Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

Enhancing perianal disease management with integrated physical and psychological approaches

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

Chyle leak following root of mesentery dissection in pancreaticoduodenectomy with inferior infracolic superior mesenteric artery first approach

BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head cancer.Intra-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic resections.Globally recognized superior mesenteric artery(SMA)first approaches are invariably performed.The mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this study.AIM To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment modalities.METHODS This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and General Surgery of Kathmandu Medical College and Teaching Hospital from January 1,2021 to February 28,2024.Intraop-erative findings and postoperative outcomes were analyzed.RESULTS In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach pancreatoduodenectomy.The mean age was 67.6 years with a male-to-female ratio of 4:5.CL was seen in four patients.With virtue of CL,Clavien-Dindo grade Ⅱ or higher morbidity was observed in four patients.Two patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition requirement.The mean operative time was 330 minutes.Curative resection was achieved in 100%of the patients.The mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,respectively.CONCLUSION Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of CL.After complete curative resection,these were managed with total parenteral nutrition without adversely impacting outcome.

The Approach of Compensation of Air Refractive Index in Thermal Expansion Coefficients Measurement Based on Laser Feedback Interferometry

We present the thermal expansion coefficient （TEC） measurement technology of compensating for the effect of variations in the refractive index based on a Nd： YA G laser feedback system, the beam frequency is shifted by a pair of aeousto-optic modulators and then the heterodyne phase measurement technique is used. The sample measured is placed in a muffle furnace with two coaxial holes opened on the opposite furnace walls. The measurement beams hit perpendicularly and coaxially on each surface of the sample. The reference beams hit on the reference mirror and the high-refiectivity mirror, respectively. By the heterodyne configuration and computing, the influences of the vibration, distortion of the sample supporter and the effect of variations in the refractive index are measured and largely minimized. For validation, the TECs of aluminum samples are determined in the temperature range of 29-748K, confirming not only the precision within 5 × 10-7 K-1 and the accuracy within 0.4% from 298K to 448K but also the high sensitivity non-contact measurement of the lower reflectivity surface induced by the sample oxidization from 448 K to 748 K.

APPROACH TO IMPROVEMENT OF ROBOT TRAJECTORY ACCURACY BY DYNAMIC COMPENSATION

Some dynamic factors, such as inertial forces and friction, may affect therobot trajectory accuracy. But these effects are not taken into account in robot motion controlschemes. Dynamic control methods, on the other hand, require the dynamic model of robot and theimplementation of new type controller. A method to improve robot trajectory accuracy by dynamiccompensation in robot motion control system is proposed. The dynamic compensation is applied as anadditional velocity feedforward and a multilayer neural network is employed to realize the robotinverse dynamics. The complicated dynamic parameter identification problem becomes a learningprocess of neural network connecting weights under supervision. The finite Fourier series is used toactivate each actuator of robot joints for obtaining training samples. Robot control system,consisting of an industrial computer and a digital motion controller, is implemented. The system isof open architecture with velocity feedforward function. The proposed method is not model-based andcombines the advantages of close-loop position control and computed torque control. Experimentalresults have shown that the method is validatities to improve the robot trajectory accuracy.

Life satisfaction approach to farmers' compensation for land acquisition:empirical study from the suburbs of Wuhan City

Farmers' compensation for land acquisition is not only critical to increasing their income and to playing a pivotal role in maintaining rural stability,but also to the promotion of sustainable land use.Based on analysis of Chinese land acquisition policy under the Land Management Law,which provides principles or guidelines for determining compensation according to agricultural land use in regard to farmers' previous quality of life,the Life Satisfaction Approach is introduced in this article to evaluate farmers' compensation for land acquisition.Employing data from a questionnaire survey on 346 farming households in Wuhan Suburbs,this article examined the influence of farmland on farmers' life satisfaction and evaluated the level of compensation for land acquisition.Results show that farmland has a significantly positive impact on life satisfaction,which fell by 0.033 on a five-point scale following a reduction farmland by of 1 mu.Respondents were willing to accept approximately RMB 3066.44 annual household income for the loss of 1 mu farmland;the level of compensation after discounting by 6.2%is RMB 750,000 per hectare.It was found in a further comparative study that the level of farmers' compensation for land acquisition is decidedly low,and it was also shown that their compensation standards,as well as the actual compensation,could be substantially improved by expanding economic compensation to non-economic compensation to embody farmland multifunction in terms of production and non-production against farmers' previous quality of life.This article proposes a compensation model that enriches the content of land acquisition compensation,extends the current literature on measuring compensation,and provides economic theory bases for increasing compensation standards and improving policies related to land acquisition.We consider that if this compensation model is applied,it could raise the cost of land acquisition and improve usage of land,reduce the speed of rural-urban land conversion,and improve farmers' well-being.

