Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technologi...Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technological revolution and industrial transformation to higher education,cultivating top-notch innovative intellectuals with comprehensive engineering qualities,meeting the requirements of being able to solve complex engineering problems rather than just cognitive capabilities,forming two core courses through reconstructing and reshaping the core courses of the major.The core courses include Drive,Measurement,and Control I and Drive,Measurement,and Control II,which highlight the comprehensive framework of mechanical and electronic engineering professional knowledge,continuing the comprehensive practical course system based on the unity of knowledge and practice,following the trend of new engineering,highlighting the practicality of professional innovation,assisting engineering education reform,and promoting high-quality development of new engineering professionals cultivation.展开更多
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the d...Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes.展开更多
Previous studies have demonstrated that reactions to unfair offers in the ultimatum game are correlated with negative emotion. However, little is known about the difference in neural activity between a proposer's dec...Previous studies have demonstrated that reactions to unfair offers in the ultimatum game are correlated with negative emotion. However, little is known about the difference in neural activity between a proposer's decision-making in the ultimatum game compared with the dictator game. The present functional magnetic resonance imaging study revealed that proposing fair offers in the dictator game elicited greater activation in the right supramarginal gyrus, right medial frontal gyrus and left anterior cingulate cortex compared with proposing fair offers in the ultimatum game in 23 Chinese undergraduate and graduate students from Beijing Normal University in China. However, greater activation was found in the right superior temporal gyrus and left cingulate gyrus for the reverse contrast. "The results indicate that proposing fair offers in the dictator game is more strongly associated with cognitive control and conflicting information processing compared with proposing fair offers in the ultimatum game.展开更多
A neural network integrated classifier(NNIC) designed with a new modulation recognition algorithm based on the decision-making tree is proposed in this paper.Firstly,instantaneous parameters are extracted in the time ...A neural network integrated classifier(NNIC) designed with a new modulation recognition algorithm based on the decision-making tree is proposed in this paper.Firstly,instantaneous parameters are extracted in the time domain by the coordinated rotation digital computer(CORDIC) algorithm based on the extended convergence domain and feature parameters of frequency spectrum and power spectrum are extracted by the time-frequency analysis method.All pattern identification parameters are calculated under the I/Q orthogonal two-channel structure,and constructed into the feature vector set.Next,the classifier is designed according to the modulation pattern and recognition performance of the feature parameter set,the optimum threshold is selected for each feature parameter based on the decision-making mechanism in a single classifier,multi-source information fusion and modulation recognition are realized based on feature parameter judge process in the NNIC.Simulation results show NNIC is competent for all modulation recognitions,8 kinds of digital modulated signals are effectively identified,which shows the recognition rate and anti-interference capability at low SNR are improved greatly,the overall recognition rate can reach 100%when SNR is12dB.展开更多
The comprehensive benefit evaluation of the existing building energy efficient renovation project cannot be separated from the scientific and effective evaluation mechanism.Based on the value-added life perspective,th...The comprehensive benefit evaluation of the existing building energy efficient renovation project cannot be separated from the scientific and effective evaluation mechanism.Based on the value-added life perspective,this paper analyzes the implementation subject,standard,system and principle of the comprehensive benefit evaluation of the existing building energy efficient renovation project.It plans the process of comprehensive benefit evaluation,and builds a scientific and reasonable operation platform of evaluation system,with a view to promoting the effective implementation of the comprehensive benefit evaluation of existing building energy-saving retrofits.展开更多
For mankind’s survival and development,water,energy,and food(WEF)are essential material guarantees.In China,however,the spatial distribution of WEF is seriously unbalanced and mismatched.Here,a collaborative governan...For mankind’s survival and development,water,energy,and food(WEF)are essential material guarantees.In China,however,the spatial distribution of WEF is seriously unbalanced and mismatched.Here,a collaborative governance mechanism that aims at nexus security needs to be urgently established.In this paper,the Yellow River Basin in China with a representative WEF system,was selected as a case.Firstly,a comprehensive framework for WEF coupling coordination was constructed,and the relationship and mechanism between them were analyzed theoretically.Then,we investigated the spatiotemporal characteristics and driving mechanisms of the coupling coordination degree(CCD)with a composite evaluation method,coupling coordination degree model,spatial statistical analysis,and multiscale geographic weighted regression.Finally,policy implications were discussed to promote the coordinated development of the WEF system.The results showed that:1)WEF subsystems showed a significant imbalance of spatial pattern and diversity in temporal changes;2)the CCD for the WEF system varied little and remained at moderate coordination.Areas with moderate coordination have increased,while areas with superior coordination and mild disorder have decreased.In addition,the spatial clustering phenomenon of the CCD was significant and showed obvious characteristics of polarization;and 3)the action of each factor is self-differentiated and regionally variable.For different factors,GDP per capita was of particular importance,which contributed most to the regional development’s coupling coordination.For different regions,GDP per capita,average yearly precipitation,population density,and urbanization rate exhibited differences in geographical gradients in an east-west direction.The conclusion can provide references for regional resource allocation and sustainable development by enhancing WEF system utilization efficiency.展开更多
