The Preparation Technology Research and Composition Analysis of Anti-fatigue Yikangshu Granules

[Objectives]To optimize the preparation technology of Yikangshu granule,an anti-fatigue health food.[Methods]The process was studied from three aspects(raw material extraction,excipient selection and forming process),and then it was verified in pilot production,and the content of the three components of the product was determined.[Results]The optimum production process of the formula granules was as follows:raw materials were extracted(adding 1∶9 water,extracting twice,2.5 h each time);vacuum concentration;adding excipients and mixing after vacuum drying,crushing and sieving;granulation of 75%ethanol sifted by a 20-mesh sieve;drying at 60℃,sifting through 14-mesh,and packaging.The average content of products obtained was as follows:crude polysaccharides(3204 mg/100 g),total saponins(2295 mg/100 g),astragaloside A(21 mg/100 g).[Conclusions]The optimized preparation technology is stable and feasible,and has a quality that can be controlled,which can provide a reference for the development of health food in food industry.

Predictive Value of Body Composition Analysis for the Prognosis of Patients with Advanced Gastrointestinal Tumors

Objective There is strong evidence that the body composition can affect the progression-free survival(PFS)and overall survival(OS)in patients with a variety of cancers.The main objective of this study was to investigate the effect of body composition on the prognosis of patients with advanced gastrointestinal and colorectal cancers who received first-line palliative chemotherapy.Methods Patients who were newly-diagnosed with advanced gastrointestinal or colorectal cancer and received standard first-line palliative chemotherapy from January 2017 to December 2018 were included in this retrospective study.An analysis of computed tomography images was performed to determine the skeletal muscle index(SMI),which reflects the skeletal muscle mass and skeletal muscle density(SMD)related to muscle strength.A Kaplan-Meier survival analysis and log-rank test were used to compare the survival relationships among groups stratified by the SMI,and a Cox proportional hazard model was used for a multivariate analysis.Results A total of 108 patients met the inclusion criteria,including 41 cases of gastric cancer,46 cases of left colorectal cancer,and 21 cases of right colon cancer.In patients with gastric cancer,the OS of women was significantly shorter than that of men.The OS of patients with a low SMI,low SMD,and low phase angle(PA)was significantly shorter than that of patients with high values(P≤0.05).In the multivariate analysis,the SMD was significantly associated with the patients'long-term survival[Hazard Ratio(HR)=0.904,95%CI:0.840~0.974,P=0.008].For patients with a low SMI and PA,the PFS was significantly shorter than that of patients with high values(P≤0.05).In patients with left colon cancer,the PA and SMD were both independent risk factors for a poorer long-term prognosis(HR=0.375,95%CI:=0.167~0.840,P=0.017;HR=0.887,95%CI:0.824~0.954,P=0.001).Among right colon cancer patients,the PFS and OS of those with a low SMD were significantly lower than those for patients with high values(P≤0.05).Conclusion The PA is an independent risk factor for the OS of left colon cancer patients;the SMD is an independent risk factor for the survival of patients with gastric cancer,left colon cancer,and right colon cancer.

Composition analysis of Compound Shenhua Tablet,a seven-herb Chinese medicine for IgA nephropathy:evaluation of analyte-capacity of the assays

Compound Shenhua Tablet,a medicine comprising seven herbs,is employed in treating IgA nephropathy.This study aimed to meticulously analyze its chemical composition.Based on a list of candidate compounds,identified through extensive literature review pertinent to the tablet’s herbal components,the composition analysis entailed the systematic identification,characterization,and quantification of the constituents.The analyte-capacity of LC/ESI-MS-based and GC/EI-MS-based assays was evaluated.The identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents’daily doses.A total of 283 constituents,classified into 12 distinct categories,were identified and characterized in the Compound Shenhua Tablet.These constituents exhibited content levels of 1−10982μg·g^(−1),with daily doses of 0.01−395μmol·d^(−1).The predominant constituents,with daily doses of≥10μmol·d^(−1),include nine organic acids(citric acid,quinic acid,chlorogenic acid,cryptochlorogenic acid,gallic acid,neochlorogenic acid,isochlorogenic acid C,isochlorogenic acid B,and linoleic acid),five iridoids(specnuezhenide,nuezhenoside G13,nuezhenidic acid,secoxyloganin,and secologanoside),two monoterpene glycosides(paeoniflorin and albiflorin),a sesquiterpenoid(curzerenone),a triterpenoid(oleanolic acid),and a phenylethanoid(salidroside).Additionally,there were 83,126,and 55 constituents detected in the medicine with daily doses of 1–10,0.1–1,and 0.01–0.1μmol·d^(−1),respectively.The combination of the LC/ESI-MS-based and GC/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the medicine.This comprehensive composition analysis establishes a solid foundation for further pharmacological research on Compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine.

