Development of a Decision Aid for Family Surrogate Decision Makers of Critically Ill Patients Requiring Renal Replacement Therapy in ICU:A User-Centered Design for Rapid Prototyping

Objectives Renal replacement therapy(RRT)is increasingly adopted for critically ill patients diagnosed with acute kidney injury,but the optimal time for initiation remains unclear and prognosis is uncertain,leading to medical complexity,ethical conflicts,and decision dilemmas in intensive care unit(ICU)settings.This study aimed to develop a decision aid(DA)for the family surrogate of critically ill patients to support their engagement in shared decision-making process with clinicians.Methods Development of DA employed a systematic process with user-centered design(UCD)principle,which included:(i)competitive analysis:searched,screened,and assessed the existing DAs to gather insights for design strategies,developmental techniques,and functionalities;(ii)user needs assessment:interviewed family surrogates in our hospital to explore target user group's decision-making experience and identify their unmet needs;(iii)evidence syntheses:integrate latest clinical evidence and pertinent information to inform the content development of DA.Results The competitive analysis included 16 relevant DAs,from which we derived valuable insights using existing resources.User decision needs were explored among a cohort of 15 family surrogates,revealing four thematic issues in decision-making,including stuck into dilemmas,sense of uncertainty,limited capacity,and delayed decision confirmation.A total of 27 articles were included for evidence syntheses.Relevant decision making knowledge on disease and treatment,as delineated in the literature sourced from decision support system or clinical guidelines,were formatted as the foundational knowledge base.Twenty-one items of evidence were extracted and integrated into the content panels of benefits and risks of RRT,possible outcomes,and reasons to choose.The DA was drafted into a web-based phototype using the elements of UCD.This platform could guide users in their preparation of decision-making through a sequential four-step process:identifying treatment options,weighing the benefits and risks,clarifying personal preferences and values,and formulating a schedule for formal shared decision-making with clinicians.Conclusions We developed a rapid prototype of DA tailored for family surrogate decision makers of critically ill patients in need of RRT in ICU setting.Future studies are needed to evaluate its usability,feasibility,and clinical effects of this intervention.

Computer Aided Design Technology for Convex Faceted Gem Cuts Based on the Half-Edge Data Structure

Aiming to increase the efficiency of gem design and manufacturing, a new method in computer-aided-design (CAD) of convex faceted gem cuts (CFGC) based on Half-edge data structure (HDS), including the algorithms for the implementation is presented in this work. By using object-oriented methods, geometrical elements of CFGC are classified and responding geometrical feature classes are established. Each class is implemented and embedded based on the gem process. Matrix arithmetic and analytical geometry are used to derive the affine transformation and the cutting algorithm. Based on the demand for a diversity of gem cuts, CAD functions both for free-style faceted cuts and parametric designs of typical cuts and visualization and human-computer interactions of the CAD system including two-dimensional and three-dimensional interactions have been realized which enhances the flexibility and universality of the CAD system. Furthermore, data in this CAD system can also be used directly by the gem CAM module, which will promote the gem CAD/CAM integration.

AIDD与CADD提升药物成功率的思考

随着人工智能(AI)和计算科学的迅速发展,特别是人工智能药物设计(AIDD)与计算机辅助药物设计(CADD)技术的引入,自然语言处理、图像识别、深度学习和机器学习等多种技术为新药开发提供了革命性的新途径,大幅提升了研发流程的效率和成功率。在药物发现过程中,AI技术加速了药物靶点的识别、候选药物的筛选、药理评估及质量检验,有效降低了研发风险和成本。本文深入探讨AIDD和CADD技术在药物研发中的应用,分析它们在提升药物设计成功率和药物研发效率方面的思考与探索,并探讨这些技术的未来发展趋势及可能面临的挑战。

Application of computer-aided engineering optimum design method in aluminum profile extrusion mould

The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.