To solve the problem of excavation face dust control,the theory of dust removal after collection was put forward.Through a large number of theoretical and experimental researches,a new wind screen dust-collection syst...To solve the problem of excavation face dust control,the theory of dust removal after collection was put forward.Through a large number of theoretical and experimental researches,a new wind screen dust-collection system which was applied to comprehen- sive excavation face was developed.To set a wind dam in jet stream box,achieve the function of multi-stage and multiple-level regulation,lots of experimentation was carried out to obtain higher jet stream velocity with the minimum loss of energy.Experiments show that the slit width in the exports of wind screen dust-collection system should be 10 to 15 mm.For the general excavation roadway,after wind attenuation,the velocity can be greater than 3 m/s at the roof which meets the requirements of respirable dust control.展开更多
The human serotonin transporter(SERT)terminates neurotransmission by removing serotonin from the synaptic cleft,which is an essential process that plays an important role in depression.In addition to natural substrate...The human serotonin transporter(SERT)terminates neurotransmission by removing serotonin from the synaptic cleft,which is an essential process that plays an important role in depression.In addition to natural substrate serotonin,SERT is also the target of the abused drug cocaine and,clinically used antidepressants,escitalopram,and paroxetine.To date,few studies have attempted to investigate the unbinding mechanism underlying the orthosteric and allosteric modulation of SERT.In this article,the conserved property of the orthosteric and allosteric sites(S1 and S2)of SERT was revealed by combining the high resolutions of x-ray crystal structures and molecular dynamics(MD)simulations.The residues Tyr95 and Ser438 located within the S1 site,and Arg104 located within the S2 site in SERT illustrate conserved interactions(hydrogen bonds and hydrophobic interactions),as responses to selective serotonin reuptake inhibitors.Van der Waals interactions were keys to designing effective drugs inhibiting SERT and further,electrostatic interactions highlighted escitalopram as a potent antidepressant.We found that cocaine,escitalopram,and paroxetine,whether the S1 site or the S2 site,were more competitive.According to this potential of mean force(PMF)simulations,the new insights reveal the principles of competitive inhibitors that lengths of trails from central SERT to an opening were~18A for serotonin and~22 A for the above-mentioned three drugs.Furthermore,the distance between the natural substrate serotonin and cocaine(or escitalopram)at the allosteric site was~3A.Thus,it can be inferred that the potent antidepressants tended to bind at deeper positions of the S1 or the S2 site of SERT in comparison to the substrate.Continuing exploring the processes of unbinding four ligands against the two target pockets of SERT,this study observed a broad pathway in which serotonin,cocaine,escitalopram(at the S1 site),and paroxetine all were pulled out to an opening between MT1b and MT6a,which may be helpful to understand the dissociation mechanism of antidepressants.展开更多
To study the safety and stability of large slopes, taking the right side slope of the Yuxi’an tunnel of the Yuchu Expressway Bridge in Yunnan Province as an example, limit equilibrium and finite element analysis were...To study the safety and stability of large slopes, taking the right side slope of the Yuxi’an tunnel of the Yuchu Expressway Bridge in Yunnan Province as an example, limit equilibrium and finite element analysis were applied to engineering examples to calculate the stability coefficient of the slope before and after excavation in the natural state. After comparative analysis, it was concluded that the former had a clear mechanical model and concept, which could quickly provide stability results;the latter could accurately determine the sliding surface of the slope and simulate the stress state changes of the rock and soil mass. The stability coefficients calculated by the two methods were within the stable range, but their values were different. On this basis, combined with the calculation principles, advantages and disadvantages of the two methods, a comprehensive analysis method of slope stability based on the limit equilibrium and finite element methods was proposed, and the rationality of the stability coefficient calculated by this method was judged for a slope case.展开更多
