Efficiency of Chalcone Compounds Inhibitors for Acid Corrosion of Al and Al-3.5Mg Alloy

Corrosion inhibition of Al and Al-3.5Mg alloy by organic compounds, namely chalcones in hydrochloric acid solutions has been investigated by rapid polarization technique and weight loss method. Polarization measurements show that, the inhibitors act cathodically both in case of Al and Al-3.5Mg alloy. It was found from the weight loss measurements that, the inhibition efficiency depends on the substituent in the chalcone compound. The relative inhibitive efficiency of these compounds has been explained on the basis of structure dependent electron donor properties of the inhibitors and the metal inhibitor interaction on the surface. The inhibition efficiency ranges from 16 to 64% for Al and from 30% to 91% for Al-3.5Mg alloy

Design, Synthesis and Biological Evaluation of Novel Selective Thiol-based Histone Deacetylase（HDAC） Ⅵ Inhibitors Bearing Indeno[1,2-c]pyrazole or Benzoindazole Scaffold

A series of thiol-based mdeno[1,2-c]pyrazoles and benzoindazole compounds was designed and synthesized according to the structural specificity of his-tone deacetylase VI（HDAC6） and the structural characteristics of HDAC inhibitors. The inhibitory activities of the target compounds against HDAC6 and HDAC1 were screened by fluorescence analysis. Most of the target compounds showed moderate inhibitory activity against HDAC6（IC50=44-598 nmol/L）. Among them, compound A-4 displayed the highest selectivity against HDAC6 and similar inhibitory activity（IC50=44 nmol/L） to that of the positive drug SAHA（IC50=41 nmol/L） against HDAC6.

NMR identification of anti-influenza lead compound targeting at PA_C subunit of H5N1 polymerase

PA_C subunit from avian influenza（H5N1） viral RNA polymerase was used in this work as a target in the screening for anti-influenza agents from licorice-derived compounds.As a result,18β-glycyrrhetinic acid was suggested to be PA_C ligand by flexible docking,and was then confirmed by relaxation-edited NMR.The result of ApG primer extension assay indicated that this PA_C ligand can inhibit the polymerase activity,and thus may potentially be valuable as anti-influenza lead compound.This work validated the possibility of screening polymerase inhibitors by using PA_C as a target,and provided a starting point for the further discovery of new anti-influenza drugs.