Engineering practice is the key bridge between college education and actual work in the industry.In order to deliver qualified talents with engineering quality to the industry,this paper explores integrating software ...Engineering practice is the key bridge between college education and actual work in the industry.In order to deliver qualified talents with engineering quality to the industry,this paper explores integrating software engineering thinking into the Embedded System Design course.A practical and effective teaching mode is designed consisting of immersive learning,case-based learning,progressive practice,interactive learning,and autonomous learning.Through this teaching mode,multi-levels of closed-loop have been established including final project cycle closed-loop,testing cycle closed-loop,and product cycle closed-loop.During this process,students gradually transition to putting forward product requirements,carrying out design and development,thinking and solving problems,collaborating,and assuring quality from the perspective of software engineering.The practice results show that students’engineering quality has been significantly improved.展开更多
A new kind offl biomedical titanium alloy, Ti-35Nb-4Sn-6Mo-9Zr, composed of non-toxic elements Nb, Mo, Zr and Sn with lower elastic modulus and higher strength was designed based on d-electron alloy design theory and ...A new kind offl biomedical titanium alloy, Ti-35Nb-4Sn-6Mo-9Zr, composed of non-toxic elements Nb, Mo, Zr and Sn with lower elastic modulus and higher strength was designed based on d-electron alloy design theory and JMatPro software using orthogonal experiment. The microstructure and basic mechanical properties of designed alloy were investigated. The results show that the alloy is composed of single fl equiaxed grains after solution treatment at 800 ~C. Compared with Ti-6A1-4V, the mechanical properties of the designed alloy are more excellent: E=65 GPa, σb=834 MPa, σ0.2=802 MPa, and σ=11%, which is expected to become a promising new type implanted material. The research approach adopted can reduce the experimental time and cost effectively, and get the ideal experimental results.展开更多
According to the morphological structure characteristics of plants, the de- velopment mode for component-based virtual plants software was put forward, and the internal structure of plant organs component under this m...According to the morphological structure characteristics of plants, the de- velopment mode for component-based virtual plants software was put forward, and the internal structure of plant organs component under this mode were analyzed, thereby, the overall design mode for virtual plants software was given out, and its characteristics were estimated. Compared with traditional development modes of virtual plants software, component-based virtual plants software had significant advantages in code reusing, development efficiency and expansion of software functions.展开更多
Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle...Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.展开更多
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine...The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.展开更多
In order to assure quality and control process in the development of the aircraft collaborative design software, a maturity assessment model is proposed. The requirements designing—house of quality is designed to eva...In order to assure quality and control process in the development of the aircraft collaborative design software, a maturity assessment model is proposed. The requirements designing—house of quality is designed to evaluate the maturity degree of the solution, and the evaluation results can help to manage and control the development process. Furthermore, a fuzzy evaluation method based on the minimum deviation is proposed to deal with the fuzzy information. The quantitative evaluation result of the maturity degree can be calculated by optimizing the semantic discount factor aim for the minimum deviation. Finally, this model is illustrated and analyzed by an example study of the aircraft collaborative design software.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
The advent of Industry 4.0 has compelled businesses to adopt digital approaches that combine software toenhance production efficiency. In this rapidly evolving market, software development is an ongoing process thatmu...The advent of Industry 4.0 has compelled businesses to adopt digital approaches that combine software toenhance production efficiency. In this rapidly evolving market, software development is an ongoing process thatmust be tailored to meet the dynamic needs of enterprises. However, internal research and development can beprohibitively expensive, driving many enterprises to outsource software development and upgrades to externalservice providers. This paper presents a software upgrade outsourcing model for enterprises and service providersthat accounts for the impact of market fluctuations on software adaptability. To mitigate the risk of adverseselection due to asymmetric information about the service provider’s cost and asymmetric information aboutthe enterprise’s revenues, we propose pay-per-time and revenue-sharing contracts in two distinct informationasymmetry scenarios. These two contracts specify the time and transfer payments for software upgrades. Througha comparative analysis of the optimal solutions under the two contracts and centralized decision-making withfull-information, we examine the characteristics of the solutions under two information asymmetry scenarios andanalyze the incentive effects of the two contracts on the various stakeholders. Overall, our study offers valuableinsights for firms seeking to optimize their outsourcing strategies and maximize their returns on investment insoftware upgrades.展开更多
3D digital design for cranes’ structures based on hybrid software architecture of Client/Server and Browser/Server is introduced in this paper. Based on Pro/ENGINEER platform,3D parametric model family is built to al...3D digital design for cranes’ structures based on hybrid software architecture of Client/Server and Browser/Server is introduced in this paper. Based on Pro/ENGINEER platform,3D parametric model family is built to allow generation of feasible configurations of cranes’ structures in Client/Server framework. Taking use of Visual C++,the second exploiting software kit provided by Pro/ENGINEER and ANSYS GUI/APDL modeling patterns,an integration method of 3D CAD and CAE is achieved,which includes regeneration of 3D parametric model,synchronous updating and analysis of FEA model. As in Browser/Server framework,the 3D CAD models of parts,components and the whole structure could also be displayed in the customer’s browser in VRML format.展开更多
Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice mo...Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C (M= Ti, Ta, Nh) systems and Co-V-C system were modeled. Solution parameters and thermodynamic: properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.展开更多
Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced...Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity (TRIP) steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.展开更多
The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the...The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system (FMCAD) used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented (O-O) technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.展开更多
Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage dis...Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.展开更多
Design patterns are object oriented software design practices for solving common design problems and they affect software quality. In this study, we investigate the relationship of design patterns and software defects...Design patterns are object oriented software design practices for solving common design problems and they affect software quality. In this study, we investigate the relationship of design patterns and software defects in a number of open source software projects. Design pattern instances are extracted from the source code repository of these open source software projects. Software defect metrics are extracted from the bug tracking systems of these projects. Using correlation and regression analysis on extracted data, we examine the relationship between design patterns and software defects. Our findings indicate that there is little correlation between the total number of design pattern instances and the number of defects. However, our regression analysis reveals that individual design pattern instances as a group have strong influences on the number of defects. Furthermore, we find that the number of design pattern instances is positively correlated to defect priority. Individual design pattern instances may have positive or negative impacts on defect priority.展开更多
Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to...Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.展开更多
This paper points out various relationships between Design Knowledge and Software Engineering. After introduction of human design, the relationships between industrial Software Engineering is discussed, then further d...This paper points out various relationships between Design Knowledge and Software Engineering. After introduction of human design, the relationships between industrial Software Engineering is discussed, then further details of human design knowledge are revealed with discussions on humanistic aspects of design.展开更多
The technologies of software architecture are introduced, and the software analysis-and-design process is divided into requirement analysis, software architecture design and system design. Using these technologies, a ...The technologies of software architecture are introduced, and the software analysis-and-design process is divided into requirement analysis, software architecture design and system design. Using these technologies, a model of architecture-centric software analysis and design process(ACSADP) is proposed. Meanwhile, with regard to the completeness, consistency and correctness between the software requirements and design results, the theories of function and process control are applied to ACSADP. Finally, a model of integrated development environnment (IDE) for ACSADP is propcsed. It can be demonstrated by the practice that the model of ACSADP can aid developer to manage software process effectively and improve the quality of software analysis and design.展开更多
Presents the design scheme developed for design of software for Integrated Passive and Active Vibration Control(IPAVC) and the coding of a prototyne system, and the selection of the famous finite element program MSC/N...Presents the design scheme developed for design of software for Integrated Passive and Active Vibration Control(IPAVC) and the coding of a prototyne system, and the selection of the famous finite element program MSC/NASTRAN as an important module of software to deal with large and complicated structures and systems with an example to demonstrate the prototype system.展开更多
In this paper, we propose a novel methodology to guide and assist practitioners supporting software architecture and design activities in agile environments. Software architecture and design is the skeleton of a syste...In this paper, we propose a novel methodology to guide and assist practitioners supporting software architecture and design activities in agile environments. Software architecture and design is the skeleton of a system. It defines how the system has to behave in terms of different functional and non-functional requirements. Currently, a clear specification of software architectural design activities and processes in agile environments does not exist. Our methodology describes in detail the phases in the agile software design process and proposes techniques and tools to implement these phases.展开更多
This paper presents the design of a computational software system that enables solutions of multi-phase and multi-scale problems in mechanics. It demonstrated how mechanicians can design “process-driven” software sy...This paper presents the design of a computational software system that enables solutions of multi-phase and multi-scale problems in mechanics. It demonstrated how mechanicians can design “process-driven” software systems directly, and that such efforts are more suitable in solving multi-phase or multi-scale problems, rather than utilizing the “data-driven” approaches of legacy network systems. Specifically, this paper demonstrates how this approach can be used to solve problems in flexible dynamics. Then it suggests a view of mechanics algorithms as ‘state equilibrium’ enforcers residing as servers, rather than as computer programs that solve field equations. It puts forth the need for identical input/output files to ensure widespread deployment on laptops. Then it presents an assessment of the laptop platform. A software system such as the one presented here can also be used to supply virtual environments, animations and entertainment/education software with physics.展开更多
文摘Engineering practice is the key bridge between college education and actual work in the industry.In order to deliver qualified talents with engineering quality to the industry,this paper explores integrating software engineering thinking into the Embedded System Design course.A practical and effective teaching mode is designed consisting of immersive learning,case-based learning,progressive practice,interactive learning,and autonomous learning.Through this teaching mode,multi-levels of closed-loop have been established including final project cycle closed-loop,testing cycle closed-loop,and product cycle closed-loop.During this process,students gradually transition to putting forward product requirements,carrying out design and development,thinking and solving problems,collaborating,and assuring quality from the perspective of software engineering.The practice results show that students’engineering quality has been significantly improved.