The multi-energy complementary ecosystem is an important form of the modern energy system.However,standardized evaluation criteria and the corresponding method framework have not yet been formed,resulting in unclear s...The multi-energy complementary ecosystem is an important form of the modern energy system.However,standardized evaluation criteria and the corresponding method framework have not yet been formed,resulting in unclear standards and irregular processes of its construction.To cope with this issue,a novel comprehensive evaluation framework for multi-energy complementary ecosystems is proposed in this study.First,a 5D comprehensive evaluation criteria system,including environment,economy,technology,safety and systematicness,is constructed.Then,a novel multicriteria decision-making model integrating an analytic network process,entropy and preference-ranking organization method for enrichment evaluation under an intuitional fuzzy environment is proposed.Finally,four practical cases are used for model testing and empirical analysis.The results of the research show that the unit cost of the energy supply and the internal rate of return indexes have the highest weights of 0.142 and 0.010,respectively.It means that they are the focus in the construction of a multi-energy complementary ecosystem.The net flows of four cases are 0.015,0.123,-0.132 and-0.005,indicating that cases with a variety of energy supply forms and using intelligent management and control platforms to achieve cold,heat and electrical coupling have more advantages.展开更多
Land consolidation(LC) stands as a globally recognized strategy for rural development. In China, it has evolved towards comprehensive land consolidation(CLC) to support the rural revitalization initiative. However, th...Land consolidation(LC) stands as a globally recognized strategy for rural development. In China, it has evolved towards comprehensive land consolidation(CLC) to support the rural revitalization initiative. However, there are ongoing challenges in understanding CLC's specific pathway and mechanism, particularly its role in stimulating rural endogenous development. This study aims to investigate the localization process of international experiences, examine the pathway of CLC, and scrutinize its mechanism in rural development from a novel perspective of neo-endogenous development. Field research and semi-structured interviews were conducted in Nanzhanglou village, renowned for its early adoption of CLC practices inspired by German experiences since 1988. Overall, key findings underscore the advantages of CLC in spatial restructuring, industrial development, and human capital enhancement in rural areas. Additionally, international experiences emerge as crucial exogenous forces, primarily by knowledge embedding, which catalyzes rural neo-endogenous development via the “resource-engagement-identity-endogenous” mechanism. Collectively, by introducing a neo-endogenous theoretical framework, this study offers valuable insights into the CLC implementation in China and beyond, and emphasizes the positive impact of knowledge embedding as an exogenous force in promoting rural neo-endogenous development to address existing research gaps. Recommendations for sustainable rural development involve enhancing rural planning practicality, governance capacity, and local leadership, while prioritizing agricultural modernization and increasing investments in education and vocational training to ensure that villagers benefit from industrial development.展开更多
The reasonable model of fuzzy comprehensive judgment is found by means of the theory and method of multi-level fuzzy judgment on the basis of the judging index system of mechanical equipment bid sheets. The scientific...The reasonable model of fuzzy comprehensive judgment is found by means of the theory and method of multi-level fuzzy judgment on the basis of the judging index system of mechanical equipment bid sheets. The scientific method is supplied for the judging bids, the key chain of the judging process of the mechanical equipment bid sheet. All factors are considered, especially quantitative factors or qualitative factors in the process of judgment.展开更多
In recent years, end-to-end models have been widely used in the fields of machine comprehension (MC) and question answering (QA). Recurrent neural network (RNN) or convolutional neural network (CNN) is combined with a...In recent years, end-to-end models have been widely used in the fields of machine comprehension (MC) and question answering (QA). Recurrent neural network (RNN) or convolutional neural network (CNN) is combined with attention mechanism to construct models to improve their accuracy. However, a single attention mechanism does not fully express the meaning of the text. In this paper, recurrent neural network is replaced with the convolutional neural network to process the text, and a superimposed attention mechanism is proposed. The model was constructed by combining a convolutional neural network with a superimposed attention mechanism. It shows that good results are achieved on the Stanford question answering dataset (SQuAD).展开更多
Joint clearance,as an important stochastic factor,can significantly deteriorate positioning and repeatability accuracies and lower assembly quality of a 6-DOF docking mechanism.Considering pose accuracy with tradition...Joint clearance,as an important stochastic factor,can significantly deteriorate positioning and repeatability accuracies and lower assembly quality of a 6-DOF docking mechanism.Considering pose accuracy with traditional error model that possesses inherent imprecision,both probabilistic and deterministic approaches based on forward kinematics are presented to analyze comprehensive pose error(CPE)in simulation.Results indicate an identical trend emerges for each CPE with both approaches,and both CPEs perform opposite variations as the moving platform upgrades.The findings provide theoretical reference for refinement of assembly quality evaluation of this mechanism.展开更多
According to the modern theory of human resource management, the condition of buyout mainly depends on two variables of an employee: his interior value of product and exterior work reward. There exist shortages in eva...According to the modern theory of human resource management, the condition of buyout mainly depends on two variables of an employee: his interior value of product and exterior work reward. There exist shortages in evaluating the value of the employees in an enterprise. Consequently, a lot of employees might be laid off. Hence, this paper puts forward a two-stage method for decision-making to carry out a selective plan of buyout, based on the fuzzy synthetic evaluation involing many factors impacting on human resource. Moreover, a positive analysis is also given.展开更多
