07, 0.02±0.07 logMAR, respectively; these were better than those of group R, which were 0.08±0.06, 0.15±0.12, and 0.09±0.08 logMAR, respectively(P<0.05). aMTF, SR, and spectacle independence rates were not significantly different. All patients were satisfied with postoperative results.CONCLUSION: ART2 is more suitable than ReSTOR for cataract patients with regular corneal astigmatism 0.75-1.0 D with-the-rule or 0.5-0.75 D against-the-rule.

Energy Comparison of Seven MPPT Techniques for PV Systems

In the future, solar energy will be a very important energy source. Several studies suppose that more than 45% of the energy in the world will be generated by photovoltaic array. Therefore it is necessary to concentrate our forces to reduce the application costs and to increment their performance. In order to reach the last aspect, it is important to note that the output characteristic of a photovoltaic array is nonlinear and changes with solar irradiation and cell’s temperature. Therefore a Maximum Power Point Tracking (MPPT) technique is needed to maximize the produced energy. This paper presents a comparative study of seven widely-adopted MPPT algorithms;their performance is evaluated using, for all the techniques, a common device with minimum hardware variations. In particular, this study compares the behaviors of each technique in presence of solar irradiation variations.

Accuracy comparison and improvement for state of health estimation of lithium-ion battery based on random partial recharges and feature engineering

State of health(SOH)estimation of e-mobilities operated in real and dynamic conditions is essential and challenging.Most of existing estimations are based on a fixed constant current charging and discharging aging profiles,which overlooked the fact that the charging and discharging profiles are random and not complete in real application.This work investigates the influence of feature engineering on the accuracy of different machine learning(ML)-based SOH estimations acting on different recharging sub-profiles where a realistic battery mission profile is considered.Fifteen features were extracted from the battery partial recharging profiles,considering different factors such as starting voltage values,charge amount,and charging sliding windows.Then,features were selected based on a feature selection pipeline consisting of filtering and supervised ML-based subset selection.Multiple linear regression(MLR),Gaussian process regression(GPR),and support vector regression(SVR)were applied to estimate SOH,and root mean square error(RMSE)was used to evaluate and compare the estimation performance.The results showed that the feature selection pipeline can improve SOH estimation accuracy by 55.05%,2.57%,and 2.82%for MLR,GPR and SVR respectively.It was demonstrated that the estimation based on partial charging profiles with lower starting voltage,large charge,and large sliding window size is more likely to achieve higher accuracy.This work hopes to give some insights into the supervised ML-based feature engineering acting on random partial recharges on SOH estimation performance and tries to fill the gap of effective SOH estimation between theoretical study and real dynamic application.

杰尔系统收购3G／UMTS处理器领先开发商MODEM-ART——强强联手为大众市场推提供领先的手机 W-EDGE解决方案

杰尔系统公司日前宣布收购了Modem—Art公司，该公司是一家私有的从事3G／UMTS移动设备高级处理器技术开发的供应商。此次收购使杰尔系统的现有产品得到了很好的补充，并且进一步增强了公司凭借集成芯片及软件方案更快速适应不断演进的蜂窝技术的能力，以满足3G市场以及对更先进高速下行链路分组接入（HSDPA}技术的需求。迄今为止，杰尔系统已与Modem—Art合作为电话和PC卡应用无线设备的领先制造商提供了三个UMTS／3G设计方案。

The Focal Depth Analysis of the Inner Mongolia-Ningxia Border Area Earthquakes

We selected the 103 M_L≥2. 5 earthquake waveform data from the Inner Mongolia-Ningxia border during 2009-2015,which was recorded by the Inner Mongolia Digital Seismic Networks and used the simplex method, Hyposat method, double difference location method,and deterministic method (PTD) for the determination of focal depth,and compared the results. The CAP moment tensor inversion method is used to determine the focal depths of the Alxa Left Banner M5. 8 and M4. 2 earthquakes. The final results of the focal depth by the deterministic method (PTD) and the double difference location method fit well with the tectonic characteristics of the Inner Mongolia-Ningxia border area,but those of the simplex method and the Hyposat method do not. The average depth of the Inner Mongolia-Ningxia border seismic tectonic zone is 13. 32 ± 8 km.