High-spatial-resolution composition analysis of micro/nanostructures with a nanoscale compositional variation

The composition of materials in a micro-/nano-devices plays a key role in determining their mechanical,physical,and chemical properties.Especially,for devices with a compositional change on nanoscale which can often be achieved by point-by-point direct writing technology using a focused ion beam(FIB),electron beam(EB),or laser beam(LB),but so far,nanoscale composition analysis of a large-area micro/nano structures with a variation composition remains a big challenge in cost,simpleness,and flexibility.Here we present a feasible route to realize large-area composition analysis with nanoscale spatial resolution by using Raman spectroscopy.We experimentally verified the capability of this method by analyzing a complex Sn-SnOx system of a microscale grayscale mask with nanoscale spatial resolution of composition.Further analyses using Auger electron spectroscopy,transmission electron microscopy,and atomic force microscopy indicated the effectiveness and practicality of our method.This work opens up a way to analyze the composition of a large-area complex system at a nanoscale spatial resolution,and the method can be extended to many other material systems.

Elemental composition x-ray fluorescence analysis with a TES-based high-resolution x-ray spectrometer

The accurate analysis of the elemental composition plays a crucial role in the research of functional materials.The emitting characteristic x-ray fluorescence(XRF)photons can be used for precisely discriminating the specified element.The detection accuracy of conventional XRF methodology using semiconductor detector is limited by the energy resolution,thus posing a challenge in accurately scaling the actual energy of each XRF photon.We adopt a novel high-resolution x-ray spectrometer based on the superconducting transition-edge sensor(TES)for the XRF spectroscopy measurement of different elements.Properties including high energy resolution,high detection efficiency and precise linearity of the new spectrometer will bring significant benefits in analyzing elemental composition via XRF.In this paper,we study the Ledge emission line profiles of three adjacent rare earth elements with the evenly mixed sample of their oxide components:terbium,dysprosium and holmium.Two orders of magnitude better energy resolution are obtained compared to a commercial silicon drift detector.With this TES-based spectrometer,the spectral lines overlapped or interfered by background can be clearly distinguished,thus making the chemical component analysis more accurate and quantitative.A database of coefficient values for the line strength of the spectrum can then be constructed thereafter.Equipped with the novel XRF spectrometer and an established coefficient database,a direct analysis of the composition proportion of a certain element in an unknown sample can be achieved with high accuracy.

Analysis of Effective Composition of Hippophae Rhamnoides L.

The vitamin E, proteins, amino acids, sugar, trace elements and fatty acids in the oil of Hippophae Rhamnoides L. seeds were quantitatively analyzed. Several methods for analyzing vitamin E were compared with each other and the content of gossypol in the oil was first determined.

Using compositional data analysis to explore accumulation of sedentary behavior,physical activity and youth health

