期刊文献+
共找到29篇文章
< 1 2 >
每页显示 20 50 100
Clinical comprehensive treatment protocol for managing diabetic foot ulcers:A retrospective cohort study
1
作者 Yan-Bin Wang Yan Lv +3 位作者 Guang-Yu Li Ji-Ting Zheng Qing-Xin Jiang Ran Wei 《World Journal of Clinical Cases》 SCIE 2024年第17期2976-2982,共7页
BACKGROUND Diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of life.The current standard treatment protocols for DFUs have limitations ... BACKGROUND Diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of life.The current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications.A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with DFUs.The hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing,reduced amputation rates,and improved overall patient outcomes compared to standard treatment protocols.AIM To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol.METHODS This retrospective study included 62 patients with DFUs,enrolled between January 2022 and January 2024,randomly assigned to the experimental(n=32)or control(n=30)group.The experimental group received a comprehensive treatment comprising blood circulation improvement,debridement,vacuum sealing drainage,recombinant human epidermal growth factor and anti-inflammatory dressing,and skin grafting.The control group received standard treatment,which included wound cleaning and dressing,antibiotics administration,and surgical debridement or amputation,if necessary.Time taken to reduce the white blood cell count,number of dressing changes,wound healing rate and time,and amputation rate were assessed.RESULTS The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate,wound healing time,and amputation rate.Additionally,the comprehensive treatment protocol was safe and well tolerated by the patients.CONCLUSION Comprehensive treatment for DFUs is more effective than standard treatment,promoting granulation tissue growth,shortening hospitalization time,reducing pain and amputation rate,improving wound healing,and enhancing quality of life. 展开更多
关键词 Diabetic foot ulcers comprehensive treatment protocol Clinical study White blood cell count Wound healing Amputation rate
下载PDF
Preprocessing and Efficacy Analysis of Comprehensive Anti-Inflammatory Treatment for Lymphedema in Patients with Irritating Contact Dermatitis
2
作者 Qiaoling Zhong Feng Liu +5 位作者 Huiting Zhang Liping Zhang Jinlan Li Lijuan Zhang Na Li Qinghua Luo 《Journal of Cosmetics, Dermatological Sciences and Applications》 2024年第2期188-199,共12页
Objective: To explore the pre-treatment and efficacy analysis of comprehensive anti-inflammatory treatment for lymphedema in patients with irritating contact dermatitis. Method: Convenience sampling method was used to... Objective: To explore the pre-treatment and efficacy analysis of comprehensive anti-inflammatory treatment for lymphedema in patients with irritating contact dermatitis. Method: Convenience sampling method was used to observe the skin of 160 patients with upper limb lymphedema admitted to the lymphedema outpatient department of our hospital. They were divided into an observation group (80 cases) and a control group (80 cases), and both groups received a course of comprehensive anti-inflammatory treatment (20 treatments). The control group received routine skin care;On the basis of the control group, the observation group received pre-treatment of the affected limb skin: Laofuzi herbal ointment was applied externally to the prone areas of irritating contact dermatitis (such as the upper arm, inner forearm, and cubital fossa). Result: The incidence of irritating contact dermatitis in the observation group was significantly lower than that in the control group (P 0.05). Patients in the observation group felt significantly better in terms of comfort, skin moisture, and itching relief after being wrapped with low elasticity bandages than those in the control group (P Conclusion: Preventive treatment can effectively reduce the incidence of irritating contact dermatitis, prolong the time of stress treatment, thereby increasing efficacy and improving patient compliance. 展开更多
