Background:The theory of pulse diagnosis is to assess the physiological condition of the human body using radial pulse.However,pulses can vary markedly from person to person.Further,pulse diagnosis is difficult to lea...Background:The theory of pulse diagnosis is to assess the physiological condition of the human body using radial pulse.However,pulses can vary markedly from person to person.Further,pulse diagnosis is difficult to learn and requires one-on-one teaching.Methods:To address this problem,we built a home-made pulse diagnoser and measured human pulses for studying the standardization of pulse diagnosis.Our pulse diagnoser was composed of a piezoelectric transducer,differential amplifier,data acquisition instrument,and a Matlab analysis program.The measured pulses were converted into electronic signals by a piezoelectric transducer and saved on a computer.The digitalized data were then refined and analyzed by fast Fourier transform for frequency analysis.Simulations were performed to assess the factors that affected the pulse,including phase shifts of reflected pulse waves (generate sub-peaks in pulses),inconsistent heart rates (deform pulse waves),the vessel stiffness (alter harmonic frequencies of the pulses),and the wave amplitudes (determined by the pulse strength).Results:By comparing a published report and our simulation findings,we characterized the pulse types and the effects of various factors,and then applied the findings to study actual pulses in patients.Three types of pulses were determined from the frequency spectrumchoppy pulse (Se mai) without apparent harmonic peaks,the harmonic frequencies of wiry pulse (Xian mai) that are non-integer multiples of the fundamental frequency,and surging pulse (Hong mai) that exhibit strong amplitudes in the spectrum of frequency.A normal pulse and a slippery pulse were differentiated by a phase shift,but not by assessing the frequency spectrum.Conclusion:These findings confirm that frequency domain analysis can avoid ambiguity arising in assessing the three types of pulses in the time domain.Further studies of other pulses in the frequency domain are required to develop a precise electronic pulse diagnoser.展开更多
目的观察中药复方益糖康对气阴两虚型2型糖尿病(T2DM)患者胰岛β细胞功能及炎症因子的影响。方法选取符合纳入标准的90例初诊断气阴两虚证T2DM患者,随机分成对照组和观察组,各45例。对照组予以糖尿病教育、饮食、运动治疗及二甲双胍治疗...目的观察中药复方益糖康对气阴两虚型2型糖尿病(T2DM)患者胰岛β细胞功能及炎症因子的影响。方法选取符合纳入标准的90例初诊断气阴两虚证T2DM患者,随机分成对照组和观察组,各45例。对照组予以糖尿病教育、饮食、运动治疗及二甲双胍治疗,观察组患者在对照组基础上给予中药复方益糖康,观察治疗前后两组患者的血糖水平[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、胰岛β细胞功能[空腹C肽(FCP)、餐后2 h C肽(2 h PCP)]、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、中医证候积分、血清炎症因子[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)]变化情况。结果治疗2周后,两组患者血糖水平较治疗前均显著下降(P<0.05),但组间比较差异无统计学意义(P>0.05);观察组患者血糖水平、HbA1c、FCP、2 h CP、HOMA-IR、CRP、IL-6、TNF-α均低于对照组(P<0.05),而HOMA-β高于对照组(P<0.05);观察组中医证候积分明显改善(P<0.05)。结论中药复方益糖康能够改善气阴两虚型T2DM患者的胰岛β细胞功能,增加胰岛素敏感性,减轻胰岛素抵抗,增强血糖控制效果,并可以一定程度的改善患者的乏力、手足心热、酸胀沉重等临床表现。展开更多
基金the National Natural Science Foundation of China(81473597)China National Funds for Distinguished Young Scientists(30825046)Chang Jiang Scholars Program,and the 111 Project(B07007).
文摘Background:The theory of pulse diagnosis is to assess the physiological condition of the human body using radial pulse.However,pulses can vary markedly from person to person.Further,pulse diagnosis is difficult to learn and requires one-on-one teaching.Methods:To address this problem,we built a home-made pulse diagnoser and measured human pulses for studying the standardization of pulse diagnosis.Our pulse diagnoser was composed of a piezoelectric transducer,differential amplifier,data acquisition instrument,and a Matlab analysis program.The measured pulses were converted into electronic signals by a piezoelectric transducer and saved on a computer.The digitalized data were then refined and analyzed by fast Fourier transform for frequency analysis.Simulations were performed to assess the factors that affected the pulse,including phase shifts of reflected pulse waves (generate sub-peaks in pulses),inconsistent heart rates (deform pulse waves),the vessel stiffness (alter harmonic frequencies of the pulses),and the wave amplitudes (determined by the pulse strength).Results:By comparing a published report and our simulation findings,we characterized the pulse types and the effects of various factors,and then applied the findings to study actual pulses in patients.Three types of pulses were determined from the frequency spectrumchoppy pulse (Se mai) without apparent harmonic peaks,the harmonic frequencies of wiry pulse (Xian mai) that are non-integer multiples of the fundamental frequency,and surging pulse (Hong mai) that exhibit strong amplitudes in the spectrum of frequency.A normal pulse and a slippery pulse were differentiated by a phase shift,but not by assessing the frequency spectrum.Conclusion:These findings confirm that frequency domain analysis can avoid ambiguity arising in assessing the three types of pulses in the time domain.Further studies of other pulses in the frequency domain are required to develop a precise electronic pulse diagnoser.
文摘目的观察中药复方益糖康对气阴两虚型2型糖尿病(T2DM)患者胰岛β细胞功能及炎症因子的影响。方法选取符合纳入标准的90例初诊断气阴两虚证T2DM患者,随机分成对照组和观察组,各45例。对照组予以糖尿病教育、饮食、运动治疗及二甲双胍治疗,观察组患者在对照组基础上给予中药复方益糖康,观察治疗前后两组患者的血糖水平[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、胰岛β细胞功能[空腹C肽(FCP)、餐后2 h C肽(2 h PCP)]、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、中医证候积分、血清炎症因子[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)]变化情况。结果治疗2周后,两组患者血糖水平较治疗前均显著下降(P<0.05),但组间比较差异无统计学意义(P>0.05);观察组患者血糖水平、HbA1c、FCP、2 h CP、HOMA-IR、CRP、IL-6、TNF-α均低于对照组(P<0.05),而HOMA-β高于对照组(P<0.05);观察组中医证候积分明显改善(P<0.05)。结论中药复方益糖康能够改善气阴两虚型T2DM患者的胰岛β细胞功能,增加胰岛素敏感性,减轻胰岛素抵抗,增强血糖控制效果,并可以一定程度的改善患者的乏力、手足心热、酸胀沉重等临床表现。
