The computer-aided design method of cabinet based on style imagery

Due to the practical problems of the high costs and the long development cycle of China’s cabinet production,a computer-aided design method of the cabinet based on style imagery is proposed.According to the principle of the conjoint analysis method, the rough set theory and the weight coefficient of different components of the cabinet,a multi-dimensional model of style imagery to evaluate the cabinet is built. Then the related constants of style imagery are calculated and the cabinet components library is also built by the three-dimensional modeling.Finally,with recombinant technology and the mapping model between cabinet style and external characteristics,the prototype system based on Visual Studio is proposed.This system actualizes the bidirectional reasoning between product style imagery and the shape features,which can assist designers to produce more creative designs,greatly improve the efficiency of cabinet development and increase the profits of companies.

基于Style 3D针织运动装虚拟设计与应用

基于Style 3D虚拟服装试衣软件,通过对虚拟试衣技术现状的分析,以针织运动装作为虚拟试衣对象,从四个部分进行展开,包含人体建模,版片的三维排布与缝合,运动装面料仿真与试穿效果展示,以及驳样改款与模块组合。借助于三维面料扫描技术获取面料材质纹理和相关辅料配件,进一步丰富针织运动装的装饰效果。3D快速驳样改款和虚拟展示能有效地优化设计过程,针织运动装模块组合模拟应用适应快时尚节奏下改款搭配的需求,根据现有版型快速驳样改款亦是对传统设计与展示模式的一种突破。

Application of computer-aided engineering optimum design method in aluminum profile extrusion mould

The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces.

Integrated computer-aided formulation design:A case study of andrographolide/cyclodextrin ternary formulation

Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.

Computer-Aided Design of Some Advanced Steels and Cemented Carbides

Thermodynamic and kinetic study on TRIP （transformation induced plasticity） steels, cemented carbides and mold steel for plastics were carried out in order to design modern advanced materials. With the sublattice model, equilibrium compositions of ferrite and austenite phases in TRIP steels, as well as volume fraction of austenite at inter-critical temperatures for different time were calculated. Concentration profiles of carbon, manganese, aluminum and silicon in the steels were also estimated in the lattice fixed frame of reference. The effect of Si and Mn on TRIP was discussed according to thermodynamic and kinetic analyses. In order to understand and produce the graded nanophase structure of cemented carbides, miscellaneous phases in the M-Co-C （M= Ti, Ta, Nh） systems and Co-V-C system were modeled. Solution parameters and thermodynamic： properties were listed in detail. The improvement of machining behavior of prehardened mould steel for plastics was obtained by computer-aided composition design. The results showed that the matrix composition of large-section prehardened mould steel for plastic markedly influences the precipitation of non-metallic inclusion and the composition control by the aid of Thermo-Calc software package minimizes the amount of detrimental oxide inclusion. In addition, the modification of calcium was optimized in composition design.

Computer-aided designing and manufacturing of advanced steels

Suitable optimization and simulation were performed using a powerful software package with a mature database as well as modem measurement facilities, which led to the successful designing and manufacturing of advanced steels. In the course of designing, the composition of a large section of prehardened mold steel for plastics was estimated so as to lower the quantities of oxide inclusions to change the type of carbides and to raise the machinability. The composition and process were adjusted to obtain satisfactory surface quality for the prevailing galvanization in transformation-induced plasticity （TRIP） steel. The refuting process of low-carbon steel was simulated in the light of both Thermo-Calc and Factsage. Thermodynamic and kinetic analyses were always conducted during the test and the procedure.

A Computer-aided Design System for Framed-mould in Autoclave Processing

The general computer-aided design （CAD） software cannot meet the mould design requirement of the autoclave process for composites, because many parameters such as temperature and pressure should be considered in the mould design process, in addition to the material and geometry of the part. A framed-mould computer-aided design system （FMCAD） used in the autoclave moulding process is proposed in this paper. A function model of the software is presented, in which influence factors such as part structure, mould structure, and process parameters are considered; a design model of the software is established using object oriented （O-O） technology to integrate the stiffness calculation, temperature field calculation, and deformation field calculation of mould in the design, and in the design model, a hybrid model of mould based on calculation feature and form feature is presented to support those calculations. A prototype system is developed, in which a mould design process wizard is built to integrate the input information, calculation, analysis, data storage, display, and design results of mould design. Finally, three design examples are used to verify the prototype.

A Novel Human Antibody,HF,against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

Fully human antibodies have minimal immunogenicity and safety profiles.At present,most potential antibody drugs in clinical trials are humanized or fully human.Human antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain reaction.Here,we describe a structure-based computer-aided de novo design technology for human antibody generation.Based on the complex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin.Next,these peptides were set as complementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than Herceptin.Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.

