Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer＇s disease, and brain network-connection strength, networ...Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer＇s disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations （nor- mal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer＇s disease） using the Alzheimer＇s Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer＇s disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the rest- ing-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addi- tion, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and AIz- heimer＇s disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.展开更多
Based on the partition function in statistical thermodynamics, atomic partit ion parameter fi =lg[(ni－1)0.5·Ar,i] is introduced in this paper. The fi has demonstrated good unitarity for all the ground state ato ...Based on the partition function in statistical thermodynamics, atomic partit ion parameter fi =lg[(ni－1)0.5·Ar,i] is introduced in this paper. The fi has demonstrated good unitarity for all the ground state ato ms, and excellent correlativity with the standard entropies (,J·mol－1·K －1) of 70 cations in solid compounds: = －10.247＋27.508 fi , r=0.996. A satisfactory curve equation is developed as follows: =6.229＋13.257 fi1.5, r= 0.999. On the basis of adjacency matrices and fi , a novel partition connectivit y index is developed for the study on the standard entropies of 64 S block compo unds. The linear regression equation is set up by the least square method: =－3 9.416＋33.9610H, r=0.985. The binary linear equation among and 0H, nM (princip al quantum number of the ground state atoms for S block) is drawn up: =－21.591 ＋32.0720H－31.013nM－1, R=0.990. The calculated values of basically tally w ith the experiment values. fi and 0H demonstrate that the method possesses the a dvantage of easy computation and clear physical significance.展开更多
目的基于扫描仪和STFI-Mottling Expert斑纹测试软件,提出一种使用改进型变异系数Mod Co V表征纸张印刷墨斑的新方法。方法纸张表面的印刷墨斑图像通过扫描仪获取,再经过软件分析,从数字图像处理的角度研究印刷斑纹;实验选用新闻纸、双...目的基于扫描仪和STFI-Mottling Expert斑纹测试软件,提出一种使用改进型变异系数Mod Co V表征纸张印刷墨斑的新方法。方法纸张表面的印刷墨斑图像通过扫描仪获取,再经过软件分析,从数字图像处理的角度研究印刷斑纹;实验选用新闻纸、双胶纸、铜版纸和喷墨纸等4种纸张,分析不同波长范围和不同方向的印刷墨斑情况。结果使用改进型变异系数Mod Co V表征印刷墨斑,其视觉判定的相关性比使用变异系数Co V表征印刷墨斑的传统方法更好,在研究不同波长的墨斑水平和墨斑取向问题方面也表现出一定的优越性。结论该方法操作简单,能更加客观地对印刷墨斑进行度量,更加方便地解决印刷墨斑所引起的问题,提高了印品质量。展开更多
用MicroSoft SQL Server 2000建立了化合物性能数据库,采用微软公司“.NET”平台下的ASP.NET(Active Server Pages.Net)技术、C#编程语言和当前最先进的B/S(浏览器/服务器)体系架构,构建了基于网络的化合物性能数据库智能管理系统。本...用MicroSoft SQL Server 2000建立了化合物性能数据库,采用微软公司“.NET”平台下的ASP.NET(Active Server Pages.Net)技术、C#编程语言和当前最先进的B/S(浏览器/服务器)体系架构,构建了基于网络的化合物性能数据库智能管理系统。本系统集数据智能管理与销售于一身,化合物性能数据齐全,查询快速方便,无须经过软件安装,在全国或世界各地只要能够上网即可使用本软件系统,并且提供了功能强大的化合物数据查询、动态排序、多种方式打印查询结果等。展开更多
基金sponsored by the National Natural Science Foundation of China,No.61070077,61170136,61373101the Natural Science Foundation of Shanxi Province,No.2011011015-4Beijing Postdoctoral Science Foundation,No.Q6002020201201
文摘Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer＇s disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations （nor- mal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer＇s disease） using the Alzheimer＇s Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer＇s disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the rest- ing-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addi- tion, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and AIz- heimer＇s disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.
文摘Based on the partition function in statistical thermodynamics, atomic partit ion parameter fi =lg[(ni－1)0.5·Ar,i] is introduced in this paper. The fi has demonstrated good unitarity for all the ground state ato ms, and excellent correlativity with the standard entropies (,J·mol－1·K －1) of 70 cations in solid compounds: = －10.247＋27.508 fi , r=0.996. A satisfactory curve equation is developed as follows: =6.229＋13.257 fi1.5, r= 0.999. On the basis of adjacency matrices and fi , a novel partition connectivit y index is developed for the study on the standard entropies of 64 S block compo unds. The linear regression equation is set up by the least square method: =－3 9.416＋33.9610H, r=0.985. The binary linear equation among and 0H, nM (princip al quantum number of the ground state atoms for S block) is drawn up: =－21.591 ＋32.0720H－31.013nM－1, R=0.990. The calculated values of basically tally w ith the experiment values. fi and 0H demonstrate that the method possesses the a dvantage of easy computation and clear physical significance.
文摘目的基于扫描仪和STFI-Mottling Expert斑纹测试软件,提出一种使用改进型变异系数Mod Co V表征纸张印刷墨斑的新方法。方法纸张表面的印刷墨斑图像通过扫描仪获取,再经过软件分析,从数字图像处理的角度研究印刷斑纹;实验选用新闻纸、双胶纸、铜版纸和喷墨纸等4种纸张,分析不同波长范围和不同方向的印刷墨斑情况。结果使用改进型变异系数Mod Co V表征印刷墨斑,其视觉判定的相关性比使用变异系数Co V表征印刷墨斑的传统方法更好,在研究不同波长的墨斑水平和墨斑取向问题方面也表现出一定的优越性。结论该方法操作简单,能更加客观地对印刷墨斑进行度量,更加方便地解决印刷墨斑所引起的问题,提高了印品质量。
文摘用MicroSoft SQL Server 2000建立了化合物性能数据库,采用微软公司“.NET”平台下的ASP.NET(Active Server Pages.Net)技术、C#编程语言和当前最先进的B/S(浏览器/服务器)体系架构,构建了基于网络的化合物性能数据库智能管理系统。本系统集数据智能管理与销售于一身,化合物性能数据齐全,查询快速方便,无须经过软件安装,在全国或世界各地只要能够上网即可使用本软件系统,并且提供了功能强大的化合物数据查询、动态排序、多种方式打印查询结果等。