基金Project(BE2011778)supported by Science and Technology Support Program of Jiangsu Province,ChinaProject(20133069014)supported by Aeronautical Science Foundation of China
文摘A new kind offl biomedical titanium alloy, Ti-35Nb-4Sn-6Mo-9Zr, composed of non-toxic elements Nb, Mo, Zr and Sn with lower elastic modulus and higher strength was designed based on d-electron alloy design theory and JMatPro software using orthogonal experiment. The microstructure and basic mechanical properties of designed alloy were investigated. The results show that the alloy is composed of single fl equiaxed grains after solution treatment at 800 ~C. Compared with Ti-6A1-4V, the mechanical properties of the designed alloy are more excellent: E=65 GPa, σb=834 MPa, σ0.2=802 MPa, and σ=11%, which is expected to become a promising new type implanted material. The research approach adopted can reduce the experimental time and cost effectively, and get the ideal experimental results.
基金Supported by the National Natural Science Foundation of China(61062007)the Principal Fund Project of Tarim University,China(TDZKSS201115)~~
文摘According to the morphological structure characteristics of plants, the de- velopment mode for component-based virtual plants software was put forward, and the internal structure of plant organs component under this mode were analyzed, thereby, the overall design mode for virtual plants software was given out, and its characteristics were estimated. Compared with traditional development modes of virtual plants software, component-based virtual plants software had significant advantages in code reusing, development efficiency and expansion of software functions.
基金The National Natural Science Foundation of China(No.71271053)the Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXLX13_082)
文摘Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.
文摘The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.
基金supported by the National Natural Science Foundation for Youth of China(61802174)the Natural Science Foundation for Youth of Jiangsu Province(BK20181016)+1 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(18KJB520019)the Scientific Research Foundation of Nanjing Institute of Technology of China(YKJ201614)
文摘In order to assure quality and control process in the development of the aircraft collaborative design software, a maturity assessment model is proposed. The requirements designing—house of quality is designed to evaluate the maturity degree of the solution, and the evaluation results can help to manage and control the development process. Furthermore, a fuzzy evaluation method based on the minimum deviation is proposed to deal with the fuzzy information. The quantitative evaluation result of the maturity degree can be calculated by optimizing the semantic discount factor aim for the minimum deviation. Finally, this model is illustrated and analyzed by an example study of the aircraft collaborative design software.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘The advent of Industry 4.0 has compelled businesses to adopt digital approaches that combine software toenhance production efficiency. In this rapidly evolving market, software development is an ongoing process thatmust be tailored to meet the dynamic needs of enterprises. However, internal research and development can beprohibitively expensive, driving many enterprises to outsource software development and upgrades to externalservice providers. This paper presents a software upgrade outsourcing model for enterprises and service providersthat accounts for the impact of market fluctuations on software adaptability. To mitigate the risk of adverseselection due to asymmetric information about the service provider’s cost and asymmetric information aboutthe enterprise’s revenues, we propose pay-per-time and revenue-sharing contracts in two distinct informationasymmetry scenarios. These two contracts specify the time and transfer payments for software upgrades. Througha comparative analysis of the optimal solutions under the two contracts and centralized decision-making withfull-information, we examine the characteristics of the solutions under two information asymmetry scenarios andanalyze the incentive effects of the two contracts on the various stakeholders. Overall, our study offers valuableinsights for firms seeking to optimize their outsourcing strategies and maximize their returns on investment insoftware upgrades.