Mobile Jammer-Aided Secure UAV Communications via Trajectory Design and Power Control

To further promote the achievable average secrecy rate for UAV-ground communications, a UAV-aided mobile jamming strategy was proposed in this paper. Specifically, an additional cooperative UAV is employed as a mobile jammer to transmit the jamming signal to help keep the source UAV closer to the ground destination, thus establishing more favorable legitimate link and enhancing the secrecy performance. We aimed to maximize the achievable secrecy rate by jointly optimizing the trajectories and transmit power of both source UAV and jammer UAV. To solve the considered non-convex optimization problem, we presented a block coordinate descent based iterative algorithm to address a sequence of approximated convex problems for the optimized parameter block by block to find a local optimal solution. Numerical results verify that the proposed algorithm can achieve significant secrecy rate gain compared to all the benchmark schemes.

Computer-aided Design and Custom-made Guide in Corrective Osteotomy for Complex Femoral Deformity

Summary： Preoperative planning of corrective osteotomy with traditional radiography has limitations in regards to determining the ideal osteotomy location and orientation in three-dimensional femoral de- formities. Though a successful operation can be planned preoperatively, intraoperative contingencies might adhere to the procedural plan in the performance of operation. To efficiently perform a planned procedure, proposed is a design to implement three-dimensional reconstruction photography, based on computer-tomography （CT） scan. A custom-made guide was designed to navigate the osteotomy as planned, and additionally, a personalized intramedullary nail was used for fixation after osteotomy. Three-dimensional （3D） photography of deformed femur was established based on the CT dataset and transferred into 3D photography processing software for further planning. Osteotomy planes were de- signed and adjusted at deformity sites to correct the 3D deformities. The methodology of a custom-made osteotomy guide was introduced in femoral corrective osteotomy, for the first time, to navigate the op- eration as planned. After the virtual osteotomy and reduction of bone segments, the parameters of a custom-made intramedullary nail were measured for manufacturing. Findings Virtual operation in computer shows complete correction of the 3D deformity. The osteotomy guide, obtained by rapid-prototyping techniques, navigates mimicking surgery on rapid-prototyping model of the involved femur as planned. Internal fixation was achieved using the custom-made intramedullary nail. Interpreta- tion three-dimensional visualization introduces an advantage in preoperative planning for corrective os- teotomy of 3D femoral deformity, and the custom-made osteotomy guide is crucial to realize such a de- liberate plan during the actual procedures. The internal fixator, such as an intramedullary nail, can be modified or personalized for fixation in unique cases.

DESIGN OBJECT MODEL AND DESIGN PROCESS MODEL OF COMPUTER AIDED AIRCRAFT CONCEPTUAL DESIGN SYSTEM

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A NEW SYSTEM FOR COMPUTER AIDED PATTERN DESIGN——CAPDS

This paper proposes a new computer aided pattern design system(CAPDS)in which a uniformmathematical expression is used to construct different objects. In the geometric model, 3 B-splineis adopted as a line model. The new system with uniform mathematical expression has the distin-guishing features: curve smoothness and fidelity, convenience to process graphic data in thedatabase and etc.. This paper presents the data structure, the program structure and also the implementation.

3-D MODELLING OF COMPUTER AIDED GARMENT DESIGN

This paper describes a method of the computer aided garment design,and discusses 3-D humanbody,wire frame modelling,approaches of expressing and a shading model of the 3-D garment.

Computer-aided designing and manufacturing of advanced steels

Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.

Case-based intelligent computer aided design system of welding machinery

The procedure during complex system plan design of welding position-locating machine is studied in this paper. The main difficulties in designing welding position-locating machine utilizing computer are discussed as well. A method of case-based intelligent CAD system for welding position-locating machine ( WMICAD) is put forward through wide research on design methodology. Object-oriented programming method is also applied to Ms system. The basic idea and realizing method are described.

Combine Gearbox Aided Design Based on Artificial Neural Networks

In the optimum design of the self-propelled combine gearbox, the knowledge of ANN is applied to overcome slow calculation and low design efficiency. We did the normative approach of the charts information,then solved the difficult problems in the design process and get satisfactory results. We also completed three-dimensional design of the gearbox in order to verify the rationality of the design visually.