Modeling Approach of Regression Orthogonal Experiment Design for Thermal Error Compensation of CNC Turning Center

The thermal induced errors can account for as much as 70% of the dimensional errors on a workpiece. Accurate modeling of errors is an essential part of error compensation. Base on analyzing the existing approaches of the thermal error modeling for machine tools, a new approach of regression orthogonal design is proposed, which combines the statistic theory with machine structures, surrounding condition, engineering judgements, and experience in modeling. A whole computation and analysis procedure is given. Therefore, the model got from this method are more robust and practical than those got from the present method that depends on the modeling data completely. At last more than 100 applications of CNC turning center with only one thermal error model are given. The cutting diameter variation reduces from more than 35 μm to about 12 μm with the orthogonal regression modeling and compensation of thermal error.

An approach of motion compensation and ISAR imaging for micro-motion targets

Inverse synthetic aperture radar(ISAR)imaging of the target with the non-rigid body is very important in the field of radar signal processing.In this paper,a motion compensation method combined with the preprocessing and global technique is proposed to reduce the influence of micro-motion components in the fast time domain,and the micro-Doppler(m-D)signal in the slow time domain is separated by the improved complex-valued empirical-mode decomposition(CEMD)algorithm,which makes the m-D signal more effectively distinguishable from the signal for the main body by translating the target to the Doppler center.Then,a better focused ISAR image of the target with the non-rigid body can be obtained consequently.Results of the simulated and raw data demonstrate the effectiveness of the algorithm.

Approach for electrodynamic force for compensation in low voltage circuit breaker WP 630-1.2 type

Undesirable repulsive force between contact members due to both a current path shrink near a real contact area and/or so-called pinch effect is particularly onerous for power switch applications, and results in either contact floating or bouncing which are associated with an electric arc following contact welding. This problem is of great importance for any circuit breaker especially for compact low voltage vacuum circuit breakers. To avoid contact floating at closure and during any inrush current under short circuit conditions, the electrodynamic repulsive force can be employed successfully if we use a special compensation system flexibly combined with the contact itself. However to select and design the compensation system properly, its efficiency has to be known. This paper presents an approach to obtain the electrodynamic force value depending on different shaped (rectangular, square, circle and arch) copper plates used in the compensator by using ANSYS for current values 40 kA RMS. Curve-fitting was done according to the calculating results, the optimization designing of compensation unit is based on them.

A high frequency vibration compensation approach for ultrahigh resolution SAR imaging based on sinusoidal frequency modulation Fourier-Bessel transform

Ultrahigh resolution synthetic aperture radar(SAR)imaging for ship targets is significant in SAR imaging,but it suffers from high frequency vibration of the platform,which will induce defocus into SAR imaging results.In this paper,a novel compensation method based on the sinusoidal frequency modulation Fourier-Bessel transform(SFMFBT)is proposed,it can estimate the vibration errors,and the phase shift ambiguity can be avoided via extracting the time frequency ridge consequently.By constructing the corresponding compensation function and combined with the inverse SAR(ISAR)technique,well-focused imaging results can be obtained.The simulation imaging results of ship targets demonstrate the validity of the proposed approach.

Complication rates after direct anterior vs posterior approach for hip hemiarthroplasty in elderly individuals with femoral neck fractures

BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with no consensus regarding the superiority of any single approach.AIM To compare early postoperative complications after implementing the direct anterior and posterior approaches(PL)for hip hemiarthroplasty after femoral neck fractures.METHODS This is a comparative,retrospective,single-center cohort study conducted at a university hospital.Between March 2008 and December 2018,273 patients(a total of 280 hips)underwent bipolar hemiarthroplasties(n=280)for displaced femoral neck fractures using either the PL(n=171)or the minimally invasive direct anterior approach(DAA)(n=109).The choice of approach was related to the surgeons’practices;the implant types were similar and unrelated to the approach.Dislocation rates and other complications were reviewed after a minimum followup of 6 mo.RESULTS Both treatment groups had similarly aged patients(mean age:82 years),sex ratios,patient body mass indexes,and patient comorbidities.Surgical data(surgery delay time,operative time,and blood loss volume)did not differ significantly between the groups.The 30 d mortality rate was higher in the PL group(9.9%)than in the DAA group(3.7%),but the difference was not statistically significant(P=0.052).Among the one-month survivors,a significantly higher rate of dislocation was observed in the PL group(14/154;9.1%)than in the DAA group(0/105;0%)(P=0.002).Of the 14 patients with dislocation,8 underwent revision surgery for recurrent instability(posterior group),and one of them had 2 additional procedures due to a deep infection.The rate of other complications(e.g.,perioperative and early postoperative periprosthetic fractures and infection-related complications)did not differ significantly between the groups.CONCLUSION These findings suggest that the DAA to bipolar hemiarthroplasty for patients with femoral neck fractures is associated with a lower dislocation rate(<1%)than the PL.

Implementation Approaches of Ecological Compensation Mechanism for Water Conservancy in Zhejiang Province

According to the practices in the field of ecological compensation for water conservancy in Zhejiang Province,this article points out the problems and shortcomings in the ecological compensation mechanism for water conservancy,analyzes the obstacles to the effective running of the mechanism,explains the internal reasons for the implementation process of the mechanism,and discusses the countermeasures for developing this mechanism.

A NEW APPROACH FOR ISAR TRANSLATIONAL MOTION COMPENSATION

Motion compensation is a key step of inverse synthetic aperture radar (ISAR) imaging. In this paper, the average absolute error measure (AAEM) is proposed for BAR translational motion compensation. Based on the AAEM, a technique for improving stepped-frequency IS AR imagery is presented. Image improvement is achieved in the frequency domain where the echo phase can be adjusted to compensate for translational motion. With help o f a search algorithm, the garget' s motion parameters which reduce AAEM to a minimum are determined. The signer-Vile distribution is used to find the initial values for a search algorithm. Based on AAEM, one can efficiently focus the image of the target. In the simulation, the target is assumed to fly in straight path and is illuminated by an X-band ground-based stationary stepped-frequency ISAR. The resulted image from simulation radal data is obtained. comparing the resulted image with that of the typical compensation method, the effectiveness of the proposed AAEM is verified.

A Hybrid Motion Compensation De-interlacing Approach

Motion compensation de interlacing is expected to be better than linear techniques; but all the block based motion compensation de interlacing methods cause block artifacts. The algorithm proposed in this paper is concerned with reducing the deficiency of motion compensated interpolation by using adaptive hybrid de interlacing methods. A spatio temporal tensor based approach is used to get more accurate motion field for de interlacing. Motion vector is assigned for each position with pixel precision; the block artifact is reduced significantly. To deal with the artifacts introduced by motion compensation when the motion estimation is incorrect, linear techniques are considered by adaptive weighting. Furthermore, directional filter is adapted to preserve details and the edge discontinuity could be eliminated greatly. Our approach is robust to incorrect motion vector estimation.

A FLEXIBLE OBJECTIVE-CONSTRAINT APPROACH AND A NEW ALGORITHM FOR CONSTRUCTING THE PARETO FRONT OF MULTIOBJECTIVE OPTIMIZATION PROBLEMS

In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems.

DYNAMIC COMPENSATION OF MEASURING SYSTEMS BY SYSTEM IDENTIFICATION APPROACH

A digital filtering method is presented to compensate the dynamic characteristics of measuring systems.The compensation filter has an infinite impulse response property and is designed by system identification approach from the known input output pairs of the measuring system.Applications of this method to eliminating the distortions of measured waveform in transient pulse measurement are investigated.Experimental results show that the measurement errors caused by the sensor are reduced to be very small after the use of the compensation filter.

A Novel Approach to Blind I/Q Mismatch &Carrier Offset Compensation

This paper proposes a novel approach for I/Q mismatch compensation. Simulation results proves the superior per-formance of the proposed technique.

