Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating H.pylori is crucial for treating and preventing these conditions.While conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression therapies.Potassium competitive acid blocker(P-CAB)triple and dual therapy are new regimens for H.pylori eradication.Initially used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for H.pylori eradication.AIM To assess the efficacy of regimens containing P-CABs in eradicating H.pylori infection.METHODS This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating H.pylori were included.Exclusion criteria included case reports,case series,unpublished trials,or conference abstracts.Data variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and H.pylori eradication method were gathered by two independent reviewers.Meta-analysis was performed in R software,and forest plots were generated.RESULTS A total of 256 references were initially retrieved through the search command.Ultimately,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple therapy.The intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention group and 3578 in the PPI control group across these studies.The analysis revealed a significant difference in H.pylori eradication between VPZ triple therapy and PPI triple therapy in both RCTs and observational studies[risk ratio(RR)=1.17,95%confidence interval(CI):1.11-1.22,P<0.0001]and(RR=1.13,95%CI:1.09-1.17,P<0.0001],respectively.However,no significant difference was found between tegoprazan(TPZ)triple therapy and PPI triple therapy in both RCTs and observational studies(RR=1.04,95%CI:0.93-1.16,P=0.5)and(RR=1.03,95%CI:0.97-1.10,P=0.3),respectively.CONCLUSION VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H.pylori,positioning it as a highly effective first-line regimen.Additionally,TPZ-based triple therapy was non-inferior to classical PPI triple therapy.

Assessing the Efficacy of Wheat-Soybean Based Intercropping System at Different Plant Densities in Bambili, Cameroon

Wheat is one of the most important cereals in the world, serving as a staple for millions globally. In the wake of the geopolitical crisis between Russia and Ukraine, it has become incumbent for many countries to invest in wheat production. Improving cropping systems for wheat production is paramount. Intercropping cereals with legumes has tremendous advantages. Therefore, this study was designed to optimize wheat production by intercropping it with soybean at different densities. Between March and August 2023, a randomized complete block design trial was conducted in Bambili, North West of Cameroon with treatments T1 (wheat monocrop at 200,000 plants ha−1), T2 (soybean monocrop at 250,000 plants ha−1), T3 (200,000 wheat and 125,000 soybean ha−1), T4 (100,000 wheat and 250,000 soybean ha−1), T5 (200,000 wheat and 250,000 soybean ha−1) and T6 (100,000 wheat and 125,000 soybean ha−1). Results revealed that growth parameters of wheat were not significantly influenced by monocrop or intercrop. The yield of wheat was significantly higher in the monocrop than the intercrop treatments, with slight variation amongst the intercrop treatments. Soybean yield was higher in the monocrop than in the intercrop, with no variations amongst the intercrop treatments. Only the land equivalence ratio (LER) for T5 was greater than 1.0. The competitive ratio for T5 was 0.54 for wheat and 1.90 for soybean, comparatively lower than the other monocrop treatments. Intercropping wheat and soybean at 200,000:250,000 ratio is recommended.

Impact of coupling coordination development of port and city environments on urban economic competitiveness:Evidence from the coastal port cities in eastern China

Promoting the coupling coordination development of port and its hinterland city environments is an important way to improve urban economic competitiveness.Based on relevant data of 13 coastal port cities in eastern China from 2000 to 2018,this study explores the coupling coordination development of port and city environments and its impact on urban economic competitiveness by constructing the coupling coordination degree model and the panel threshold model.The research results show that:(1)In terms of the coupling coordination development of port and city environments,most coastal ports and their hinterland cities are in a state of moderate or serious disorder.Overall,the degree of coupling coordination of port and city environments needs to be further improved;(2)The coupling coordination degree of port and city environments has a significant impact on urban economic competitiveness,and this effect gradually increases with the development of the ports and the urban economy.Among the variables that impact the urban economic competitiveness,fixed assets investment and foreign trade are significant factors that can enhance urban economic competitiveness.(3)At present,there is a“U-shaped”relationship between the coupling coordination degree of port-city environments and the urban economic competitiveness.This relationship lies on the right side of the inflection point of the“U-shaped”curve.Therefore,following the concept of assigning priority to ecological development,expanding fixed assets investment and actively developing foreign trade can further enhance the urban economic competitiveness.

