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Bionic lightweight design of limb leg units for hydraulic quadruped robots by additive manufacturing and topology optimization
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作者 Huaizhi Zong Junhui Zhang +6 位作者 Lei Jiang Kun Zhang Jun Shen Zhenyu Lu Ke Wang Yanli Wang Bing Xu 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第1期1-13,共13页
Galloping cheetahs,climbing mountain goats,and load hauling horses all show desirable locomotion capability,which motivates the development of quadruped robots.Among various quadruped robots,hydraulically driven quadr... Galloping cheetahs,climbing mountain goats,and load hauling horses all show desirable locomotion capability,which motivates the development of quadruped robots.Among various quadruped robots,hydraulically driven quadruped robots show great potential in unstructured environments due to their discrete landing positions and large payloads.As the most critical movement unit of a quadruped robot,the limb leg unit(LLU)directly affects movement speed and reliability,and requires a compact and lightweight design.Inspired by the dexterous skeleton–muscle systems of cheetahs and humans,this paper proposes a highly integrated bionic actuator system for a better dynamic performance of an LLU.We propose that a cylinder barrel with multiple element interfaces and internal smooth channels is realized using metal additive manufacturing,and hybrid lattice structures are introduced into the lightweight design of the piston rod.In addition,additive manufacturing and topology optimization are incorporated to reduce the redundant material of the structural parts of the LLU.The mechanical properties of the actuator system are verified by numerical simulation and experiments,and the power density of the actuators is far greater than that of cheetah muscle.The mass of the optimized LLU is reduced by 24.5%,and the optimized LLU shows better response time performance when given a step signal,and presents a good trajectory tracking ability with the increase in motion frequency. 展开更多
关键词 Additive manufacturing Bionic lightweight design Limb leg unit Quadruped robot Trajectory tracking
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Advancements in machine learning for material design and process optimization in the field of additive manufacturing
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作者 Hao-ran Zhou Hao Yang +8 位作者 Huai-qian Li Ying-chun Ma Sen Yu Jian shi Jing-chang Cheng Peng Gao Bo Yu Zhi-quan Miao Yan-peng Wei 《China Foundry》 SCIE EI CAS CSCD 2024年第2期101-115,共15页
Additive manufacturing technology is highly regarded due to its advantages,such as high precision and the ability to address complex geometric challenges.However,the development of additive manufacturing process is co... Additive manufacturing technology is highly regarded due to its advantages,such as high precision and the ability to address complex geometric challenges.However,the development of additive manufacturing process is constrained by issues like unclear fundamental principles,complex experimental cycles,and high costs.Machine learning,as a novel artificial intelligence technology,has the potential to deeply engage in the development of additive manufacturing process,assisting engineers in learning and developing new techniques.This paper provides a comprehensive overview of the research and applications of machine learning in the field of additive manufacturing,particularly in model design and process development.Firstly,it introduces the background and significance of machine learning-assisted design in additive manufacturing process.It then further delves into the application of machine learning in additive manufacturing,focusing on model design and process guidance.Finally,it concludes by summarizing and forecasting the development trends of machine learning technology in the field of additive manufacturing. 展开更多
关键词 additive manufacturing machine learning material design process optimization intersection of disciplines embedded machine learning
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Computer-aided designing and manufacturing of advanced steels 被引量:1
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作者 LI Lin HE Yanlin +3 位作者 B.C. De Cooman P. Wollants S. G. Huang J. Vleugels 《Rare Metals》 SCIE EI CAS CSCD 2006年第5期407-411,共5页
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced... Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity (TRIP) steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure. 展开更多
关键词 material science advanced steel computer-aided design REFINING THERMODYNAMICS KINETICS
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Ballistic performance of additive manufacturing 316l stainless steel projectiles based on topology optimization method
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作者 Hao Xue Tao Wang +2 位作者 Xinyu Cui Yifan Wang Guangyan Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第5期1-17,共17页