关键词 comprehensive Anti-Inflammatory Treatment Upper Limb Lymphedema Irritating Contact Dermatitis Effect
下载PDF
Loose Body in the Knee Joint: A Case Report
3
作者 Hussein Khudhur Joudi Habbal Waleed Mohammed 《Open Journal of Orthopedics》 2024年第10期436-440,共5页
Background: Loose bodies (LBs) within the knee joint are commonly encountered during clinical practice and are frequently observed during knee arthroscopy. The primary treatment involves the removal of loose bodies;ho... Background: Loose bodies (LBs) within the knee joint are commonly encountered during clinical practice and are frequently observed during knee arthroscopy. The primary treatment involves the removal of loose bodies;however, their complete eradication is often challenging and may not address underlying diseases, leading to persistent symptoms and the risk of new loose body formation. Aim: This case report aims to present the findings and surgical management of a 52-year-old male with an unusually large osseous loose body in the knee joint and associated pathologies. Case Presentation: The patient, a 52-year-old male, experienced recurrent episodes of severe, sudden, and painful locking of the knee joint, leading to difficulties moving. A plain MRI study was conducted to evaluate the condition of the knee joint, which revealed various degenerative changes and the presence of a loose body. Subsequently, an arthroscopic examination was performed under general anesthesia, uncovering the presence of an abnormally large loose body, as well as other pathologies including chondropathy, meniscal degeneration, and Baker’s cyst. Conclusion: Loose bodies (LBs) in the knee joint pose significant challenges and may lead to debilitating symptoms. Timely diagnosis and appropriate surgical intervention are crucial for symptom relief and the prevention of further joint damage as arthroscopic excision. Comprehensive imaging has a vital role in guiding treatment decisions and optimizing patient outcomes. In this case, the removal of the loose body improved patient outcomes and helped prevent potential joint complications. 展开更多
关键词 Loose Bodies Knee Joint ARTHROSCOPY MRI Osseous Loose Body Surgical Management Meniscal Degeneration Baker’s Cyst BURSITIS Osteoarthritic Changes comprehensive Treatment
下载PDF
Treatment Analysis of Limb Fractures Combined with Traumatic Shock
4
作者 Mingwei Wang Peng Wang +3 位作者 Wenbin Mao Yanming Qin Yong Tang Xuanxuan Xu 《Journal of Clinical and Nursing Research》 2024年第10期243-249,共7页
Objective:To evaluate the treatment regimen and efficacy for limb fractures combined with traumatic shock(TS).Methods:A total of 88 patients with limb fractures combined with TS,admitted between January 2021 and Decem... Objective:To evaluate the treatment regimen and efficacy for limb fractures combined with traumatic shock(TS).Methods:A total of 88 patients with limb fractures combined with TS,admitted between January 2021 and December 2023,were selected.Patients were divided randomly using a numerical grouping method.The observation group underwent restricted fluid resuscitation combined with comprehensive treatment,while the reference group received conventional fluid resuscitation combined with comprehensive treatment.Recovery time,fracture prognosis,complications,severity of the condition,and post-fracture joint function were compared between the two groups.Results:The observation group showed shorter symptom recovery times,a higher rate of anatomical fracture reduction,and a lower complication rate compared to the reference group(P<0.05).After one week of treatment,the severity score of the condition in the observation group was lower than that of the reference group,and all joint function scores were higher in the observation group(P<0.05).Conclusion:Restricted fluid resuscitation combined with comprehensive treatment for limb fractures with TS can alleviate symptoms,improve fracture prognosis,reduce related complications,decrease the severity of trauma,and enhance joint function.The therapeutic effect is excellent. 展开更多
关键词 Limb fractures Traumatic shock comprehensive treatment COMPLICATIONS Severity of condition
下载PDF