ON CURVED SURFACE APPROXIMATION AND HIDDEN SURFACE ELIMINATION IN 3-D COMPUTER AIDED GARMENT DESIGN

An approximation method for curved surface mannequin and hidden surface eliminationin 3-D computer aided garment design system is described. The mannequin is the basis of the3-D modeling for clothes. In terms of the requirements of computer aided garment design,the authors put forward a method for curved surface approximation in the meaning of leastsquares. Using. this method the computation of geometric modeling is simple andefficient. It is also convenient for curved surface modification and shading.

COMPUTER-AIDED DESIGN OF ADAPTIVE PULSED ARC WELDING OF ROOT WELDS BY MELTING ELECTRODE

The purpose of computer-aided design of new adaptive pulsed arc technologies of welding is: to de- sign optimum algorithms of pulsed control over main energy parameters of welding.It permits:to in- crease welding productivity, to stabilize the welding regime, to control weld formation,taking into ac- count its spatial position, to proveal specie strength of the welded and coatings. Computer- aided design reduces the time of development of new pulsed arc technology:provides the optimization of technological referes according to the operating conditions of welded joints,the prediction of the ser- vice life of the welds.The developed methodology of computer-aided design of advanced technologies, models, original software, adaptive algorithms of pulsed control, and spend equipment permits to regulate penetration,the weld shape, the sizes of heat - affected zone; to predict sired properties and quality of welded joints.

A Computer-aided Design System for Framed-mould in Autoclave Processing

The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.

Computer-Aided Design of Some Advanced Steels and Cemented Carbides

Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.

Research on Computer Aided Design （CAD） Technique and Novel Pattern for Electronic Architectural Drawing and Perspective

With the progress of computer technology, CAD technique is urgent needed. In this paper, we conduct numerical and theoretical analysis and research on computer aided design technique and novel pattern for electronic architectural drawing and perspective. AUTOCAD drawing soRware because of its versatility and easy entry, in engineering has broad user base, but also because of the basis of general drawing software, often cannot directly use of the existing order efficiently complete professional drawing. We modify the current pattern and introduce our proposed pattern for advancement. The experiment proves the effectiveness of the pattern. In addition, we will conduct more insightful research in the future to nolish the current anoroach.

A Method for Solving Computer-Aided Product Design Optimization Problem Based on Back Propagation Neural Network

Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.

Computer Aided Design and Performance Analysis of Inverse Fluidized Bed Biofilm Reactors with Special Reference to Bioplastic Synthesis

Poly Laevo Lactic Acid (PLLA), in spite of being an excellent bioplastic, has exorbitantly high market price due to the high cost of raw material (lactose, glucose, sucrose). Hence, its manufacture is being attempted starting from waste effluents such as cheese whey and molasses. Earlier studies on the same in fluidized bed and semifluidized bed biofilm reactors yielded encouraging results. The present study therefore involves design and analysis of inverse fluidized bed biofilm reactors for lactic acid synthesis. The performance features of the bioreactor have been studied both mathematically as well as experimentally. The inverse fluidized bed biofilm reactor has been found to provide more than 75% conversion of sucrose/lactose even at high capacities (high feed flow rates) exceeding 56,000 L/hr, within a reasonably low reactor volume. The fractional substrate conversion increases, though sluggishly, with increase in feed flow rate due to bed expansion and also with increase in cell mass concentration in biofilm due to enhancement in intrinsic rate of bioconversion. The inverse fluidized bed biofilm reactor of proposed design could be safely recommended for the commercial synthesis of polymer grade lactic acid from waste effluents such as cheese whey and molasses. The low operating cost of the bioreactor (due to downflow mode of operation) enhances the economy of the process. This would also help in significantly lowering the market price of the green plastic (PLLA) and shall promote its large scale manufacture and utilisation.