Purpose:The study aimed to describe youth time-use compositions,focusing on time spent in shorter and longer bouts of sedentary behavior and physical activity(PA),and to examine associations of these time-use compositions with cardiometabolic biomarkers.Methods:Accelerometer and cardiometabolic biomarker data from 2 Australian studies involving youths 7-13 years old were pooled(complete cases with accelerometry and adiposity marker data,n=782).A 9-component time-use composition was formed using compositional data analysis:time in shorter and longer bouts of sedentary behavior;time in shorter and longer bouts of light-,moderate-,or vigorous-intensity PA;and"other time"(i.e.,non-wear/sleep).Shorter and longer bouts of sedentary time were defined as<5 min and>5 min,respectively.Shorter bouts of light-,moderate-,and vigorous-intensity PA were defined as<1 min;longer bouts were defined as≥1 min.Regression models examined associations between overall time-use composition and cardiometabolic biomarkers.Then,associations were derived between ratios of longer activity patterns relative to shorter activity patterns,and of each intensity level relative to the other intensity levels and"other time",and cardiometabolic biomarkers.Results:Confounder-adjusted models showed that the overall time-use composition was associated with adiposity,blood pressure,lipids,and the summary score.Specifically,more time in longer bouts of light-intensity PA relative to shorter bouts of light-intensity PA was significantly associated with greater body mass index z-score(zBMI)(β=1.79;SE=0.68)and waist circumference(β=18.35,SE=4.78).When each activity intensity was considered relative to all higher intensities and"other time",more time in light-and vigorous-intensity PA,and less time in sedentary behavior and moderate-intensity PA,were associated with lower waist circumference.Conclusion:Accumulating PA,particularly light-intensity PA,in frequent short bursts may be more beneficial for limiting adiposity compared to accumulating the same amount of PA at these intensities in longer bouts.

Application of Three Registers of FSG to Analyze Students' Compositions

During the process of checking one of the students' composition,the author applies the field,tenor,and mode of FSC to analyze the writing in a broader way than before,which gives an enlightenment to teaching writing and assisting students in a new angle.

Development of a Laboratory Cement Quality Analysis Apparatus Based on Laser-Induced Breakdown Spectroscopy

Determination of the chemical composition of cement and ratio values of clinker plays an important role in cement plants as part of the optimal process control and product quality evaluation. In the present paper, a laboratory laser-induced breakdown spectroscopy （LIBS） apparatus mainly comprising a sealed optical module and an analysis chamber has been designed for possible application in cement plants for on-site quality analysis of cement. Emphasis is placed on the structure and operation of the LIBS apparatus, the sealed optical path, the temperature controlled spectrometer, the sample holder, the proper calibration model established for minimizing the matrix effects, and a correction method proposed for overcoming the ＇drift＇ obstacle. Good agreement has been found between the laboratory measurement results from the LIBS method and those from the traditional method. The absolute measurement errors presented here for oxides analysis are within 0.5%, while those of ratio values are in the range of 0.02 to 0.05. According to the obtained results, this laboratory LIBS apparatus is capable of performing reliable and accurate, composition and proximate analysis of cement and is suitable for application in cement plants.

Impacts of climate change and human activities on vegetation dynamics on the Mongolian Plateau, East Asia from 2000 to 2023

The Mongolian Plateau in East Asia is one of the largest contingent arid and semi-arid areas of the world.Under the impacts of climate change and human activities,desertification is becoming increasingly severe on the Mongolian Plateau.Understanding the vegetation dynamics in this region can better characterize its ecological changes.In this study,based on Moderate Resolution Imaging Spectroradiometer(MODIS)images,we calculated the kernel normalized difference vegetation index(kNDVI)on the Mongolian Plateau from 2000 to 2023,and analyzed the changes in kNDVI using the Theil-Sen median trend analysis and Mann-Kendall significance test.We further investigated the impact of climate change on kNDVI change using partial correlation analysis and composite correlation analysis,and quantified the effects of climate change and human activities on kNDVI change by residual analysis.The results showed that kNDVI on the Mongolian Plateau was increasing overall,and the vegetation recovery area in the southern region was significantly larger than that in the northern region.About 50.99%of the plateau showed dominant climate-driven effects of temperature,precipitation,and wind speed on kNDVI change.Residual analysis showed that climate change and human activities together contributed to 94.79%of the areas with vegetation improvement.Appropriate human activities promoted the recovery of local vegetation,and climate change inhibited vegetation growth in the northern part of the Mongolian Plateau.This study provides scientific data for understanding the regional ecological environment status and future changes and developing effective ecological protection measures on the Mongolian Plateau.

