In this work,we have reported the synthesis and spectroscopic characterization of captopril(Cap)coordination compounds:Cu(Cap)·2H 2O,Cr(Cap)·H 2O,Zn(Cap)·3H 2O and Mg(Cap)4.Herein,it is worthily mention...In this work,we have reported the synthesis and spectroscopic characterization of captopril(Cap)coordination compounds:Cu(Cap)·2H 2O,Cr(Cap)·H 2O,Zn(Cap)·3H 2O and Mg(Cap)4.Herein,it is worthily mentioned that the FTIR spectroscopic technique was employed to recognized the nature of coordination between captopril ligand and copper,chromium,zinc and magnesium(Ⅱ)metal ions.In view of the infrared spectroscopic tool,the copper(Ⅱ)metal ion coordinated toward captopril drug ligand through sulfur atom of SH group dependent on the absent of stretching vibration band of—SH.Based on this result,the stretching motion ofνa(COO)shifts clearly indicates that Cu 2+,Cr 2+,Zn 2+and Mg 2+the carboxylic group is employed as coordinative site for all compounds as a metal-ligand coordinative bond.As a general behavior,it is verified that the coordination compound thermal stability(considering the release of captopril molecules,not the release of water molecules)is affected by the metal cation radius:minor radius is associated with higher thermal stability,probably due to a higher metal-captopril bond dissociation enthalpy.展开更多
目的观察夏枯草汤联合卡托普利和二甲双胍治疗2型糖尿病合并高血压的临床疗效。方法选取2014年6月至2015年12月诊治的2型糖尿病合并高血压患者100例,随机分为对照组和观察组,每组50例。对照组给予卡托普利、二甲双胍治疗,观察组在对照...目的观察夏枯草汤联合卡托普利和二甲双胍治疗2型糖尿病合并高血压的临床疗效。方法选取2014年6月至2015年12月诊治的2型糖尿病合并高血压患者100例,随机分为对照组和观察组,每组50例。对照组给予卡托普利、二甲双胍治疗,观察组在对照组基础上加用夏枯草汤治疗,疗程3个月。比较2组降压效果、收缩压(SBP)、舒张压(DBP)、血压晨峰控制效果、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、血肌酐(Scr)、尿素氮(BUN)、尿微量清蛋白排泄率(UAER)、不良反应及血管并发症发生情况、SF-36心理、生理状态评分。结果对照组和观察组总有效率分别为74.00%和94.00%,差异有统计学意义(P<0.05)。与对照组比较,观察组SBP、DBP、血压晨峰控制有效率、FBG、2 h PBG、Scr、BUN、UAER、不良反应及血管并发症发生率显著降低,SF-36心理、生理状态显著升高,差异有统计学意义(P<0.05)。结论夏枯草汤联合卡托普利、二甲双胍治疗2型糖尿病合并高血压疗效良好,能够明显降低患者血压、血糖及血管并发症发生率,并有效改善患者肾功能,且安全性高。展开更多
基金The Deanship of Scientific Research at Princess Nourah bint Abdulrahman University,through the Research Groups Program Grant no.(RGP-1440-0003)
文摘In this work,we have reported the synthesis and spectroscopic characterization of captopril(Cap)coordination compounds:Cu(Cap)·2H 2O,Cr(Cap)·H 2O,Zn(Cap)·3H 2O and Mg(Cap)4.Herein,it is worthily mentioned that the FTIR spectroscopic technique was employed to recognized the nature of coordination between captopril ligand and copper,chromium,zinc and magnesium(Ⅱ)metal ions.In view of the infrared spectroscopic tool,the copper(Ⅱ)metal ion coordinated toward captopril drug ligand through sulfur atom of SH group dependent on the absent of stretching vibration band of—SH.Based on this result,the stretching motion ofνa(COO)shifts clearly indicates that Cu 2+,Cr 2+,Zn 2+and Mg 2+the carboxylic group is employed as coordinative site for all compounds as a metal-ligand coordinative bond.As a general behavior,it is verified that the coordination compound thermal stability(considering the release of captopril molecules,not the release of water molecules)is affected by the metal cation radius:minor radius is associated with higher thermal stability,probably due to a higher metal-captopril bond dissociation enthalpy.
文摘目的观察夏枯草汤联合卡托普利和二甲双胍治疗2型糖尿病合并高血压的临床疗效。方法选取2014年6月至2015年12月诊治的2型糖尿病合并高血压患者100例,随机分为对照组和观察组,每组50例。对照组给予卡托普利、二甲双胍治疗,观察组在对照组基础上加用夏枯草汤治疗,疗程3个月。比较2组降压效果、收缩压(SBP)、舒张压(DBP)、血压晨峰控制效果、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、血肌酐(Scr)、尿素氮(BUN)、尿微量清蛋白排泄率(UAER)、不良反应及血管并发症发生情况、SF-36心理、生理状态评分。结果对照组和观察组总有效率分别为74.00%和94.00%,差异有统计学意义(P<0.05)。与对照组比较,观察组SBP、DBP、血压晨峰控制有效率、FBG、2 h PBG、Scr、BUN、UAER、不良反应及血管并发症发生率显著降低,SF-36心理、生理状态显著升高,差异有统计学意义(P<0.05)。结论夏枯草汤联合卡托普利、二甲双胍治疗2型糖尿病合并高血压疗效良好,能够明显降低患者血压、血糖及血管并发症发生率,并有效改善患者肾功能,且安全性高。
