Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their ...Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review.展开更多
Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for...Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".展开更多
The search for the generating compatibility conditions (CC) of a given operator is a very recent problem met in general relativity in order to study the Killing operator for various standard useful metrics. Accordingl...The search for the generating compatibility conditions (CC) of a given operator is a very recent problem met in general relativity in order to study the Killing operator for various standard useful metrics. Accordingly, this paper can be considered as a natural continuation of a previous paper recently published in JMP under the title Minkowski, Schwarschild and Kerr metrics revisited. In particular, we prove that the intrinsic link existing between the lack of formal exactness of an operator sequence on the jet level, the lack of formal exactness of its corresponding symbol sequence and the lack of formal integrability (FI) of the initial operator is of a purely homological nature as it is based on the long exact connecting sequence provided by the so-called snake lemma in homological algebra. It is therefore quite difficult to grasp it in general and even more difficult to use it on explicit examples. It does not seem that any one of the results presented in this paper is known as most of the other authors who studied the above problem of computing the total number of generating CC are confusing this number with the degree of generality introduced by A. Einstein in his 1930 letters to E. Cartan. One of the motivating examples that we provide is so striking that it is even difficult to imagine that such an example could exist. We hope this paper could be used as a source of testing examples for future applications of computer algebra in general relativity and, more generally, in mathematical physics.展开更多
On the basis of Reiter’s default theory and Zhang Mingyi’s auto compatible default theory, a research on the characters of clausal default theory, especially the closed auto compatible default theory, is carried out...On the basis of Reiter’s default theory and Zhang Mingyi’s auto compatible default theory, a research on the characters of clausal default theory, especially the closed auto compatible default theory, is carried out. First, the theorem of monotonicity with extension number is presented. Second, the proof theory of normal default theory on auto compatible default theory is extended. Some important results are proposed.展开更多
By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong...By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong inhibition of the same time, support the weak” (抑强扶弱) based on “Yin Yang Wu Xing” Theory in image mathematics of Traditional Chinese Mathematics (TCMath). We defined generalized relations and generalized reasoning, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the intervention principle in image mathematics of TCMath and treated the research object of the image mathematics as a steady multilateral system, it has been proved that the mathematical intervening principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.展开更多
基金the project of Young Technical Talents of Tianjin Medical University General Hospital(GG-2021-08209060209507).
文摘Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review.
文摘Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".
文摘The search for the generating compatibility conditions (CC) of a given operator is a very recent problem met in general relativity in order to study the Killing operator for various standard useful metrics. Accordingly, this paper can be considered as a natural continuation of a previous paper recently published in JMP under the title Minkowski, Schwarschild and Kerr metrics revisited. In particular, we prove that the intrinsic link existing between the lack of formal exactness of an operator sequence on the jet level, the lack of formal exactness of its corresponding symbol sequence and the lack of formal integrability (FI) of the initial operator is of a purely homological nature as it is based on the long exact connecting sequence provided by the so-called snake lemma in homological algebra. It is therefore quite difficult to grasp it in general and even more difficult to use it on explicit examples. It does not seem that any one of the results presented in this paper is known as most of the other authors who studied the above problem of computing the total number of generating CC are confusing this number with the degree of generality introduced by A. Einstein in his 1930 letters to E. Cartan. One of the motivating examples that we provide is so striking that it is even difficult to imagine that such an example could exist. We hope this paper could be used as a source of testing examples for future applications of computer algebra in general relativity and, more generally, in mathematical physics.
文摘On the basis of Reiter’s default theory and Zhang Mingyi’s auto compatible default theory, a research on the characters of clausal default theory, especially the closed auto compatible default theory, is carried out. First, the theorem of monotonicity with extension number is presented. Second, the proof theory of normal default theory on auto compatible default theory is extended. Some important results are proposed.
文摘By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong inhibition of the same time, support the weak” (抑强扶弱) based on “Yin Yang Wu Xing” Theory in image mathematics of Traditional Chinese Mathematics (TCMath). We defined generalized relations and generalized reasoning, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the intervention principle in image mathematics of TCMath and treated the research object of the image mathematics as a steady multilateral system, it has been proved that the mathematical intervening principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.