Comprehensive treatment for primary liver cancer 被引量:2
5
作者 Guang-Shun Yang Zhi-Quan Wu Meng-Chao Wu the Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China Zhongshan Hospital, Fudan University, Shanghai 200433, China 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2003年第1期23-27,共5页
IntroductionPrimary liver cancer (PLC) is one of the mostcommon malignancies in China. Since the1990s, it has been the first leading cause of cancerdeath in the rural areas versus the 2nd in the urbanareas in this cou... IntroductionPrimary liver cancer (PLC) is one of the mostcommon malignancies in China. Since the1990s, it has been the first leading cause of cancerdeath in the rural areas versus the 2nd in the urbanareas in this country. 45% of all the newly en-countered cases in the world each year are from themainland of China, and the situation is extremelyworsened in its high risk southeast coastal area.Liver resection is chosen as an optimal treatmentfor liver cancer, yet the low resectability and highpostoperative recurrence prevent the long-term sur-vival of patients. Therefore, proper comprehensivetreatment of PLC for the improvement of the overalltherapeutic efficacy has been the focus of clinicalpractice and research. In comparison with single treatment, compre- 展开更多
关键词 TACE ET on for comprehensive treatment for primary liver cancer been of in that AFP
下载PDF
Guidelines and standards for comprehensive clinical diagnosis and interventional treatment for diabetic foot in China(Issue 7.0) 被引量:9
6
作者 Maoquan Li 《Journal of Interventional Medicine》 2021年第3期117-129,共13页
Diabetic foot(DF)is one of the most common complications of diabetes and is associated with high morbidity,disability,lethality and low cure-rate.The clinical diagnosis and treatment of DF need to be standardized.The ... Diabetic foot(DF)is one of the most common complications of diabetes and is associated with high morbidity,disability,lethality and low cure-rate.The clinical diagnosis and treatment of DF need to be standardized.The Chinese Diabetic Foot Cell and Interventional Therapy Technology Alliance has released six editions of guidelines and standards for clinical diagnosis and interventional treatment of DF,which filled the gap in the domestic DF treatment standard and played an important role in improving the level of diagnosis and treatment in China.In line with the latest developments in diagnosis and treatment,the Alliance,along with other 89 institutions,developed and issued the new edition based on the sixth edition to help standardize the clinical diagnosis and treatment of DF in China. 展开更多
关键词 Diabetic foot/diabetes Interventional comprehensive diagnosis and treatment Guidelines of clinical
下载PDF
The application of Meta-analysis in the latest comprehensive treatment of breast cancer 被引量:1
7
作者 Fang Guo Xiaodong Xie Zhaozhe Liu 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第12期729-733,共5页
Meta-analysis is a kind of systematic review,which uses quantitative method to summarize the results.It is a comprehensive evaluation to the findings of previous studies with higher credibility.Recently,it is applied ... Meta-analysis is a kind of systematic review,which uses quantitative method to summarize the results.It is a comprehensive evaluation to the findings of previous studies with higher credibility.Recently,it is applied to all areas of scientific research,particularly in the integrated treatment of breast cancer.Currently,breast cancer is known one of the most common malignant tumors,and its incidence is increasing year by year.Therefore,more and more clinical doctors pay attention to the effect of comprehensive treatment for patients with breast cancer.This article mainly collects the results of comprehensive treatment of breast cancer,in which the method of Meta-analysis is applied.In addition,we discuss the latest progress in order to guide the clinical treatment. 展开更多
关键词 META-ANALYSIS breast cancer comprehensive treatment
下载PDF
Comprehensive Strategy for Keloid Treatment:Experience at Shanghai Ninth People's Hospital 被引量:2
8