Enhancement of Competitiveness of Border Trade Entrepreneurs: Case Study of Su-Ngai Kolok Checkpoint, Narathiwat Province

This research aimed to analyze the enhancement of competitiveness among fruit and vegetable export entrepreneurs,with the case study of the Su-ngai Kolok checkpoint in Narathiwat Province.This research focused on three objectives:(1)examining how competitiveness is enhanced through government support and the development of border trade zones,(2)studying the supply chain dynamics,including strategic factors and opportunities in agricultural product management,and(3)developing a model for border trade to strengthen exporters’capabilities.The research employed qualitative methods,with data collected from 25 informants through interviews and employed descriptive methods.The research results revealed that:(1)government agencies play a crucial role in improving competitiveness by developing border economic zones and trade policies;additionally,(2)the research highlighted the importance of strategic partnerships,network building,and efficient logistics along the value chain;(3)the proposed Border Trade Model includes elements for instance government policy,partnerships,entrepreneurial potential,and transportation channels,aiming to enhance the overall efficiency and effectiveness of vegetable and fruit exporters in the region.

Export Competitiveness and Sustainable Development of the Ukrainian Timber Industry

This paper conducts a comprehensive analysis of the export dynamics within the Ukrainian timber industry, emphasizing its pivotal role in the national economy. The study begins by outlining the research objectives, context, and innovative methodologies, setting the stage for a deep dive into the theoretical underpinnings of sustainable and competitive trade. It explores Ukraine’s rich forest biodiversity across varied vegetation zones and its geopolitical significance. Detailed evaluations of forest resource management, policy frameworks, and institutional support form the core of the analysis. Challenges such as imbalanced export structures and legal inconsistencies are critically examined. The research employs trade gravity models and competitive indicators like the Revealed Comparative Advantage (RCA) and Market Share (MS) to assess factors influencing exports and to forecast potential growth areas. The findings inform strategic recommendations aimed at enhancing export capacity through market diversification, brand development, and legal stability. The conclusion highlights the need for strategic interventions to harness Ukraine’s timber resources sustainably, balancing economic gains with environmental stewardship.

Dilemmas and Optimization of Third-Party Assessment System in Chinese Fair Competition Review

The current predominant self-review mechanism by policy-making bodies suffers from deficiencies such as insufficient motivations, limited review capabilities, and weak external supervision. Third-party assessment, characterized by independence and specialization, is designed to mitigate these shortcomings. However, the implementation of third-party assessment faces challenges too. This paper intends to improve the third-party assessment system and to realize the legislative purpose of the system. Based on social research, discussions and exchanges with relevant parties, and the existing research results, this paper analyzes the challenges and possible optimization measures for the third-party assessment. The challenges include repulsion from policy-making bodies, insufficient independence of assessment bodies, disparity of assessment quality, and limited application of assessment outcomes. Possible optimization measures include promoting fair competition culture, increasing the acceptance of third-party assessment from policy-making bodies, enhancing the quality of third-party assessment, clarifying the relationship between policy-making bodies and assessment bodies, ensuring the independence of third-party assessments, and promoting the application of assessment results.

Reform in the Property Right System to Enhance Competitiveness—On the China Yangtze Group Corp.

The China Yangtze Group Corp. was founded in 1980. Now it has developed into a large state-owned consortium, with its business scope covering electrical appliances, automobiles, light industry and other industrial sectors. It has gross assets of RMB 1.737 billion, and net assets of RMB359 million. The Yangtze Group has been developing, with reliance on bank loans in recent years, incurring heavy debts; and its leading product-refrigerator,

Effect of Bt traits on transgenic rice's growth and weed competitiveness

Transgene escape could lead to genetically modified rice establishing wild populations in the natural environment and competing for survival space with weeds.However,whether the expression of the Bacillus thuringiensis(Bt)gene in rice will alter the relationship between transgene plants and weeds and induce undesirable environmental consequences are poorly understood.Thus,field experiments were conducted to investigate the weed competitiveness and assess the ecological risk of transgenic Bt rice under herbicide-free and lepidopterous pest-controlled environments.Results showed that weed–rice competition in the direct-sowing(DS)field was earlier and more severe than that in the transplanting(TP)field,which resulted in a significant decrease in biomass and yield in DS.However,conventional Bt and non-Bt rice yield was not significantly different.The weed number,weed coverage ratio,and weed diversity of conventional Bt rice were significantly higher than those of non-Bt rice at the early growth and mature stages,especially in DS plots,suggesting that Bt traits did not increase the weed competitiveness of transgenic rice and had no negative effect on weed diversity.Grain yield and weed number varied between different hybrid rice lines,but those differences were insignificant between Bt and non-Bt rice.The number of insects increased with the increase of weeds in hybrid rice plots,whereas the insect number and diversity did not display a significant difference between Bt and non-Bt rice.Therefore,the ecological risk of transgenic Bt rice is comparable to non-Bt rice.