Current Controversies and the State of the Art in Endovascular Treatment of Vascular Malformations

Vascular anomalies constitute some of the most difficult diagnostic and therapeutic enigmas that can be encountered in the practice of medicine. The clinical presentations are extremely protean and can range from an asymptomatic birthmark to fulminant。

Multiple Comparisons of Traditional Acupuncture Therapies of Japan, Korea and China—A Preliminary Report of Three Countries’ Acupuncture (TCA) Project

Acupuncture therapy had established in China and it distributed among Asian countries and developed in each country as traditional medicine. In this project we compared the procedures and effects of traditional acupuncture therapies in China, Korea and Japan by using 10 healthy young male volunteers with written informed consent. Total white cell counts, leukocyte subsets and noradrenalin contents were used as outcomes. Three well trained traditional acupuncture therapists were chosen and they treated the same subjects at random order with intervals of at least two months. Each acupuncturist made his diagnosis and points selection for potentiate vital conditions. Clearly different procedures and point selections were used among three traditional acupuncture therapies on the same subject and the obtained changes of outcome measures also differed. Although variations of data were quite large, these results clearly demonstrated that acupuncture therapies have developed among three countries in unique manner.

Role of Art in Tohoku After the Earthquake and Tsunami

On March 11, 2011, a major earthquake and tsunami occurred in Japan, mainly affecting the Tohoku region and causing a meltdown at the Fukushima Daiichi nuclear power plant. This disaster not only caused great damage to the affected areas but also had a serious impact on Japanese politics, economy, and society in general. The art field was no exception;Japanese artists began to consider “What art can do?” after the disaster and this question began to be a new theme of Japanese contemporary art. Artists began to find ways to engage with the affected communities, dealing directly with social problems and political issues.

The Comparison of Chinese and Western Cultures from the Perspective of Chinese Culture “Going Global”: With Confucius and Socrates’ Thoughts as Examples

Chinese culture “going global” is an inevitable requirement for China’s economic and social development.As an important part of Chinese traditional culture,the dissemination of Confucian thought is just the spread of Chinese culture.Therefore,the spread of Chinese Confucian thought abroad is also the key to Chinese culture “going global”.However,there are some cultural hinders between China and the West due to the differences in cultures.On the basis of summarizing Confucius and Socrates’ thoughts,this paper analyzes their essence of thoughts by contrast,which represent the eastern and Western cultures respectively.From the perspective of cross-cultural communication,the paper adopts the methods of multiculturalism,criticism and down-to-earth attitudes to deal with Chinese and Western cultures in order to make Chinese go global and share China’s wisdom with the world.

Comparison, Selection and Progeny Test of Natural Populations of White Birch (Betula platyphylla Suk.) in Northern China

[Objectives]This study was conducted to rationally and effectively use natural genetic resources of white birch(Betula platyphylla Suk.),and improve the scientific and technological content of improved varieties.[Methods]With the progeny of the white birch populations naturally distributed in northern China as objects,based on genetic effect analysis and comprehensive evaluation,the genetic variation,heritability and genetic gain of the growth characters in the progeny forest were systematically analyzed,by which populations or individuals with good growth vigor and strong stress resistance and adaptability were finally selected.[Results]There were extremely significant differences in the growth characters between the natural populations of white birch in northern China.The variation was the smallest in tree height,followed by crown width,and largest in DBH,and the average coefficients of variation were 20.56%,32.25%and 33.00%,respectively.The differences in characters between progeny of the same population were also extremely significant.The growth characters of white birch were more controlled by genes,and the genetic gains were larger.The heritability of tree height,DBH and crown width was 0.971,0.816 and 0.576,respectively,and the genetic gains were 15.97%,21.54%and 13.87%,respectively.[Conclusions]With the growth characters as the main evaluation indexes,taking various influencing factors into account,the Shanxi[SX]population,Hebei[HB]population and Liaoning[LN]population were selected to be excellent populations,and LN305,SX516 and HB403 were excellent individuals,which are advised to be widely used in multi-generation genetic improvement breeding.

人类ART中卵巢反应性与子宫内膜容受性超声检查研究

人类生殖过程中女性能否成功妊娠的两个重要因素是卵巢的反应性和子宫内膜的容受性。超声波通过测定卵巢、卵泡的血流指数以及对子宫内膜的形态学(内膜回声类型、厚度、体积、子宫结构的改变等)和功能学(内膜、子宫动脉的血流指数和子宫收缩性的变化等)的评价,提供了大量信息,较普遍认为最好的妊娠条件是发育卵泡血供丰富,内膜呈三线征、厚度>7mm,子宫动脉搏动指数(PI)<3,内膜下可探及血流。但是一些学者尚有不同的观点,需要实验研究进一步证实。

Multi-party semi-quantum private comparison protocol of size relation based on two-dimensional Bell states

Currently,all quantum private comparison protocols based on two-dimensional quantum states can only compare equality,via using high-dimensional quantum states that it is possible to compare the size relation in existing work.In addition,it is difficult to manipulate high-dimensional quantum states under the existing conditions of quantum information processing,leading to low practicality and engineering feasibility of protocols for comparing size relation.Considering this situation,we propose an innovative protocol.The proposed protocol can make size comparison by exploiting more manageable two-dimensional Bell states,which significantly enhances its feasibility with current quantum technologies.Simultaneously,the proposed protocol enables multiple participants to compare their privacies with the semi-quantum model.The communication process of the protocol is simulated on the IBM Quantum Experience platform to verify its effectiveness.Security analysis shows that the proposed protocol can withstand common attacks while preserving the privacies of all participants.Thus,the devised protocol may provide an important reference for implementation of quantum private size comparison protocols.