In order to perform better in target control, this paper proposed a decision-making system method based on fuzzy automata. The decision-making system first preprocessed the signal and then performed a two-level decisi...In order to perform better in target control, this paper proposed a decision-making system method based on fuzzy automata. The decision-making system first preprocessed the signal and then performed a two-level decision on the target to achieve optimal control. The system consisted of four parts: signal preprocessing, contrast decision-making, comprehensive judgment of decision-making and decision-making result. These decision algorithms in target control were given. A concrete application of this decision-making system in target control was described. Being compared with other existing methods, this paper used both global features and local features of target, and used the decision-making system of fuzzy automata for the target control. Simulation results showed that the control effect based on the decision-making system was better than that of the other existing methods. Not only it was faster, but also its correct control rate was higher to be 95.18% for the target control. This research on the control system not only developed the FA theory, but also strengthened its application scope in the field of control engineering.展开更多
Background: The integration of relevant high-quality research evidence into the health decision and policy formulation process is a key strategy for improving health systems especially in developing countries such as ...Background: The integration of relevant high-quality research evidence into the health decision and policy formulation process is a key strategy for improving health systems especially in developing countries such as Zambia. However, the lack of capacity to understand and value research evidence by policy and decision makers makes it difficult for them to find and use research evidence in a timely manner even when motivated to do so. This study aimed to establish the views, attitudes and practices of policy makers on the use of research evidence in policy and decision-making process in Zambia. Methodology: This descriptive cross-sectional study was conducted in Lusaka, Zambia among selected public health decision and policy making institutions. A purposive sample of 21 consenting policy makers who were working in different positions in the Ministry of Health Headquarters, Provincial and District Health Offices, Health Professions Regulatory Bodies, United Nations Agencies, International Non-Governmental Organizations and University Deans from the University of Zambia participated in the study. A self-administered questionnaire was used to collect data. The IBM? SPSS? Statistics for Windows Version 20.0 was used for data analysis. Results: The concept of Evidence Informed Health Policy was not well understood such that only less than half (47.5%) of the participants reported having heard specifically about Evidence Informed Health Policy meanwhile almost two thirds (61.9%) reported that they used research evidence in decision making and policy formulation. Similar discrepancy was expressed in the understanding of and use of rapid response mechanisms such that although (47.6%) of the participants reported having heard about it, (57%) had never used rapid response mechanisms for deci-sion-making. With regard to the sources of information, about half (52.3) of the participants reported scholarly articles as their main source of evidence. Con-clusion and Recommendations: There is need for more sensitization and ca-pacity building among the decision and policy makers on the importance of using research evidence in decision and policy making process as incorporation of relevant high-quality research evidence into the health policy making pro-cess is a key strategy for improving health systems.展开更多
The study manipulated semantic and syntactic variables to explore the cognitive neuroscience mechanisms of Chinese classifier construction"yi+N(CL)+N".It was indicated:First,the mismatch could be dissolved i...The study manipulated semantic and syntactic variables to explore the cognitive neuroscience mechanisms of Chinese classifier construction"yi+N(CL)+N".It was indicated:First,the mismatch could be dissolved if and only if the CL and modified noun were semantically related,which implied the significance of semantics in dissolving syntactic conflicts and processing linguistic items.Second,syntactic and semantic information were both activated at the early and late stages of language processing,which is consistent with the claims of the extended Concurrent Model.Third,the Access Mechanism of CLs,i.e.items in ordinary partitive phrases and temporary partitive phrases was identified.The former were addressed in a direct way,while the latter were processed in an assembled way.展开更多
文摘Under the background of new engineering,the reform of the comprehensive practical course system for mechanical and electronic engineering majors actively responds to the challenges posed by the new round of technological revolution and industrial transformation to higher education,cultivating top-notch innovative intellectuals with comprehensive engineering qualities,meeting the requirements of being able to solve complex engineering problems rather than just cognitive capabilities,forming two core courses through reconstructing and reshaping the core courses of the major.The core courses include Drive,Measurement,and Control I and Drive,Measurement,and Control II,which highlight the comprehensive framework of mechanical and electronic engineering professional knowledge,continuing the comprehensive practical course system based on the unity of knowledge and practice,following the trend of new engineering,highlighting the practicality of professional innovation,assisting engineering education reform,and promoting high-quality development of new engineering professionals cultivation.