Forge ahead and improve the core competitiveness of Animal Models and Experimental Medicine(AMEM)

After 5 years of accumulation, Animal Models and Experimental Medicine(AMEM) has received 396 manuscripts from 46 countries and regions, including Chinese mainland, Iran, the United States, India, Israel, Nigeria, Brazil, Bangladesh, Sri Lanka, the Netherlands, Denmark, Australia, Japan, and Spain. It has become an important international exchange and display platform for innovative research results in the field of laboratory animal science and basic medicine.

ENTIRE SOLUTIONS OF LOTKA-VOLTERRA COMPETITION SYSTEMS WITH NONLOCAL DISPERSAL

This paper is mainly concerned with entire solutions of the following two-species Lotka-Volterra competition system with nonlocal(convolution)dispersals:{u_(t)=k*u-u+u(1-u-av),x∈R,t∈R,vt=d(k*v-v)+rv(1-v-bu),c∈R,t∈R.(0.1)Here a≠1,b≠1,d,and r are positive constants.By studying the eigenvalue problem of(0.1)linearized at(ϕc(ξ),0),we construct a pair of super-and sub-solutions for(0.1),and then establish the existence of entire solutions originating from(ϕc(ξ),0)as t→−∞,whereϕc denotes the traveling wave solution of the nonlocal Fisher-KPP equation ut=k*u−u+u(1−u).Moreover,we give a detailed description on the long-time behavior of such entire solutions as t→∞.Compared to the known works on the Lotka-Volterra competition system with classical diffusions,this paper overcomes many difficulties due to the appearance of nonlocal dispersal operators.

Cultivation system influenced the critical period for weed control in cotton field

Background The critical period of weed control(CPWC) refers to the period of time during the crop growth cycle when weeds must be controlled to prevent yield losses.Ultra-narrow row(UNR) is a method of planting of cotton in rows that are 25 cm or less apart.Amongst cultural techniques for weed control,the use of narrow row spacing is considered to be a most promising approach that can effectively suppress weed growth and provide greater yields in cotton.This cultivation system can shorten the length of the critical weed-crop interference duration and results in greater yield.The current research aimed to determination of critical time of weed control in cotton(Gossypium hirsutum L.) under conventional and ultra-narrow row spacing conditions.Field experiments were arranged as factorial experiment in a randomized complete block design with three replications.Factors were cultivation system(conventional(50 cm row spacing) and ultra narrow row(25 cm row spacing and weed treatment including 30,45,60,and 75 days weeding after emergence during the growing season(weed free),and 30,45,60,and 75 without weeding(weed infested) in the growing season along with weedy and weed-free from sowing to harvesting.A four-parameter loglogistic model was fit to the two sets of relating relative crop yield to data obtained from increasing durations of weed interference and lengths of weed-free period.Results In both years and cultivation systems,the relative yield of cotton decreased with the increasing duration of weed-interference but increased with the increasing duration of weed-free period.Ultra-narrow row cultivation delayed the beginning of the CPWC in cotton.Under ultra-narrow row condition,the CPWC ranged from 21 to 99 days after germination in 2021 and 23 to 91 days in 2022 based on the 5% acceptable yield loss.Under conventional cultivation CPWC ranged from 17 to 102 days after emergence in 2021 and 18 to 95 days after emergence in 2022.Conclusions Under both conventional and Ultra-narrow row conditions,weed interference reduces seed yield.Under ultra-narrow row condition,weed interference until 21.1–23.5 days after cotton emergence and under conventional condition,weed interference until 16.9–18.5 days after cotton emergence had not significant reduction on cotton yield.