COMPOSITE ANALYSIS OF SUMMER MONSOON ONSET PROCESS OVER SOUTH CHINA SEA

Based on the method of composite analysis, the onset process and preceding signs of summer monsoon over the South China Sea (SCS) is investigated. The result indicates that convection activities appear first over the Indo-China Peninsula prior to the onset of the monsoon, then around the Philippines just at the point of onset, implying that the convection activities around the Philippines serve as one of the reasons leading to the SCS monsoon onset. Before the SCS monsoon onset, the equatorial westerly over the Indian Ocean (75(E ～ 95(E ) experiences noticeable enhancement and plays an important role on the SCS monsoon onset. It propagates eastward rapidly and causes the establishment and strengthening of equatorial westerly in the southern SCS, on the one hand, it results in the migration southward of the westerly on south side of the south-China stationary front by means of shift northeastward of the westerly and convection over the Bay of Bengal, on the other. Further study also shows that the intensification of equatorial westerly in the Indian Ocean (75(E ～ 95(E) and the southern SCS is closely related to the reinforcement of the Southern-Hemisphere Mascarene high and Australian high, and cross-equatorial flow northward around Somali, at 85(E and 105(E, respectively.

COMPARATIVE ANALYSIS OF THE INTENSIFYING AND WEAKENING LANDFALL TROPICAL CYCLONES DURING EXTRATROPICAL TRANSITION OVER CHINA

Based on the Tropical Cyclone(TC) Yearbooks data and JRA-25 reanalysis data from the Japan Meteorological Agency(JMA) during 1979-2008, dynamic composite analysis and computation of kinetic energy budget are used to study the intensifying and weakening TCs during Extratropical Transition over China. The TCI shows strong upper-level divergence, strengthened low-level convergence and significantly enhanced upward motion under the influence of strong upper-level troughs and high-level jets. The TCI is correspondingly intensified after Extratropical Transition(ET); TCW exhibits strong upper-level divergence, subdued low-level convergence and slightly enhanced upward motion under the influence of weak upper-level troughs and high-level jets. It then weakens after ET. The increase(decrease) of the generation of kinetic energy by divergence wind in TCI(TCW) at low level is one of the major reasons for TCI's intensification(TCW's weakening) after transformation. The generation of kinetic energy by divergence wind is closely related to the development of a low-level baroclinic frontal zone. The growth of the generation of kinetic energy by rotational wind in TCI at upper level is favorable for TCI's maintenance, which is affected by strong upper-level troughs. The dissipation of the generation of kinetic energy by rotational wind in TCW at upper level is unfavorable for TCW's maintenance, which is affected by weak upper-level troughs.

STRUCTURE FEATURES AND COMPOSITE ANALYSIS OF CONVECTIVE CELLS IN A WARM SECTOR HEAVY RAINFALL EVENT OVER SOUTHERN CHINA

This paper uses the ARW-WRF model to carry out a numerical simulation of a warm-sector heavy rainfall event over southern China on the 22-23 May, 2014. A composite analysis method was used to analyze the evolution process and structural features of the convective cells on a convection line during this rainfall event. This analysis identified three stages:(1) Stage of activation: the equivalent potential temperature surfaces as lower layers start to bulge and form warm cells and weak vertical convective cloud towers which are subject to the impact of low-level warm moist updrafts in the rainfall sector;(2) Stage of development: the warm cells continue to bulge and form warm air columns and the convective cloud towers develop upwards becoming stronger as they rise;(3) Stage of maturity: the warm air columns start to connect with the stable layer in the upper air; the convective cloud tower will bend and tilt westward with each increasing in height, and the convection cell is characterized by a "crescent-shaped echo" above the 700 h Pa plane. During this stage the internal temperature of the cell is higher than the ambient temperature and the dynamic structural field is manifested as intensive vertical upward movement. The large-value centers of the northerly and westerly winds in the middle layer correspond to the warm moist center in the cells and the relatively cold center south of the warm air column. Further analysis shows that the formation of the "crescent-shaped" convective cell is associated with horizontal vorticity. Horizontal vorticity in the center and west of the warm cell experiences stronger cyclonic and anticyclonic shear transformation over time; this not only causes the original suborbicular cell echo shape to develop into a crescent-like shape, but also makes a convection line consisting of cells that develop to the northwest.