作者 Xiaoli WU Yating YANG +5 位作者 Wei LIU Wenbo WANG Lingling XIA Xiaoqing WANG Qiong ZHAO Zhen GAO 《Chinese Journal of Plastic and Reconstructive Surgery》 2020年第2期88-92,共5页
Keloids are a notorious fibroproliferative disorder that may cause cosmetic concerns and life inconvenience.Various methods such as surgery,injection,and laser have been used;however,single treatments are at risk of r... Keloids are a notorious fibroproliferative disorder that may cause cosmetic concerns and life inconvenience.Various methods such as surgery,injection,and laser have been used;however,single treatments are at risk of recurrence;therefore,comprehensive therapy is the better solution.Here,we focused on the management of different medical interventions according to subjective and objective conditions of keloid patients and summarized several clinical comprehensive strategies based on our clinical experience.One original concept of laser combined with radiotherapy was also introduced as a promising method,especially for wide-based pathological scars. 展开更多
关键词 KELOIDS hypertrophic scar comprehensive treatment laser RADIOTHERAPY injection surgery
下载PDF
Comprehensive treatment for primary right renal diffuse large B-cell lymphoma with a renal vein tumor thrombus:A case report
9
作者 Jun He Yi Mu +4 位作者 Bang-Wei Che Miao Liu Wen-Jun Zhang Sheng-Han Xu Kai-Fa Tang 《World Journal of Clinical Cases》 SCIE 2022年第16期5352-5358,共7页
BACKGROUND Renal involvement in lymphoma is commonly associated with widespread nodal or extranodal lymphoma.Primary renal diffuse large B-cell lymphoma is an extremely rare extranodal lymphoma,accounting for fewer th... BACKGROUND Renal involvement in lymphoma is commonly associated with widespread nodal or extranodal lymphoma.Primary renal diffuse large B-cell lymphoma is an extremely rare extranodal lymphoma,accounting for fewer than 1%of all renal masses.Interestingly,the patient in this study had a renal vein tumor thrombus that was observed after laparoscopic radical nephrectomy.CASE SUMMARY We report the case of a 56-year-old female patient with primary renal lymphoma and a renal vein tumor thrombus whose first symptom was right pain in the back and gross hematuria.Histopathology revealed primary renal diffuse large B-cell lymphoma.The patient received 8 standard cycles of rituximab with cyclophosphamide,doxorubicin,vincristine,and prednisone chemotherapy after surgery,and no obvious signs of recurrence were observed during the one-year follow-up.CONCLUSION We evaluated comprehensive treatment of primary renal diffuse large B-cell lymphoma and multidisciplinary management of this malignancy. 展开更多
关键词 Primary renal lymphoma Renal diffuse large B-cell lymphoma Renal vein tumor thrombus DIAGNOSIS comprehensive treatment Case report
下载PDF
INTERVENTION CHEMOTHERAPY IN COMPREHENSIVE TREATMENT OF ADVANCED NASOPHARYNGEAL CARCINOMA
10
作者 崔英 马亦龙 +5 位作者 王安宇 许坚 赖少侣 齐锋 李伟 张则 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2000年第2期141-143,共3页
Objective: To study the use of interventional chemotherapy in comprehensive treatment for advanced nasopharyngeal carcinoma. Methods: Interventional chemotherapy with multi-drugs including cisplatin (DDP) 100 mg, 5-fl... Objective: To study the use of interventional chemotherapy in comprehensive treatment for advanced nasopharyngeal carcinoma. Methods: Interventional chemotherapy with multi-drugs including cisplatin (DDP) 100 mg, 5-fluorouracil (5-FU) 1000 mg and bleomycin (BLM) 16 mg was used to treat 30 cases with advanced nasopharyngeal carcinoma before radiotherapy. 50 cases that received radiotherapy alone were used as a control group. The methods, time and dose schedule of radiotherapy were similar in the two groups. Results: The primary lesions in 16 cases and the cervical lymph nodes in 12 cases were reduced hi size after interventional chemotherapy. Radiation doses of those in complete response in their primary lesion and cervical lymph nodes were lower than that of the control group (P<0.05). The complete response rate of study group was 83.3% and that of control group was 72.0% (P<0.05). Conclusion: Interventional chemotherapy plus radiotherapy is a valuable treatment method in advanced nasopharyngeal carcinoma. 展开更多
