Osteoarthritis:toward a comprehensive understanding of pathological mechanism

Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway（s） controlling these pathological processes.

Development of dust collection and removal technology of comprehensive mechanized excavation face

To solve the problem of excavation face dust control,the theory of dust removal after collection was put forward.Through a large number of theoretical and experimental researches,a new wind screen dust-collection system which was applied to comprehen- sive excavation face was developed.To set a wind dam in jet stream box,achieve the function of multi-stage and multiple-level regulation,lots of experimentation was carried out to obtain higher jet stream velocity with the minimum loss of energy.Experiments show that the slit width in the exports of wind screen dust-collection system should be 10 to 15 mm.For the general excavation roadway,after wind attenuation,the velocity can be greater than 3 m/s at the roof which meets the requirements of respirable dust control.

Geomechanics model test research on large deformation control mechanism of roadway disturbed by strong dynamic pressure

Comprehensive mechanized top-coal caving mining is one of the efficient mining methods in coal mines.However,the goaf formed by comprehensive mechanized top-coal caving mining is high,and the goaf roof collapse will cause strong dynamic pressure disturbance,especially the collapse of thick hard roof.Strong dynamic pressure disturbance has an influence on the stability of the roadway,which can lead to large deformation.In order to solve the above problem,a comprehensive pressure releasing and constant resistance energy absorbing control method is proposed.Comprehensive pressure releasing can change the roadway roof structure and cut off the stress transfer between goaf and roadway,which can improve the stress environment of the roadway.The constant resistance energy absorbing(CREA)anchor cable can absorb the energy of surrounding rock deformation and resist the impact load of gangue collapse,so as to ensure the stability of roadway disturbed by strong dynamic pressure.A three-dimensional geomechanics model test is carried out,based on the roadway disturbed by strong dynamic pressure of the extra-large coal mine in western China,to verify the control effect of the new control method.The stress and displacement evolution laws of the roadway with traditional control method and new control method are analyzed.The pressure releasing and energy absorbing control mechanism of the new control method is clarified.The geomechanics model test results show that the new control method can increase the range of low stress zone by 150%and reduce the average stress and the displacement by 34.7%and 67.8%respectively,compared with the traditional control method.The filed application results show that the new control method can reduce the roadway surrounding rock displacement by 67.4%compared with the traditional control method.It shows that the new control method can effectively control the displacement of the roadway disturbed by strong dynamic pressure and ensure that the roadway meets the safety requirements.On this basis,the engineering suggestions for large deformation control of this kind of roadway are put forward.The new control method can provide a control idea for the roadway disturbed by strong dynamic pressure.