Prescription analysis of traditional chinese medicine for COVID-19treatment

Background:Coronavirus disease 2019 is still spreading all over the world and without any specific medicine.Traditional Chinese medicine has played an important role in the control of epidemics in China and accumulated many experiences.The aim of this study is to summarize the law of traditional Chinese medicine and provide reference for coronavirus disease 2019 traditional Chinese medicine treatment.Methods:We collected the treatment plans of traditional Chinese medicine for coronavirus disease 2019 in 24 provinces of China to evaluate the basic Chinese medicine formulas,and the efficacy types,frequency,“Four Characters”,“Five Tastes”,“Channel Tropism”of herbal medicines.Combination rules between medicines were calculated by Apriori algorithm and Clementine12.0.Results:The formulas for“Relieving Exterior Syndrome”,“Expelling Dampness”,“Clearing Heat”and“Supplementing”have highest proportion.In prevention period and medical observation period,the medicines mainly have effect for“Clearing Heat”,“Relieving Exterior Syndrome”and“Supplementing”.In treatment period,medicines for“Clearing Heat”,“Relieving Superficies”and“Relieving Dampness”had higher frequency.The“Four Characters”of Chinese medicines in all treatment plans were mainly“Cold”and“Warm”.Medicines in the treatment plans always belong to“Pungent Taste”,“Bitter Taste”and“Sweet Taste”.For“Channel Tropism”,most medicines turned over to the“Lung”,“Stoma”and“Spleen”.The common medicine combinations in the recommended formulas during the prevention period and medical observation period were medicines for“Qi-Supplementing”and“Relieving Superficies”.In treatment period(mild,moderate,severe/critical),medicines for“Dampness Expelling”,“Relieving Superficies”and“Qi-Supplementing”were combined in a high frequency.In recovery period,the medicines for“Dispelling Dampness”combined the medicines for“Promoting Blood Circulation”with highest frequency.Conclusions:We found the characteristics of medicine and prescription rules of traditional Chinese medicine for the treatment of coronavirus disease 2019 and provided scientificity and effectiveness of it.More importantly,it provides reference for the development of new clinical prescriptions for coronavirus disease 2019.

Analysis of Solidification in Spray Atomized and Codeposited Metal-matrix Composites Part Ⅱ:Reinforcement Injection and Deposition

The influence of the injection of reinforcing particles (for the production of metal matrix composites and of the droplets-to-substrate heat transfer on the resulting microstructural uniformity of spray atomized and codeposited composite material is analyzed. The reinforcement particles injection velocity has to be limited between an upper and a lower critical values. in order to ensure entrapment into the matrix droplets in flight. The thermal history of the injected droplets during the deposition stage is calculated with the assumption that the in-flight solidifying droplets reach the substrate while containing still at least 20% liquid volume fraction, in order to avoid porosity of the deposited material. The substrate to pouring-tube orifice distance where that condition is achieved depends strongly on the atomization pressure and the convective heat transfer coefficient of the substrate. It is demonstrated that 'tailoring' the microstructures and the reinforcement volume percent in the deposited material is feasible. The critical process parameters : the atomization pressure, the melt flow rate. the substrate to pouring-tube orifice distance, the reinforcement particles injection location and rate can all be adequately chosen in order to obtain any desired microstructure, grain size, reinforcement volume percent, with the additional benefit, if wanted, of rapid solidification processing

CAUSATION ANALYSIS OF THE DIRECT CLIMATE EFFECTS OF ANTHROPOGENIC AEROSOL ON EAST-ASIAN SUMMER MONSOON

A regional climate model coupled with an aerosol model is employed to numerically simulate the direct climate effects of the anthropogenic aerosol emitted in South Asia and China in the East Asian summer monsoon during1988 to 2009.Based on the data of the numerical simulation,composite analysis and correlation analysis are used to make diagnostic study of climate dynamics.Results show that the month of maximum emission of the mean column burden of the anthropogenic aerosol in the main emission areas of South Asia is opposite in phase to that in China.Summer is the season of maximum emission amount in China,but the emission amounts are more in South Asia in spring and winter.On the whole,the mean column burden of the anthropogenic aerosol in China is relatively high compared with that in South Asia.The trend of distribution of aerosol is SW-NE in China,and Sichuan Basin is the emission center of aerosol.The effect of negative short wave radiative forcing alters the gradient of pressure between land and sea,weakening the development of East Asian summer monsoon over the northern part of Yangtze-Huaihe River Basin.We also discuss the feedback effect of East-Asian summer monsoon which is changed by the anthropogenic aerosol on the concentration and distribution of aerosol in China.