Exploring an eco-friendly approach to improve soil tensile behavior and cracking resistance

Soil tensile strength is a critical parameter governing the initiation and propagation of tensile cracking.This study proposes an eco-friendly approach to improve the tensile behavior and crack resistance of clayey soils.To validate the feasibility and efficacy of the proposed approach,direct tensile tests were employed to determine the tensile strength of the compacted soil with different W-OH treatment concentrations and water contents.Desiccation tests were also performed to evaluate the effectiveness of W-OH treatment in enhancing soil tensile cracking resistance.During this period,the effects of W-OH treatment concentration and water content on tensile properties,soil suction and microstructure were investigated.The tensile tests reveal that W-OH treatment has a significant impact on the tensile strength and failure mode of the soil,which not only effectively enhances the tensile strength and failure displacement,but also changes the brittle failure behavior into a more ductile quasi-brittle failure behavior.The suction measurements and mercury intrusion porosimetry(MIP)tests show that W-OH treatment can slightly reduce soil suction by affecting skeleton structure and increasing macropores.Combined with the microstructural analysis,it becomes evident that the significant improvement in soil tensile behavior through W-OH treatment is mainly attributed to the W-OH gel's ability to provide additional binding force for bridging and encapsulating the soil particles.Moreover,desiccation tests demonstrate that W-OH treatment can significantly reduce or even inhibit the formation of soil tensile cracking.With the increase of W-OH treatment concentration,the surface crack ratio and total crack length are significantly reduced.This study enhances a fundamental understanding of eco-polymer impacts on soil mechanical properties and provides valuable insight into their potential application for improving soil crack resistance.

Laparoscopic left hemihepatectomy guided by indocyanine green fluorescence: A cranial-dorsal approach

BACKGROUND Advancements in laparoscopic technology and a deeper understanding of intra-hepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy(LH)techniques.The indocyanine green(ICG)fluorescence navi-gation technique has emerged as the most effective method for identifying hepatic regions,potentially overcoming the limitations of LH.While laparoscopic left hemihepatectomy(LLH)is a standardized procedure,there is a need for innova-tive strategies to enhance its outcomes.important anatomical markers,surgical skills,and ICG staining methods.METHODS Thirty-seven patients who underwent ICG fluorescence-guided LLH at Qujing Second People's Hospital between January 2019 and February 2022 were retrospectively analyzed.The cranial-dorsal approach was performed which involves dissecting the left hepatic vein cephalad,isolating the Arantius ligament,exposing the middle hepatic vein,and dissecting the parenchyma from the dorsal to the foot in order to complete the anatomical LLH.The surgical methods,as well as intra-and post-surgical data,were recorded and analyzed.Our hospital’s Medical Ethics Committee approved this study(Ethical review:2022-019-01).RESULTS Intraoperative blood loss during LLH was 335.68±99.869 mL and the rates of transfusion and conversion to laparotomy were 13.5%and 0%,respectively.The overall incidence of complications throughout the follow-up(median of 18 months;range 1-36 months)was 21.6%.No mortality or severe complications(level IV)were reported.CONCLUSION LLH has the potential to become a novel,standardized approach that can effectively,safely,and simply expose the middle hepatic vein and meet the requirements of precision surgery.

Construction and Implementation Approaches of Ecological Compensation Mechanism for Coordinated Control of Air Pollution in Beijing-Tianjin-Hebei Region

The spatial spillover of air pollution in Beijing-Tianjin-Hebei region makes the territorial governance model inefficient.At the same time,it is facing the contradiction between environmental governance and economic development.So far,there is still no regional long-term mechanism for coordinated governance of air pollution.Ecological compensation theory is becoming an effective guiding theory to coordinate economic and environmental benefits.There is relatively little research on ecological compensation mechanism in the coordinated control of regional air pollution.Ecological compensation mechanism is an effective tool to promote air pollution control.At the same time,regional cooperation can realize the efficient control of air pollution.Scientifically constructing the cross regional cooperative control model of Beijing,Tianjin and Hebei is a favorable way to implement comprehensive control of air pollution.This paper discusses the necessity of ecological compensation mechanism for regional coordinated control of air pollution.Referring to practical experience of provinces and cities that have implemented the ecological compensation mechanism for air pollution control,and the effective way to distribute the compensation amount,compensation subject and compensation standard determination method that can be implemented in Beijing-Tianjin-Hebei region are analyzed,further proposing an effective way to establish an ecological compensation mechanism for regional air pollution collaborative control according to its reality.