Core Competitiveness Construction of Clothing Brands in Low-Carbon Economy

The climate issue has become an environmental concern for all sectors of the world and the low-carbon economy has thus become a new economic development model to combat climate change.With the development of low-carbon economy era,the textile and clothing industry plays an important role in stabilizing the development of low-carbon economy and society,and China has put forward the development requirements of low-carbon transformation for the textile and clothing industry,and also it has an important strategic value to promote the high-quality development of low-carbon economy and society,and the construction of brands’ core competitiveness is an inevitable choice for clothing brands in the face of the new form of international competition.As a result,the evaluation indicator of clothing brands’ core competitiveness in the low-carbon economy is used to measure the core competitiveness of clothing brands.Based on the corresponding verification results obtained by analytic hierarchy process(AHP) analysis,it can guide the low-carbon development of the clothing industry,thus proposing a more reasonable way to build the core competitiveness of clothing brands.It can promote the low-carbon transformation and upgrading of the clothing industry,effectively increase the market share of clothing brands,and promote the high-quality development of clothing brands.

Comparative Analysis of Rice Export Competitiveness in Heilongjiang Province of China Based on Index Method

Based on the analysis of rice planting and export development in Heilongjiang Province in 2013-2021,this paper comprehensively used three export competitiveness analysis methods,namely,trade competitiveness index,revealed comparative advantage(RCA)analysis and international market share analysis,to compare the four major rice exporters in the world and the three major rice export provinces and cities in China.Besides,it evaluated the rice export competitiveness of Heilongjiang Province from multiple perspectives.It analyzed the reasons for low competitiveness in terms of export product structure,export market structure,production and processing technology,and brand building.Finally,it is recommended to clarify the positioning of rice export quality and take more measures to ensure product quality;improve the level of industrialization of rice production and processing,and extend the rice industry chain;develop diversified rice export markets and improve export flexibility;adhere to the principle of"opening the door and going out",expand the international popularity of high-quality brands,so as to enhance the rice export competitiveness of Heilongjiang Province.

Determinates of the competitiveness of provincial forest health care industry in China

Due to the late start of China’s forest health industry,related research is lagging behind,which results in the inability to propose a corresponding path to enhance competitiveness.Based on this,the evaluation index system of provincial forest health industry competitiveness was constructed by using the Porter diamond model,and the Entropy-TOPSIS model is used to evaluate the competitiveness of China’s provincial forest health industry,and the key influencing factors of the forest health industry competitiveness are identified by using the grey correlation analysis method,and the specific promotion path was designed.The empirical results show that the grey correlation degree between related and supporting industries and the competitiveness score of the forest health industry is the highest,which confirms that it is the key influencing factor of the competitiveness of the forest health industry.Therefore,government departments should vigorously promote the integration of cultural tourism,medical care,pension and other related industries with the forest health care industry;enterprises should strengthen the construction of forest health infrastr ucture and supporting facilities to improve the level of forest health services.

Existence of Two Limit Cycles in Zeeman’s Class 30 for 3D Lotka-Volterra Competitive System

Gyllenberg and Yan(Discrete Contin Dyn Syst Ser B 11(2):347–352,2009)presented a system in Zeeman’s class 30 of 3-dimensional Lotka-Volterra(3D LV)competitive systems to admit at least two limit cycles,one of which is generated by the Hopf bifurcation and the other is obtained by the Poincaré-Bendixson theorem.Yu et al.(J Math Anal Appl 436:521–555,2016,Sect.3.4)recalculated the first Liapunov coefficient of Gyllenberg and Yan’s system to be positive,rather than negative as in Gyllenberg and Yan(2009),and pointed out that the Poincaré-Bendixson theorem is not applicable for that system.Jiang et al.(J Differ Equ 284:183–218,2021,p.213)proposed an open question:“whether Zeeman’s class 30 can be rigorously proved to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem?”This paper provides four systems in Zeeman’s class 30 to admit at least two limit cycles by the Hopf theorem and the Poincaré-Bendixson theorem and gives an answer to the above question.