Critique in the Field of Immanence: The Case of New Polish Art

In the presented paper,the author,referring to several examples of Polish contemporary art,reflects on the concept of criticism.The author asks the question:Whether are we dealing in late capitalism with a post-critical turn in art and philosophical thinking at all?He analyzes the post-critical turn by referring to other concepts such as immanent critique(S.Turkle),critique in the field of immanence(G.Deleuze),post-theoretical culture(T.Eagelton),assembly art(G.Didi-Huberman),“technical perfection”(M.Heidegger),mnemotechnics(J.Derrida),mechanosphere(G.Deleuze&F.Guattari),and finally the famous distinction of Walter Benjamin between“display value”of the work of art and its“cult value”.The ultimate goal of the article is to determine the possibility of criticism(critique)in the age of techno-or affective capitalism(L.Berlant&B.Stiergler).At the end,the author poses the question:To what society we belong?Are we part of the“society of display value”or a“co-creative society”?

Evolution of art form of video animation design under the background of computer graphics system development

According to the development of discipline and teaching situation of computer graphics, computer graphics analysis in thecurriculum system, the reform of teaching contents and teaching methods, improve students＇ computer graphics theory teaching and practiceteaching effects by using limited time, adapt to the social demand for graphics software R ＆ D personnel. Motion design and production are ofgreat importance to film and television animation. This article mainly elaborates the present situation, the characteristic and the master method ofthe movie animation movement design and manufacture. Including the animation, motion animation design and production of organized, plannedproduction features that emphasize the characteristics of movement, exaggeration, force and rhythm, this paper presents the common problemsand solutions in the animation language, and the main differences between the animation design and performance in different forms of animation.Through the animation design and expression of the past and present situation analysis, looking forward to the future animation art movementdesign development. Aesthetic lens performance is the artistic pursuit of many film and television creators. Animation, as a highly hypotheticalart form, which is one of the distinctive artistic features of film and television animation, which is based on the limitation of the camera and is fullof expressive lenses.

Comparison of Design and Analysis of Concrete Gravity Dam

Gravity dams are solid concrete structures that maintain their stability against design loads from the geometric shape, mass and strength of the concrete. The purposes of dam construction may include navigation, flood damage reduction, hydroelectric power generation, fish and wildlife enhancement, water quality, water supply, and recreation. The design and evaluation of concrete gravity dam for earthquake loading must be based on appropriate criteria that reflect both the desired level of safety and the choice of the design and evaluation procedures. In Bangladesh, the entire country is divided into 3 seismic zones, depending upon the severity of the earthquake intensity. Thus, the main aim of this study is to design high concrete gravity dams based on the U.S.B.R. recommendations in seismic zone II of Bangladesh, for varying horizontal earthquake intensities from 0.10 g - 0.30 g with 0.05 g increment to take into account the uncertainty and severity of earthquake intensities and constant other design loads, and to analyze its stability and stress conditions using analytical 2D gravity method and finite element method. The results of the horizontal earthquake intensity perturbation suggest that the stabilizing moments are found to decrease significantly with the increment of horizontal earthquake intensity while dealing with the U.S.B.R. recommended initial dam section, indicating endanger to the dam stability, thus larger dam section is provided to increase the stabilizing moments and to make it safe against failure. The vertical, principal and shear stresses obtained using ANSYS 5.4 analyses are compared with those obtained using 2D gravity method and found less compares to 2D gravity method, except the principal stresses at the toe of the gravity dam for 0.10 g - 0.15 g. Although, it seems apparently that smaller dam section may be sufficient for stress analyses using ANSYS 5.4, it would not be possible to achieve the required factors of safety with smaller dam section. It is observed during stability analyses that the factor of safety against sliding is satisfied at last than other factors of safety, resulting huge dam section to make it safe against sliding. Thus, it can be concluded that it would not be feasible to construct a concrete gravity dam for horizontal earthquake intensity greater than 0.30 g without changing other loads and or dimension of the dam and keeping provision for drainage gallery to reduce the uplift pressure significantly.