基金Supported by Shanghai Leading Academic Discipline Project ,Project Number :T0601
文摘3D digital design for cranes’ structures based on hybrid software architecture of Client/Server and Browser/Server is introduced in this paper. Based on Pro/ENGINEER platform,3D parametric model family is built to allow generation of feasible configurations of cranes’ structures in Client/Server framework. Taking use of Visual C++,the second exploiting software kit provided by Pro/ENGINEER and ANSYS GUI/APDL modeling patterns,an integration method of 3D CAD and CAE is achieved,which includes regeneration of 3D parametric model,synchronous updating and analysis of FEA model. As in Browser/Server framework,the 3D CAD models of parts,components and the whole structure could also be displayed in the customer’s browser in VRML format.
文摘Thermodynamic and kinetic study on TRIP (transformation induced plasticity) steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C (M= Ti, Ta, Nh) systems and Co-V-C system were modeled. Solution parameters and thermodynamic: properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.
基金The study was financially supported by the key project of Science and Technology Commission of Shanghai Local Gov-ernment (No. 015211010), the National Natural Science Foundation of China (No. 50171038) and the China-Belgium bi-lateral project (No. 2001-242).
文摘Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity (TRIP) steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.
文摘The general computer-aided design (CAD) software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system (FMCAD) used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented (O-O) technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.
基金This work was supported by grants from the National Sciences Fund(31370938 and 81272528)The Fund(81272528)offered experiment material and collected the data for analysisThe Fund(31370938)helped design the study and was helpful in preparing the manuscript.
文摘Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.
文摘Design patterns are object oriented software design practices for solving common design problems and they affect software quality. In this study, we investigate the relationship of design patterns and software defects in a number of open source software projects. Design pattern instances are extracted from the source code repository of these open source software projects. Software defect metrics are extracted from the bug tracking systems of these projects. Using correlation and regression analysis on extracted data, we examine the relationship between design patterns and software defects. Our findings indicate that there is little correlation between the total number of design pattern instances and the number of defects. However, our regression analysis reveals that individual design pattern instances as a group have strong influences on the number of defects. Furthermore, we find that the number of design pattern instances is positively correlated to defect priority. Individual design pattern instances may have positive or negative impacts on defect priority.
文摘Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.
文摘This paper points out various relationships between Design Knowledge and Software Engineering. After introduction of human design, the relationships between industrial Software Engineering is discussed, then further details of human design knowledge are revealed with discussions on humanistic aspects of design.
文摘The technologies of software architecture are introduced, and the software analysis-and-design process is divided into requirement analysis, software architecture design and system design. Using these technologies, a model of architecture-centric software analysis and design process(ACSADP) is proposed. Meanwhile, with regard to the completeness, consistency and correctness between the software requirements and design results, the theories of function and process control are applied to ACSADP. Finally, a model of integrated development environnment (IDE) for ACSADP is propcsed. It can be demonstrated by the practice that the model of ACSADP can aid developer to manage software process effectively and improve the quality of software analysis and design.
文摘Presents the design scheme developed for design of software for Integrated Passive and Active Vibration Control(IPAVC) and the coding of a prototyne system, and the selection of the famous finite element program MSC/NASTRAN as an important module of software to deal with large and complicated structures and systems with an example to demonstrate the prototype system.
文摘In this paper, we propose a novel methodology to guide and assist practitioners supporting software architecture and design activities in agile environments. Software architecture and design is the skeleton of a system. It defines how the system has to behave in terms of different functional and non-functional requirements. Currently, a clear specification of software architectural design activities and processes in agile environments does not exist. Our methodology describes in detail the phases in the agile software design process and proposes techniques and tools to implement these phases.
文摘This paper presents the design of a computational software system that enables solutions of multi-phase and multi-scale problems in mechanics. It demonstrated how mechanicians can design “process-driven” software systems directly, and that such efforts are more suitable in solving multi-phase or multi-scale problems, rather than utilizing the “data-driven” approaches of legacy network systems. Specifically, this paper demonstrates how this approach can be used to solve problems in flexible dynamics. Then it suggests a view of mechanics algorithms as ‘state equilibrium’ enforcers residing as servers, rather than as computer programs that solve field equations. It puts forth the need for identical input/output files to ensure widespread deployment on laptops. Then it presents an assessment of the laptop platform. A software system such as the one presented here can also be used to supply virtual environments, animations and entertainment/education software with physics.