China's low-carbon competitiveness and its effect decomposition from the perspective of wellbeing performance of ecological input

From the perspective of wellbeing performance of ecological input,this paper constructs a low-carbon competitiveness evaluation model with wellbeing performance of carbon emissions as the measurement standard,and uses the LMDI factor decomposition method to decompose the total effect of low-carbon competitiveness changes into technology effect and service effect.And then it conducts positive analysis and comparison of the low-carbon competitiveness and its effect contribution of G20 countries from1990 to 2018.The results are as follows:Firstly,in 2018,the UK,France,Argentina,Brazil,and Germany had higher low-carbon competitiveness.From 1990 to 2018,the low-carbon competitiveness of the UK,Turkey,Germany,Italy,and Brazil increase rapidly.Secondly,from 1990 to 2018,the total effect of low-carbon competitiveness of G20 member states was all positive,that is to say,the overall wellbeing performance of carbon emissions increased,technology effect and service effect are positive in 17 countries and negative in 2 countries respectively.Thirdly,China's low-carbon competitiveness is low,lacking static and dynamic advantages,although the technology effect is the highest,but the service effect is the lowest,resulting in a low total effect,which indicates that the wellbeing performance of economic growth is the main bottleneck of China's low-carbon development.Finally,the policy recommendations for China's future low-carbon transition and sustainable development are put forward.

Platform Strategies of the Chinese Commercial Drone Manufacturer:A Theoretical and Empirical Study of Ecosystem Development

From the perspective of the business ecosystem,this paper analyzes the competitive advantage and platform strategy of Da-Jiang Innovations Science and Technology Co.,Ltd.(DJI),a Chinese commercial drone manufacturer that is currently leading the global commercial drone industry.DJI was established in 2006 and developed the industry’s first core components such as drone control system.DJI released its“Phantom”in the United States in 2013 and occupied the global commercial drone market accounting for 70%in a short period of time.Its market share has maintained its superiority till present.During the inflection transition from the formation of a new ecosystem to expansion,DJI has defended and strengthened its core technology through a strong containment strategic action of competing with GoPro;therefore,DJI has obtained its hub position of multiple markets with bargaining power.In addition,DJI has entered the surrounding markets of corporate market from the general consumer market,and instilled its own product standards&design standards(reference design).Furthermore,it has stimulated and revitalized coexisting companies,individual&corporate customers for expanding the ecosystem of drone industry.

Countermeasures to Improve the Competitiveness of Medicine Circulation Enterprises in China under the New Situation

Objective To analyze the current situation of medicine circulation enterprises and summarize the influence of frequently introduced industry policies on the pharmaceutical field,so as to provide suggestions on improving the competitiveness and maintaining sustainable development of medicine circulation enterprises in China.Methods Industry policy analysis,literature inquiry,expert interview and questionnaire survey were used to study the challenges that medicine circulation faced under the new situation.Then,the key indexes were found out to improve its competitiveness.Results and Conclusion Through the analysis of the current situation of the industry,policy orientation and market demand,some suggestions are put forward for related enterprises to improve their competitiveness.

Weight Analysis of the Influencing Factors of Homestay Competitiveness in Rural Guangzhou,China

At present,Guangzhou homestay industry is facing a bottleneck.Therefore,it is particularly important to analyze the factors that influence the competitiveness of rural homestays in Guangzhou,determine the evaluation system of competitiveness,and determine the weight of each factor.Based on Porter’s diamond theory,this paper analyzes and summarizes the influencing factors of homestay competitiveness,and divides the influencing factors into 5 primary factors and 34 secondary factors.The analytic hierarchy process(AHP)was used to determine the judgment matrix to form the weight results of each factor,and the results show that product characteristics account for the largest proportion among first level factors.Secondary factors such as theme creativity,personalized brand and the overall score account for a large proportion.The research results can act as a reference for the construction of competitiveness evaluation mechanism and model of local rural quality homestays.

Entrepreneurial Orientation and Innovation Ecosystems in the Industrial Sector, Central Region, Kampala, Uganda: A Review

This review explores entrepreneurial orientation and innovation ecosystems in the industrial sector of the Central Region, Kampala, Uganda, through an analysis of ten scholarly articles. The study contextualizes the research within the regional landscape and establishes a theoretical framework through a focused literature review. Key findings highlight the intersection of entrepreneurial activities and innovation dynamics, emphasizing the region’s unique contributions to the broader field. Discussions on discrepancies and unexplored territories within the articles offer insights into limitations and research gaps. The manuscript concludes by identifying future research avenues, providing a roadmap for ongoing inquiry into the entrepreneurial and innovative dimensions of the Central Region’s industrial sector. This synthesis underscores the importance of cultivating an entrepreneurial mindset and collaborative innovation strategies for sustainable industrial development in the region.