基金supported by NIH grants AR055915 and AR054465 to DC
文摘Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes.
基金supported by the National Laboratory of Cognitive Neuroscience and Learning at Beijing Normal University (the 973 program),No. 2010CB8339004the National Natural Science Foundation of China,No. 30970911+1 种基金the Fundamental Research Fund for the Central Universities,No.SWJTU11BR192the Humanity and Social Science Youth foundation of Ministry of Education of China,No. 12YJC630317
文摘Previous studies have demonstrated that reactions to unfair offers in the ultimatum game are correlated with negative emotion. However, little is known about the difference in neural activity between a proposer's decision-making in the ultimatum game compared with the dictator game. The present functional magnetic resonance imaging study revealed that proposing fair offers in the dictator game elicited greater activation in the right supramarginal gyrus, right medial frontal gyrus and left anterior cingulate cortex compared with proposing fair offers in the ultimatum game in 23 Chinese undergraduate and graduate students from Beijing Normal University in China. However, greater activation was found in the right superior temporal gyrus and left cingulate gyrus for the reverse contrast. "The results indicate that proposing fair offers in the dictator game is more strongly associated with cognitive control and conflicting information processing compared with proposing fair offers in the ultimatum game.
基金Supported by the National Natural Science Foundation of China(No.61001049)Key Laboratory of Computer Architecture Opening Topic Fund Subsidization(CARCH201103)Beijing Natural Science Foundation(No.Z2002012201101)
文摘A neural network integrated classifier(NNIC) designed with a new modulation recognition algorithm based on the decision-making tree is proposed in this paper.Firstly,instantaneous parameters are extracted in the time domain by the coordinated rotation digital computer(CORDIC) algorithm based on the extended convergence domain and feature parameters of frequency spectrum and power spectrum are extracted by the time-frequency analysis method.All pattern identification parameters are calculated under the I/Q orthogonal two-channel structure,and constructed into the feature vector set.Next,the classifier is designed according to the modulation pattern and recognition performance of the feature parameter set,the optimum threshold is selected for each feature parameter based on the decision-making mechanism in a single classifier,multi-source information fusion and modulation recognition are realized based on feature parameter judge process in the NNIC.Simulation results show NNIC is competent for all modulation recognitions,8 kinds of digital modulated signals are effectively identified,which shows the recognition rate and anti-interference capability at low SNR are improved greatly,the overall recognition rate can reach 100%when SNR is12dB.
文摘The comprehensive benefit evaluation of the existing building energy efficient renovation project cannot be separated from the scientific and effective evaluation mechanism.Based on the value-added life perspective,this paper analyzes the implementation subject,standard,system and principle of the comprehensive benefit evaluation of the existing building energy efficient renovation project.It plans the process of comprehensive benefit evaluation,and builds a scientific and reasonable operation platform of evaluation system,with a view to promoting the effective implementation of the comprehensive benefit evaluation of existing building energy-saving retrofits.