关键词 Nasopharyngeal carcinoma Interventional chemotherapy comprehensive treatment
下载PDF
COMPREHENSIVE TREATMENT FOR SARCOMA BOTRYOIDES OF UTERINE CERVIX
11
作者 张国玲 陈鸣之 吴百生 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1991年第2期71-73,共3页
Seven cases of sarcoma botryoides of the uterine cervix are reviewed. The age of the patients ranged from 19 to 40 years, with a median age of 23 years. Four patients were diagnosed as stage Ia, two as Ib and one as ... Seven cases of sarcoma botryoides of the uterine cervix are reviewed. The age of the patients ranged from 19 to 40 years, with a median age of 23 years. Four patients were diagnosed as stage Ia, two as Ib and one as Ⅱ a, 6 cases were treated with surgery, chemotherapy and/or radiotherapy, and 1 with surgery only, 5 cases in this group survived more than 5 years with a mean 7.9 years of follow-up. The prognosis for cervical sarcoma botryoides is similar to that of other female genital tract embryonal rhabdomyosarcomas. Primary therapy should consist of vincristine and dactinomycin based chemotherapy. Surgery should be guided by the response to initial chemotherapy and should attempt to conserve the function of the bladder, rectum, vagina, and ovaries. Radiotherapy was used for involved surgical margins or positive nodes. The effect of radiotherapy is unclear for stage Ia cases. 展开更多
关键词 IRS comprehensive TREATMENT FOR SARCOMA BOTRYOIDES OF UTERINE CERVIX
下载PDF
Comprehensive Treatment Technology of Pesticidecontaminated Soil
12
作者 Liu Wei 《Plant Diseases and Pests》 CAS 2016年第2期36-38,共3页
Access approach of pesticide into soil and its migration and transformation process in soil are analyzed in the paper. Furthermore, it is put forward that soil pollution can be prevented by enhancing farmers' conscio... Access approach of pesticide into soil and its migration and transformation process in soil are analyzed in the paper. Furthermore, it is put forward that soil pollution can be prevented by enhancing farmers' consciousness of safe and reasonable application of pesticide, strengthening production and management of pesticide, adopting comprehensive prevention and control measures, and developing treatment technology of pesticide-contaminated soil. 展开更多
关键词 SOIL Pesticide pollution comprehensive treatment
下载PDF
Comprehensive rehabilitation treatment of lumbar disk hernia
13
作者 吴军 宫春凤 +2 位作者 马哲 刁凤声 王黎光 《中国组织工程研究与临床康复》 CAS CSCD 2001年第24期146-,共1页
关键词 CM comprehensive rehabilitation treatment of lumbar disk hernia
下载PDF
Effect of the comprehensive rehabilitative treatment on rigidity of knee joint
14
作者 刘亚丽 《中国组织工程研究与临床康复》 CAS CSCD 2001年第18期153-,共1页
关键词 Effect of the comprehensive rehabilitative treatment on rigidity of knee joint
下载PDF
Study on effect of comprehensive rehabilitative treatment on elbow dysfunction following fracture
15
作者 孟冬娅 胡晓芳 《中国组织工程研究与临床康复》 CAS CSCD 2001年第18期151-,共1页
关键词 Study on effect of comprehensive rehabilitative treatment on elbow dysfunction following fracture
下载PDF
Long-term survival of patients with hepatocellular carcinoma with hepatic,pulmonary,peritoneal and rare colon metastasis:A case report
16
作者 Yong-Qiang Gong Tai-Liang Lu Chao-Wu Chen 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第8期1819-1824,共6页
BACKGROUND Hepatocellular carcinoma(HCC)is a highly malignant cancer that often metastasizes and has a poor prognosis.Gastrointestinal tract metastases are rare,and colon metastases are even rarer.The long-term surviv... BACKGROUND Hepatocellular carcinoma(HCC)is a highly malignant cancer that often metastasizes and has a poor prognosis.Gastrointestinal tract metastases are rare,and colon metastases are even rarer.The long-term survival of patients with multiple intrahepatic and extrahepatic metastases,especially to the colon,has not been previously reported.CASE SUMMARY We present an atypical clinical case of a patient with liver,right lung,peritoneal,and colon metastases diagnosed successively following hepatic resection for primary HCC.Comprehensive treatment,including partial liver,lung and colon resection,palliative management such as systemic chemotherapy,trans-arterial chemoembolization,targeted therapy with sorafenib,and cryotherapy were attempted.Despite his early metastases,the patient remained relatively healthy for 8 years after diagnosis.CONCLUSION This case indicates that comprehensive treatment is beneficial for certain patients with metastatic HCC.Clinicians should be alert as to the possibility of rare site metastatic tumors that may be easily misdiagnosed as primary tumors. 展开更多