Material and structure made by additive manufacturing(AM)have received much attention lately due to their flexibility and ability to customize complex structures.This study first implements multiple objective topology... Material and structure made by additive manufacturing(AM)have received much attention lately due to their flexibility and ability to customize complex structures.This study first implements multiple objective topology optimization simulations based on a projectile perforation model,and a new topologic projectile is obtained.Then two types of 316L stainless steel projectiles(the solid and the topology)are printed in a selective laser melt(SLM)machine to evaluate the penetration performance of the projectiles by the ballistic test.The experiment results show that the dimensionless specific kinetic energy value of topologic projectiles is higher than that of solid projectiles,indicating the better penetration ability of the topologic projectiles.Finally,microscopic studies(scanning electron microscope and X-ray micro-CT)are performed on the remaining projectiles to investigate the failure mechanism of the internal structure of the topologic projectiles.An explicit dynamics simulation was also performed,and the failure locations of the residual topologic projectiles were in good agreement with the experimental results,which can better guide the design of new projectiles combining AM and topology optimization in the future. 展开更多
关键词 Additive manufacturing Topology optimization Ballistic performance Projectile design
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Additive manufactured osseointegrated screws with hierarchical design
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作者 Wenbo Yang Hao Chen +6 位作者 Haotian Bai Yifu Sun Aobo Zhang Yang Liu Yuchao Song Qing Han Jincheng Wang 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第2期206-235,共30页
Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,s... Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,screws are evolving from solid and smooth to porous and rough.Additive manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and rough.This paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw breakage.Next,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing osseointegration.At the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore shape.In addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi structure.At the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated screws.Simultaneously,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated screws.AM osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength. 展开更多
关键词 Bone screws Additive manufacturing Architecture design Surface modification
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Research progress in CALPHAD assisted metal additive manufacturing
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作者 Ya-qing Hou Xiao-qun Li +5 位作者 Wei-dong Cai Qing Chen Wei-ce Gao Du-peng He Xue-hui Chen Hang Su 《China Foundry》 SCIE EI CAS CSCD 2024年第4期295-310,共16页
Metal additive manufacturing(MAM)technology has experienced rapid development in recent years.As both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology ba... Metal additive manufacturing(MAM)technology has experienced rapid development in recent years.As both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology based on high energy sources has become a key factor influencing the future development of MAM.The calculation of phase diagrams(CALPHAD)is an essential method and tool for constructing multi-component phase diagrams by employing experimental phase diagrams and Gibbs free energy models of simple systems.By combining with the element mobility data and non-equilibrium phase transition model,it has been widely used in the analysis of traditional metal materials.The development of CALPHAD application technology for MAM is focused on the compositional design of printable materials,the reduction of metallurgical imperfections,and the control of microstructural attributes.This endeavor carries considerable theoretical and practical significance.This paper summarizes the important achievements of CALPHAD in additive manufacturing(AM)technology in recent years,including material design,process parameter optimization,microstructure evolution simulation,and properties prediction.Finally,the limitations of applying CALPHAD technology to MAM technology are discussed,along with prospective research directions. 展开更多
关键词 metal additive manufacturing CALPHAD integrated computational material engineering powder bed fusion material design microstructure simulation
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A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy designed using cluster-plus-glue-atom model for laser additive manufacturing 被引量:1
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作者 Tian-yu Liu Yan-chun Lou +5 位作者 Shuang Zhang Zhi-hao Zhu Jun Zhao Shi-bing Liu Kun Shi Ning Zhao 《China Foundry》 SCIE CAS CSCD 2023年第5期414-422,共9页