A Method for Solving Computer-Aided Product Design Optimization Problem Based on Back Propagation Neural Network

Because of the powerful mapping ability, back propagation neural network (BP-NN) has been employed in computer-aided product design (CAPD) to establish the property prediction model. The backward problem in CAPD is to search for the appropriate structure or composition of the product with desired property, which is an optimization problem. In this paper, a global optimization method of using the a BB algorithm to solve the backward problem is presented. In particular, a convex lower bounding function is constructed for the objective function formulated with BP-NN model, and the calculation of the key parameter a is implemented by recurring to the interval Hessian matrix of the objective function. Two case studies involving the design of dopamine β-hydroxylase (DβH) inhibitors and linear low density polyethylene (LLDPE) nano composites are investigated using the proposed method.

Computer-Aided Design and Fabrication of Finger Prosthesis

Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual skill. Here we propose a computer-aided method for fabricating finger pros-theses to save time and allow fabrications that do not require considerable manual skill. In this method, the dimensions of a patient’s healthy finger on the contralateral hand are first measured using a caliper. Using these dimensions, a three-dimensional model is constructed for fabricating a prosthesis for the patient’s impaired finger. Using the 3D model, a mold is designed using 3D modeling tools and a computer-aided design system. The resulting mold is then fabricated using a 3D printer. A finger prosthesis is fabricated by pouring silicone resin into the mold. A finger prosthesis for a volunteer was experimentally fabricated according to the proposed method. To evaluate the size and shape of the finger prosthesis, the difference between the finger prosthesis and the original finger of the volunteer was analyzed. Because the average difference between them was 0.25 mm, it was concluded that the proposed method could be used to fabricate a finger prosthesis of adequate size and shape.

Computer-Aided Design of X-Ray Microtomographic Scanners

The article is to study the development of computer-aided design of X-ray microtomography—the device for investigating the structure and construction of three-dimensional images of organic and inorganic objects on the basis of shadow projections. This article provides basic information regarding CAD of X-ray microtomography and a scheme consisting of three levels. The article also shows basic relations of X-ray computed tomography, the generalized scheme of an X-ray microtomographic scanner. The methods of X-ray imaging of the spatial microstructure and morphometry of materials are described. The main characteristics of an X-ray microtomographic scanner, the X-ray source, X-ray optical elements and mechanical components of the positioning system are shown. The block scheme and software functional scheme for intelligent neural network system of analysis of the internal microstructure of objects are presented. The method of choice of design parameters of CAD of X-ray microtomography aims at improving the quality of design and reducing costs of it. It is supposed to reduce the design time and eliminate the growing number of engineers involved in development and construction of X-ray microtomographic scanners.

基于多尺度扩张注意力的Styleformer汽车造型设计

为了提升汽车设计图像的质量,开发了两个专门的数据集并通过多尺度扩张注意力机制优化现有的图像生成模型,以便捕获汽车的主体特征和结构细节.首先,创建了“WhiteCarSet”和“WhiteCarContour”数据集,分别聚焦于汽车的本体特征采集和汽车轮廓的精确收集.其次,针对图像生成模型,我们对Styleformer进行了改进,引入了多尺度扩张注意力操作,以增强模型捕获长距离依赖和理解对象全局结构的能力.在多个数据集上的实验结果显示,改进后的模型FID值相较于传统模型实现了15.57%的提升.在相同的改进模型Styleformer-M而数据集不同的情况下,使用我们开发的数据集,FID值比其它数据集提高了约22.29%.

Headwear design:Relationship between the headwear and the overall styling

This article examines the relationship between headwear design and overall clothing styling,emphasizing the importance of headwear in conveying personal style and cultural identity.It traces the evolution of Chinese and Western headwear throughout history,highlighting the interplay between headwear and the wearer's personal charac-teristics,life events,and cultural background.The article concludes by emphasizing that headwear design is not only a reflection of fashion,but also a manifestation of cultural depth and individuality.