关键词 Hepatocellular carcinoma Multiple metastasis Rare colon metastasis comprehensive treatments Long-term survival Case report
下载PDF
Malignant melanoma resection and reconstruction with the first manifestation of lumbar metastasis:A case report
17
作者 Zi-Xuan Guo Xue-Lin Zhao +3 位作者 Zi-Yi Zhao Qing-Yan Zhu Zi-Ying Wang Meng Xu 《World Journal of Clinical Cases》 SCIE 2023年第15期3571-3577,共7页
BACKGROUND Malignant melanoma(MM)has shown an increasing incidence worldwide,and a potential to metastasize to almost any part of the body.Clinically,MM with bone metastasis as the initial manifestation is extremely r... BACKGROUND Malignant melanoma(MM)has shown an increasing incidence worldwide,and a potential to metastasize to almost any part of the body.Clinically,MM with bone metastasis as the initial manifestation is extremely rare.Spinal metastatic MM can cause spinal cord or nerve root compression,resulting in severe pain and paralysis.Currently,the primary clinical treatments for MM are surgical resection in conjunction with chemotherapy,radiotherapy,and immunotherapy.CASE SUMMARY Here,we report the case of a 52-year-old male who presented to the clinic with progressive low back pain and limited nerve function.No primary lesion or spinal cord compression was detected from computed tomography and magnetic resonance imaging of the lumbar vertebrae and positron emission tomography scan.A lumbar puncture biopsy confirmed the diagnosis of lumbar spine metastatic MM.Following surgical resection,the patient’s quality of life improved,symptoms were relieved,and comprehensive treatment was initiated,which prevented recurrence.CONCLUSION Spinal metastatic MM is clinically rare,and may cause neurological symptoms,including paraplegia.Currently,the clinical treatment plan consists of surgical resection in combination with chemotherapy,radiotherapy,and immunotherapy. 展开更多
关键词 Spinal metastatic malignant melanoma Surgical resection comprehensive treatment Pathological report Case report
下载PDF
Valve repair after infective endocarditis secondary to perforation caused by Streptococcus gordonii:A case report
18
作者 Yi-Fan Qu Jun Yang +4 位作者 Jun-Yu Wang Bing Wei Xing-Hua Ye Yi-Xuan Li Si-Lu Han 《World Journal of Clinical Cases》 SCIE 2023年第16期3822-3829,共8页
BACKGROUND We report a case of infective endocarditis(IE)in a patient with congenital heart valve lesions accompanied by IE,which was diagnosed based on blood culture analysis that revealed the presence of a gram-nega... BACKGROUND We report a case of infective endocarditis(IE)in a patient with congenital heart valve lesions accompanied by IE,which was diagnosed based on blood culture analysis that revealed the presence of a gram-negative bacterium,Streptococcus gordonii.CASE SUMMARY The patient had a history of precordial valve disease diagnosed by cardiac ultrasound,as well as a 4-mo history of fever.He was subjected to comprehensive anti-infection and anti-heart failure treatment in the internal medicine department.Further examination revealed sudden dislodgement from and perforation through the aortic valve by the superfluous organisms,as well as occurrence of bacterial emboli dislodgement,which caused bacteremia and infectious shock.He recovered and was discharged from the hospital after surgical and postoperative anti-infection treatments.CONCLUSION We review the treatment process and highlight inspirations and reflections from this case;suggest possible future changes in treatment modalities. 展开更多
关键词 BACTEREMIA comprehensive medical and surgical treatment Streptococcus gordonii Infective endocarditis Case report
下载PDF