基金Under the auspices of Graduate Innovation Program of China University of Mining and Technology (No.2022WLKXJ095)National Natural Science Foundation of China (No.71874192)Youth Project of Fundamental Research Funds for the Central Universities (No.2021QN1076)。
文摘For mankind’s survival and development,water,energy,and food(WEF)are essential material guarantees.In China,however,the spatial distribution of WEF is seriously unbalanced and mismatched.Here,a collaborative governance mechanism that aims at nexus security needs to be urgently established.In this paper,the Yellow River Basin in China with a representative WEF system,was selected as a case.Firstly,a comprehensive framework for WEF coupling coordination was constructed,and the relationship and mechanism between them were analyzed theoretically.Then,we investigated the spatiotemporal characteristics and driving mechanisms of the coupling coordination degree(CCD)with a composite evaluation method,coupling coordination degree model,spatial statistical analysis,and multiscale geographic weighted regression.Finally,policy implications were discussed to promote the coordinated development of the WEF system.The results showed that:1)WEF subsystems showed a significant imbalance of spatial pattern and diversity in temporal changes;2)the CCD for the WEF system varied little and remained at moderate coordination.Areas with moderate coordination have increased,while areas with superior coordination and mild disorder have decreased.In addition,the spatial clustering phenomenon of the CCD was significant and showed obvious characteristics of polarization;and 3)the action of each factor is self-differentiated and regionally variable.For different factors,GDP per capita was of particular importance,which contributed most to the regional development’s coupling coordination.For different regions,GDP per capita,average yearly precipitation,population density,and urbanization rate exhibited differences in geographical gradients in an east-west direction.The conclusion can provide references for regional resource allocation and sustainable development by enhancing WEF system utilization efficiency.
基金the National Natural Science Foundation of China(f010206)
文摘To solve the problem of excavation face dust control,the theory of dust removal after collection was put forward.Through a large number of theoretical and experimental researches,a new wind screen dust-collection system which was applied to comprehen- sive excavation face was developed.To set a wind dam in jet stream box,achieve the function of multi-stage and multiple-level regulation,lots of experimentation was carried out to obtain higher jet stream velocity with the minimum loss of energy.Experiments show that the slit width in the exports of wind screen dust-collection system should be 10 to 15 mm.For the general excavation roadway,after wind attenuation,the velocity can be greater than 3 m/s at the roof which meets the requirements of respirable dust control.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11904036 and 12175081)Fundamental Research Funds for the Central Universities(Grant No.CCNU22QNOO4)。
文摘The human serotonin transporter(SERT)terminates neurotransmission by removing serotonin from the synaptic cleft,which is an essential process that plays an important role in depression.In addition to natural substrate serotonin,SERT is also the target of the abused drug cocaine and,clinically used antidepressants,escitalopram,and paroxetine.To date,few studies have attempted to investigate the unbinding mechanism underlying the orthosteric and allosteric modulation of SERT.In this article,the conserved property of the orthosteric and allosteric sites(S1 and S2)of SERT was revealed by combining the high resolutions of x-ray crystal structures and molecular dynamics(MD)simulations.The residues Tyr95 and Ser438 located within the S1 site,and Arg104 located within the S2 site in SERT illustrate conserved interactions(hydrogen bonds and hydrophobic interactions),as responses to selective serotonin reuptake inhibitors.Van der Waals interactions were keys to designing effective drugs inhibiting SERT and further,electrostatic interactions highlighted escitalopram as a potent antidepressant.We found that cocaine,escitalopram,and paroxetine,whether the S1 site or the S2 site,were more competitive.According to this potential of mean force(PMF)simulations,the new insights reveal the principles of competitive inhibitors that lengths of trails from central SERT to an opening were~18A for serotonin and~22 A for the above-mentioned three drugs.Furthermore,the distance between the natural substrate serotonin and cocaine(or escitalopram)at the allosteric site was~3A.Thus,it can be inferred that the potent antidepressants tended to bind at deeper positions of the S1 or the S2 site of SERT in comparison to the substrate.Continuing exploring the processes of unbinding four ligands against the two target pockets of SERT,this study observed a broad pathway in which serotonin,cocaine,escitalopram(at the S1 site),and paroxetine all were pulled out to an opening between MT1b and MT6a,which may be helpful to understand the dissociation mechanism of antidepressants.
