Objective:To study the effect of Compound Biejiaruangan Tablets combined with entecavir therapy on liver fibrosis process and immune response state in patients with chronic hepatitis b.Methods: Patients with chronic v...Objective:To study the effect of Compound Biejiaruangan Tablets combined with entecavir therapy on liver fibrosis process and immune response state in patients with chronic hepatitis b.Methods: Patients with chronic viral hepatitis b who were treated in the Affiliated Hospital of Inner Mongolia Medical University between May 2015 and March 2017 were selected as the research subjects and divided into the combined group who accepted Compound Biejiaruangan Tablets combined with entecavir therapy and the control group who accepted entecavir monotherapy. The contents of collagen metabolism indexes and inflammatory response molecules in serum as well as the contents of immune cells in peripheral blood were determined before treatment and 24 weeks after treatment.Results: 24 weeks after treatment, PC-III, C-IV, MMP1, MMP2, TIMP1, IL-1β, IL-18, MIF, RANTES, MIP-1 and MIP-1β contents in serum as well as Th2, Treg and Th17 contents in peripheral blood of both groups of patients were significantly lower than those before treatment whereas Th1 contents in peripheral blood were significantly higher than those before treatment, and PC-III, C-IV, MMP1, MMP2, TIMP1, IL-1β, IL-18, MIF, RANTES, MIP-1 and MIP-1β contents in serum as well as Th2, Treg and Th17 contents in peripheral blood of combined group of patients were significantly lower than those of control group whereas Th1 content in peripheral blood was significantly higher than that of control group.Conclusion: Compound Biejiaruangan Tablets combined with entecavir therapy can delay the liver fibrosis process and improve the immune response state in patients with chronic hepatitis b.展开更多
AIM A RP HPLC method was developed for the determination of nicotinamide and vitamin B 6 in compound vitamin B injection. METHODS The sample was analysed on C 18 column. The mobile phase is acetonitrile 0.01 mol/L Na ...AIM A RP HPLC method was developed for the determination of nicotinamide and vitamin B 6 in compound vitamin B injection. METHODS The sample was analysed on C 18 column. The mobile phase is acetonitrile 0.01 mol/L Na 2SO 4 solution (5∶95) adjusted at pH 3.4 by sulfate acid and the detective wavelength is 254 nm. RESULTS A good linearity can be found in the range of 4.26~24.36 μg/ml and 40.26~240.1 μg/ml. The recovery of nicotinamide and vitamin B 6 was 97.53%, 97.87% respectively and the RSD (%) was not more than 1.0. CONCLUSION The method was found to be simple, rapid and reproducible for determination of nicotinamide and vitamin B 6 in compound vitamin B injection.展开更多
文摘Objective:To study the effect of Compound Biejiaruangan Tablets combined with entecavir therapy on liver fibrosis process and immune response state in patients with chronic hepatitis b.Methods: Patients with chronic viral hepatitis b who were treated in the Affiliated Hospital of Inner Mongolia Medical University between May 2015 and March 2017 were selected as the research subjects and divided into the combined group who accepted Compound Biejiaruangan Tablets combined with entecavir therapy and the control group who accepted entecavir monotherapy. The contents of collagen metabolism indexes and inflammatory response molecules in serum as well as the contents of immune cells in peripheral blood were determined before treatment and 24 weeks after treatment.Results: 24 weeks after treatment, PC-III, C-IV, MMP1, MMP2, TIMP1, IL-1β, IL-18, MIF, RANTES, MIP-1 and MIP-1β contents in serum as well as Th2, Treg and Th17 contents in peripheral blood of both groups of patients were significantly lower than those before treatment whereas Th1 contents in peripheral blood were significantly higher than those before treatment, and PC-III, C-IV, MMP1, MMP2, TIMP1, IL-1β, IL-18, MIF, RANTES, MIP-1 and MIP-1β contents in serum as well as Th2, Treg and Th17 contents in peripheral blood of combined group of patients were significantly lower than those of control group whereas Th1 content in peripheral blood was significantly higher than that of control group.Conclusion: Compound Biejiaruangan Tablets combined with entecavir therapy can delay the liver fibrosis process and improve the immune response state in patients with chronic hepatitis b.
文摘AIM A RP HPLC method was developed for the determination of nicotinamide and vitamin B 6 in compound vitamin B injection. METHODS The sample was analysed on C 18 column. The mobile phase is acetonitrile 0.01 mol/L Na 2SO 4 solution (5∶95) adjusted at pH 3.4 by sulfate acid and the detective wavelength is 254 nm. RESULTS A good linearity can be found in the range of 4.26~24.36 μg/ml and 40.26~240.1 μg/ml. The recovery of nicotinamide and vitamin B 6 was 97.53%, 97.87% respectively and the RSD (%) was not more than 1.0. CONCLUSION The method was found to be simple, rapid and reproducible for determination of nicotinamide and vitamin B 6 in compound vitamin B injection.