ANALYSIS OF STRUCTURE EVOLUTION AND ENVIRONMENTAL CONDITIONS OF TROPICAL CYCLONES OVER THE WESTERN NORTH PACIFIC DURING EXTRATROPICAL TRANSITION

Fifty-eight extratropical transition(ET) cases in the years 2000-2008, including 2,021 observations(at 6-hour intervals), over the western North Pacific are analyzed using the cyclone phase space(CPS) method, in an effort to get the characteristics of the structure evolution and environmental conditions of tropical cyclones(TCs) during ET over this area. Cluster analysis of the CPS dataset shows that strong TCs are more likely to undergo ET. ET begins with the increment of thermal asymmetry in TCs, along with the generation and intensification of an upper-level cold core, and ends with the occurrence of a lower-level cold core. ET lasts an average duration of about 28 hours. Dynamic composite analysis of the environmental field of different clusters shows that, in general, when TCs move northward,they are gradually embedded in the westerlies and gradually transform into extratropical cyclones under the influence of the mid-and higher-latitude baroclinic systems. As for those TCs which complete ET, there is always much greater potential vorticity gradient in the northwest of them and obvious water vapor transport channels in the environment.

Sea Breeze Front Storm and Its Composite Analysis in Beibu Gulf

[Objective] The aim was to study the sea breeze front storm and its composite analysis in Beibu Gulf. [Method] By dint of routine observation data, ground automatic meteorology data and European numerical mode grid data, rainstorm caused by sea breeze in Guangxi during 1990 and 2007 and the strong convection triggered by sea breeze on June 5 in 2008 were expounded. The main characteristics of the configuration of circulation in the low and high latitude of breeze front of middle scale were summarized. [Result] Sea breeze front storm system was an important middle scale sea breeze front system that triggered storm in the Beibu Gulf. Sea breeze in Beibu Gulf occurred most easily during the southwest monsoon eruption period. Case study pointed out that after sunrise, the continental and island temperature in Beibu Gulf turned from warm-ocean-cold-island into warm-island-cold-ocean. The southerly airstream of high temperature and high humidity met with the relatively low temperature and dry northerly airstream in Beibu Gulf, and triggered vertical circulation and stimulated ground middle scale sea breeze front system. Composite analysis referred to the circulation characteristics of the ocean and continental temperature in Beibu Gulf. The upper air of south China was in strong divergence center. The air pressure was high in the east and low in the west. Beibu Gulf was in the southerly torrent belt in front of the trough and after the latitude in cyclonic circulation convergence area. The strata unstable structure of the divergence in the upper air and the convergence in the lower layer and the 'pumping effect' provided upward dynamics for the ocean circulation development. The southerly brought rich water vapor to the Beibu Gulf, which was conductive to the formation of strong convective cloud system in the lower layer and the generation of precipitation. [Conclusion] The research provided references for the study on the characteristics of middle scale convective system.

Analysis of Solidification in Spray Atomized and Codeposited Metal-matrix Composites Part Ⅰ: Atomization

Fluid mechanics, heat transfer and liquid-to-solid phase transformation are assessed in optimizing the spray atomization and codeposition process parameters for size refinement and microstructural uniformity of the deposited material. Atomization gas velocities, atomized droplets velocities, convective heat transfer coefficients, thermal histories of the solidifying droplets, freezing rates, fraction solid evolution and solid-liquid interface propagation velocity are calculated. The influence, on the deposit microstructural features, of process parameters like the atomization gas pressure, the pouring tube orifice diameter, the geometrical features of the atomization device,the potency of , pre-existing or injected as reinforcement, nucleation sites, the wetting angle between the liquid melt bnd impurity particles acting as preferred nucleation sites, the in-flight distance of the solidifying droplets in the atomization chamber, i5 evaluated. As a result of the evaluation, appropriate choice of the adjustable process parameters for the production of powders and/or deposits with desired grain size and microstructure, can be made.

The finite element analysis of articular cartilage fiber-reinforced composite model under rolling load

Articular cartilage is a layer of low-friction,load-bearing soft hydrated tissue covering bone-ends in diarthrosis,which plays an important role in spreading the load,reducing the joint contact stress,joint friction and wear during exercise.The vital mechanical function