A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy was designed using the cluster formula approach(cluster-plus-glue-atom model)and prepared by laser melting deposition(LMD).Its composition formula 12[Al-Ti_(12... A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy was designed using the cluster formula approach(cluster-plus-glue-atom model)and prepared by laser melting deposition(LMD).Its composition formula 12[Al-Ti_(12)](AlTi_(2))+5[Al_(0.8)Si_(0.2)-Ti_(12)Zr_(2)](V_(0.8)Mo_(0.2)Nb_(1)Ti)features an enhancedβ-Ti via co-alloying of Zr,V,Mo,Nb and Si.The experimental results show that the cluster formula ofαandβphases in the novel alloy are respectivelyα-[Al-Ti_(11.5)Zr_(0.5)](Al_(1)Ti_(2))andβ-[Al_(0.8)Si_(0.2)-Ti_(13.2)Zr_(0.8)](V_(1)Mo_(0.4)Nb_(1.6)),both containing Zr elements.The fitted composition via the α andβphase cluster formulas has little difference with the actual alloy composition,suggesting that the validity of cluster-plus-glue-atom model in the alloy composition design.After hot isostatic pressing(HIP),both the Ti-6Al-4V and the novel alloy by LMD are characterized by prior-βcolumnar grains,while the typical<100>texture disappears.Compared with Ti-6Al-4V,Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy exhibits a combination of higher strength(1,056 MPa)and higher ductility(14%)at room temperature and higher strength(580 MPa)at 550℃ after HIP,and can potentially serves as LMD materials. 展开更多
关键词 additive manufacturing laser melting deposition novel titanium alloy composition design cluster-plus-glue-atom model
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Design and In Situ Additive Manufacturing of Multifunctional Structures
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作者 Yan Zhang Guangyu Zhang +1 位作者 Jing Qiao Longqiu Li 《Engineering》 SCIE EI CAS CSCD 2023年第9期58-68,共11页
Multifunctional structures(MFSs)integrate diverse functions to achieve superior properties.However,conventional design and manufacturing methods—which generally lack quality control and largely depend on complex equi... Multifunctional structures(MFSs)integrate diverse functions to achieve superior properties.However,conventional design and manufacturing methods—which generally lack quality control and largely depend on complex equipment with multiple stations to achieve the integration of distinct materials and devices—are unable to satisfy the requirements of MFS applications in emerging industries such as aerospace engineering.Motivated by the concept of design for manufacturing,we adopt a layer regulation method with an established optimization model to design typical MFSs with load-bearing,electric,heat-conduction,and radiation-shielding functions.A high-temperature in situ additive manufacturing(AM)technology is developed to print various metallic wires or carbon fiber-reinforced high-meltingpoint polyetheretherketone(PEEK)composites.It is found that the MFS,despite its low mass,exceeds the stiffness of the PEEK substrate by 21.5%.The embedded electrics remain functional after the elastic deformation stage.Compared with those of the PEEK substrate,the equivalent thermal conductivity of the MFS beneath the central heat source area is enhanced by 568.0%,and the radiation shielding is improved by 27.9%.Moreover,a satellite prototype with diverse MFSs is rapidly constructed as an illustration.This work provides a systematic approach for high-performance design and advanced manufacturing,which exhibits considerable prospects for both the function expansion and performance enhancement of industrial equipment. 展开更多
关键词 Additive manufacturing Multifunctional structure Optimal design SATELLITE POLYETHERETHERKETONE
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The computer-aided design method of cabinet based on style imagery 被引量:2
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作者 沈张帆 薛澄岐 +3 位作者 王海燕 牛亚峰 邵将 张晶 《Journal of Southeast University(English Edition)》 EI CAS 2015年第3期369-374,共6页
Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle... Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies. 展开更多
关键词 CABINET computer-aided design style imagery component recombinant shape features
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The design, manufacture and application of multistable mechanical metamaterials-a state-of-the-art review 被引量:2
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作者 Rui Xu Chuanqing Chen +4 位作者 Jiapeng Sun Yulong He Xin Li Ming-Hui Lu Yanfeng Chen 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第4期416-452,共37页