Generalized periodontitis treated with periodontal,orthodontic,and prosthodontic therapy:A case report 被引量:3
19
作者 Masato Kaku Shinji Matsuda +4 位作者 Takayasu Kubo Saiji Shimoe Kazuhiro Tsuga Hidemi Kurihara Kotaro Tanimoto 《World Journal of Clinical Cases》 SCIE 2021年第21期6110-6124,共15页
BACKGROUND Generalized periodontitis is a severe periodontal disease characterized by rapid periodontal destruction in healthy persons.This case report describes the treatment of a severe crowding,large overjet,and oc... BACKGROUND Generalized periodontitis is a severe periodontal disease characterized by rapid periodontal destruction in healthy persons.This case report describes the treatment of a severe crowding,large overjet,and occlusal collapse due to the loss of anterior guidance with generalized periodontitis.CASE SUMMARY A 35-year-old female patient with a chief complaint of crowding and maxillary protrusion was diagnosed with generalized periodontitis by clinical and radiographic examinations.To improve crowding and overjet,orthodontic treatment was performed after basic periodontal therapy.Severely damaged upper right lateral incisor and left canine were extracted,and lower right first premolar and left second premolar were also removed to treat severe crowding.After orthodontic treatment,periodontal flap surgery for upper left molars and guided tissue regeneration for the lower left second molar was performed.Then,a dental implant was inserted in the upper left canine legion.The esthetics of the maxillary anterior tooth was improved by prosthetic restorations.The treatment result showed a well-improved occlusion with proper anterior guidance and healthy periodontal tissue after a retention period of 10 years.CONCLUSION Periodontal,orthodontic,and prosthodontic treatments are extremely useful to improve function and stable periodontal tissue for generalized periodontitis. 展开更多
关键词 Generalized periodontitis Orthodontic treatment Periodontal regenerative therapy Prosthodontic treatment comprehensive dental treatment Long-term case study Case report
下载PDF
A self-guidance biological hybrid drug delivery system driven by anaerobes to inhibit the proliferation and metastasis of colon cancer 被引量:1
20
作者 Huijuan Zhang Yaping Wang +5 位作者 Mengting Li Kexuan Cao Zijun Qi Ling Zhu Zhenzhong Zhang Lin Hou 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2022年第6期892-907,共16页
Colorectal cancer is often accompanied by multiple organ metastasis.Anaerobic Bifidobacterium Infantis(BI)bacterial can selectively grow in hypoxic colorectal tumor microenvironment(TME),to own the natural advantage o... Colorectal cancer is often accompanied by multiple organ metastasis.Anaerobic Bifidobacterium Infantis(BI)bacterial can selectively grow in hypoxic colorectal tumor microenvironment(TME),to own the natural advantage of preferentially colorectal tumor targeting.Herein,a self-guidance biological hybrid drug delivery system(BI-ES-Fe Alg/DOX)based on BI was constructed to inhibit the proliferation and metastasis of colon cancer.Results demonstrated that BI-ES-Fe Alg/DOX could overcome physical barriers to target and accumulate in colon tumor tissues.Then DOX was released to kill tumor cells along with the phase transition(solid to liquid)of Fe Alg hydrogel,due to Fe3+was reduced to Fe^(2+)by intracellular GSH.Meanwhile,BI-ES selectively colonized into tumors and expressed endostatin(ES)protein to down-regulate VEGF and b FGF expression,exerting anti-angiogenic effect.Moreover,Fe Alg catalyzed H_(2)O_(2)in the local tumor to generate cytotoxic·OH,further enhancing the antitumor effect.The pharmacodynamic result in AOM/DSS model proved that BI-ES-Fe Alg/DOX had the best therapeutic effect,with the final V/V0of 2.19±0.57,which was significantly lower than the other groups.Meanwhile,on CT-26tumor-bearing model,it also showed an outstanding anti-tumor effect with inhibition rate of 82.12%±3.08%.In addition,lung metastases decreased significantly in tumor metastasis model after BI-ES-Fe Alg/DOX treatment. 展开更多
关键词 Bifidobacterium Infantis Hypoxia targeting TME-responsive drug release comprehensive treatment Colon tumor
下载PDF
上一页 1 2 下一页 到第
使用帮助 返回顶部