文摘To study the safety and stability of large slopes, taking the right side slope of the Yuxi’an tunnel of the Yuchu Expressway Bridge in Yunnan Province as an example, limit equilibrium and finite element analysis were applied to engineering examples to calculate the stability coefficient of the slope before and after excavation in the natural state. After comparative analysis, it was concluded that the former had a clear mechanical model and concept, which could quickly provide stability results;the latter could accurately determine the sliding surface of the slope and simulate the stress state changes of the rock and soil mass. The stability coefficients calculated by the two methods were within the stable range, but their values were different. On this basis, combined with the calculation principles, advantages and disadvantages of the two methods, a comprehensive analysis method of slope stability based on the limit equilibrium and finite element methods was proposed, and the rationality of the stability coefficient calculated by this method was judged for a slope case.
基金supported by the second batch of the soft subject research project of China Southern Power Grid Corporation in 2022,‘Exploring the construction path of multi energy complementary ecosystem of industrial parks in Qianhai’(XNXM_20221209003).
文摘The multi-energy complementary ecosystem is an important form of the modern energy system.However,standardized evaluation criteria and the corresponding method framework have not yet been formed,resulting in unclear standards and irregular processes of its construction.To cope with this issue,a novel comprehensive evaluation framework for multi-energy complementary ecosystems is proposed in this study.First,a 5D comprehensive evaluation criteria system,including environment,economy,technology,safety and systematicness,is constructed.Then,a novel multicriteria decision-making model integrating an analytic network process,entropy and preference-ranking organization method for enrichment evaluation under an intuitional fuzzy environment is proposed.Finally,four practical cases are used for model testing and empirical analysis.The results of the research show that the unit cost of the energy supply and the internal rate of return indexes have the highest weights of 0.142 and 0.010,respectively.It means that they are the focus in the construction of a multi-energy complementary ecosystem.The net flows of four cases are 0.015,0.123,-0.132 and-0.005,indicating that cases with a variety of energy supply forms and using intelligent management and control platforms to achieve cold,heat and electrical coupling have more advantages.
基金National Natural Science Foundation of China,No.42271259The Open Fund of Key Laboratory of Coastal Zone Exploitation and Protection,Ministry of Natural Resources,China,No.2021CZEPK07。
文摘Land consolidation(LC) stands as a globally recognized strategy for rural development. In China, it has evolved towards comprehensive land consolidation(CLC) to support the rural revitalization initiative. However, there are ongoing challenges in understanding CLC's specific pathway and mechanism, particularly its role in stimulating rural endogenous development. This study aims to investigate the localization process of international experiences, examine the pathway of CLC, and scrutinize its mechanism in rural development from a novel perspective of neo-endogenous development. Field research and semi-structured interviews were conducted in Nanzhanglou village, renowned for its early adoption of CLC practices inspired by German experiences since 1988. Overall, key findings underscore the advantages of CLC in spatial restructuring, industrial development, and human capital enhancement in rural areas. Additionally, international experiences emerge as crucial exogenous forces, primarily by knowledge embedding, which catalyzes rural neo-endogenous development via the “resource-engagement-identity-endogenous” mechanism. Collectively, by introducing a neo-endogenous theoretical framework, this study offers valuable insights into the CLC implementation in China and beyond, and emphasizes the positive impact of knowledge embedding as an exogenous force in promoting rural neo-endogenous development to address existing research gaps. Recommendations for sustainable rural development involve enhancing rural planning practicality, governance capacity, and local leadership, while prioritizing agricultural modernization and increasing investments in education and vocational training to ensure that villagers benefit from industrial development.
文摘The reasonable model of fuzzy comprehensive judgment is found by means of the theory and method of multi-level fuzzy judgment on the basis of the judging index system of mechanical equipment bid sheets. The scientific method is supplied for the judging bids, the key chain of the judging process of the mechanical equipment bid sheet. All factors are considered, especially quantitative factors or qualitative factors in the process of judgment.
文摘In recent years, end-to-end models have been widely used in the fields of machine comprehension (MC) and question answering (QA). Recurrent neural network (RNN) or convolutional neural network (CNN) is combined with attention mechanism to construct models to improve their accuracy. However, a single attention mechanism does not fully express the meaning of the text. In this paper, recurrent neural network is replaced with the convolutional neural network to process the text, and a superimposed attention mechanism is proposed. The model was constructed by combining a convolutional neural network with a superimposed attention mechanism. It shows that good results are achieved on the Stanford question answering dataset (SQuAD).