Multistable mechanical metamaterials are a type of mechanical metamaterials with special features,such as reusability,energy storage and absorption capabilities,rapid deformation,and amplified output forces.These meta... Multistable mechanical metamaterials are a type of mechanical metamaterials with special features,such as reusability,energy storage and absorption capabilities,rapid deformation,and amplified output forces.These metamaterials are usually realized by series and/or parallel of bistable units.They can exhibit multiple stable configurations under external loads and can be switched reversely among each other,thereby realizing the reusability of mechanical metamaterials and offering broad engineering applications.This paper reviews the latest research progress in the design strategy,manufacture and application of multistable mechanical metamaterials.We divide bistable structures into three categories based on their basic element types and provide the criterion of their bistability.Various manufacturing techniques to fabricate these multistable mechanical metamaterials are introduced,including mold casting,cutting,folding and three-dimensional/4D printing.Furthermore,the prospects of multistable mechanical metamaterials for applications in soft driving,mechanical computing,energy absorption and wave controlling are discussed.Finally,this paper highlights possible challenges and opportunities for future investigations.The review aims to provide insights into the research and development of multistable mechanical metamaterials. 展开更多
关键词 multistable mechanical metamaterials bistable units mechanical properties design and manufacture
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Special Issue on Future Digital Design and Manufacturing:Embracing Industry 4.0 and Beyond 被引量:6
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作者 QIN Shengfeng CHENG Kai 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第6期1045-1045,共1页
Industry 4.0 as referred to the fourth industrial revolution has endorsed in several national manufacturing initiatives or development plans such as in Germany, the UK, USA and China. A set of important pervasive and ... Industry 4.0 as referred to the fourth industrial revolution has endorsed in several national manufacturing initiatives or development plans such as in Germany, the UK, USA and China. A set of important pervasive and secondary technologies for future manufacturing activities have been identified such as additive manufacturing, sensor technology, 展开更多
关键词 design In USA Special Issue on Future Digital design and manufacturing
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Future Digital Design and Manufacturing: Embracing Industry 4.0 and Beyond 被引量:3
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作者 Sheng-Feng Qin Kai Cheng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2017年第5期1047-1049,共3页
Digital design and manufacturing have been around for several decades from the numerical control of machine tools and automating engineering design in 1960s, through early Computer Aided Design (CAD)/Computer Aided ... Digital design and manufacturing have been around for several decades from the numerical control of machine tools and automating engineering design in 1960s, through early Computer Aided Design (CAD)/Computer Aided Engineering analysis (CAE)/Computer Aided Manufacturing (CAM), to modem digital design and manufacturing [1], and cloud manufacturing [2] converging into product lifecycle management (PLM) [3, 4] and Internet-enabled personalized manufacturing [5]. 展开更多
关键词 Digital design Future manufacturing Industry 4.0
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Application of computer-aided engineering optimum design method in aluminum profile extrusion mould 被引量:8
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作者 帅词俊 肖刚 +1 位作者 倪正顺 钟掘 《Journal of Central South University of Technology》 2003年第1期64-68,共5页
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine... The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces. 展开更多
关键词 EXTRUSION MOULD computer-aided ENGINEERING OPTIMUM design ANSYS
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Motion/Posture Modeling and Simulation Verification of Physically Handicapped in Manufacturing System Design 被引量:3
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作者 FU Yan LI Shiqi CHEN Gwen-guo 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第2期225-231,共7页
Non-obstacle design is critical to tailor physically handicapped workers in manufacturing system. Simultaneous consideration of variability in physically disabled users, machines and environment of the manufacturing s... Non-obstacle design is critical to tailor physically handicapped workers in manufacturing system. Simultaneous consideration of variability in physically disabled users, machines and environment of the manufacturing system is extremely complex and generally requires modeling of physically handicapped interaction with the system. Most current modeling either concentrates on the task results or functional disability. The integration of physical constraints with task constraints is far more complex because of functional disability and its extended influence on adjacent body parts. A framework is proposed to integrate the two constraints and thus model the specific behavior of the physical handicapped in virtual environment generated by product specifications. Within the framework a simplified model of physical disabled body is constructed, and body motion is generated based on 3 levels of constraints(effecter constraints, kinematics constraints and physical constraints). The kinematics and dynamic calculations are made and optimized based on the weighting manipulated by the kinematics constraints and dynamic constraints. With object transferring task as example, the model is validated in Jack 6.0. Modelled task motion elements except for squatting and overreaching well matched with captured motion elements. The proposed modeling method can model the complex behavior of the physically handicapped by integrating both task and physical disability constraints. 展开更多
