Objective: To observe the clinical effect of Rebixiao granule (热痹消颗粒剂, RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXG's therape...Objective: To observe the clinical effect of Rebixiao granule (热痹消颗粒剂, RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXG's therapeutic mechanism. Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group ( n =60) and control group ( n =30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest, low purine diet, sufficient water drinking and urine alkalization, etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models. Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won, insignificant difference ( P >0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group was 10.0%, with significant difference ( P <0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different ( P <0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice. Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects, proving to be superior to single drugs.展开更多
The World Meteorological Organization estimates that about 90 percent of all natural disasters is extreme meteorological hazards like typhoon/hurricane and tropical cyclone triggered disasters. With the increasing ten...The World Meteorological Organization estimates that about 90 percent of all natural disasters is extreme meteorological hazards like typhoon/hurricane and tropical cyclone triggered disasters. With the increasing tendency of natural hazards, the typhoon induced surge, wave, precipitation, flood and wind as extreme external loads menacing Nuclear Power Plants (NPP) in coastal and inland provinces of China. For all of the planned, designed and constructed NPP in China the National Nuclear Safety Administration of China and IAEA recommended Probable Maximum Hurricane/ Typhoon/(PMH/T), Probable Maximum Storm Surge (PMSS), Probable Maximum Flood (PMF), Design Basis Flood (DBF) as safety regulations recommended for NPP defense infrastructures. This paper discusses the joint probability analysis of simultaneous occurrence typhoon induced extreme external hazards and compared with IAEA 2003-2011 recommended safety regulations for some NPP along China coast to make safety assessment based on the “As Low As Reasonable Practice” (ALARP) principle.展开更多
Microsoft Office是使用最为广泛的办公软件,Office文件的安全性主要是通过对Office文件进行加密来实现的。尽管自Office97发布以来,Microsoft公司对Office办公软件的文件加密功能进行了不断改进,但是,Office加密文件的安全性仍然难以...Microsoft Office是使用最为广泛的办公软件,Office文件的安全性主要是通过对Office文件进行加密来实现的。尽管自Office97发布以来,Microsoft公司对Office办公软件的文件加密功能进行了不断改进,但是,Office加密文件的安全性仍然难以保证。通过对Office文件加/解密过程进行分析,提出了存在的攻击,同时分析了各版本Office所采用的具体加/解密算法,设计了破解实验,得出了实验测试数据,并以时间代价为指标,对Office加密文件是否安全进行了详细的论证。展开更多
基金Supported by Project of Science and Technology Commis sion Foundation of Jiangsu Province in 1998
文摘Objective: To observe the clinical effect of Rebixiao granule (热痹消颗粒剂, RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXG's therapeutic mechanism. Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group ( n =60) and control group ( n =30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest, low purine diet, sufficient water drinking and urine alkalization, etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models. Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won, insignificant difference ( P >0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group was 10.0%, with significant difference ( P <0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different ( P <0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice. Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects, proving to be superior to single drugs.
文摘The World Meteorological Organization estimates that about 90 percent of all natural disasters is extreme meteorological hazards like typhoon/hurricane and tropical cyclone triggered disasters. With the increasing tendency of natural hazards, the typhoon induced surge, wave, precipitation, flood and wind as extreme external loads menacing Nuclear Power Plants (NPP) in coastal and inland provinces of China. For all of the planned, designed and constructed NPP in China the National Nuclear Safety Administration of China and IAEA recommended Probable Maximum Hurricane/ Typhoon/(PMH/T), Probable Maximum Storm Surge (PMSS), Probable Maximum Flood (PMF), Design Basis Flood (DBF) as safety regulations recommended for NPP defense infrastructures. This paper discusses the joint probability analysis of simultaneous occurrence typhoon induced extreme external hazards and compared with IAEA 2003-2011 recommended safety regulations for some NPP along China coast to make safety assessment based on the “As Low As Reasonable Practice” (ALARP) principle.