基于Style 3D的一片袖造型结构变化设计应用

衣袖的结构变化非常丰富,不同的结构可以给服装带来不同的穿着效果。通过分析一片袖的特征及结构设计要素,利用Style 3D虚拟试衣技术实现衣袖和衣身的组合设计,可提高服装结构设计的效率,较为具象化地展现了衣袖结构变化对服装款式设计的影响。

Computer-aided molecular design and optimization of potent inhibitors disrupting APC-Asef interaction

Colorectal cancer(CRC)is the second leading cause of cancer mortality worldwide.At initial diagnosis,approximately 20%of patients are diagnosed with metastatic CRC(mCRC).Although the APC-Asef interaction is a well-established target for mCRC therapy,the discovery and development of effective and safe drugs for mCRC patients remains an urgent and challenging endeavor.In this study,we identified a novel structural scaffold based on MAI inhibitors,the first-in-class APC-Asef inhibitors we reported previously.ONIOM model-driven optimizations of the N-terminal cap and experimental evaluations of inhibitory activity were performed,and 24-fold greater potency was obtained with the best inhibitor compared to the parental compound.In addition,the cocrystal structure validated that the two-layerπ-πstacking interactions were essential for inhibitor stabilization in the bound state.Furthermore,in vitro and in vivo studies have demonstrated that novel inhibitors suppressed lung metastasis in CRC by disrupting the APC-Asef interaction.These results provide an intrinsic structural basis to further explore drug-like molecules for APC-Asef-mediated CRC therapy.

基于Style 3D虚拟仿真技术的袖子样板设计

袖子作为服装结构中的重要部分,绘制样板不仅要考虑人体尺寸,还要考虑面料特性和服装整体造型的美观性。为了设计出更符合要求的袖子样板,运用二维CAD调整袖山吃势和袖山高,绘制不同的袖子造型结构图,将绘制的二维样板导入Style 3D系统进行模特虚拟试穿,直观地体现不同袖子结构穿着效果。Style 3D虚拟仿真技术为服装样板设计提供了很好的验证方法,对比样衣制作节省了90%的时间,同时节省了人力和原材料成本。此外,服装3D虚拟设计方法还可以运用至高校技术研发和教学,为服装行业实现碳达峰、碳中和提供思路。

Application of Garden Design Style in Tang Dynasty to the Design of Modern City Public Gardens: A Case Study of Tang Paradise

Public garden, as a type of Chinese classical garden, is an important historical heritage and cultural landscape of the current traditional city. However, under the background of modern urbanization, urban living environment is out of the traditional history and culture and facing such issue as cement jungle. In order to improve the living environment and make the city coordinate with the natural environment, the development of modern urban gardens needs inheritance and development of traditional garden practices. The planning and design methods with scientific guidance were studied in this paper through exploring the application of garden design style in Tang Dynasty in the design of modern city public gardens, so as to inherit the classical garden culture and create a city open space that meets the needs of contemporary citizens as well.

基于StyleGAN的草图生成产品设计效果图方法研究

目的解决当前产品设计表达中存在对设计师要求高、设计思维具有局限性、设计周期长等问题。方法提出基于StyleGAN的草图快速生成产品效果图像的方法,该方法利用图像变形技术,将不同程度的产品草图生成真实产品效果图像。结果该方法可有效地满足设计师创作需求,也能为没有绘画基础的用户生成高质量的产品设计方案。结论将基于深度学习的StyleGAN模型应用于草图生成真实产品效果图像中,能快速、高效地完成产品设计表达过程,为产品设计表达提供了一个基于深度学习技术的参考框架,也是传统产品设计在人工智能时代的一次创新性探索。

Finite Element Analysis and Optimal Design Based on ANSYS in a XH2408 Gantry Style NC Machining Center

ANSYS, the software of construction analysis, is used to analyze static and dynamic performances of a XH2408 gantry style numerical control （NC） milling machining center and optimize its construction using the finite element method. First, a finite element model is established and the static and dynamic analysis are completed as constraints and loads applied on the finite element model. It is found that both spindle box and gantry are the worst components of assembly in performance. Secondly, the spindle box and gantry are chosen as objects of optimal design separately, aiming to improve their performance. The optimal plans are accomplished on the basis of the minimum volume for the spindle box and the maximum inherent frequency for the gantry subject to the constrains. Finally, the machine tool improved is analyzed statically and dynamically based on the optimal results of the spindle box and gantry. The results show that optimal design with the finite element method increases static and dynamical performances of the XH2408 gantry style numerical control milling machining center and the technique is effective and practical in engineering applications.

Research on Teaching Method of Packaging Design Course Based on Chinese Style

The teaching of Packaging Design started late in China,but develops fast.After experiencing the changes of economy,politics and culture,it has entered a new era of self-publicity.The Chinese style has come out quietly with a strong momentum.The contents of packaging design in the new era pay more attention to the spiritual level,and become a bridge between the society and people,forming an aesthetics concept with the spirit of the Chinese people.Based on the application of Chinese style in the course of Packaging Design,this paper discusses the characteristics of Packaging Design with Chinese style and the problems of traditional Packaging Design,and puts forward how to better apply Chinese elements in Packaging Design.