关键词 physical handicapped motion/posture modeling manufacturing system design
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Additive Design and Manufacturing of Jet Engine Parts 被引量:7
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作者 Pinlian Han 《Engineering》 SCIE EI 2017年第5期648-652,共5页
The additive design (AD) and additive manufacturing (AM) of jet engine parts will revolutionize the traditional aerospace industry. The unique characteristics of AM, such as gradient materials and micro-structures... The additive design (AD) and additive manufacturing (AM) of jet engine parts will revolutionize the traditional aerospace industry. The unique characteristics of AM, such as gradient materials and micro-structures, have opened up a new direction in jet engine design and manufacturing. Engineers have been liberated from many constraints associated with traditional methodologies and technologies. One of the most significant features of the AM process is that it can ensure the consistency of parts because it starts from point(s), continues to line(s) and layer(s), and ends with the competed part. Collaboration between design and manufacturing is the key to success in fields including aerodynamics, thermodynamics, structural integration, heat transfer, material development, and machining. Engineers must change the way they design a part, as they shift from the traditional method of "subtracting material" to the new method of "adding material" in order to manufacture a part. AD is not the same as designing for AM, A new method and new tools are required to assist with this new way of designing and manufacturing. This paper discusses in detail what is required in AD and AM, and how current problems can be solved. 展开更多
关键词 Additive manufacturing Additive design Jet engine Porous structure
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Design for Ti-Al-V-Mo-Nb alloys for laser additive manufacturing based on a cluster model and on their microstructure and properties 被引量:6
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作者 Tian-yu Liu Zhi-hao Zhu +2 位作者 Shuang Zhang Xiao-hua Min Chuang Dong 《China Foundry》 SCIE CAS 2021年第4期424-432,共9页
In this study,α+βTi-Al-V-Mo-Nb alloys with the addition of multiple elements that are suitable for laser additive manufacturing(LAM)were designed according to a Ti-6Al-4V cluster formula.This formula can be expresse... In this study,α+βTi-Al-V-Mo-Nb alloys with the addition of multiple elements that are suitable for laser additive manufacturing(LAM)were designed according to a Ti-6Al-4V cluster formula.This formula can be expressed as 12[Al-Ti12](AlTi2)+5[Al-Ti14]((Mo,V,Nb)2Ti),in which Mo and Nb were added into the alloys partially instead of V to give alloys with nominal compositions of Ti-6.01Al-3.13V-1.43Nb,Ti-5.97Al-2.33V-2.93Mo,and Ti-5.97Al-2.33V-2.20Mo-0.71Nb(wt.%).The microstructures and mechanical properties of the as-deposited and heat-treated samples prepared via LAM were examined.The sizes of theβcolumnar grains andαlaths in the Nb-containing samples are found to be larger than those of the Ti-6Al-4V alloy,whereas Mo-or Mo/Nb-added alloys contain finer grains.It indicates that Nb gives rise to coarsenedβcolumnar grains andαlaths,while Mo significantly refines them.Furthermore,the single addition of Nb improves the elongation,whereas the single addition of Mo enhances the strength of the alloys.The simultaneous addition of Mo/Nb significantly improves the comprehensive mechanical properties of the alloys,leading to the best properties with an ultimate tensile strength of 1,070 MPa,a yield strength of 1,004 MPa,an elongation of 9%,and micro-hardness of 355 HV.The fracture modes of all the alloys are ductile-brittle mixed fracture. 展开更多
关键词 titanium alloy laser additive manufacturing cluster-plus-glue-atom model composition design microstructure mechanical properties
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Design and Manufacturing Strategies for Fused Deposition Modelling in Additive Manufacturing:A Review 被引量:3
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作者 Hugo I.Medellin-Castillo Jorge Zaragoza-Siqueiros 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2019年第3期1-16,共16页
