Simulation of temperature and stress in 6061 aluminum alloy during online quenching process

The cooling curves of 6061 aluminum alloy were acquired through water quenching experiment. The heat transfer coefficient was accurately calculated based on the cooling curves and the law of cooling. The online quenching process of complex cross-section profile was dynamically simulated by the ABAQUS software. The results suggest that the heat transfer coefficient changes during online quenching process. Different parts of the profile have different cooling velocity, and it was verified by water quenching experiment. The maximum residual stress of the profile was predicted using FEM simulation based on ABAQUS software The relations between the temperature and stress were presented by analyzing the data of key points.

Radar automatic target recognition based on feature extraction for complex HRRP

Radar high-resolution range profile （HRRP） has received intensive attention from the radar automatic target recognition （RATR） community. Usually, since the initial phase of a complex HRRP is strongly sensitive to target position variation, which is referred to as the initial phase sensitivity in this paper, only the amplitude information in the complex HRRP, called the real HRRP in this paper, is used for RATR, whereas the phase information is discarded. However, the remaining phase information except for initial phases in the complex HRRP also contains valuable target discriminant information. This paper proposes a novel feature extraction method for the complex HRRP. The extracted complex feature vector, referred to as the complex feature vector with difference phases, contains the difference phase information between range cells but no initial phase information in the complex HRRR According to the scattering center model, the physical mechanism of the proposed complex feature vector is similar to that of the real HRRP, except for reserving some phase information independent of the initial phase in the complex HRRP. The recognition algorithms, frame-template establishment methods and preprocessing methods used in the real HRRP-based RATR can also be applied to the proposed complex feature vector-based RATR. Moreover, the components in the complex feature vector with difference phases approximate to follow Gaussian distribution, which make it simple to perform the statistical recognition by such complex feature vector. The recognition experiments based on measured data show that the proposed complex feature vector can obtain better recognition performance than the real HRRP if only the cell interval parameters are properly selected.

Drug-polymer inclusion complex as a new pharmaceutical solid form

The solid forms of drugs play a central role in controlling their physicochemical properties and consequently the bioavailability. Multiple types of drug solid forms have been developed to achieve the desirable pharmaceutical profiles, but new solid forms will provide more options for the solid-state property optimization and hence are highly desirable. This review focuses on a new pharmaceutical solid form, drug-polymer inclusion complexes （ICs）, and summarizes their structural features, structure- property relationships, as well as potential pharmaceutical applications

ACCELERATED DISCOVERY AND PROFILING OF PHYSIOLOGICALLY ACTIVE COMPONENTS IN COMPLEX SAMPLES BY HPTLC-EDA-HRMS

On the one hand,the separation of thousands of compounds in a complex extract is thrilling,but may be still be separated unsatisfactorily.Hence,the question arises where to stop in high-sophisticated separation science?Which technical effort is economically justifiable in routine?On the other hand,the separation itself does not imply an effect-directed answer to questions such

Crystalline inclusion complexes formed between the drug diflunisal and block copolymers

The solid form of drugs plays a central role in optimizing the physicochemical properties of drugs,and new solid forms will provide more options to achieve the desirable pharmaceutical profiles of drugs.Recently,certain drugs have been found to form crystalline inclusion complexes（ICs） with multiple types of linear polymers,representing a new subcategory of pharmaceutical solids.In this study,we used diflunisal（DIF） as the model drug host and extended the guest of drug/polymer ICs from homopolymers to block copolymers of poly（ethylene glycol）（PEG） and poly（s-caprolactone）（PCL）.The block length in the guest copolymers showed a significant influence on the formation,thermal stability and dissolution behavior of the DIF ICs.Though the PEG block could hardly be included alone,it could indeed be included in the DIF ICs when the PCL block was long enough.The increase of the PCL block length produced IC crystals with improved thermal stability.The dissolution profiles of DIF/block copolymer ICs exhibited gradually decreased aqueous solubility and dissolution rate with the increasing PCL block length.These results demonstrate the possibility of using drug/polymer ICs to modulate the desired pharmaceutical profiles of drugs in a predictable and controllable manner.