We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomies, Pvoteomies ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and ...We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomies, Pvoteomies ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue （to be published in the Spring of 2016）.展开更多
We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomics, Proteomics ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and ...We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomics, Proteomics ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue （to be published in the Spring of 2016）. Dr. Benjamin Meder （University of Heidelberg and German Center for Cardiovascular Research - DZHK, Germany） and Dr. Andreas Keller （Saarland University, Germany） are Guest Editors of this issue.展开更多
Over the past two decades, improved diagnosis, pharmaceutical therapies, and interventional strategies have impressively improved the armamentarium of modern cardiologists in the fight against the most incident and le...Over the past two decades, improved diagnosis, pharmaceutical therapies, and interventional strategies have impressively improved the armamentarium of modern cardiologists in the fight against the most incident and lethal diseases： heart failure, ischemic heart disease, and arrhythmia. The innovations in the field have mostly been enabled by inventions based on hypothesis-driven approaches. The invention and development of key cardiac biomarkers, such as natriuretic peptides and cardiac-specific troponins, may serve as examples.展开更多
For several decades, cardiovascular disease has been the leading cause of death throughout all countries. There is a strong genetic component to many disease subtypes （e.g., cardiomyopa- thy） and we are just beginni...For several decades, cardiovascular disease has been the leading cause of death throughout all countries. There is a strong genetic component to many disease subtypes （e.g., cardiomyopa- thy） and we are just beginning to understand the relevant genetic factors. Several studies have related RNA splicing to cardiovascular disease and circular RNAs （circRNAs） are an emerging player, circRNAs, which originate through back-splicing events from primary transcripts, are resis- tant to exonucleases and typically not polyadenylated. Initial functional studies show clear phenotypic outcomes for selected circRNAs. We provide, for the first time, a comprehensive catalogue of RNase R-resistant circRNA species for the adult murine heart. This work combines state-of-the-art circle sequencing with our novel DCC software to explore the circRNA landscape of heart tissue. Overall, we identified 575 circRNA species that pass a beta-binomial test for enrichment （false discovery rate of 1%） in the exonuclease-treated sequencing sample. Several circRNAs can be directly attributed to host genes that have been previously described as associated with cardiovascular disease. Further studies of these candidate circRNAs may reveal disease-relevant properties or functions of specific circRNAs.展开更多
文摘We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomies, Pvoteomies ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue （to be published in the Spring of 2016）.
文摘We are pleased to announce a special issue on ＂Computational Cardiology＂ of the journal Genomics, Proteomics ＆ Bioinformatics （GPB）, aiming to provide a platform for high-quality papers focusing on the topic and we invite submissions for this special issue （to be published in the Spring of 2016）. Dr. Benjamin Meder （University of Heidelberg and German Center for Cardiovascular Research - DZHK, Germany） and Dr. Andreas Keller （Saarland University, Germany） are Guest Editors of this issue.
基金supported by grants from the German Ministry of Education and Research (BMBF)Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK, German Centre for Cardiovascular Research), and Siemens Health Care Gmb H (Siemens/University Heidelberg Joint Research Project: Care4DCM) of Germany as well as the European Union (FP7 Best Ageing)supported by grants from Siemens Health Care Gmb H (Siemens/University Heidelberg Joint Research Project: Care4DCM) of Germany and the European Union (FP7 Best Ageing)
文摘Over the past two decades, improved diagnosis, pharmaceutical therapies, and interventional strategies have impressively improved the armamentarium of modern cardiologists in the fight against the most incident and lethal diseases： heart failure, ischemic heart disease, and arrhythmia. The innovations in the field have mostly been enabled by inventions based on hypothesis-driven approaches. The invention and development of key cardiac biomarkers, such as natriuretic peptides and cardiac-specific troponins, may serve as examples.
基金supported by the Klaus Tschira Stiftung, Heidelberg, Germany
文摘For several decades, cardiovascular disease has been the leading cause of death throughout all countries. There is a strong genetic component to many disease subtypes （e.g., cardiomyopa- thy） and we are just beginning to understand the relevant genetic factors. Several studies have related RNA splicing to cardiovascular disease and circular RNAs （circRNAs） are an emerging player, circRNAs, which originate through back-splicing events from primary transcripts, are resis- tant to exonucleases and typically not polyadenylated. Initial functional studies show clear phenotypic outcomes for selected circRNAs. We provide, for the first time, a comprehensive catalogue of RNase R-resistant circRNA species for the adult murine heart. This work combines state-of-the-art circle sequencing with our novel DCC software to explore the circRNA landscape of heart tissue. Overall, we identified 575 circRNA species that pass a beta-binomial test for enrichment （false discovery rate of 1%） in the exonuclease-treated sequencing sample. Several circRNAs can be directly attributed to host genes that have been previously described as associated with cardiovascular disease. Further studies of these candidate circRNAs may reveal disease-relevant properties or functions of specific circRNAs.