Although several research works in the literature have focused on studying the capabilities of additive manufacturing(AM) systems, few works have addressed the development of Design for Additive Manufacturing(DfAM) kn... Although several research works in the literature have focused on studying the capabilities of additive manufacturing(AM) systems, few works have addressed the development of Design for Additive Manufacturing(DfAM) knowledge,tools, rules, and methodologies, which has limited the penetration and impact of AM in industry. In this paper a comprehensive review of design and manufacturing strategies for Fused Deposition Modelling(FDM) is presented.Consequently, several DfAM strategies are proposed and analysed based on existing research works and the operation principles, materials, capabilities and limitations of the FDM process. These strategies have been divided into four main groups: geometry, quality, materials and sustainability. The implementation and practicality of the proposed DfAM is illustrated by three case studies. The new proposed DfAM strategies are intended to assist designers and manufacturers when making decisions to satisfy functional needs, while ensuring manufacturability in FDM systems.Moreover, many of these strategies can be applied or extended to other AM processes besides FDM. 展开更多
关键词 Additive manufacturing(AM) design for additive manufacturing(DfAM) Fused Deposition Modelling(FDM) design and manufacturing strategies
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Integrated computer-aided formulation design:A case study of andrographolide/cyclodextrin ternary formulation 被引量:3
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作者 Haoshi Gao Yan Su +6 位作者 Wei Wang Wei Xiong Xiyang Sun Yuanhui Ji Hua Yu Haifeng Li Defang Ouyang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2021年第4期494-507,共14页
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario... Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design. 展开更多
关键词 Integrated computer-aided formulation design Machine learning Molecular dynamic simulation Physiologically based absorption modeling ANDROGRAPHOLIDE Cyclodextrins
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Architectural Design and Additive Manufacturing of Mechanical Metamaterials:A Review 被引量:3
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作者 Chenxi Lu Mengting Hsieh +5 位作者 Zhifeng Huang Chi Zhang Yaojun Lin Qiang Shen Fei Chen Lianmeng Zhang 《Engineering》 SCIE EI CAS 2022年第10期44-63,共20页
Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent materials.While... Mechanical metamaterials can be defined as a class of architected materials that exhibit unprecedented mechanical properties derived from designed artificial architectures rather than their constituent materials.While macroscale and simple layouts can be realized by conventional top-down manufacturing approaches,many of the sophisticated designs at various length scales remain elusive,due to the lack of adequate manufacturing methods.Recent progress in additive manufacturing(AM)has led to the realization of a myriad of novel metamaterial concepts.AM methods capable of fabricating microscale architectures with high resolution,arbitrary complexity,and high feature fidelity have enabled the rapid development of architected meta materials and drastically reduced the design-computation and experimental-validation cycle.This paper first provides a detailed review of various topologies based on the desired mechanical properties,including stiff,strong,and auxetic(negative Poisson’s ratio)metamaterials,followed by a discussion of the AM technologies capable of fabricating these metamaterials.Finally,we discuss current challenges and recommend future directions for AM and mechanical metamaterials. 展开更多
关键词 Mechanical metamaterials Auxetic materials Architectural design Additive manufacturing
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Test and Experiment Study on Synchronous Cooperative Design System Over Networked Manufacturing Platform 被引量:1
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作者 LUO Yabo~1 ZHENG Li~2 ZOU Shiwei~1 ZHAO Liang~1 1.School of Mechanical and Electrical Engineering,Wuhan University of Technology,Wuhan 430070,China 2.Department of Biology and Light Industry,Changsha University of Science and Technology,Changsha 410076,China 《武汉理工大学学报》 CAS CSCD 北大核心 2006年第S2期656-658,共3页
Based on the analysis on the previous research in virtual manufacturing and virtual enterprises,this paper pro- vides a novel architecture of networked manufacturing system around the cooperative design.The key techno... Based on the analysis on the previous research in virtual manufacturing and virtual enterprises,this paper pro- vides a novel architecture of networked manufacturing system around the cooperative design.The key technologies for synchronous cooperative design in networked manufacturing platform,such as the cooperative mechanism,cooperative rules,control authority conveyed,cooperative efficiency,are detailed,with which a synchronous cooperative design system is developed.Due to the cooper- ative efficiency is the major bottleneck of the synchronous cooperative design over Internet,this research details the test and experi- ment to demonstrate the practicality of the system.Finally the advantages of the system are illustrated compared with current soft- ware tools. 展开更多
关键词 NETWORKED manufacturing SYNCHRONOUS COOPERATIVE design RESOURCE SHARING
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