基金supported by the National Defense Basic Scientific Research Program(No.A0320110019)the Shanghai Science and Technology Innovation Action Plan(No.11DZ1120800)
文摘Joint clearance,as an important stochastic factor,can significantly deteriorate positioning and repeatability accuracies and lower assembly quality of a 6-DOF docking mechanism.Considering pose accuracy with traditional error model that possesses inherent imprecision,both probabilistic and deterministic approaches based on forward kinematics are presented to analyze comprehensive pose error(CPE)in simulation.Results indicate an identical trend emerges for each CPE with both approaches,and both CPEs perform opposite variations as the moving platform upgrades.The findings provide theoretical reference for refinement of assembly quality evaluation of this mechanism.
文摘According to the modern theory of human resource management, the condition of buyout mainly depends on two variables of an employee: his interior value of product and exterior work reward. There exist shortages in evaluating the value of the employees in an enterprise. Consequently, a lot of employees might be laid off. Hence, this paper puts forward a two-stage method for decision-making to carry out a selective plan of buyout, based on the fuzzy synthetic evaluation involing many factors impacting on human resource. Moreover, a positive analysis is also given.
文摘In order to perform better in target control, this paper proposed a decision-making system method based on fuzzy automata. The decision-making system first preprocessed the signal and then performed a two-level decision on the target to achieve optimal control. The system consisted of four parts: signal preprocessing, contrast decision-making, comprehensive judgment of decision-making and decision-making result. These decision algorithms in target control were given. A concrete application of this decision-making system in target control was described. Being compared with other existing methods, this paper used both global features and local features of target, and used the decision-making system of fuzzy automata for the target control. Simulation results showed that the control effect based on the decision-making system was better than that of the other existing methods. Not only it was faster, but also its correct control rate was higher to be 95.18% for the target control. This research on the control system not only developed the FA theory, but also strengthened its application scope in the field of control engineering.
文摘Background: The integration of relevant high-quality research evidence into the health decision and policy formulation process is a key strategy for improving health systems especially in developing countries such as Zambia. However, the lack of capacity to understand and value research evidence by policy and decision makers makes it difficult for them to find and use research evidence in a timely manner even when motivated to do so. This study aimed to establish the views, attitudes and practices of policy makers on the use of research evidence in policy and decision-making process in Zambia. Methodology: This descriptive cross-sectional study was conducted in Lusaka, Zambia among selected public health decision and policy making institutions. A purposive sample of 21 consenting policy makers who were working in different positions in the Ministry of Health Headquarters, Provincial and District Health Offices, Health Professions Regulatory Bodies, United Nations Agencies, International Non-Governmental Organizations and University Deans from the University of Zambia participated in the study. A self-administered questionnaire was used to collect data. The IBM? SPSS? Statistics for Windows Version 20.0 was used for data analysis. Results: The concept of Evidence Informed Health Policy was not well understood such that only less than half (47.5%) of the participants reported having heard specifically about Evidence Informed Health Policy meanwhile almost two thirds (61.9%) reported that they used research evidence in decision making and policy formulation. Similar discrepancy was expressed in the understanding of and use of rapid response mechanisms such that although (47.6%) of the participants reported having heard about it, (57%) had never used rapid response mechanisms for deci-sion-making. With regard to the sources of information, about half (52.3) of the participants reported scholarly articles as their main source of evidence. Con-clusion and Recommendations: There is need for more sensitization and ca-pacity building among the decision and policy makers on the importance of using research evidence in decision and policy making process as incorporation of relevant high-quality research evidence into the health policy making pro-cess is a key strategy for improving health systems.
基金This paper is a partial fulfillment of the philosophy and social science researches in colleges and universities of Jiangsu Province(No.2018SJA2133)National Social Science Fund Project(No.19BYY089).
文摘The study manipulated semantic and syntactic variables to explore the cognitive neuroscience mechanisms of Chinese classifier construction"yi+N(CL)+N".It was indicated:First,the mismatch could be dissolved if and only if the CL and modified noun were semantically related,which implied the significance of semantics in dissolving syntactic conflicts and processing linguistic items.Second,syntactic and semantic information were both activated at the early and late stages of language processing,which is consistent with the claims of the extended Concurrent Model.Third,the Access Mechanism of CLs,i.e.items in ordinary partitive phrases and temporary partitive phrases was identified.The former were addressed in a direct way,while the latter were processed in an assembled way.